Wojciech Panek

Works (20)

Updated: April 25th, 2025 05:06

2023 article

Age-associated changes in electroretinography measures in companion dogs

Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). Documenta Ophthalmologica, Vol. 6.

By: M. Salzman *, N. Merten *, W. Panek n , G. Fefer n, A. Mondino n , H. Westermeyer n , M. Gruen n , N. Olby n , F. Mowat n

author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
topics (OpenAlex): Retinal Development and Disorders; Olfactory and Sensory Function Studies; Retinal Diseases and Treatments
TL;DR: Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs, as aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs

Mondino, A., Khan, M., Case, B., Fefer, G., Panek, W. K., Gruen, M. E., & Olby, N. J. (2023, June 15). Frontiers in Veterinary Science, Vol. 10.

By: A. Mondino n , M. Khan n, B. Case n, G. Fefer n, W. Panek n , M. Gruen n , N. Olby n 

author keywords: canine cognitive dysfunction syndrome; canine gerontology; mobility; walking speed; memory; attention
topics (OpenAlex): Human-Animal Interaction Studies; Veterinary Orthopedics and Neurology; Veterinary Oncology Research
TL;DR: Dogs' food-motivated gait speed off leash is correlated with fractional lifespan and cognitive performance in dogs, particularly in the domains of attention and working memory and proves to be a more effective indicator of age-related deterioration and cognitive decline than gaitspeed on leash. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023

2022 article

Relationship between hearing, cognitive function, and quality of life in aging companion dogs

Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., & Olby, N. J. (2022, August 6). Journal of Veterinary Internal Medicine, Vol. 8.

By: G. Fefer n, M. Khan n, W. Panek n , B. Case n, M. Gruen n  & N. Olby n 

author keywords: canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; presbycusis
MeSH headings : Aging; Animals; Cognition; Dementia / epidemiology; Dog Diseases; Dogs; Hearing; Humans; Pets; Presbycusis / epidemiology; Presbycusis / veterinary; Prospective Studies; Quality of Life
topics (OpenAlex): Human-Animal Interaction Studies; Ear Surgery and Otitis Media; Hearing Loss and Rehabilitation
TL;DR: Presbycusis negatively alters owner‐pet interactions and is associated with poor executive performance and owner‐assessed dementia severity, and in multivariate analysis, higher CADES score was associated with worse hearing. (via Semantic Scholar)
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1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 22, 2022

2022 article

Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population

Fefer, G., Panek, W. K., Khan, M. Z., Singer, M., Westermeyer, H. D., Mowat, F. M., … Gruen, M. E. (2022, April 15). Journal of Alzheimer s Disease.

By: G. Fefer n, W. Panek n , M. Khan n, M. Singer n, H. Westermeyer n , F. Mowat n, D. Murdoch *, B. Case n, N. Olby n , M. Gruen n 

author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
MeSH headings : Aging; Animals; Biomarkers; Cognitive Dysfunction / diagnostic imaging; Dogs; Humans; Neuropsychological Tests; Surveys and Questionnaires
topics (OpenAlex): Human-Animal Interaction Studies; Neuroinflammation and Neurodegeneration Mechanisms; Gut microbiota and health
TL;DR: It is suggested that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs. (via Semantic Scholar)
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10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2021 article

Computed tomography findings in a cohort of 169 dogs with elbow dysplasia - a retrospective study

Hebel, M., Panek, W. K., Ruszkowski, J. J., Nabzdyk, M., Niedzielski, D., Pituch, K. C., … Pomorska-Mól, M. (2021, September 6). BMC Veterinary Research, Vol. 9.

