Works (14)

Updated: May 22nd, 2024 06:25

2024 article

A novel <i>ITGA2B</i> double cytosine frameshift variant (c.1986_1987insCC) leads to Glanzmann&apos;s thrombasthenia in a cat

Rivas, V. N., Tan, A. W. K., Shaverdian, M., Nguyen, N. P., Wouters, J. R., Stern, J. A., & Li, R. H. L. (2024, March 1). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 3.

By: V. Rivas n, A. Tan*, M. Shaverdian*, N. Nguyen*, J. Wouters*, J. Stern n, R. Li n

author keywords: congenital; feline; glycoprotein IIb/IIIa; macrothrombocytopenia; precision medicine; thrombopathia
TL;DR: This study provides a small-volume, standardized, successful protocol for adequate platelet RNA isolation and subsequent molecular assessment of gene expression in cats and identified yet another variant that may be of utility for screening in the feline population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 8, 2024

2023 journal article

Advancing Treatments for Feline Hypertrophic Cardiomyopathy The Role of Animal Models and Targeted

Veterinary Clinics of North America - Small Animal Practice.

Contributors: J. Kaplan*, V. Rivas* & D. Connolly*

TL;DR: This article outlines the key work performed using cellular and animal models that has led to and continues to guide the development of new innovative therapeutic strategies for HCM in cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 6, 2024

2023 journal article

Delayed-release rapamycin halts progression of left ventricular hypertrophy in subclinical feline hypertrophic results of the RAPACAT trial

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(11), 1628–1637.

By: J. Kaplan*, V. Rivas n, A. Walker*, L. Grubb, A. Farrell, S. Fitzgerald, S. Kennedy, C. Pjauregui ...

Contributors: J. Kaplan*, V. Rivas n, A. Walker*, L. Grubb, A. Farrell, S. Fitzgerald, S. Kennedy, C. Pjauregui ...

author keywords: HCM; sirolimus; occult; cat; mTOR
TL;DR: It is demonstrated that DR rapamycin was well tolerated and may prevent or delay progressive LV hypertrophy in cats with subclinical HCM and no demographic, echocardiographic, or clinicopathologic values were significantly different between study groups at baseline, confirming successful randomization. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 6, 2024

2023 journal article

Effects of <i>Aficamten</i> on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy

Scientific Reports.

Contributors: A. Sharpe*, M. Oldach*, V. Rivas*, J. Kaplan*, A. Walker*, S. Kovacs*, D. Hwee*, P. Cremin* ...

TL;DR: Promising beneficial effects of reduced systolic function warrant further studies of this next-in-class therapeutic to evaluate the benefit of long-term administration in this patient population of HCM-affected patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 6, 2024

2023 journal article

Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C

SCIENTIFIC REPORTS, 13(1).

By: J. Stern n, V. Rivas n, J. Kaplan*, Y. Ueda n, M. Oldach*, E. Ontiveros*, K. Kooiker*, S. Dijk*, S. Harris*

Contributors: J. Stern n, V. Rivas n, J. Kaplan*, Y. Ueda n, M. Oldach*, E. Ontiveros*, K. Kooiker*, S. Dijk*, S. Harris*

TL;DR: The occurrence of a more severe phenotype in later generations of cats, and the occasional occurrence of HCM in wildtype cats suggests the presence of at least one gene modifier or a second causal variant in this research colony that exacerbates the HCM phenotype when inherited in combination with the A31P mutation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 18, 2023

2023 journal article

Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study

ANIMALS, 13(20).

By: V. Rivas n, J. Kaplan*, S. Kennedy, S. Fitzgerald, A. Crofton*, A. Farrell, L. Grubb, C. Jauregui n ...

author keywords: mTOR (mammalian/mechanistic target of rapamycin); transcriptomics (RNA sequencing); proteomics (LCMS); sirolimus; autophagy; cat; translational; large animal model
TL;DR: Following repeated weekly dosing, transcriptomic differences between the low- and high-dose groups support dose-responsive suppressive effects on myocardial hypertrophy and stimulatory effects on autophagy, and rapamycin treatment continues to show great mechanistic promise in addressing the pathophysiologic features of HCM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 13, 2023

2023 journal article

Pharmacokinetics of a single dose of <i>Aficamten</i> (CK-274) on cardiac contractility in a A31P <i>MYBPC3</i> hypertrophic cardiomyopathy cat model

Journal of Veterinary Pharmacology and Therapeutics.

