Veronica B. Hubble

Works (3)

Updated: July 5th, 2023 15:39

2020 article

Augmenting the Activity of Macrolide Adjuvants against Acinetobacter baumannii

Hubble, V. B., Bartholomew, K. R., Weig, A. W., Brackett, S. M., Barlock, S. L., Mattingly, A. E., … Melander, C. (2020, August 12). ACS Medicinal Chemistry Letters.

By: V. Hubble*, K. Bartholomew n, A. Weig*, S. Brackett*, S. Barlock*, A. Mattingly *, A. Nemeth*, R. Melander*, C. Melander *

author keywords: Acinetobacter baumannii; adjuvant; antibiotic resistance; macrolide potentiation
topics (OpenAlex): Antibiotic Resistance in Bacteria; Pneumocystis jirovecii pneumonia detection and treatment; Cancer therapeutics and mechanisms
TL;DR: A structure-activity relationship study of a panel of derivatives structurally inspired by the previously reported aryl 2-AI leads finds a lead that potentiates clarithromycin by 64- and 32-fold against AB5075 at 10 and 7.5 μM, exceeding the dose response of the original lead. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 12, 2020

2018 article

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa

Hubble, V. B., Hubbard, B. A., Minrovic, B. M., Melander, R. J., & Melander, C. (2018, November 16). ACS Infectious Diseases.

By: V. Hubble*, B. Hubbard n, B. Minrovic*, R. Melander* & C. Melander*

author keywords: antibiotic resistance; antibiotic adjuvant; cystic fibrosis; Pseudomonas aeruginosa
MeSH headings : Adjuvants, Pharmaceutic / chemistry; Animals; Anti-Bacterial Agents / pharmacology; Azithromycin / pharmacology; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Cystic Fibrosis / drug therapy; Cystic Fibrosis / microbiology; Disease Models, Animal; Drug Repositioning; Larva / drug effects; Larva / microbiology; Microbial Sensitivity Tests; Moths / drug effects; Moths / microbiology; Pseudomonas aeruginosa / drug effects; Respiratory Tract Infections / drug therapy
topics (OpenAlex): Cystic Fibrosis Research Advances; Antibiotic Resistance in Bacteria; Bacterial biofilms and quorum sensing
TL;DR: A novel approach to combatting pseudomonal infections through the use of bis-2-aminoimidazole adjuvants that can potentiate the activity of a macrolide antibiotic commonly prescribed to CF patients as an anti-inflammatory agent is described. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 20, 2020

2015 article

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

Stephens, M. D., Hubble, V. B., Ernst, R. K., Hoek, M. L., Melander, R. J., Cavanagh, J., & Melander, C. (2015, September 30). MedChemComm.

By: M. Stephens n, V. Hubble n, R. Ernst *, M. Hoek *, R. Melander n, J. Cavanagh n, C. Melander n

topics (OpenAlex): Bacillus and Francisella bacterial research; Antibiotic Resistance in Bacteria; Bacterial biofilms and quorum sensing; Energetic Materials and Combustion
TL;DR: A screen of 20 compounds identified small molecule adjuvants capable of potentiating anitbiotic activty against Francisella philomiragia and led to the discovery of a potentially new class of small molecule aduvants containg an indole core. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.