By: M. Hebel *, W. Panek n , J. Ruszkowski *, M. Nabzdyk *, D. Niedzielski*, K. Pituch*, A. Jackson, M. Kiełbowicz*, M. Pomorska-Mól *

Contributors: M. Hebel *, W. Panek n , J. Ruszkowski *, M. Nabzdyk *, D. Niedzielski*, K. Pituch*, A. Jackson, M. Kiełbowicz*, M. Pomorska-Mól *

author keywords: Canine elbow dysplasia; CED; CT; Imaging; Dogs
MeSH headings : Age Factors; Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dogs; Female; Forelimb / diagnostic imaging; Joint Diseases / diagnostic imaging; Joint Diseases / epidemiology; Joint Diseases / veterinary; Male; Prevalence; Retrospective Studies; Species Specificity; Tomography, X-Ray Computed / veterinary
topics (OpenAlex): Veterinary Orthopedics and Neurology; Elbow and Forearm Trauma Treatment; Tendon Structure and Treatment
TL;DR: IN H-U, FMCP and MCD were among the most frequently found components of CED found in dogs with clinical evidence of elbow dysplasia found in the present study. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 20, 2021

2020 article

BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine

Kanojia, D., Panek, W. K., Cordero, A., Fares, J., Xiao, A., Savchuk, S., … Lesniak, M. S. (2020, August 26). Science Translational Medicine, Vol. 12.

By: D. Kanojia *, W. Panek* , A. Cordero*, J. Fares *, A. Xiao *, S. Savchuk *, K. Kumar *, T. Xiao * ...

Contributors: D. Kanojia *, W. Panek* , A. Cordero*, J. Fares *, A. Xiao *, S. Savchuk *, K. Kumar *, T. Xiao * ...

MeSH headings : Brain / metabolism; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Trastuzumab; Tubulin / metabolism; Vinorelbine
topics (OpenAlex): Protein Degradation and Inhibitors; Histone Deacetylase Inhibitors Research; Multiple Myeloma Research and Treatments
TL;DR: A regulatory mechanism of TUBB3 is demonstrated and support for an application of BET inhibition to sensitize breast cancer metastases to VRB-mediated therapy is provided and a reduction in tumor volume is revealed with BET inhibition and VRB treatment. (via Semantic Scholar)
Source: ORCID
Added: October 31, 2021

2020 article

Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs

Panek, W. K., Murdoch, D. M., Gruen, M. E., Mowat, F. M., Marek, R. D., & Olby, N. J. (2020, September 24). Molecular Neurobiology, Vol. 58, pp. 483–489.

By: W. Panek n , D. Murdoch *, M. Gruen n , F. Mowat n, R. Marek * & N. Olby n 

Contributors: W. Panek n , D. Murdoch *, M. Gruen n , F. Mowat n, R. Marek * & N. Olby n 

author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; CDS; Amyloid beta 42; Amyloid beta 40
MeSH headings : Aging / blood; Amyloid beta-Peptides / blood; Animals; Cognitive Dysfunction / blood; Dogs / blood; Female; Male; Pets / blood
topics (OpenAlex): Alzheimer's disease research and treatments; Neuroinflammation and Neurodegeneration Mechanisms; Human-Animal Interaction Studies
TL;DR: The findings suggest the dynamics of canine plasma amyloid concentrations are analogous to that found in aging humans with and without AD. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020

2020 article

Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs

Panek, W. K., Gruen, M. E., Murdoch, D. M., Marek, R. D., Stachel, A. F., Mowat, F. M., … Olby, N. J. (2020, May 30). Molecular Neurobiology, Vol. 57, pp. 3143–3149.

By: W. Panek n , M. Gruen n , D. Murdoch *, R. Marek *, A. Stachel n, F. Mowat n, K. Saker n, N. Olby n 

