Whitney Stutts

Works (16)

Updated: November 25th, 2024 21:40

2024 journal article

Developmental regulation of cellular metabolism is required for intestinal elongation and rotation

DEVELOPMENT, 151(1).

By: J. Grzymkowski n, Y. Chiu, D. Jima n, B. Wyatt n, S. Jayachandran n, W. Stutts n , N. Nascone-Yoder n 

author keywords: Intestine; Metabolism; Rotation; Electron transport chain; Elongation; Atrazine; Xenopus
TL;DR: Roles for metabolism in gut morphogenesis are revealed and implicate defective gut tube elongation and/or metabolic perturbations in the etiology of intestinal malrotation. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 22, 2024

2022 journal article

An adaptive teosinte mexicana introgression modulates phosphatidylcholine levels and is associated with maize flowering time

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(27).

By: A. Barnes n, F. Rodriguez-Zapata  n, K. Juarez-Nunez *, D. Gates *, G. Janzen *, A. Kur  n, L. Wang *, S. Jensen * ...

Contributors: P. Thompson n 

author keywords: phospholipid metabolism; maize genetics; highland adaptation; flowering time; selection
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 3, 2022

2021 report

Teosinte introgression modulates phosphatidylcholine levels and induces early maize flowering time

In [] (Vol. 1) [BioRxiv preprint].

By: A. Barnes, F. Rodrı́guez-Zapata *, K. Blöcher-Juárez, D. Gates *, A. Kur, L. Wang *, G. Janzen *, S. Jensen ...

UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 20, 2021

2021 journal article

Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish

JOURNAL OF LIPID RESEARCH, 62.

By: M. Knuth  n, W. Stutts n , M. Ritter  n, K. Garrard n & S. Kullman n 

author keywords: MS; metabolomics; lipidomics; lipids; nutrition; endocannabinoid biosynthesis; MSI; IR-MALDESI; anandamide
MeSH headings : Animals; Endocannabinoids / metabolism; Lipid Metabolism; Lipids / chemistry; Vitamin D Deficiency / metabolism; Zebrafish
TL;DR: Investigation of putative linkages between vitamin D deficiency and metabolic disruption of bioactive lipids by MS imaging and expression of genes involved in EC biosynthesis, metabolism, and receptor signaling in adipose tissue and liver suggest that VDD may promote accumulation of bio active lipids and increased EC tone in zebrafish. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 19, 2021

2020 journal article

Characterization of Dinophysis spp. (Dinophyceae, Dinophysiales) from the mid-Atlantic region of the United States

JOURNAL OF PHYCOLOGY, 56(2), 404–424.

By: J. Wolny *, T. Egerton *, S. Handy *, W. Stutts* , J. Smith *, E. Whereat *, T. Bachvaroff *, D. Henrichs *, L. Campbell *, J. Deeds*

author keywords: diarrhetic shellfish poisoning; dinoflagellate; Dinophysis; dinophysistoxin; environmental clones; harmful algal bloom; okadaic acid; phylogeny
MeSH headings : Dinoflagellida / genetics; Gulf of Mexico; Marine Toxins; Mediterranean Sea; Mid-Atlantic Region
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 27, 2020

2020 journal article

Dihydrodinophysistoxin-1 Produced by <i>Dinophysis norvegica</i> in the Gulf of Maine, USA and Its Accumulation in Shellfish.

Toxins.

Whitney Stutts

author keywords: diarrhetic shellfish poisoning; dihydro-DTX1; Dinophysis norvegica; Gulf of Maine USA
MeSH headings : Animals; Dinoflagellida / chemistry; Dinoflagellida / isolation & purification; Maine; Marine Toxins / analysis; Marine Toxins / toxicity; Okadaic Acid / analogs & derivatives; Okadaic Acid / analysis; Okadaic Acid / toxicity; Phytoplankton / chemistry; Phytoplankton / isolation & purification; Shellfish / analysis; Shellfish / toxicity; Shellfish Poisoning / diagnosis; Shellfish Poisoning / etiology; Tandem Mass Spectrometry / methods
TL;DR: Dihydrodinophysistoxin-1 was detected in multiple species of commercial shellfish collected from the central coast of the Gulf of Maine, USA in 2016 and in 2018 during blooms of the dinoflagellate Dinophysis norvegica, confirming the source of this compound in shellfish. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: May 20, 2021

2020 journal article

Methods for Cryosectioning and Mass Spectrometry Imaging of Whole-Body Zebrafish

Journal of the American Society for Mass Spectrometry, 31(4), 768–772.

