Works (36)

Updated: July 5th, 2023 15:34

2021 journal article

Epistasis for head morphology in Drosophila melanogaster

G3-GENES GENOMES GENETICS, 11(10).

By: E. Ozsoy*, M. Yilmaz*, B. Patlar*, G. Emecen*, E. Durmaz*, M. Magwire*, S. Zhou*, W. Huang*, R. Anholt n, T. Mackay n

author keywords: Drosophila Genetic Reference Panel; genome-wide association analyses; modifier loci; genetic interaction network
MeSH headings : Alleles; Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Epistasis, Genetic; Genome-Wide Association Study
TL;DR: The Drosophila melanogaster Genetic Reference Panel of sequenced inbred lines is used to evaluate the magnitude of naturally occurring epistasis modifying the effects of mutations in jing and inv, two transcription factors that have subtle quantitative effects on head morphology as homozygotes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: January 10, 2022

2021 journal article

Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(23).

By: B. Baker*, M. Carbone n, W. Huang*, R. Anholt* & T. Mackay*

author keywords: extreme QTL genome-wide association mapping; Drosophila Genetic Reference Panel; RNA interference; advanced intercross population
MeSH headings : Animals; Cocaine / pharmacology; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster; Epistasis, Genetic; Female; Genome-Wide Association Study; Humans; Male; Methamphetamine / pharmacology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Sex Characteristics
TL;DR: It is shown that the genetic architecture underlying variation in voluntary cocaine and methamphetamine consumption differs between sexes and is dominated by variants in genes associated with connectivity and function of the nervous system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 23, 2021

2020 journal article

Context-dependent genetic architecture of Drosophila life span

PLOS BIOLOGY, 18(3).

By: W. Huang n, T. Campbell n, M. Carbone n, W. Jones n, D. Unselt n, R. Anholt n, T. Mackay n

MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene-Environment Interaction; Genetic Variation; Genome-Wide Association Study; Longevity / genetics; Male; RNA Interference; Temperature
TL;DR: The results implicate novel candidate genes affecting life span and suggest that variation for life span may be maintained by variable allelic effects in heterogeneous environments. (via Semantic Scholar)
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Gene expression networks in the Drosophila Genetic Reference Panel

GENOME RESEARCH, 30(3), 485–496.

By: L. Everett n, W. Huang n, S. Zhou n, M. Carbone n, R. Lyman n, G. Arya n, M. Geisz n, J. Ma* ...

MeSH headings : Animals; DNA Transposable Elements; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Drosophila melanogaster / microbiology; Female; Gene Expression Regulation; Gene Regulatory Networks; Genetic Variation; High-Throughput Nucleotide Sequencing; Male; Microbiota / genetics; Quantitative Trait Loci; Sequence Analysis, RNA
TL;DR: This study performed deep RNA sequencing of 200 Drosophila Genetic Reference Panel inbred lines with complete genome sequences and mapped expression quantitative trait loci for annotated genes, novel transcribed regions, transposable elements and microbial species, providing new insights regarding the role of natural genetic variation in regulating gene expression. (via Semantic Scholar)
Source: Web Of Science
Added: April 14, 2020

2020 journal article

Genetic Basis of Increased Lifespan and Postponed Senescence in Drosophila melanogaster

G3-GENES GENOMES GENETICS, 10(3), 1087–1098.

By: G. Parker n, N. Kohn, A. Spirina, A. McMillen, W. Huang* & T. Mackay n

author keywords: Laboratory evolution; candidate genes; RNAi
MeSH headings : Aging / genetics; Animals; Drosophila melanogaster / genetics; Female; Gene Expression; Genes, Insect; Longevity / genetics; Male; Ovary / metabolism; RNA Interference; Reproduction / genetics
TL;DR: Identifying evolutionarily conserved genes affecting increased lifespan and delayed reproductive senescence is the first step toward understanding the evolutionary forces that maintain segregating variation at these loci in nature and may provide potential targets for therapeutic intervention to delay senescences while increasing lifespan. (via Semantic Scholar)
Source: Web Of Science
Added: May 8, 2020

2020 journal article

Genetic Basis of Natural Variation in Spontaneous Grooming in Drosophila melanogaster

G3-GENES GENOMES GENETICS, 10(9), 3453–3460.