Contributors: W. Panek n , M. Gruen n , D. Murdoch *, R. Marek *, A. Stachel n, F. Mowat n, K. Saker n, N. Olby n 

author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; Amyotrophic lateral sclerosis; Degenerative myelopathy
MeSH headings : Aging / blood; Animals; Biomarkers / blood; Dog Diseases / blood; Dog Diseases / diagnosis; Dogs; Female; Male; Neurodegenerative Diseases / blood; Neurodegenerative Diseases / diagnosis; Neurodegenerative Diseases / veterinary; Neurofilament Proteins / blood
topics (OpenAlex): Neurological diseases and metabolism; Prion Diseases and Protein Misfolding; Veterinary Orthopedics and Neurology
TL;DR: This work identified plasma NfL as a key clinical index of neuro-aging and neurodegeneration in pet dogs using an ultrasensitive single-molecule array assay to measure plasma concentrations and found it increases in an age-dependent manner and is significantly elevated in dogs diagnosed with Neurodegenerative disease. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 13, 2020

2019 article

FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis

Cordero, A., Kanojia, D., Miska, J., Panek, W. K., Xiao, A., Han, Y., … Lesniak, M. S. (2019, July 19). Oncogene, Vol. 38, pp. 6445–6460.

By: A. Cordero*, D. Kanojia *, J. Miska *, W. Panek* , A. Xiao *, Y. Han *, N. Bonamici*, W. Zhou * ...

Contributors: A. Cordero*, D. Kanojia *, J. Miska *, W. Panek* , A. Xiao *, Y. Han *, N. Bonamici*, W. Zhou * ...

MeSH headings : Animals; Brain / metabolism; Brain / pathology; Brain Neoplasms / genetics; Brain Neoplasms / metabolism; Brain Neoplasms / secondary; Breast Neoplasms / genetics; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Proliferation / genetics; Fatty Acid-Binding Protein 7 / genetics; Fatty Acid-Binding Protein 7 / physiology; Female; Humans; Lipid Droplets / metabolism; Lipid Droplets / pathology; Lipid Metabolism / genetics; Mice; Oxidative Phosphorylation; Receptor, ErbB-2 / genetics; Receptor, ErbB-2 / metabolism; Tumor Microenvironment; Tumor Suppressor Proteins / genetics; Tumor Suppressor Proteins / physiology
topics (OpenAlex): Lung Cancer Treatments and Mutations; Lung Cancer Research Studies; Brain Metastases and Treatment
TL;DR: The results uncover a key role of FABP7 in metabolic reprogramming of HER2 + breast cancer cells, supporting a glycolytic phenotype and storage of lipid droplets that enable their adaptation and survival in the brain microenvironment. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 31, 2021

2019 article

GCN2 is essential for CD8+ T cell survival and function in murine models of malignant glioma

Rashidi, A., Miska, J., Lee-Chang, C., Kanojia, D., Panek, W. K., Lopez-Rosas, A., … Lesniak, M. S. (2019, December 16). Cancer Immunology Immunotherapy, Vol. 69, pp. 81–94.

By: A. Rashidi *, J. Miska *, C. Lee-Chang *, D. Kanojia *, W. Panek* , A. Lopez-Rosas *, P. Zhang *, Y. Han * ...

Contributors: A. Rashidi *, J. Miska *, C. Lee-Chang *, D. Kanojia *, W. Panek* , A. Lopez-Rosas *, P. Zhang *, Y. Han * ...

author keywords: GCN2; CD8(+) T-cell; Glioma; ISRIB
MeSH headings : Adoptive Transfer; Animals; Brain Neoplasms / immunology; Brain Neoplasms / pathology; Brain Neoplasms / therapy; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / transplantation; Cell Line, Tumor / transplantation; Cell Survival / immunology; Disease Models, Animal; Glioblastoma / immunology; Glioblastoma / pathology; Glioblastoma / therapy; Humans; Lymphocyte Activation; Mice; Mice, Knockout; Necrosis / genetics; Necrosis / immunology; Phosphorylation / immunology; Protein Biosynthesis / immunology; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / immunology; Protein Serine-Threonine Kinases / metabolism; Tumor Escape / immunology
topics (OpenAlex): Immune Cell Function and Interaction; Cancer Immunotherapy and Biomarkers; Endoplasmic Reticulum Stress and Disease
TL;DR: The results show that GCN2 deficiency limited CD8+ T-cell activation and expression of cytotoxic markers in two separate murine models of glioblastoma in vivo, and demonstrate the vital importance of intactGCN2 signaling on CD8- T- cell function and survival in gliOBlastoma. (via Semantic Scholar)
Source: ORCID
Added: October 31, 2021

2019 article

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

Miska, J., Lee-Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., … Lesniak, M. S. (2019, April 1). Cell Reports, Vol. 27, pp. 226–237.e4.

