Veronica B. Hubble

Works (3)

Updated: July 5th, 2023 15:39

2020 journal article

Augmenting the Activity of Macrolide Adjuvants against Acinetobacter baumannii

ACS MEDICINAL CHEMISTRY LETTERS, 11(9), 1723–1731.

By: V. Hubble*, K. Bartholomew n, A. Weig*, S. Brackett*, S. Barlock*, A. Mattingly*, A. Nemeth*, R. Melander*, C. Melander *

author keywords: Acinetobacter baumannii; adjuvant; antibiotic resistance; macrolide potentiation
TL;DR: A structure-activity relationship study of a panel of derivatives structurally inspired by the previously reported aryl 2-AI leads finds a lead that potentiates clarithromycin by 64- and 32-fold against AB5075 at 10 and 7.5 μM, exceeding the dose response of the original lead. (via Semantic Scholar)
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Source: Web Of Science
Added: October 12, 2020

2019 journal article

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa

ACS INFECTIOUS DISEASES, 5(1), 141–151.

By: V. Hubble*, B. Hubbard n, B. Minrovic*, R. Melander* & C. Melander*

author keywords: antibiotic resistance; antibiotic adjuvant; cystic fibrosis; Pseudomonas aeruginosa
MeSH headings : Adjuvants, Pharmaceutic / chemistry; Animals; Anti-Bacterial Agents / pharmacology; Azithromycin / pharmacology; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Cystic Fibrosis / drug therapy; Cystic Fibrosis / microbiology; Disease Models, Animal; Drug Repositioning; Larva / drug effects; Larva / microbiology; Microbial Sensitivity Tests; Moths / drug effects; Moths / microbiology; Pseudomonas aeruginosa / drug effects; Respiratory Tract Infections / drug therapy
TL;DR: A novel approach to combatting pseudomonal infections through the use of bis-2-aminoimidazole adjuvants that can potentiate the activity of a macrolide antibiotic commonly prescribed to CF patients as an anti-inflammatory agent is described. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 20, 2020

2016 journal article

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

MEDCHEMCOMM, 7(1), 128–131.

By: M. Stephens n, V. Hubble n, R. Ernst *, M. Hoek *, R. Melander n, J. Cavanagh n, C. Melander n

TL;DR: A screen of 20 compounds identified small molecule adjuvants capable of potentiating anitbiotic activty against Francisella philomiragia and led to the discovery of a potentially new class of small molecule aduvants containg an indole core. (via Semantic Scholar)
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Added: August 6, 2018

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