Works (20)
Updated: August 13th, 2023 21:17
2023 article
Age-associated changes in electroretinography measures in companion dogs
Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). DOCUMENTA OPHTHALMOLOGICA, Vol. 6.
author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
TL;DR:
Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs, as aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023
2023 journal article
Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: canine cognitive dysfunction syndrome; canine gerontology; mobility; walking speed; memory; attention
TL;DR:
Dogs' food-motivated gait speed off leash is correlated with fractional lifespan and cognitive performance in dogs, particularly in the domains of attention and working memory and proves to be a more effective indicator of age-related deterioration and cognitive decline than gaitspeed on leash.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023
2022 article
Relationship between hearing, cognitive function, and quality of life in aging companion dogs
Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., & Olby, N. J. (2022, August 6). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.
author keywords: canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; presbycusis
MeSH headings : Aging; Animals; Cognition; Dementia / epidemiology; Dog Diseases; Dogs; Hearing; Humans; Pets; Presbycusis / epidemiology; Presbycusis / veterinary; Prospective Studies; Quality of Life
TL;DR:
Presbycusis negatively alters owner‐pet interactions and is associated with poor executive performance and owner‐assessed dementia severity, and in multivariate analysis, higher CADES score was associated with worse hearing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 22, 2022
2022 journal article
Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population
JOURNAL OF ALZHEIMERS DISEASE, 87(3), 1367–1378.
author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
TL;DR:
It is suggested that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022
2021 journal article
Computed tomography findings in a cohort of 169 dogs with elbow dysplasia-a retrospective study
BMC VETERINARY RESEARCH, 17(1).
Contributors: M. Hebel*, n , J. Ruszkowski *, M. Nabzdyk *, D. Niedzielski*, K. Pituch*, A. Jackson, M. Kiełbowicz*, M. Pomorska-Mól *
author keywords: Canine elbow dysplasia; CED; CT; Imaging; Dogs
MeSH headings : Age Factors; Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dogs; Female; Forelimb / diagnostic imaging; Joint Diseases / diagnostic imaging; Joint Diseases / epidemiology; Joint Diseases / veterinary; Male; Prevalence; Retrospective Studies; Species Specificity; Tomography, X-Ray Computed / veterinary
TL;DR:
IN H-U, FMCP and MCD were among the most frequently found components of CED found in dogs with clinical evidence of elbow dysplasia found in the present study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 20, 2021
2021 journal article
Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs
MOLECULAR NEUROBIOLOGY, 58(2), 483–489.
Contributors: n , D. Murdoch *, M. Gruen n , F. Mowat n, R. Marek* & N. Olby n
author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; CDS; Amyloid beta 42; Amyloid beta 40
MeSH headings : Aging / blood; Amyloid beta-Peptides / blood; Animals; Cognitive Dysfunction / blood; Dogs / blood; Female; Male; Pets / blood
TL;DR:
The findings suggest the dynamics of canine plasma amyloid concentrations are analogous to that found in aging humans with and without AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020
2020 journal article
BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine
Science Translational Medicine, 12(558).
Contributors: D. Kanojia *, * , A. Cordero *, J. Fares *, A. Xiao*, S. Savchuk*, K. Kumar *, T. Xiao *
MeSH headings : Brain / metabolism; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Trastuzumab; Tubulin / metabolism; Vinorelbine
TL;DR:
A regulatory mechanism of TUBB3 is demonstrated and support for an application of BET inhibition to sensitize breast cancer metastases to VRB-mediated therapy is provided and a reduction in tumor volume is revealed with BET inhibition and VRB treatment.
(via Semantic Scholar)
Source: ORCID
Added: October 31, 2021
2020 journal article
GCN2 is essential for CD8<sup>+</sup> T cell survival and function in murine models of malignant glioma
Cancer Immunology, Immunotherapy, 69(1), 81–94.