By: A. Yanagawa*, W. Huang*, A. Yamamoto n, A. Wada-Katsumata n, C. Schal n & T. Mackay*

Contributors: A. Yanagawa*, W. Huang*, A. Yamamoto n, A. Wada-Katsumata n, C. Schal n & T. Mackay*

author keywords: Drosophila Genetic Reference Panel; genome wide association analysis; RNA interference; behavioral genetics
MeSH headings : Animals; Drosophila melanogaster / genetics; Epistasis, Genetic; Female; Genetic Variation; Genome-Wide Association Study; Grooming
TL;DR: Although grooming behavior is highly correlated between males and females, significant sex by genotype interactions are observed, indicating that the genetic basis of spontaneous grooming is partially distinct in the two sexes. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: October 5, 2020

2020 journal article

Genotype by environment interaction for gene expression in Drosophila melanogaster

NATURE COMMUNICATIONS, 11(1).

By: W. Huang n, M. Carbone n, R. Lyman n, R. Anholt n & T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Female; Gene Expression; Gene Expression Regulation; Gene Regulatory Networks; Gene-Environment Interaction; Genes, Insect; Genetic Variation; Genotype; Male; Quantitative Trait Loci; RNA-Seq; Temperature; Transcriptome
TL;DR: It is shown that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co- expression network remains robust, and data suggest that stabilizing selection on gene expression may promote co-expression network robustness. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 30, 2020

2020 journal article

Leveraging Multiple Layers of Data To Predict Drosophila Complex Traits

G3-GENES GENOMES GENETICS, 10(12), 4599–4613.

By: F. Morgante n, W. Huang n, P. Sorensen*, C. Maltecca n & T. Mackay n

Contributors: F. Morgante n, W. Huang n, P. Sørensen*, C. Maltecca n & T. Mackay n

author keywords: Genomic prediction; Transcriptomic prediction; Gene Ontology informed prediction; Drosophila Genetic Reference Panel; GenPred; Shared data resources
MeSH headings : Animals; Drosophila; Drosophila melanogaster / genetics; Female; Genotype; Male; Models, Genetic; Multifactorial Inheritance; Phenotype; Polymorphism, Single Nucleotide
TL;DR: This study shows that integrating different sources of information can improve prediction accuracy, especially when large samples are not available, as well as a limited number of GO terms were strongly predictive of the traits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID
Added: January 4, 2021

2020 journal article

Rapid and Predictable Evolution of Admixed Populations Between Two Drosophila Species Pairs

GENETICS, 214(1), 211–230.

By: D. Matute*, A. Comeault*, E. Earley*, A. Serrato-Capuchina*, D. Peede*, A. Monroy-Eklund*, W. Huang n, C. Jones*, T. Mackay n, J. Coyne*

author keywords: hybridization; introgression; reproductive isolation; speciation
MeSH headings : Animals; Biological Evolution; Chromosome Mapping; Drosophila / classification; Drosophila / genetics; Genetic Speciation; Genetic Variation; Genetics, Population; Genome; Hybridization, Genetic; Reproduction; Sexual Behavior, Animal
TL;DR: The results indicate that nearly all foreign genes were quickly eliminated after hybridization and that selection against the minor species genome might be similar across experimental replicates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: January 21, 2020

2019 journal article

Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster

BEHAVIOR GENETICS, 49(1), 60–82.

By: S. Harbison n, S. Kumar*, W. Huang n, L. McCoy n, K. Smith* & T. Mackay n

author keywords: Drosophila melanogaster; Circadian rhythms; Genome-wide association; Period; Rhythmicity index
MeSH headings : Animals; Chromosome Mapping / methods; Circadian Rhythm / genetics; Drosophila Proteins / metabolism; Drosophila Proteins / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic / genetics; Genetic Variation / genetics; Genome-Wide Association Study / methods; Genotype; Mutation / genetics; Phenotype; Sex Characteristics
TL;DR: The observed differences among transcripts for nine genes predicted to interact among themselves and canonical clock genes in the long period line and a control reveal that complex genetic interactions influence high levels of variation in circadian phenotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 28, 2019

2018 journal article

Effect of genetic architecture on the prediction accuracy of quantitative traits in samples of unrelated individuals

HEREDITY, 120(6), 500–514.

