William Anthony Cantara

Works (4)

Updated: July 5th, 2023 15:51

2013 journal article

Expanded use of sense codons is regulated by modified cytidines in tRNA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(27), 10964–10969.

By: W. Cantara n, F. Murphy *, H. Demirci * & P. Agris *

author keywords: modified nucleosides; ribosome crystallography; tautomerism
MeSH headings : Base Pairing; Codon / chemistry; Codon / genetics; Crystallography, X-Ray; Cytidine / analogs & derivatives; Cytidine / chemistry; Humans; Isomerism; Models, Molecular; Nucleic Acid Conformation; RNA, Transfer / chemistry; RNA, Transfer / genetics; RNA, Transfer, Met / chemistry; RNA, Transfer, Met / genetics
TL;DR: A modification of cytidine, 5-formylcytidine (f5C), at the wobble position-34 of human mitochondrial () enables expanded decoding of AUA, resulting in a deviation in the genetic code. (via Semantic Scholar)
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2012 journal article

Modifications Modulate Anticodon Loop Dynamics and Codon Recognition of E. coli tRNA (Arg1,2)

JOURNAL OF MOLECULAR BIOLOGY, 416(4), 579–597.

By: W. Cantara n, Y. Bilbille n, J. Kim  n, R. Kaiser*, G. Leszczynska *, A. Malkiewicz*, P. Agris *

author keywords: 2-thiocytidine; inosine; 2-methyladenosine; RNA structure; RNA function
MeSH headings : Anticodon / chemistry; Base Pairing; Binding Sites; Circular Dichroism; Codon / chemistry; Crystallography, X-Ray; Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli Proteins / chemistry; Nucleic Acid Conformation; Protein Conformation; Protein Isoforms / chemistry; Protein Processing, Post-Translational; RNA, Transfer, Arg / chemistry; Thermodynamics
TL;DR: The results suggest that, by allowing loop flexibility, the modifications modulate the conformation of the ASL(Arg1,2), which takes one structure free in solution and two others when bound to the cognate arginyl-tRNA synthetase or to codons on the ribosome where modifications reduce or restrict binding to specific codons. (via Semantic Scholar)
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Added: August 6, 2018

2011 journal article

Human tRNA(UUU)(LYs3) Is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto-Enol Tautomerism

JOURNAL OF MOLECULAR BIOLOGY, 416(4), 467–485.

By: F. Vendeix n, F. Murphy *, W. Cantara n, G. Leszczynska *, E. Gustilo n, B. Sproat, A. Malkiewicz*, P. Agris n

author keywords: modifications; wobble decoding; anticodon structure; tRNA(LYs3)
MeSH headings : Anticodon / chemistry; Base Pairing; Circular Dichroism; Codon / chemistry; Crystallography, X-Ray; Humans; Hydrogen Bonding; Models, Molecular; Nucleic Acid Conformation; Pseudouridine / chemistry; RNA, Transfer, Lys / chemistry; Thermodynamics; Thiouridine / analogs & derivatives; Thiouridine / chemistry
TL;DR: The results unambiguously demonstrate that modifications pre-structure the anticodon as a key prerequisite for efficient and accurate recognition of cognate and wobble codons. (via Semantic Scholar)
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Added: August 6, 2018

2008 journal article

Synthesis and investigation of the 5-formylcytidine modified, anticodon stem and loop of the human mitochondrial tRNA(Met)

NUCLEIC ACIDS RESEARCH, 36(20), 6548–6557.

By: H. Lusic n, E. Gustilo n, F. Vendeix n, R. Kaiser n, M. Delaney n, W. Graham n, V. Moye n, W. Cantara n, P. Agris n, A. Deiters n

MeSH headings : Anticodon / chemistry; Base Sequence; Codon / metabolism; Cytidine / analogs & derivatives; Cytidine / chemistry; Humans; Molecular Sequence Data; Nucleic Acid Conformation; Protein Biosynthesis; RNA / chemistry; RNA, Mitochondrial; RNA, Transfer, Met / chemical synthesis; RNA, Transfer, Met / chemistry; RNA, Transfer, Met / metabolism; Thermodynamics
TL;DR: The first synthesis and analyses of the tRNA's anticodon stem and loop domain containing the 5-formylcytidine modification are reported, contributing to the tRNAs anticodon domain structure, thermodynamic properties and its ability to bind codons AUA and AUG in translational initiation and elongation. (via Semantic Scholar)
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