Contributors: A. Rashidi*, J. Miska *, C. Lee-Chang *, D. Kanojia *, * , A. Lopez-Rosas*, P. Zhang *, Y. Han *
author keywords: GCN2; CD8(+) T-cell; Glioma; ISRIB
MeSH headings : Adoptive Transfer; Animals; Brain Neoplasms / immunology; Brain Neoplasms / pathology; Brain Neoplasms / therapy; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / transplantation; Cell Line, Tumor / transplantation; Cell Survival / immunology; Disease Models, Animal; Glioblastoma / immunology; Glioblastoma / pathology; Glioblastoma / therapy; Humans; Lymphocyte Activation; Mice; Mice, Knockout; Necrosis / genetics; Necrosis / immunology; Phosphorylation / immunology; Protein Biosynthesis / immunology; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / immunology; Protein Serine-Threonine Kinases / metabolism; Tumor Escape / immunology
TL;DR:
The results show that GCN2 deficiency limited CD8+ T-cell activation and expression of cytotoxic markers in two separate murine models of glioblastoma in vivo, and demonstrate the vital importance of intactGCN2 signaling on CD8- T- cell function and survival in gliOBlastoma.
(via Semantic Scholar)
Source: ORCID
Added: October 31, 2021
2020 journal article
Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs
MOLECULAR NEUROBIOLOGY, 57(7), 3143–3149.
Contributors: n , M. Gruen n , D. Murdoch *, R. Marek*, A. Stachel n, F. Mowat*, K. Saker n, N. Olby n
author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; Amyotrophic lateral sclerosis; Degenerative myelopathy
TL;DR:
This work identified plasma NfL as a key clinical index of neuro-aging and neurodegeneration in pet dogs using an ultrasensitive single-molecule array assay to measure plasma concentrations and found it increases in an age-dependent manner and is significantly elevated in dogs diagnosed with Neurodegenerative disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 13, 2020
2019 journal article
FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis
Oncogene, 38(37), 6445–6460.
Contributors: A. Cordero *, D. Kanojia *, J. Miska *, * , A. Xiao*, Y. Han *, N. Bonamici*, W. Zhou *
MeSH headings : Animals; Brain / metabolism; Brain / pathology; Brain Neoplasms / genetics; Brain Neoplasms / metabolism; Brain Neoplasms / secondary; Breast Neoplasms / genetics; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Proliferation / genetics; Fatty Acid-Binding Protein 7 / genetics; Fatty Acid-Binding Protein 7 / physiology; Female; Humans; Lipid Droplets / metabolism; Lipid Droplets / pathology; Lipid Metabolism / genetics; Mice; Oxidative Phosphorylation; Receptor, ErbB-2 / genetics; Receptor, ErbB-2 / metabolism; Tumor Microenvironment; Tumor Suppressor Proteins / genetics; Tumor Suppressor Proteins / physiology
TL;DR:
The results uncover a key role of FABP7 in metabolic reprogramming of HER2 + breast cancer cells, supporting a glycolytic phenotype and storage of lipid droplets that enable their adaptation and survival in the brain microenvironment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 31, 2021
2019 journal article
HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
Cell Reports, 27(1), 226–237.e4.
Contributors: J. Miska *, C. Lee-Chang *, A. Rashidi*, M. Muroski*, A. Chang *, A. Lopez-Rosas*, P. Zhang *, *
MeSH headings : Aged; Aged, 80 and over; Animals; Brain Neoplasms / genetics; Brain Neoplasms / immunology; Brain Neoplasms / metabolism; Brain Neoplasms / pathology; Cell Hypoxia / genetics; Cell Hypoxia / physiology; Cell Movement / genetics; Cells, Cultured; Energy Metabolism / genetics; Female; Genes, Switch / physiology; Glioblastoma / genetics; Glioblastoma / immunology; Glioblastoma / metabolism; Glioblastoma / pathology; Glycolysis / genetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / physiology; Immunosuppression Therapy; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Phosphorylation; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Tumor Escape / genetics; Tumor Escape / immunology; Tumor Microenvironment / genetics
TL;DR:
HIF-1α acts as a metabolic switch for Tregs between glycolytic-driven migration and oxidative phosphorylation-driven immunosuppression, explaining their reduced abundance in tumor-bearing mice.
(via Semantic Scholar)
Source: ORCID
Added: October 31, 2021
2019 journal article
Local Application of Autologous Platelet-Rich Fibrin Patch (PRF-P) Suppresses Regulatory T Cell Recruitment in a Murine Glioma Model
Molecular Neurobiology, 56(7), 5032–5040.