By: F. Morgante n, W. Huang n, C. Maltecca n & T. Mackay n

Contributors: F. Morgante n, W. Huang n, C. Maltecca n & T. Mackay n

MeSH headings : Algorithms; Alleles; Animals; Computer Simulation; Data Interpretation, Statistical; Databases, Genetic; Drosophila melanogaster / genetics; Epistasis, Genetic; Gene Frequency; Genetic Association Studies; Genetic Variation; Genetics, Population; Genome-Wide Association Study / methods; Genotype; Linkage Disequilibrium; Models, Genetic; Quantitative Trait Loci; Quantitative Trait, Heritable; Reproducibility of Results
TL;DR: The results indicate that accounting for genetic architecture can improve prediction accuracy for quantitative traits, especially when predictions are informed by the genetic architecture inferred from mapping the top variants affecting main effects and interactions in the training data, provided there is sufficient power for mapping. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

The Pacific decadal oscillation and changes in anchovy populations in the Northwest Pacific

Journal of Asian Earth Sciences, 114, 504–511.

By: X. Zhou, Y. Sun, W. Huang, J. Smol, Q. Tang & L. Sun

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

From sea to land: assessment of the bio-transport of phosphorus by penguins in Antarctica

Chinese Journal of Oceanology and Limnology = Zhongguo Hai Yang Hu Zhao Xue Bao, 32(1), 148–154.

By: X. Qin, L. Sun, J. Blais, Y. Wang, T. Huang, W. Huang, Z. Xie

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Genome Research, 24(7), 1193–1208.

By: W. Huang, A. Massouras, Y. Inoue, J. Peiffer, M. Ramia, A. Tarone, L. Turlapati, T. Zichner ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Relationship between magnetic susceptibility and grain size of sediments in the China Seas and its implications

Continental Shelf Research, 72, 131–137.

By: X. Zhou, L. Sun, W. Huang, Y. Liu, N. Jia & W. Cheng

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Knockdown of CDKN1C (p57(kip2)) and PHLDA2 results in developmental changes in bovine pre-implantation embryos

PLoS One, 8(7).

By: A. Driver, W. Huang, J. Kropp, F. Penagaricano & H. Khatib

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Alternative splicing regulated by butyrate in bovine epithelial cells

PLoS One, 7(6).

By: S. Wu, C. Li, W. Huang, W. Li & R. Li

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Precipitation in the Yellow River drainage basin and East Asian monsoon strength on a decadal time scale

Quaternary Research, 78(3), 486–491.

By: X. Zhou, L. Sun, W. Huang, W. Cheng & N. Jia

Source: NC State University Libraries
Added: August 6, 2018

journal article

Accounting for genetic architecture improves sequence based genomic prediction for a Drosophila fitness trait

Ober, U., Huang, W., Magwire, M., Schlather, M., Simianer, H., & Mackay, T. F. C. PLoS One, 10(5).

By: U. Ober, W. Huang, M. Magwire, M. Schlather, H. Simianer & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior

Swarup, S., Huang, W., Mackay, T. F. C., & Anholt, R. R. H. Proceedings of the National Academy of Sciences of the United States of America, 110(3), 1017–1022.

By: S. Swarup, W. Huang, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Epistasis dominates the genetic architecture of Drosophila quantitative traits

Huang, W., Richards, S., Carbone, M. A., Zhu, D. H., Anholt, R. R. H., Ayroles, J. F., … Muzny, D. Proceedings of the National Academy of Sciences of the United States of America, 109(39), 15553–15559.

By: W. Huang, S. Richards, M. Carbone, D. Zhu, R. Anholt, J. Ayroles, L. Duncan, K. Jordan ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic and genomic response to selection for food consumption in Drosophila melanogaster

Garlapow, M. E., Everett, L. J., Zhou, S. S., Gearhart, A. W., Fay, K. A., Huang, W., … Mackay, T. F. C. Behavior Genetics, 47(2), 227–243.

By: M. Garlapow, L. Everett, S. Zhou, A. Gearhart, K. Fay, W. Huang, T. Morozova, G. Arya ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic architecture of abdominal pigmentation in Drosophila melanogaster

Dembeck, L. M., Huang, W., Magwire, M. M., Lawrence, F., Lyman, R. F., & Mackay, T. F. C. PLoS Genetics, 11(5).