By: W. Stutts n , M. Knuth  n, M. Ekelöf n, D. Mahapatra  n, S. Kullman n  & D. Muddiman n 

author keywords: zebrafish; mass spectrometry imaging; cryosectioning; IR-MALDESI; lipids
MeSH headings : Animals; Cryoultramicrotomy / methods; Lipids / analysis; Male; Molecular Imaging; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Zebrafish / metabolism
TL;DR: The zebrafish (Danio rerio) is an ideal model for whole animal studies of lipid metabolism and lipid-related disease, and infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging (MSI) was applied for direct visualization of lipid and metabolite distributions across various organs in whole-body zebra fish tissue sections. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: ORCID, Crossref, NC State University Libraries
Added: February 6, 2021

2020 journal article

Microcystin Toxins at Potentially Hazardous Levels in Algal Dietary Supplements Revealed by a Combination of Bioassay, Immunoassay, and Mass Spectrometric Methods.

Journal of Agricultural and Food Chemistry.

Whitney Stutts

author keywords: microcystin; Microcystis; harmful algae; Aphanizomenon flos-aquae; ELISA; food supplement; LC-MS; PPIA
MeSH headings : Biological Assay / methods; Cyanobacteria / chemistry; Cyanobacteria / metabolism; Dietary Supplements / analysis; Food Contamination / analysis; Immunoassay; Microcystins / analysis; Microcystins / metabolism; Microcystins / toxicity; Tandem Mass Spectrometry / methods
TL;DR: The need for monitoring microcystins in algal dietary supplements is confirmed, and strategies to fully describe the total MC pool in environmental samples and algal products are presented. (via Semantic Scholar)
Source: ORCID
Added: May 20, 2021

2019 journal article

Elucidation and partial NMR assignment of monosulfated maitotoxins from the Caribbean

TOXICON, 164, 44–50.

By: E. Mazzola*, J. Deeds*, W. Stutts* , C. Ridge *, R. Dickey *, K. White*, R. Williamson*, G. Martin *

Contributors: E. Mazzola*, J. Deeds*, W. Stutts* , C. Ridge *, R. Dickey *, K. White*, R. Williamson*, G. Martin *

author keywords: Dinoflagellate; Gambierdiscus; NMR spectroscopy; Liquid chromatography-mass spectrometry; High resolution mass spectrometry
MeSH headings : Caribbean Region; Chromatography, Liquid; Dinoflagellida / chemistry; Magnetic Resonance Spectroscopy; Marine Toxins / chemistry; Mass Spectrometry; Molecular Structure; Oxocins / chemistry
TL;DR: NMR experiments, using approximately 50 nmol of one of these compounds, have demonstrated that the 9-sulfo group ofMTX is still present, suggesting that these compounds are 40-desulfo congeners of MTX. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 17, 2019

2018 journal article

Evaluation of microcystin contamination in blue-green algal dietary supplements using a protein phosphatase inhibition-based test kit

Heliyon, 4(3).

By: D. Marsan *, S. Conrad*, W. Stutts* , C. Parker * & J. Deeds*

Contributors: D. Marsan *, S. Conrad*, W. Stutts* , C. Parker * & J. Deeds*

author keywords: Food safety; Food analysis
TL;DR: A commercial protein phosphatase inhibition assay (PPIA), based on the enzyme PP2A, was found to have acceptable relative enzyme inhibition and accuracy for the majority of MC variants tested, including those most commonly identified in commercial samples, making the kit fit for purpose. (via Semantic Scholar)
Source: ORCID
Added: May 20, 2021

2017 journal article

Identification of Azadinium species and a new azaspiracid from Azadinium poporum in Puget Sound, Washington State, USA

Harmful Algae, 68, 152–167.

By: J. Kim *, U. Tillmann *, N. Adams *, B. Krock *, W. Stutts* , J. Deeds*, M. Han*, V. Trainer*

Contributors: J. Kim *, U. Tillmann *, N. Adams *, B. Krock *, W. Stutts* , J. Deeds*, M. Han*, V. Trainer*

author keywords: Azadinium; Azaspiracid; Puget sound; Washington state; Harmful algae
MeSH headings : Dinoflagellida / chemistry; Dinoflagellida / isolation & purification; Dinoflagellida / ultrastructure; Geography; Likelihood Functions; Marine Toxins / chemistry; Marine Toxins / toxicity; Nucleic Acid Conformation; Phylogeny; Spiro Compounds / chemistry; Spiro Compounds / toxicity; Washington
TL;DR: Using a combination of molecular methods for species detection and solid phase resin deployment to target shellfish monitoring of toxin at high-risk sites, the risk of azaspiracid shellfish poisoning can be minimized. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: May 20, 2021

2015 journal article

Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantitation of Microcystins in Blue-Green Algal Dietary Supplements

Journal of Agricultural and Food Chemistry, 63(47), 10303–10312.

