Works (20)
Updated: August 13th, 2023 21:17
2023 article
Age-associated changes in electroretinography measures in companion dogs
Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). DOCUMENTA OPHTHALMOLOGICA, Vol. 6.
author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
Sources: Web Of Science, ORCID
Added: June 19, 2023
2023 journal article
Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: canine cognitive dysfunction syndrome; canine gerontology; mobility; walking speed; memory; attention
www.frontiersin.org (publisher PDF)
Sources: Web Of Science, ORCID
Added: July 24, 2023
2022 article
Relationship between hearing, cognitive function, and quality of life in aging companion dogs
Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., & Olby, N. J. (2022, August 6). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.
author keywords: canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; presbycusis
MeSH headings : Aging; Animals; Cognition; Dementia / epidemiology; Dog Diseases; Dogs; Hearing; Humans; Pets; Presbycusis / epidemiology; Presbycusis / veterinary; Prospective Studies; Quality of Life
Sources: Web Of Science, ORCID
Added: August 22, 2022
2022 journal article
Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population
JOURNAL OF ALZHEIMERS DISEASE, 87(3), 1367–1378.
author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
Sources: Web Of Science, ORCID
Added: June 20, 2022
2021 journal article
Computed tomography findings in a cohort of 169 dogs with elbow dysplasia-a retrospective study
BMC VETERINARY RESEARCH, 17(1).
author keywords: Canine elbow dysplasia; CED; CT; Imaging; Dogs
MeSH headings : Age Factors; Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dogs; Female; Forelimb / diagnostic imaging; Joint Diseases / diagnostic imaging; Joint Diseases / epidemiology; Joint Diseases / veterinary; Male; Prevalence; Retrospective Studies; Species Specificity; Tomography, X-Ray Computed / veterinary
Sources: Web Of Science, ORCID
Added: September 20, 2021
2021 journal article
Plasma Amyloid Beta Concentrations in Aged and Cognitively Impaired Pet Dogs
MOLECULAR NEUROBIOLOGY, 58(2), 483–489.
author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; CDS; Amyloid beta 42; Amyloid beta 40
MeSH headings : Aging / blood; Amyloid beta-Peptides / blood; Animals; Cognitive Dysfunction / blood; Dogs / blood; Female; Male; Pets / blood
Sources: Web Of Science, ORCID
Added: October 12, 2020
2020 journal article
BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine
Science Translational Medicine, 12(558).
MeSH headings : Brain / metabolism; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Trastuzumab; Tubulin / metabolism; Vinorelbine
Source: ORCID
Added: October 31, 2021
2020 journal article
GCN2 is essential for CD8+ T cell survival and function in murine models of malignant glioma
Cancer Immunology, Immunotherapy, 69(1), 81–94.
author keywords: GCN2; CD8(+) T-cell; Glioma; ISRIB
MeSH headings : Adoptive Transfer; Animals; Brain Neoplasms / immunology; Brain Neoplasms / pathology; Brain Neoplasms / therapy; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / transplantation; Cell Line, Tumor / transplantation; Cell Survival / immunology; Disease Models, Animal; Glioblastoma / immunology; Glioblastoma / pathology; Glioblastoma / therapy; Humans; Lymphocyte Activation; Mice; Mice, Knockout; Necrosis / genetics; Necrosis / immunology; Phosphorylation / immunology; Protein Biosynthesis / immunology; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / immunology; Protein Serine-Threonine Kinases / metabolism; Tumor Escape / immunology
Source: ORCID
Added: October 31, 2021
2020 journal article
Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs
MOLECULAR NEUROBIOLOGY, 57(7), 3143–3149.
author keywords: Canine; Cognitive dysfunction; Alzheimer's disease; Amyotrophic lateral sclerosis; Degenerative myelopathy
Sources: Web Of Science, ORCID
Added: July 13, 2020
2019 journal article
FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis
Oncogene, 38(37), 6445–6460.
MeSH headings : Animals; Brain / metabolism; Brain / pathology; Brain Neoplasms / genetics; Brain Neoplasms / metabolism; Brain Neoplasms / secondary; Breast Neoplasms / genetics; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Proliferation / genetics; Fatty Acid-Binding Protein 7 / genetics; Fatty Acid-Binding Protein 7 / physiology; Female; Humans; Lipid Droplets / metabolism; Lipid Droplets / pathology; Lipid Metabolism / genetics; Mice; Oxidative Phosphorylation; Receptor, ErbB-2 / genetics; Receptor, ErbB-2 / metabolism; Tumor Microenvironment; Tumor Suppressor Proteins / genetics; Tumor Suppressor Proteins / physiology
Source: ORCID
Added: October 31, 2021
2019 journal article
HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
Cell Reports, 27(1), 226–237.e4.
MeSH headings : Aged; Aged, 80 and over; Animals; Brain Neoplasms / genetics; Brain Neoplasms / immunology; Brain Neoplasms / metabolism; Brain Neoplasms / pathology; Cell Hypoxia / genetics; Cell Hypoxia / physiology; Cell Movement / genetics; Cells, Cultured; Energy Metabolism / genetics; Female; Genes, Switch / physiology; Glioblastoma / genetics; Glioblastoma / immunology; Glioblastoma / metabolism; Glioblastoma / pathology; Glycolysis / genetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / physiology; Immunosuppression Therapy; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Phosphorylation; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Tumor Escape / genetics; Tumor Escape / immunology; Tumor Microenvironment / genetics
Source: ORCID
Added: October 31, 2021
2019 journal article
Local Application of Autologous Platelet-Rich Fibrin Patch (PRF-P) Suppresses Regulatory T Cell Recruitment in a Murine Glioma Model
Molecular Neurobiology, 56(7), 5032–5040.