Contributors: * , K. Pituch*, J. Miska *, J. Kim*, A. Rashidi*, D. Kanojia *, A. Lopez-Rosas*, Y. Han *
author keywords: Glioblastoma multiforme; Immunosuppressive microenvironment; Platelet-rich fibrin patch; Regulatory Tcells and glioma immune therapies
MeSH headings : Animals; Autografts; Brain Neoplasms / immunology; Brain Neoplasms / metabolism; Brain Neoplasms / therapy; Cell Line, Tumor; Cells, Cultured; Craniotomy / methods; Glioma / immunology; Glioma / metabolism; Glioma / therapy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Platelet-Rich Fibrin / physiology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Tumor Microenvironment / immunology
TL;DR:
It is shown that a local implantation of platelet-rich fibrin patch (PRF-P) into the brain of GL261 glioma-bearing mice prolonged the survival of affected animals by 42.85% and revealed the soluble CD40 ligand (sCD40L) as a major Treg inhibitory player produced by activated platelets entrapped within the fibr in matrix of the PRF-p.
(via Semantic Scholar)
Source: ORCID
Added: October 31, 2021
2019 journal article
Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma
Proceedings of the National Academy of Sciences of the United States of America, 116(47), 23714–23723.
Contributors: P. Zhang *, J. Miska *, C. Lee-Chang *, A. Rashidi*, * , S. An*, M. Zannikou, A. Lopez-Rosas*
author keywords: immunotherapy; glioblastoma; myeloid cell; PD-L1; radiotherapy
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; B7-H1 Antigen / metabolism; Brain Neoplasms / drug therapy; Brain Neoplasms / pathology; Brain Neoplasms / radiotherapy; Bridged Bicyclo Compounds, Heterocyclic / administration & dosage; Bridged Bicyclo Compounds, Heterocyclic / therapeutic use; Cyclic N-Oxides; Glioblastoma / drug therapy; Glioblastoma / pathology; Glioblastoma / radiotherapy; Humans; Indolizines; Mice; Myeloid Cells / drug effects; Myeloid Cells / pathology; Myeloid Cells / radiation effects; Nanoparticles; Pyridinium Compounds / administration & dosage; Pyridinium Compounds / therapeutic use; Tumor Microenvironment; Xenograft Model Antitumor Assays
TL;DR:
A lipid nanoparticle (LNP) platform capable of actively targeting and delivering therapeutics to mouse and human TAMCs by recognizing highly expressed PD-L1 in TAMCs is reported, which establishes a therapeutic approach with immense potential to improve the clinical response in the treatment of GBM and warrants a rapid translation into clinical practice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 31, 2021
2018 journal article
A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model
Neurotherapeutics, 15(4), 1127–1138.
Contributors: J. Kim*, J. Kane *, * , J. Young *, A. Rashidi*, D. Yu *, D. Kanojia *, T. Hasan*
author keywords: glioblastoma; adenovirus; dendritic cells; cytomegalovirus; vaccine
MeSH headings : Adaptive Immunity / genetics; Adenoviridae / genetics; Analysis of Variance; Animals; Antigens, CD / metabolism; Antigens, Neoplasm / metabolism; Brain Neoplasms / immunology; Brain Neoplasms / pathology; Brain Neoplasms / therapy; Dendritic Cells / immunology; Dendritic Cells / virology; Disease Models, Animal; Genetic Vectors / metabolism; Glioma / immunology; Glioma / pathology; Glioma / therapy; HEK293 Cells; Humans; Lectins, C-Type / metabolism; Lymph Nodes / cytology; Mice; Minor Histocompatibility Antigens / metabolism; Receptors, Cell Surface / metabolism; Spleen / cytology; Transduction, Genetic; Transfection; Xenograft Model Antitumor Assays
TL;DR:
This study developed a DC-specific adenoviral vector, named Ad5scFvDEC205FF, targeting the DC surface receptor, DEC205, and shows a prolonged survival benefit in GL261CMV-IE-implanted murine glioma models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 31, 2021
2018 journal article
Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma
Molecular Therapy, 26(4), 986–995.
