Works (36)
Updated: July 5th, 2023 15:34
2021 journal article
Epistasis for head morphology in Drosophila melanogaster
G3-GENES GENOMES GENETICS, 11(10).
author keywords: Drosophila Genetic Reference Panel; genome-wide association analyses; modifier loci; genetic interaction network
MeSH headings : Alleles; Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Epistasis, Genetic; Genome-Wide Association Study
TL;DR:
The Drosophila melanogaster Genetic Reference Panel of sequenced inbred lines is used to evaluate the magnitude of naturally occurring epistasis modifying the effects of mutations in jing and inv, two transcription factors that have subtle quantitative effects on head morphology as homozygotes.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: January 10, 2022
2021 journal article
Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(23).
author keywords: extreme QTL genome-wide association mapping; Drosophila Genetic Reference Panel; RNA interference; advanced intercross population
MeSH headings : Animals; Cocaine / pharmacology; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster; Epistasis, Genetic; Female; Genome-Wide Association Study; Humans; Male; Methamphetamine / pharmacology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Sex Characteristics
TL;DR:
It is shown that the genetic architecture underlying variation in voluntary cocaine and methamphetamine consumption differs between sexes and is dominated by variants in genes associated with connectivity and function of the nervous system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 23, 2021
2020 journal article
Context-dependent genetic architecture of Drosophila life span
PLOS BIOLOGY, 18(3).
MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene-Environment Interaction; Genetic Variation; Genome-Wide Association Study; Longevity / genetics; Male; RNA Interference; Temperature
TL;DR:
The results implicate novel candidate genes affecting life span and suggest that variation for life span may be maintained by variable allelic effects in heterogeneous environments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2020 journal article
Gene expression networks in the Drosophila Genetic Reference Panel
GENOME RESEARCH, 30(3), 485–496.
MeSH headings : Animals; DNA Transposable Elements; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Drosophila melanogaster / microbiology; Female; Gene Expression Regulation; Gene Regulatory Networks; Genetic Variation; High-Throughput Nucleotide Sequencing; Male; Microbiota / genetics; Quantitative Trait Loci; Sequence Analysis, RNA
TL;DR:
This study performed deep RNA sequencing of 200 Drosophila Genetic Reference Panel inbred lines with complete genome sequences and mapped expression quantitative trait loci for annotated genes, novel transcribed regions, transposable elements and microbial species, providing new insights regarding the role of natural genetic variation in regulating gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 14, 2020
2020 journal article
Genetic Basis of Increased Lifespan and Postponed Senescence in Drosophila melanogaster
G3-GENES GENOMES GENETICS, 10(3), 1087–1098.
author keywords: Laboratory evolution; candidate genes; RNAi
MeSH headings : Aging / genetics; Animals; Drosophila melanogaster / genetics; Female; Gene Expression; Genes, Insect; Longevity / genetics; Male; Ovary / metabolism; RNA Interference; Reproduction / genetics
TL;DR:
Identifying evolutionarily conserved genes affecting increased lifespan and delayed reproductive senescence is the first step toward understanding the evolutionary forces that maintain segregating variation at these loci in nature and may provide potential targets for therapeutic intervention to delay senescences while increasing lifespan.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 8, 2020
2020 journal article
Genetic Basis of Natural Variation in Spontaneous Grooming in Drosophila melanogaster
G3-GENES GENOMES GENETICS, 10(9), 3453–3460.
Contributors: A. Yanagawa*, *, A. Yamamoto n, A. Wada-Katsumata n , C. Schal n & T. Mackay *
author keywords: Drosophila Genetic Reference Panel; genome wide association analysis; RNA interference; behavioral genetics
MeSH headings : Animals; Drosophila melanogaster / genetics; Epistasis, Genetic; Female; Genetic Variation; Genome-Wide Association Study; Grooming
TL;DR:
Although grooming behavior is highly correlated between males and females, significant sex by genotype interactions are observed, indicating that the genetic basis of spontaneous grooming is partially distinct in the two sexes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 5, 2020
2020 journal article
Genotype by environment interaction for gene expression in Drosophila melanogaster
NATURE COMMUNICATIONS, 11(1).
