Kathy Nguyen

College of Sciences

Works (5)

Updated: April 24th, 2025 09:20

2023 article

Tolyporphins–Exotic Tetrapyrrole Pigments in a Cyanobacterium—A Review

Nguyen, K.-U., Zhang, Y., Liu, Q., Zhang, R., Jin, X., Taniguchi, M., … Lindsey, J. S. (2023, August 18). Molecules, Vol. 28.

By: K. Nguyen n, Y. Zhang n, Q. Liu n, R. Zhang n, X. Jin  n, M. Taniguchi n , E. Miller n , J. Lindsey n 

author keywords: bacteriochlorin; bioinformatics; biosynthesis; chlorophyll; cyanobacteria; field biology; gene cluster; genomics; natural products; tolyporphins
MeSH headings : Tetrapyrroles; Cyanobacteria / genetics; Porphyrins / pharmacology; Cardiac Glycosides
topics (OpenAlex): Marine Sponges and Natural Products; Porphyrin and Phthalocyanine Chemistry; Photosynthetic Processes and Mechanisms
TL;DR: The identification of putative biosynthetic gene clusters in the HT-58-2 cyanobacterial genome and accompanying studies suggest a new biosynthesis paradigm in the tetrapyrrole arena, which stands alone in the large pigments-of-life family. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 2, 2023

2022 article

Tailoring the AIE Chromogen 2-(2-Hydroxyphenyl)benzothiazole for Use in Enzyme-Triggered Molecular Brachytherapy

Wu, Z., Dou, J., Nguyen, K.-U., Eppley, J. C., Siwawannapong, K., Zhang, Y., & Lindsey, J. S. (2022, December 8). Molecules, Vol. 27.

By: Z. Wu n, J. Dou n, K. Nguyen n, J. Eppley  n, K. Siwawannapong n, Y. Zhang n, J. Lindsey n 

author keywords: aggregation; cancer; insolubilization; molecular design; phosphodiester; precipitation; radiotherapy
MeSH headings : Prodrugs; Brachytherapy; Benzothiazoles; Polyethylene Glycols
topics (OpenAlex): Luminescence and Fluorescent Materials; Nanoplatforms for cancer theranostics; Click Chemistry and Applications
TL;DR: Several 2-(2-hydroxyphenyl)benzothiazole substrates that readily aggregate in aqueous solution (and afford AIE) were elaborated, taking a step forward on the long road toward molecular brachytherapy. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023

2021 article

Fluorescence Assay for Tolyporphins Amidst Abundant Chlorophyll in Crude Cyanobacterial Extracts

Nguyen, K. U., Zhang, R., Taniguchi, M., & Lindsey, J. S. (2021, June 21). Photochemistry and Photobiology, Vol. 7, pp. 1507–1515.

By: K. Nguyen n, R. Zhang n, M. Taniguchi n  & J. Lindsey n 

Contributors: K. Nguyen n, R. Zhang n, M. Taniguchi n  & J. Lindsey n 

MeSH headings : Chlorophyll / chemistry; Chlorophyll A; Cyanobacteria / chemistry; Fluorescence; Spectrometry, Fluorescence
topics (OpenAlex): Photosynthetic Processes and Mechanisms; Algal biology and biofuel production; Marine and coastal ecosystems
TL;DR: Tolyporphins were readily detected in cultures of HT‐58‐2 at reasonable growth periods in the absence of environmental stressors, which was not possible previously. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 26, 2021

2021 article

Identification of Putative Biosynthetic Gene Clusters for Tolyporphins in Multiple Filamentous Cyanobacteria

Jin, X., Zhang, Y., Zhang, R., Nguyen, K.-U., Lindsey, J. S., & Miller, E. S. (2021, July 28). Life, Vol. 8.

By: X. Jin n, Y. Zhang n, R. Zhang n, K. Nguyen n, J. Lindsey n  & E. Miller n 

author keywords: tolyporphins; tetrapyrroles; cyanobacteria; biosynthetic gene cluster; Brasilonema; Nostoc; Oculatella
topics (OpenAlex): Algal biology and biofuel production; Photosynthetic Processes and Mechanisms; Biocrusts and Microbial Ecology
TL;DR: Phylogenetic analysis based on 16S rRNA and a common component of the BGCs, TolD, points to a close evolutionary history between each strain and their respective tolyporphins BGC, and a collection of candidate cyanobacteria for genetic and biochemical analysis pertaining to these unusual tetrapyrrole macrocycles. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021

2020 article

Engineering of an archaeal phosphodiesterase to trigger aggregation-induced emission (AIE) of synthetic substrates

Zhang, Y., Wu, Z., Takashima, I., Nguyen, K.-U., Matsumoto, N., & Lindsey, J. S. (2020, January 1). New Journal of Chemistry, Vol. 44, pp. 14266–14277.

By: Y. Zhang n, Z. Wu n, I. Takashima  n, K. Nguyen n, N. Matsumoto n & J. Lindsey n 

topics (OpenAlex): Luminescence and Fluorescent Materials; Nicotinic Acetylcholine Receptors Study; Molecular Sensors and Ion Detection
TL;DR: The development of enzymatically triggered substrates and the complementary heterologous enzymes may support diverse applications in the life sciences. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 14, 2020

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