Contributors: A. Sharpe*, M. Oldach*, J. Kaplan*, V. Rivas*, S. Kovacs*, D. Hwee*, B. Morgan*, F. Malik*, S. Harris*, J. Stern*

TL;DR: The marked reduction in systolic function and reduced IVRT coupled with an increased heart rate in treated cats, suggest a lower dose may be optimal, and further studies to determine optimal dosing of aficamten are indicated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 6, 2024

2023 article

Sex-specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta)

Rivas, V. N., Ueda, Y., & Stern, J. A. (2023, July 17). JOURNAL OF MEDICAL PRIMATOLOGY, Vol. 7.

By: V. Rivas n, Y. Ueda n & J. Stern n

author keywords: diastology; E/A; hemodynamics; HFpEF; IVRT; monkey
TL;DR: Diastolic dysfunction in humans is an age‐related process with an overrepresentation in women, and in rhesus macaques (Macaca mulatta), the incidence and predictors have yet to be reported. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 21, 2023

2023 journal article

Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet‐dependent thrombin generation in cats

Journal of Veterinary Internal Medicine, 37(4), 1390–1400.

By: S. Lo*, R. Li*, C. Georges*, N. Nguyen*, C. Chen*, C. Stuhlmann*, M. Oldach*, V. Rivas* ...

TL;DR: Treatment combining clopidogrel and rivaroxaban (DAT) safely decreases platelet activation, platelet response to agonists, and thrombin generation in feline platelets more effectively than monotherapy with either clopIDogrel or rivroxaban. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 10, 2023

2023 article

The Role of Personalized Medicine in Companion Animal Cardiology

Rivas, V. N., Stern, J. A., & Ueda, Y. (2023, November). VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, Vol. 53, pp. 1255–1276.

By: V. Rivas n, J. Stern n & Y. Ueda n

Contributors: V. Rivas n, J. Stern n & Y. Ueda n

author keywords: Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy (DCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cats; Dogs; Pharmacogenetics; Pharmacogenomics; Genetics
TL;DR: The need and use of personalized one-health approaches to cardiovascular case management and advancement in pharmacogenetic-based therapy in veterinary medicine are highlighted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 6, 2024

2021 journal article

Increased alpha-tocopherol metabolism in horses with equine neuroaxonal dystrophy

Journal of Veterinary Internal Medicine.

Contributors: E. Hales*, H. Habib*, G. Favro*, S. Katzman*, R. Sakai*, S. Marquardt*, M. Bordbari*, B. Ming-Whitfield* ...

TL;DR: Increased α-tocopherol metabolism in eNAD/EDM-affected QHs provides novel insight into alterations in vitamin E processing in e nad/edM and highlights the need for high-dose supplementation to prevent the clinical phenotype in genetically susceptible horses. (via Semantic Scholar)
Source: ORCID
Added: February 6, 2024

2020 journal article

A nonsense variant in Rap Guanine Nucleotide Exchange Factor 5 (RAPGEF5) is associated with equine familial isolated hypoparathyroidism in Thoroughbred Foals

PLOS Genetics.

Contributors: V. Rivas*, K. Magdesian*, S. Fagan*, N. Slovis*, D. Luethy*, L. Javsicas, B. Caserto, A. Miller* ...

TL;DR: This RAPGEF5 variant represents the first genetic variant for hypoparathyroidism identified in any domestic animal species and was tested in the authors' Xenopus overexpression model and demonstrated RAP GEF5 loss-of-function. (via Semantic Scholar)
Source: ORCID
Added: February 6, 2024

2019 journal article

TRIM39-RPP21 Variants (Delta 19InsCCC) Are Not Associated with Juvenile Idiopathic Epilepsy in Egyptian Arabian Horses

Genes.

TL;DR: A new sample set consisting of nine EEG-phenotyped affected and nine unaffected Egyptian Arabian horses were genotyped using Sanger sequencing and found no significant genotypic or allelic association with the ∆19InsCCC variant and JIE status. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 6, 2024

2018 journal article

An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in <i>Ttpa</i>-null mice

Free Radical Biology and Medicine.

Contributors: C. Finno*, M. Bordbari*, G. Gianino*, B. Ming-Whitfield*, E. Burns*, J. Merkel*, M. Britton*, B. Durbin-Johnson* ...

TL;DR: It is found that &agr;‐TOH deficiency induces LXR, which may lead to a molecular signature of microglial activation and contribute to sensory neurodegeneration and neurologic deficits can be observed as early as 6 months of age in Ttpa‐/‐ mice. (via Semantic Scholar)
Source: ORCID
Added: February 6, 2024

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