By: J. Miska *, C. Lee-Chang *, A. Rashidi *, M. Muroski*, A. Chang *, A. Lopez-Rosas *, P. Zhang *, W. Panek*  ...

Contributors: J. Miska *, C. Lee-Chang *, A. Rashidi *, M. Muroski*, A. Chang *, A. Lopez-Rosas *, P. Zhang *, W. Panek*  ...

MeSH headings : Aged; Aged, 80 and over; Animals; Brain Neoplasms / genetics; Brain Neoplasms / immunology; Brain Neoplasms / metabolism; Brain Neoplasms / pathology; Cell Hypoxia / genetics; Cell Hypoxia / physiology; Cell Movement / genetics; Cells, Cultured; Energy Metabolism / genetics; Female; Genes, Switch / physiology; Glioblastoma / genetics; Glioblastoma / immunology; Glioblastoma / metabolism; Glioblastoma / pathology; Glycolysis / genetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / physiology; Immunosuppression Therapy; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Phosphorylation; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Tumor Escape / genetics; Tumor Escape / immunology; Tumor Microenvironment / genetics
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Glioma Diagnosis and Treatment; Immune cells in cancer
TL;DR: HIF-1α acts as a metabolic switch for Tregs between glycolytic-driven migration and oxidative phosphorylation-driven immunosuppression, explaining their reduced abundance in tumor-bearing mice. (via Semantic Scholar)
Source: ORCID
Added: October 31, 2021

2019 article

Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma

Zhang, P., Miska, J., Lee-Chang, C., Rashidi, A., Panek, W. K., An, S., … Lesniak, M. S. (2019, November 11). Proceedings of the National Academy of Sciences, Vol. 116, pp. 23714–23723.

By: P. Zhang *, J. Miska *, C. Lee-Chang *, A. Rashidi *, W. Panek* , S. An*, M. Zannikou, A. Lopez-Rosas * ...

Contributors: P. Zhang *, J. Miska *, C. Lee-Chang *, A. Rashidi *, W. Panek* , S. An*, M. Zannikou, A. Lopez-Rosas * ...

author keywords: immunotherapy; glioblastoma; myeloid cell; PD-L1; radiotherapy
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; B7-H1 Antigen / metabolism; Brain Neoplasms / drug therapy; Brain Neoplasms / pathology; Brain Neoplasms / radiotherapy; Bridged Bicyclo Compounds, Heterocyclic / administration & dosage; Bridged Bicyclo Compounds, Heterocyclic / therapeutic use; Cyclic N-Oxides; Glioblastoma / drug therapy; Glioblastoma / pathology; Glioblastoma / radiotherapy; Humans; Indolizines; Mice; Myeloid Cells / drug effects; Myeloid Cells / pathology; Myeloid Cells / radiation effects; Nanoparticles; Pyridinium Compounds / administration & dosage; Pyridinium Compounds / therapeutic use; Tumor Microenvironment; Xenograft Model Antitumor Assays
topics (OpenAlex): Immune cells in cancer; Nanoparticle-Based Drug Delivery; Phagocytosis and Immune Regulation
TL;DR: A lipid nanoparticle (LNP) platform capable of actively targeting and delivering therapeutics to mouse and human TAMCs by recognizing highly expressed PD-L1 in TAMCs is reported, which establishes a therapeutic approach with immense potential to improve the clinical response in the treatment of GBM and warrants a rapid translation into clinical practice. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 31, 2021

2018 article

A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model

Kim, J. W., Kane, J. R., Panek, W. K., Young, J. S., Rashidi, A., Yu, D., … Lesniak, M. S. (2018, July 19). Neurotherapeutics, Vol. 15, pp. 1127–1138.

