William Darnell Graham

Works (7)

Updated: July 5th, 2023 15:53

2012 article

Functional Recognition of the Modified Human tRNA (Lys3) (UUU) Anticodon Domain by HIV's Nucleocapsid Protein and a Peptide Mimic (vol 410, pg 698, year 2011)

Journal of Molecular Biology, Vol. 420, pp. 259–259.

By: W. Graham, L. Barley-Maloney, C. Stark, A. Kaur, C. Stolarchuk, B. Sproat, G. Leszczynska, A. Malkiewicz ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Functional recognition of the modified human tRNA(UUU)(Lys3) anticodon domain by HIV's nucleocapsid protein and a peptide mimic

Journal of Molecular Biology, 410(4), 698–715.

By: W. Graham, L. Barley-Maloney, C. Stark, A. Kaur, K. Stolyarchuk, B. Sproat, G. Leszczynska, A. Malkiewicz ...

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Binding of aminoglycoside antibiotics to helix 69 of 23S rRNA

Nucleic Acids Research, 38(9), 3094–3105.

By: A. Scheunemann, W. Graham, F. Vendeix & P. Agris

Source: NC State University Libraries
Added: August 6, 2018

2008 article

A Disease-causing Point Mutation in Human Mitochondrial tRNAMet Results in tRNA Misfolding Leading to Defects in Translational Initiation and Elongation

Jones, C. N., Jones, C. I., Graham, W. D., Agris, P. F., & Spremulli, L. L. (2008, October 4). Journal of Biological Chemistry.

By: C. Jones *, C. Jones n, W. Graham n, P. Agris n & L. Spremulli*

MeSH headings : Animals; Base Sequence; Binding Sites; Cattle; Escherichia coli / enzymology; Humans; Mitochondria / enzymology; Mitochondria / metabolism; Mutation; Nucleic Acid Conformation; Nucleic Acid Denaturation; Optic Atrophy, Hereditary, Leber / genetics; Point Mutation; Protein Biosynthesis; RNA, Transfer, Met / chemistry; Thermodynamics
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Mitochondrial Function and Pathology
TL;DR: It is shown that the single 8U→C mutation leads to a failure of the tRNA to respond conformationally to Mg2+. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

Anticodon Domain Modifications Contribute Order to tRNA for Ribosome-Mediated Codon Binding

Vendeix, F. A. P., Dziergowska, A., Gustilo, E. M., Graham, W. D., Sproat, B., Malkiewicz, A., & Agris, P. F. (2008, May 13). Biochemistry.

By: F. Vendeix n, A. Dziergowska  n, E. Gustilo n, W. Graham n, B. Sproat n, A. Malkiewicz n, P. Agris n

MeSH headings : Anticodon / chemistry; Base Sequence; Binding Sites; Codon / chemistry; Codon / metabolism; Dinucleoside Phosphates / chemistry; Escherichia coli / genetics; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Oligoribonucleotides / chemistry; RNA, Bacterial / chemistry; RNA, Bacterial / genetics; RNA, Transfer / genetics; Ribosomes / metabolism
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Genomics and Phylogenetic Studies
TL;DR: Results clearly demonstrate that the xo (5)U 34-type modifications order the anticodon loop prior to A-site codon binding for an expanded codon reading, possibly reducing an entropic energy barrier to codonbinding. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

Synthesis and investigation of the 5-formylcytidine modified, anticodon stem and loop of the human mitochondrial tRNAMet

Lusic, H., Gustilo, E. M., Vendeix, F. A. P., Kaiser, R., Delaney, M. O., Graham, W. D., … Deiters, A. (2008, October 16). Nucleic Acids Research.

By: H. Lusic*, E. Gustilo n, F. Vendeix n, R. Kaiser n, M. Delaney n, W. Graham n, V. Moye n, W. Cantara n, P. Agris n, A. Deiters n

MeSH headings : Anticodon / chemistry; Base Sequence; Codon / metabolism; Cytidine / analogs & derivatives; Cytidine / chemistry; Humans; Molecular Sequence Data; Nucleic Acid Conformation; Protein Biosynthesis; RNA / chemistry; RNA, Mitochondrial; RNA, Transfer, Met / chemical synthesis; RNA, Transfer, Met / chemistry; RNA, Transfer, Met / metabolism; Thermodynamics
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; RNA Research and Splicing
TL;DR: The first synthesis and analyses of the tRNA's anticodon stem and loop domain containing the 5-formylcytidine modification are reported, contributing to the tRNAs anticodon domain structure, thermodynamic properties and its ability to bind codons AUA and AUG in translational initiation and elongation. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 review

tRNA's wobble decoding of the genome: 40 years of modification

[Review of ]. Journal of Molecular Biology, 366(1), 1–13.

By: P. Agris, F. Vendeix & W. Graham

Source: NC State University Libraries
Added: August 6, 2018

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