MeSH headings : Animals; Drosophila melanogaster / genetics; Female; Gene Expression; Gene Expression Regulation; Gene Regulatory Networks; Gene-Environment Interaction; Genes, Insect; Genetic Variation; Genotype; Male; Quantitative Trait Loci; RNA-Seq; Temperature; Transcriptome
TL;DR:
It is shown that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co- expression network remains robust, and data suggest that stabilizing selection on gene expression may promote co-expression network robustness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 30, 2020
2020 journal article
Leveraging Multiple Layers of Data To Predict Drosophila Complex Traits
G3-GENES GENOMES GENETICS, 10(12), 4599–4613.
Contributors: F. Morgante n, n, P. Sørensen *, C. Maltecca n & T. Mackay n
author keywords: Genomic prediction; Transcriptomic prediction; Gene Ontology informed prediction; Drosophila Genetic Reference Panel; GenPred; Shared data resources
MeSH headings : Animals; Drosophila; Drosophila melanogaster / genetics; Female; Genotype; Male; Models, Genetic; Multifactorial Inheritance; Phenotype; Polymorphism, Single Nucleotide
TL;DR:
This study shows that integrating different sources of information can improve prediction accuracy, especially when large samples are not available, as well as a limited number of GO terms were strongly predictive of the traits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 4, 2021
2020 journal article
Rapid and Predictable Evolution of Admixed Populations Between Two Drosophila Species Pairs
GENETICS, 214(1), 211–230.
author keywords: hybridization; introgression; reproductive isolation; speciation
MeSH headings : Animals; Biological Evolution; Chromosome Mapping; Drosophila / classification; Drosophila / genetics; Genetic Speciation; Genetic Variation; Genetics, Population; Genome; Hybridization, Genetic; Reproduction; Sexual Behavior, Animal
TL;DR:
The results indicate that nearly all foreign genes were quickly eliminated after hybridization and that selection against the minor species genome might be similar across experimental replicates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: January 21, 2020
2019 journal article
Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster
BEHAVIOR GENETICS, 49(1), 60–82.
author keywords: Drosophila melanogaster; Circadian rhythms; Genome-wide association; Period; Rhythmicity index
MeSH headings : Animals; Chromosome Mapping / methods; Circadian Rhythm / genetics; Drosophila Proteins / metabolism; Drosophila Proteins / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic / genetics; Genetic Variation / genetics; Genome-Wide Association Study / methods; Genotype; Mutation / genetics; Phenotype; Sex Characteristics
TL;DR:
The observed differences among transcripts for nine genes predicted to interact among themselves and canonical clock genes in the long period line and a control reveal that complex genetic interactions influence high levels of variation in circadian phenotypes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 28, 2019
2018 journal article
Effect of genetic architecture on the prediction accuracy of quantitative traits in samples of unrelated individuals
HEREDITY, 120(6), 500–514.
Contributors: F. Morgante n, n, C. Maltecca n & T. Mackay n
MeSH headings : Algorithms; Alleles; Animals; Computer Simulation; Data Interpretation, Statistical; Databases, Genetic; Drosophila melanogaster / genetics; Epistasis, Genetic; Gene Frequency; Genetic Association Studies; Genetic Variation; Genetics, Population; Genome-Wide Association Study / methods; Genotype; Linkage Disequilibrium; Models, Genetic; Quantitative Trait Loci; Quantitative Trait, Heritable; Reproducibility of Results
TL;DR:
The results indicate that accounting for genetic architecture can improve prediction accuracy for quantitative traits, especially when predictions are informed by the genetic architecture inferred from mapping the top variants affecting main effects and interactions in the training data, provided there is sufficient power for mapping.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
The Pacific decadal oscillation and changes in anchovy populations in the Northwest Pacific
Journal of Asian Earth Sciences, 114, 504–511.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
From sea to land: assessment of the bio-transport of phosphorus by penguins in Antarctica
Chinese Journal of Oceanology and Limnology = Zhongguo Hai Yang Hu Zhao Xue Bao, 32(1), 148–154.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines
Genome Research, 24(7), 1193–1208.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Relationship between magnetic susceptibility and grain size of sediments in the China Seas and its implications
Continental Shelf Research, 72, 131–137.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Knockdown of CDKN1C (p57(kip2)) and PHLDA2 results in developmental changes in bovine pre-implantation embryos
PLoS One, 8(7).
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Alternative splicing regulated by butyrate in bovine epithelial cells
PLoS One, 7(6).