By: J. Kim*, J. Kane *, W. Panek* , J. Young *, A. Rashidi *, D. Yu *, D. Kanojia *, T. Hasan * ...

Contributors: J. Kim*, J. Kane *, W. Panek* , J. Young *, A. Rashidi *, D. Yu *, D. Kanojia *, T. Hasan * ...

author keywords: glioblastoma; adenovirus; dendritic cells; cytomegalovirus; vaccine
MeSH headings : Adaptive Immunity / genetics; Adenoviridae / genetics; Analysis of Variance; Animals; Antigens, CD / metabolism; Antigens, Neoplasm / metabolism; Brain Neoplasms / immunology; Brain Neoplasms / pathology; Brain Neoplasms / therapy; Dendritic Cells / immunology; Dendritic Cells / virology; Disease Models, Animal; Genetic Vectors / metabolism; Glioma / immunology; Glioma / pathology; Glioma / therapy; HEK293 Cells; Humans; Lectins, C-Type / metabolism; Lymph Nodes / cytology; Mice; Minor Histocompatibility Antigens / metabolism; Receptors, Cell Surface / metabolism; Spleen / cytology; Transduction, Genetic; Transfection; Xenograft Model Antitumor Assays
topics (OpenAlex): Immunotherapy and Immune Responses; RNA Interference and Gene Delivery; Virus-based gene therapy research
TL;DR: This study developed a DC-specific adenoviral vector, named Ad5scFvDEC205FF, targeting the DC surface receptor, DEC205, and shows a prolonged survival benefit in GL261CMV-IE-implanted murine glioma models. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 31, 2021

2018 article

Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma

Pituch, K. C., Miska, J., Krenciute, G., Panek, W. K., Li, G., Rodriguez-Cruz, T., … Balyasnikova, I. V. (2018, February 8). Molecular Therapy, Vol. 26, pp. 986–995.

By: K. Pituch*, J. Miska *, G. Krenciute *, W. Panek* , G. Li*, T. Rodriguez-Cruz*, M. Wu*, Y. Han * ...

Contributors: K. Pituch*, J. Miska *, G. Krenciute *, W. Panek* , G. Li*, T. Rodriguez-Cruz*, M. Wu*, Y. Han * ...

MeSH headings : Animals; CD28 Antigens / immunology; CD28 Antigens / metabolism; Cell Line, Tumor; Cytotoxicity, Immunologic; Disease Models, Animal; Female; Gene Expression; Genetic Vectors / genetics; Glioblastoma / genetics; Glioblastoma / immunology; Glioblastoma / metabolism; Glioblastoma / therapy; Humans; Immunotherapy, Adoptive / methods; Inflammation / immunology; Inflammation / metabolism; Inflammation / pathology; Interleukin-13 Receptor alpha2 Subunit / antagonists & inhibitors; Interleukin-13 Receptor alpha2 Subunit / immunology; Male; Mice; Receptors, Chimeric Antigen / genetics; Receptors, Chimeric Antigen / metabolism; T-Lymphocytes / immunology; T-Lymphocytes / metabolism; Treatment Outcome; Tumor Microenvironment / immunology; Xenograft Model Antitumor Assays
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; T-cell and B-cell Immunology
TL;DR: The data underline the significance of CAR T cell studies in immunocompetent hosts and further validate IL13Rα2-CAR T cells as an efficacious therapeutic strategy for MG. (via Semantic Scholar)
Source: ORCID
Added: October 31, 2021

2018 article

Gene/Viral Treatment Approaches for Malignant Brain Cancer

Kim, J. W., Pituch, K. C., Xiao, A., Young, J. S., Panek, W. K., Muroski, M. E., … Lesniak, M. S. (2018, January 1). Elsevier EBooks, pp. 211–227.