Contributors: K. Pituch*, J. Miska *, G. Krenciute *, * , G. Li *, T. Rodriguez-Cruz*, M. Wu*, Y. Han *
MeSH headings : Animals; CD28 Antigens / immunology; CD28 Antigens / metabolism; Cell Line, Tumor; Cytotoxicity, Immunologic; Disease Models, Animal; Female; Gene Expression; Genetic Vectors / genetics; Glioblastoma / genetics; Glioblastoma / immunology; Glioblastoma / metabolism; Glioblastoma / therapy; Humans; Immunotherapy, Adoptive / methods; Inflammation / immunology; Inflammation / metabolism; Inflammation / pathology; Interleukin-13 Receptor alpha2 Subunit / antagonists & inhibitors; Interleukin-13 Receptor alpha2 Subunit / immunology; Male; Mice; Receptors, Chimeric Antigen / genetics; Receptors, Chimeric Antigen / metabolism; T-Lymphocytes / immunology; T-Lymphocytes / metabolism; Treatment Outcome; Tumor Microenvironment / immunology; Xenograft Model Antitumor Assays
TL;DR:
The data underline the significance of CAR T cell studies in immunocompetent hosts and further validate IL13Rα2-CAR T cells as an efficacious therapeutic strategy for MG.
(via Semantic Scholar)
Source: ORCID
Added: October 31, 2021
2018 chapter
Gene/Viral Treatment Approaches for Malignant Brain Cancer
In Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy: Second Edition (pp. 211–227).
Contributors: J. Kim*, K. Pituch*, A. Xiao*, J. Young *, * , M. Muroski*, A. Rashidi*, J. Kane *, D. Kanojia *, M. Lesniak *
TL;DR:
Gene therapy is a rapidly developing treatment modality that functions on its ability to deliver genes directly to the tumor site in order to yield antitumoral effects and thus prolong patient survival.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 31, 2021
2017 journal article
A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model
Molecular Therapy - Oncolytics, 5, 97–104.
Contributors: J. Kim*, J. Miska *, J. Young *, A. Rashidi*, J. Kane *, * , D. Kanojia *, Y. Han *, I. Balyasnikova *, M. Lesniak *
TL;DR:
It is suggested that cell death caused by replication-competent adenoviral vectors is required to induce a significant anti-tumor immune response and survival benefits in immunocompetent mice bearing intracranial glioma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 31, 2021
2017 journal article
Hitting the nail on the head: Combining oncolytic adenovirusmediated virotherapy and immunomodulation for the treatment of glioma
Oncotarget, 8(51), 89391–89405.
Contributors: * , J. Kane *, J. Young *, A. Rashidi*, J. Kim*, D. Kanojia *, M. Lesniak *
author keywords: combinatory therapy; glioma; immunomodulator(s); checkpoint blockade; oncolytic adenovirus
TL;DR:
The strengths and weaknesses of adenoviral oncolytic therapy are discussed, and the genetic modifications that result in more effective and targeted viral agents are highlighted and areas for which more work is needed are considered.
(via Semantic Scholar)
Source: ORCID
Added: October 31, 2021
2017 journal article
Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression
Proceedings of the National Academy of Sciences of the United States of America, 114(30), E6147–E6156.
author keywords: siRNA; lipopolymeric nanoparticle; glioblastoma transcription factor; brain tumor-initiating cells; convection-enhanced delivery
MeSH headings : Animals; Carcinogenesis / genetics; Drug Resistance, Neoplasm; Female; Genetic Therapy / methods; Glioblastoma / drug therapy; Glioblastoma / genetics; Glioblastoma / pathology; Humans; Male; Mice; Mice, Nude; Nanoparticles / therapeutic use; RNA Interference; Xenograft Model Antitumor Assays
TL;DR:
A lipopolymeric nanoparticle (LPNP) formulation is reported that demonstrates a surprisingly high affinity for BTICs and the capacity to encapsulate multiple siRNAs for potent and targeted anti-BTIC therapy and establishes a flexible nonviral gene therapy platform with thecapacity to channel multiplexed RNAi schemes to address the challenges posed by tumor heterogeneity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 31, 2021
2017 journal article
Multiplexed nanomedicine for brain tumors: Nanosized Hercules to tame our Lernaean Hydra inside?
Nanomedicine, 12(20), 2435–2439.
Contributors: * , O. Khan *, D. Yu * & M. Lesniak *
author keywords: GBM; nanoparticle; nanomedicine; brain tumor; siRNA; convection enhanced delivery; BTIC/brain tumor-initiating cells; stem cell transcription factor
Source: ORCID
Added: October 31, 2021
Employment
Updated: November 14th, 2023 14:43
2023 - present
University of Pennsylvania Philadelphia, Pennsylvania, US
Assistant Professor
Department of Clinical Sciences and Advanced Medicine
2020 - 2023
University of California Davis Davis, CA, US
Small Animal Neurology/Neurosurgery Resident
Surgical and CLinical Sciences
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