By: L. Dembeck, W. Huang, M. Magwire, F. Lawrence, R. Lyman & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster

Dembeck, L. M., Boroczky, K., Huang, W., Schal, C., Anholt, R. R. H., & Mackay, T. F. C. Elife, 4.

By: L. Dembeck, K. Boroczky, W. Huang, C. Schal, R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic architecture of natural variation in visual senescence in Drosophila

Carbone, M. A., Yamamoto, A., Huang, W., Lyman, R. A., Meadors, T. B., Yamamoto, R., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 113(43), E6620–6629.

By: M. Carbone, A. Yamamoto, W. Huang, R. Lyman, T. Meadors, R. Yamamoto, R. Anholt, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic basis of natural variation in body pigmentation in Drosophila melanogaster

Dembeck, L. M., Huang, W., Carbone, M. A., & Mackay, T. F. C. Fly, 9(2), 75–81.

By: L. Dembeck, W. Huang, M. Carbone & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic basis of transcriptome diversity in Drosophila melanogaster

Huang, W., Carbone, M. A., Magwire, M. M., Peiffer, J. A., Lyman, R. F., Stone, E. A., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 112(44), E6010–6019.

By: W. Huang, M. Carbone, M. Magwire, J. Peiffer, R. Lyman, E. Stone, R. Anholt, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways

Montgomery, S. L., Vorojeikina, D., Huang, W., Mackay, T. F. C., Anholt, R. R. H., & Rand, M. D. PLoS One, 9(10).

By: S. Montgomery, D. Vorojeikina, W. Huang, T. Mackay, R. Anholt & M. Rand

Source: NC State University Libraries
Added: August 6, 2018

journal article

Intrapopulation genome size variation in D. melanogaster reflects life history variation and plasticity

Ellis, L. L., Huang, W., Quinn, A. M., Ahuja, A., Alfrejd, B., Gomez, F. E., … Tarone, A. M. PLoS Genetics, 10(7).

By: L. Ellis, W. Huang, A. Quinn, A. Ahuja, B. Alfrejd, F. Gomez, C. Hjelmen, K. Moore ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila

Morozova, T. V., Huang, W., Pray, V. A., Whitham, T., Anholt, R. R. H., & Mackay, T. F. C. BMC Genomics, 16.

By: T. Morozova, W. Huang, V. Pray, T. Whitham, R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Quantitative genetics of food intake in Drosophila melanogaster

Garlapow, M. E., Huang, W., Yarboro, M. T., Peterson, K. R., & Mackay, T. F. C. PLoS One, 10(9).

By: M. Garlapow, W. Huang, M. Yarboro, K. Peterson & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Spontaneous mutations and the origin and maintenance of quantitative genetic variation

Huang, W., Lyman, R. F., Lyman, R. A., Carbone, M. A., Harbison, S. T., Magwire, M. M., & Mackay, T. F. C. Elife, 5.

By: W. Huang, R. Lyman, R. Lyman, M. Carbone, S. Harbison, M. Magwire, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

conference paper

The Persuasive phish: examining the social psychological principles hidden in phishing emails

Zielinska, O., Welk, A., Mayhorn, C. B., & Murphy-Hill, E. Symposium and Bootcamp on the Science of Security, 126–126.

By: O. Zielinska, A. Welk, C. Mayhorn & E. Murphy-Hill

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genetic architecture of natural variation in recombination rate in Drosophila melanogaster

Hunter, C. M., Huang, W., Mackay, T. F. C., & Singh, N. D. PLoS Genetics, 12(4).

By: C. Hunter, W. Huang, T. Mackay & N. Singh

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genetic basis for variation in olfactory behavior in Drosophila melanogaster

Arya, G. H., Magwire, M. M., Huang, W., Serrano-Negron, Y. L., Mackay, T. F. C., & Anholt, R. R. H. Chemical Senses, 40(4), 233–243.

By: G. Arya, M. Magwire, W. Huang, Y. Serrano-Negron, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genomic basis of postponed senescence in Drosophila melanogaster

Carnes, M. U., Campbell, T., Huang, W., Butler, D. G., Carbone, M. A., Duncan, L. H., … Mackay, T. F. C. PLoS One, 10(9).

By: M. Carnes, T. Campbell, W. Huang, D. Butler, M. Carbone, L. Duncan, S. Harbajan, E. King ...

Source: NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.