By: J. Kim*, K. Pituch*, A. Xiao *, J. Young *, W. Panek* , M. Muroski*, A. Rashidi *, J. Kane *, D. Kanojia *, M. Lesniak *

Contributors: J. Kim*, K. Pituch*, A. Xiao *, J. Young *, W. Panek* , M. Muroski*, A. Rashidi *, J. Kane *, D. Kanojia *, M. Lesniak *

topics (OpenAlex): Virus-based gene therapy research; RNA Interference and Gene Delivery; CRISPR and Genetic Engineering
TL;DR: Gene therapy is a rapidly developing treatment modality that functions on its ability to deliver genes directly to the tumor site in order to yield antitumoral effects and thus prolong patient survival. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 31, 2021

2018 article

Local Application of Autologous Platelet-Rich Fibrin Patch (PRF-P) Suppresses Regulatory T Cell Recruitment in a Murine Glioma Model

Panek, W. K., Pituch, K. C., Miska, J., Kim, J. W., Rashidi, A., Kanojia, D., … Lesniak, M. S. (2018, November 20). Molecular Neurobiology, Vol. 56, pp. 5032–5040.

By: W. Panek* , K. Pituch*, J. Miska *, J. Kim*, A. Rashidi *, D. Kanojia *, A. Lopez-Rosas *, Y. Han * ...

Contributors: W. Panek* , K. Pituch*, J. Miska *, J. Kim*, A. Rashidi *, D. Kanojia *, A. Lopez-Rosas *, Y. Han * ...

author keywords: Glioblastoma multiforme; Immunosuppressive microenvironment; Platelet-rich fibrin patch; Regulatory Tcells and glioma immune therapies
MeSH headings : Animals; Autografts; Brain Neoplasms / immunology; Brain Neoplasms / metabolism; Brain Neoplasms / therapy; Cell Line, Tumor; Cells, Cultured; Craniotomy / methods; Glioma / immunology; Glioma / metabolism; Glioma / therapy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Platelet-Rich Fibrin / physiology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Tumor Microenvironment / immunology
topics (OpenAlex): Immune cells in cancer; Neuroinflammation and Neurodegeneration Mechanisms; Immunotherapy and Immune Responses
TL;DR: It is shown that a local implantation of platelet-rich fibrin patch (PRF-P) into the brain of GL261 glioma-bearing mice prolonged the survival of affected animals by 42.85% and revealed the soluble CD40 ligand (sCD40L) as a major Treg inhibitory player produced by activated platelets entrapped within the fibr in matrix of the PRF-p. (via Semantic Scholar)
Source: ORCID
Added: October 31, 2021

2017 article

A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model

Kim, J. W., Miska, J., Young, J. S., Rashidi, A., Kane, J. R., Panek, W. K., … Lesniak, M. S. (2017, May 6). Molecular Therapy — Oncolytics, Vol. 5, pp. 97–104.

By: J. Kim*, J. Miska *, J. Young *, A. Rashidi *, J. Kane *, W. Panek* , D. Kanojia *, Y. Han *, I. Balyasnikova *, M. Lesniak *

Contributors: J. Kim*, J. Miska *, J. Young *, A. Rashidi *, J. Kane *, W. Panek* , D. Kanojia *, Y. Han *, I. Balyasnikova *, M. Lesniak *

topics (OpenAlex): Virus-based gene therapy research; RNA Interference and Gene Delivery; CAR-T cell therapy research
TL;DR: It is suggested that cell death caused by replication-competent adenoviral vectors is required to induce a significant anti-tumor immune response and survival benefits in immunocompetent mice bearing intracranial glioma. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 31, 2021

2017 article

Hitting the nail on the head: combining oncolytic adenovirus-mediated virotherapy and immunomodulation for the treatment of glioma

Panek, W. K., Kane, J. R., Young, J. S., Rashidi, A., Kim, J. W., Kanojia, D., & Lesniak, M. S. (2017, September 11). Oncotarget, Vol. 8, pp. 89391–89405.