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Precipitation in the Yellow River drainage basin and East Asian monsoon strength on a decadal time scale
Quaternary Research, 78(3), 486–491.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Accounting for genetic architecture improves sequence based genomic prediction for a Drosophila fitness trait
Ober, U., Huang, W., Magwire, M., Schlather, M., Simianer, H., & Mackay, T. F. C. PLoS One, 10(5).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior
Swarup, S., Huang, W., Mackay, T. F. C., & Anholt, R. R. H. Proceedings of the National Academy of Sciences of the United States of America, 110(3), 1017–1022.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Epistasis dominates the genetic architecture of Drosophila quantitative traits
Huang, W., Richards, S., Carbone, M. A., Zhu, D. H., Anholt, R. R. H., Ayroles, J. F., … Muzny, D. Proceedings of the National Academy of Sciences of the United States of America, 109(39), 15553–15559.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetic and genomic response to selection for food consumption in Drosophila melanogaster
Garlapow, M. E., Everett, L. J., Zhou, S. S., Gearhart, A. W., Fay, K. A., Huang, W., … Mackay, T. F. C. Behavior Genetics, 47(2), 227–243.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetic architecture of abdominal pigmentation in Drosophila melanogaster
Dembeck, L. M., Huang, W., Magwire, M. M., Lawrence, F., Lyman, R. F., & Mackay, T. F. C. PLoS Genetics, 11(5).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster
Dembeck, L. M., Boroczky, K., Huang, W., Schal, C., Anholt, R. R. H., & Mackay, T. F. C. Elife, 4.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetic architecture of natural variation in visual senescence in Drosophila
Carbone, M. A., Yamamoto, A., Huang, W., Lyman, R. A., Meadors, T. B., Yamamoto, R., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 113(43), E6620–6629.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetic basis of natural variation in body pigmentation in Drosophila melanogaster
Dembeck, L. M., Huang, W., Carbone, M. A., & Mackay, T. F. C. Fly, 9(2), 75–81.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genetic basis of transcriptome diversity in Drosophila melanogaster
Huang, W., Carbone, M. A., Magwire, M. M., Peiffer, J. A., Lyman, R. F., Stone, E. A., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 112(44), E6010–6019.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways
Montgomery, S. L., Vorojeikina, D., Huang, W., Mackay, T. F. C., Anholt, R. R. H., & Rand, M. D. PLoS One, 9(10).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Intrapopulation genome size variation in D. melanogaster reflects life history variation and plasticity
Ellis, L. L., Huang, W., Quinn, A. M., Ahuja, A., Alfrejd, B., Gomez, F. E., … Tarone, A. M. PLoS Genetics, 10(7).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila
Morozova, T. V., Huang, W., Pray, V. A., Whitham, T., Anholt, R. R. H., & Mackay, T. F. C. BMC Genomics, 16.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Quantitative genetics of food intake in Drosophila melanogaster
Garlapow, M. E., Huang, W., Yarboro, M. T., Peterson, K. R., & Mackay, T. F. C. PLoS One, 10(9).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Spontaneous mutations and the origin and maintenance of quantitative genetic variation
Huang, W., Lyman, R. F., Lyman, R. A., Carbone, M. A., Harbison, S. T., Magwire, M. M., & Mackay, T. F. C. Elife, 5.
Source: NC State University Libraries
Added: August 6, 2018
conference paper
The Persuasive phish: examining the social psychological principles hidden in phishing emails
Zielinska, O., Welk, A., Mayhorn, C. B., & Murphy-Hill, E. Symposium and Bootcamp on the Science of Security, 126–126.
Source: NC State University Libraries
Added: August 6, 2018
journal article
The genetic architecture of natural variation in recombination rate in Drosophila melanogaster
Hunter, C. M., Huang, W., Mackay, T. F. C., & Singh, N. D. PLoS Genetics, 12(4).
Source: NC State University Libraries
Added: August 6, 2018
journal article
The genetic basis for variation in olfactory behavior in Drosophila melanogaster
Arya, G. H., Magwire, M. M., Huang, W., Serrano-Negron, Y. L., Mackay, T. F. C., & Anholt, R. R. H. Chemical Senses, 40(4), 233–243.
Source: NC State University Libraries
Added: August 6, 2018
journal article
The genomic basis of postponed senescence in Drosophila melanogaster
Carnes, M. U., Campbell, T., Huang, W., Butler, D. G., Carbone, M. A., Duncan, L. H., … Mackay, T. F. C. PLoS One, 10(9).
Source: NC State University Libraries
Added: August 6, 2018
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