William Smith

Works (3)

Updated: April 5th, 2024 12:46

2023 journal article

Cytoplasmic male sterility and abortive seed traits generated through mitochondrial genome editing coupled with allotopic expression of atp1 in tobacco

FRONTIERS IN PLANT SCIENCE, 14.

By: R. Dewey n, D. Selote n, H. Griffin n, A. Dickey n, D. Jantz*, J. Smith*, A. Matthiadis *, J. Strable n, C. Kestell n, W. Smith n

author keywords: hybrid seed systems; allotopic expression; stenospermocarpy; atp1; transgene containment; substoichiometric shifting; mitoarcus; custom-designed meganucleases
TL;DR: Should the results reported here in tobacco prove to be translatable to other crop species, then multiple applications of allotopic expression of an essential mitochondrial gene followed by its elimination through genome editing can be envisaged. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: October 16, 2023

2022 journal article

Knockout of a key gene of the nicotine biosynthetic pathway severely affects tobacco growth under field, but not greenhouse conditions

BMC RESEARCH NOTES, 15(1).

By: W. Smith n, Y. Matsuba n & R. Dewey n

MeSH headings : Alkaloids; Biosynthetic Pathways / genetics; Gene Expression Regulation, Plant; Nicotine; Plant Proteins / genetics; Plant Proteins / metabolism; Plants, Genetically Modified / genetics; Tobacco / genetics; Tobacco / metabolism
TL;DR: Two conclusions can be inferred from this work: (1) QPT1 gene function alone appears to be inadequate for meeting the QPT demands of the plant for primary metabolism when grown in a field environment; and (2) the complete knockout of QPT2 function is not a viable strategy for producing agronomically useful, low nicotine tobaccos. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Source: Web Of Science
Added: September 19, 2022

2020 journal article

Genetic and Agronomic Analysis of Tobacco Genotypes Exhibiting Reduced Nicotine Accumulation Due to Induced Mutations in Berberine Bridge Like (BBL) Genes

FRONTIERS IN PLANT SCIENCE, 11.

By: R. Lewis n , K. Drake-Stowe n, C. Heim n, T. Steede n, W. Smith n & R. Dewey n

author keywords: tobacco; Nicotiana tabacum; nicotine; alkaloids; gene editing; regulation
TL;DR: Genetic methodologies for reducing nicotine accumulation in the tobacco plant (Nicotiana tabacum L.) are of interest because of potential future regulations that could mandate lowering of this alkaloid in conventional cigarettes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 18, 2020

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