author keywords: Glioblastoma multiforme; Immunosuppressive microenvironment; Platelet-rich fibrin patch; Regulatory Tcells and glioma immune therapies
MeSH headings : Animals; Autografts; Brain Neoplasms / immunology; Brain Neoplasms / metabolism; Brain Neoplasms / therapy; Cell Line, Tumor; Cells, Cultured; Craniotomy / methods; Glioma / immunology; Glioma / metabolism; Glioma / therapy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Platelet-Rich Fibrin / physiology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Tumor Microenvironment / immunology
Source: ORCID
Added: October 31, 2021
2019 journal article
Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma
Proceedings of the National Academy of Sciences of the United States of America, 116(47), 23714–23723.
author keywords: immunotherapy; glioblastoma; myeloid cell; PD-L1; radiotherapy
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; B7-H1 Antigen / metabolism; Brain Neoplasms / drug therapy; Brain Neoplasms / pathology; Brain Neoplasms / radiotherapy; Bridged Bicyclo Compounds, Heterocyclic / administration & dosage; Bridged Bicyclo Compounds, Heterocyclic / therapeutic use; Cyclic N-Oxides; Glioblastoma / drug therapy; Glioblastoma / pathology; Glioblastoma / radiotherapy; Humans; Indolizines; Mice; Myeloid Cells / drug effects; Myeloid Cells / pathology; Myeloid Cells / radiation effects; Nanoparticles; Pyridinium Compounds / administration & dosage; Pyridinium Compounds / therapeutic use; Tumor Microenvironment; Xenograft Model Antitumor Assays
Source: ORCID
Added: October 31, 2021
2018 journal article
A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model
Neurotherapeutics, 15(4), 1127–1138.
author keywords: glioblastoma; adenovirus; dendritic cells; cytomegalovirus; vaccine
MeSH headings : Adaptive Immunity / genetics; Adenoviridae / genetics; Analysis of Variance; Animals; Antigens, CD / metabolism; Antigens, Neoplasm / metabolism; Brain Neoplasms / immunology; Brain Neoplasms / pathology; Brain Neoplasms / therapy; Dendritic Cells / immunology; Dendritic Cells / virology; Disease Models, Animal; Genetic Vectors / metabolism; Glioma / immunology; Glioma / pathology; Glioma / therapy; HEK293 Cells; Humans; Lectins, C-Type / metabolism; Lymph Nodes / cytology; Mice; Minor Histocompatibility Antigens / metabolism; Receptors, Cell Surface / metabolism; Spleen / cytology; Transduction, Genetic; Transfection; Xenograft Model Antitumor Assays
Source: ORCID
Added: October 31, 2021
2018 journal article
Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma
Molecular Therapy, 26(4), 986–995.
MeSH headings : Animals; CD28 Antigens / immunology; CD28 Antigens / metabolism; Cell Line, Tumor; Cytotoxicity, Immunologic; Disease Models, Animal; Female; Gene Expression; Genetic Vectors / genetics; Glioblastoma / genetics; Glioblastoma / immunology; Glioblastoma / metabolism; Glioblastoma / therapy; Humans; Immunotherapy, Adoptive / methods; Inflammation / immunology; Inflammation / metabolism; Inflammation / pathology; Interleukin-13 Receptor alpha2 Subunit / antagonists & inhibitors; Interleukin-13 Receptor alpha2 Subunit / immunology; Male; Mice; Receptors, Chimeric Antigen / genetics; Receptors, Chimeric Antigen / metabolism; T-Lymphocytes / immunology; T-Lymphocytes / metabolism; Treatment Outcome; Tumor Microenvironment / immunology; Xenograft Model Antitumor Assays
Source: ORCID
Added: October 31, 2021
2018 chapter
Gene/Viral Treatment Approaches for Malignant Brain Cancer
In Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy: Second Edition (pp. 211–227).
Source: ORCID
Added: October 31, 2021
2017 journal article
A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model
Molecular Therapy - Oncolytics, 5, 97–104.
Source: ORCID
Added: October 31, 2021
2017 journal article
Hitting the nail on the head: Combining oncolytic adenovirusmediated virotherapy and immunomodulation for the treatment of glioma
Oncotarget, 8(51), 89391–89405.
author keywords: combinatory therapy; glioma; immunomodulator(s); checkpoint blockade; oncolytic adenovirus
Source: ORCID
Added: October 31, 2021
2017 journal article
Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression
Proceedings of the National Academy of Sciences of the United States of America, 114(30), E6147–E6156.
author keywords: siRNA; lipopolymeric nanoparticle; glioblastoma transcription factor; brain tumor-initiating cells; convection-enhanced delivery
MeSH headings : Animals; Carcinogenesis / genetics; Drug Resistance, Neoplasm; Female; Genetic Therapy / methods; Glioblastoma / drug therapy; Glioblastoma / genetics; Glioblastoma / pathology; Humans; Male; Mice; Mice, Nude; Nanoparticles / therapeutic use; RNA Interference; Xenograft Model Antitumor Assays
Source: ORCID
Added: October 31, 2021
2017 journal article
Multiplexed nanomedicine for brain tumors: Nanosized Hercules to tame our Lernaean Hydra inside?
Nanomedicine, 12(20), 2435–2439.
author keywords: GBM; nanoparticle; nanomedicine; brain tumor; siRNA; convection enhanced delivery; BTIC/brain tumor-initiating cells; stem cell transcription factor
Source: ORCID
Added: October 31, 2021
Employment
Updated: October 30th, 2021 19:36
2020 - 2023
University of California Davis Davis, CA, US
Small Animal Neurology/Neurosurgery Resident
Surgical and CLinical Sciences