By: W. Panek* , J. Kane *, J. Young *, A. Rashidi *, J. Kim*, D. Kanojia *, M. Lesniak *

Contributors: W. Panek* , J. Kane *, J. Young *, A. Rashidi *, J. Kim*, D. Kanojia *, M. Lesniak *

author keywords: combinatory therapy; glioma; immunomodulator(s); checkpoint blockade; oncolytic adenovirus
topics (OpenAlex): Virus-based gene therapy research; CAR-T cell therapy research; RNA Interference and Gene Delivery
TL;DR: The strengths and weaknesses of adenoviral oncolytic therapy are discussed, and the genetic modifications that result in more effective and targeted viral agents are highlighted and areas for which more work is needed are considered. (via Semantic Scholar)
Source: ORCID
Added: October 31, 2021

2017 article

Multiplexed Nanomedicine for Brain Tumors: Nanosized Hercules to Tame Our Lernaean Hydra inside?

Panek, W. K., Khan, O. F., Yu, D., & Lesniak, M. S. (2017, October 1). Nanomedicine, Vol. 12, pp. 2435–2439.

By: W. Panek* , O. Khan *, D. Yu * & M. Lesniak *

Contributors: W. Panek* , O. Khan *, D. Yu * & M. Lesniak *

author keywords: GBM; nanoparticle; nanomedicine; brain tumor; siRNA; convection enhanced delivery; BTIC/brain tumor-initiating cells; stem cell transcription factor
topics (OpenAlex): Molecular Communication and Nanonetworks; Advanced biosensing and bioanalysis techniques; Nanoplatforms for cancer theranostics
Source: ORCID
Added: October 31, 2021

2017 article

Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression

Yu, D., Khan, O. F., Suvà, M. L., Dong, B., Panek, W. K., Xiao, T., … Lesniak, M. S. (2017, July 10). Proceedings of the National Academy of Sciences, Vol. 114, pp. E6147–E6156.

By: D. Yu *, O. Khan *, M. Suvà *, B. Dong *, W. Panek* , T. Xiao *, M. Wu*, Y. Han * ...

Contributors: D. Yu *, O. Khan *, M. Suvà *, B. Dong *, W. Panek* , T. Xiao *, M. Wu*, Y. Han * ...

author keywords: siRNA; lipopolymeric nanoparticle; glioblastoma transcription factor; brain tumor-initiating cells; convection-enhanced delivery
MeSH headings : Animals; Carcinogenesis / genetics; Drug Resistance, Neoplasm; Female; Genetic Therapy / methods; Glioblastoma / drug therapy; Glioblastoma / genetics; Glioblastoma / pathology; Humans; Male; Mice; Mice, Nude; Nanoparticles / therapeutic use; RNA Interference; Xenograft Model Antitumor Assays
topics (OpenAlex): RNA Interference and Gene Delivery; MicroRNA in disease regulation; Nanoplatforms for cancer theranostics
TL;DR: A lipopolymeric nanoparticle (LPNP) formulation is reported that demonstrates a surprisingly high affinity for BTICs and the capacity to encapsulate multiple siRNAs for potent and targeted anti-BTIC therapy and establishes a flexible nonviral gene therapy platform with thecapacity to channel multiplexed RNAi schemes to address the challenges posed by tumor heterogeneity. (via Semantic Scholar)
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Source: ORCID
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Employment

Updated: November 14th, 2023 14:43

2023 - present

University of Pennsylvania Philadelphia, Pennsylvania, US
Assistant Professor Department of Clinical Sciences and Advanced Medicine

2020 - 2023

University of California Davis Davis, CA, US
Small Animal Neurology/Neurosurgery Resident Surgical and CLinical Sciences

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