By: C. Parker *, W. Stutts*  & S. Degrasse*

Contributors: C. Parker *, W. Stutts*  & S. Degrasse*

author keywords: microcystin; cyanotoxin; blue-green algae; dietary supplements; Aphanizomenon flos-aquae; tandem mass spectrometry
MeSH headings : Bacterial Toxins / chemistry; Chromatography, High Pressure Liquid / methods; Cyanobacteria / chemistry; Dietary Supplements / analysis; Food Contamination / analysis; Microcystins / chemistry; Tandem Mass Spectrometry / methods
TL;DR: A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous detection and quantitation of seven microcystin congeners and nodularin-R in blue-green algal dietary supplements, confirming the presence of microcyStin contamination at the Oregon-mandated guidance concentration of 1.0 μg of microCystin-LReq/g. (via Semantic Scholar)
Source: ORCID
Added: May 20, 2021

2015 journal article

Effects of a Proline Endopeptidase on the Detection and Quantitation of Gluten by Antibody-Based Methods during the Fermentation of a Model Sorghum Beer

Journal of Agricultural and Food Chemistry, 63(48), 10525–10535.

By: R. Panda *, K. Fiedler *, C. Cho *, R. Cheng *, W. Stutts* , L. Jackson *, E. Garber *

Contributors: R. Panda *, K. Fiedler *, C. Cho *, R. Cheng *, W. Stutts* , L. Jackson *, E. Garber *

author keywords: gluten; proline endopeptidase; beer; fermentation
MeSH headings : Antibodies / analysis; Beer / analysis; Beer / microbiology; Enzyme-Linked Immunosorbent Assay / instrumentation; Enzyme-Linked Immunosorbent Assay / methods; Fermentation; Food Contamination / analysis; Glutens / analysis; Glutens / metabolism; Mass Spectrometry / methods; Prolyl Oligopeptidases; Serine Endopeptidases / analysis; Sorghum / chemistry; Sorghum / microbiology; Triticum / chemistry; Triticum / microbiology
TL;DR: Western blot results indicated partial resistance of the high molecular weight (HMW) glutenins to the action of PEP, questioning the ability of P EP in digesting all immunopathogenic sequences present in gluten. (via Semantic Scholar)
Source: ORCID
Added: May 20, 2021

2013 journal article

Characterization of phosphatidylcholine oxidation products by MALDI MS <inf>n</inf>

Analytical Chemistry, 85(23), 11410–11419.

By: W. Stutts* , R. Menger*, A. Kiss *, R. Heeren * & R. Yost *

Contributors: W. Stutts* , R. Menger*, A. Kiss *, R. Heeren * & R. Yost *

MeSH headings : Animals; Female; Oxidation-Reduction; Phosphatidylcholines / analysis; Phosphatidylcholines / metabolism; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: This work illustrates the enhanced selectivity afforded by MS(n) on the linear ion trap and develops a method for the identification of individual products of PC oxidation. (via Semantic Scholar)
Source: ORCID
Added: May 20, 2021

2011 journal article

MALDI mass spectrometric imaging of cardiac tissue following myocardial infarction in a rat coronary artery ligation model

Analytical Chemistry, 84(2), 1117–1125.

By: R. Menger*, W. Stutts* , D. Anbukumar *, J. Bowden *, D. Ford * & R. Yost *

Contributors: R. Menger*, W. Stutts* , D. Anbukumar *, J. Bowden *, D. Ford * & R. Yost *

MeSH headings : Animals; Coronary Vessels / metabolism; Coronary Vessels / pathology; Heart / physiology; Image Processing, Computer-Assisted; Ligation; Male; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry
TL;DR: The investigation of an in vivo rat model of MI using mass spectrometric imaging (MSI) and multivariate data analysis suggests increased activity of phospholipase A(2), an enzyme that has been implicated in coronary heart disease and inflammation. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: May 20, 2021

2009 journal article

Enhanced analysis of steroids by gas chromatography/mass spectrometry using microwave-accelerated derivatization

Analytical Chemistry, 81(16), 6725–6734.

By: J. Bowden *, D. Colosi*, W. Stutts* , D. Mora-Montero*, T. Garrett * & R. Yost *

Contributors: J. Bowden *, D. Colosi*, W. Stutts* , D. Mora-Montero*, T. Garrett * & R. Yost *

MeSH headings : Gas Chromatography-Mass Spectrometry / methods; Microwaves; Reproducibility of Results; Steroids / analysis
TL;DR: This study highlights the best methods for analyzing a comprehensive variety of steroids and also provides ideal strategies for MAD of steroids on an individual or class level. (via Semantic Scholar)
Source: ORCID
Added: May 20, 2021

Employment

Updated: November 25th, 2024 21:36

2024 - present

University of North Carolina at Chapel Hill Chapel Hill, US
Research Associate Professor Pharmacology

2018 - present

North Carolina State University Raleigh, NC, US
Senior Research Scholar Molecular Education, Technology and Research Innovation Center (METRIC)

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