William Anthony Cantara

Works (4)

Updated: July 5th, 2023 15:51

2013 article

Expanded use of sense codons is regulated by modified cytidines in tRNA

Cantara, W. A., Murphy, F. V., Demirci, H., & Agris, P. F. (2013, June 18). Proceedings of the National Academy of Sciences.

By: W. Cantara n, F. Murphy *, H. Demirci * & P. Agris *

author keywords: modified nucleosides; ribosome crystallography; tautomerism
MeSH headings : Base Pairing; Codon / chemistry; Codon / genetics; Crystallography, X-Ray; Cytidine / analogs & derivatives; Cytidine / chemistry; Humans; Isomerism; Models, Molecular; Nucleic Acid Conformation; RNA, Transfer / chemistry; RNA, Transfer / genetics; RNA, Transfer, Met / chemistry; RNA, Transfer, Met / genetics
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Genomics and Phylogenetic Studies
TL;DR: A modification of cytidine, 5-formylcytidine (f5C), at the wobble position-34 of human mitochondrial () enables expanded decoding of AUA, resulting in a deviation in the genetic code. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Modifications Modulate Anticodon Loop Dynamics and Codon Recognition of E. coli tRNAArg1,2

Cantara, W. A., Bilbille, Y., Kim, J., Kaiser, R., Leszczyńska, G., Malkiewicz, A., & Agris, P. F. (2012, January 3). Journal of Molecular Biology.

By: W. Cantara n, Y. Bilbille n, J. Kim  n, R. Kaiser*, G. Leszczyńska *, A. Malkiewicz*, P. Agris *

author keywords: 2-thiocytidine; inosine; 2-methyladenosine; RNA structure; RNA function
MeSH headings : Anticodon / chemistry; Base Pairing; Binding Sites; Circular Dichroism; Codon / chemistry; Crystallography, X-Ray; Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli Proteins / chemistry; Nucleic Acid Conformation; Protein Conformation; Protein Isoforms / chemistry; Protein Processing, Post-Translational; RNA, Transfer, Arg / chemistry; Thermodynamics
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Genomics and Phylogenetic Studies
TL;DR: The results suggest that, by allowing loop flexibility, the modifications modulate the conformation of the ASL(Arg1,2), which takes one structure free in solution and two others when bound to the cognate arginyl-tRNA synthetase or to codons on the ribosome where modifications reduce or restrict binding to specific codons. (via Semantic Scholar)
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Added: August 6, 2018

2011 article

Human tRNALys3UUU Is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto–Enol Tautomerism

Vendeix, F. A. P., Murphy, F. V., Cantara, W. A., Leszczyńska, G., Gustilo, E. M., Sproat, B., … Agris, P. F. (2011, December 29). Journal of Molecular Biology.

By: F. Vendeix n, F. Murphy *, W. Cantara n, G. Leszczyńska *, E. Gustilo n, B. Sproat, A. Malkiewicz*, P. Agris n

author keywords: modifications; wobble decoding; anticodon structure; tRNA(LYs3)
MeSH headings : Anticodon / chemistry; Base Pairing; Circular Dichroism; Codon / chemistry; Crystallography, X-Ray; Humans; Hydrogen Bonding; Models, Molecular; Nucleic Acid Conformation; Pseudouridine / chemistry; RNA, Transfer, Lys / chemistry; Thermodynamics; Thiouridine / analogs & derivatives; Thiouridine / chemistry
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Genomics and Phylogenetic Studies
TL;DR: The results unambiguously demonstrate that modifications pre-structure the anticodon as a key prerequisite for efficient and accurate recognition of cognate and wobble codons. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

Synthesis and investigation of the 5-formylcytidine modified, anticodon stem and loop of the human mitochondrial tRNAMet

Lusic, H., Gustilo, E. M., Vendeix, F. A. P., Kaiser, R., Delaney, M. O., Graham, W. D., … Deiters, A. (2008, October 16). Nucleic Acids Research.

By: H. Lusic*, E. Gustilo n, F. Vendeix n, R. Kaiser n, M. Delaney n, W. Graham n, V. Moye n, W. Cantara n, P. Agris n, A. Deiters n

MeSH headings : Anticodon / chemistry; Base Sequence; Codon / metabolism; Cytidine / analogs & derivatives; Cytidine / chemistry; Humans; Molecular Sequence Data; Nucleic Acid Conformation; Protein Biosynthesis; RNA / chemistry; RNA, Mitochondrial; RNA, Transfer, Met / chemical synthesis; RNA, Transfer, Met / chemistry; RNA, Transfer, Met / metabolism; Thermodynamics
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; RNA Research and Splicing
TL;DR: The first synthesis and analyses of the tRNA's anticodon stem and loop domain containing the 5-formylcytidine modification are reported, contributing to the tRNAs anticodon domain structure, thermodynamic properties and its ability to bind codons AUA and AUG in translational initiation and elongation. (via Semantic Scholar)
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Added: August 6, 2018

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