Whitney Mcrae Jones

author keywords: Tum; RacGAP; Pav; Wg; Wnt; Drosophila; Embryo; Signal transduction

MeSH headings : Animals; Armadillo Domain Proteins / genetics; Armadillo Domain Proteins / metabolism; Body Patterning / physiology; Cell Nucleus / metabolism; Cells, Cultured; Cytokinesis / physiology; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / cytology; Drosophila melanogaster / embryology; Epistasis, Genetic; GTPase-Activating Proteins / genetics; GTPase-Activating Proteins / metabolism; Genes, Reporter; Humans; Microtubule-Associated Proteins / genetics; Microtubule-Associated Proteins / metabolism; Phenotype; Signal Transduction / physiology; Transcription Factors / genetics; Transcription Factors / metabolism; Two-Hybrid System Techniques; Wings, Animal / anatomy & histology; Wings, Animal / physiology; Wnt Proteins / genetics; Wnt Proteins / metabolism; Wnt1 Protein / genetics; Wnt1 Protein / metabolism; beta Catenin / genetics; beta Catenin / metabolism

TL;DR: Two modulators of the Wnt pathway that have shared functions in cell division are identified, which hints at a possible link between cytokinesis and Wnt activity during tumorigenesis. (via Semantic Scholar)

MeSH headings : Actomyosin / metabolism; Animals; Cell Division / physiology; Contractile Proteins / analysis; Contractile Proteins / metabolism; Contractile Proteins / physiology; Drosophila / cytology; Drosophila / metabolism; Drosophila Proteins / analysis; Drosophila Proteins / metabolism; Drosophila Proteins / physiology; Fluorescence Resonance Energy Transfer; GTPase-Activating Proteins / analysis; GTPase-Activating Proteins / metabolism; GTPase-Activating Proteins / physiology; Microtubules / metabolism; Protein Interaction Mapping; Spindle Apparatus / metabolism

TL;DR: The spindle-associated component, RacGAP50C, which specifies the site of cleavage, interacts directly with Anillin, an actin and myosin binding protein found in the contractile ring, and these results account for the long-observed dependence of cytokinesis on the continual presence of microtubules at the cortex. (via Semantic Scholar)

author keywords: SoxN; Wg; Wnt; Drosophila; embryo; signal transduction

MeSH headings : Animals; Body Patterning; Cells, Cultured; Drosophila / embryology; Drosophila / metabolism; Drosophila Proteins / genetics; Drosophila Proteins / physiology; Epidermis / embryology; Epidermis / physiology; Epistasis, Genetic; High Mobility Group Proteins / genetics; High Mobility Group Proteins / physiology; Humans; Mutation; Protein Binding; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / physiology; Repressor Proteins / physiology; SOX Transcription Factors; Signal Transduction; Transcription Factors / genetics; Transcription Factors / physiology; Wnt1 Protein

TL;DR: It is shown that SoxN negatively regulates Wg pathway activity in the embryonic epidermis, and interacts with the repressor form of Tcf to influence Wg/Wnt target gene transcription. (via Semantic Scholar)

MeSH headings : Alleles; Animals; Armadillo Domain Proteins; Axin Protein; Body Patterning; Crosses, Genetic; Drosophila Proteins / biosynthesis; Drosophila Proteins / chemistry; Drosophila Proteins / metabolism; Epidermis / embryology; Epidermis / metabolism; GTPase-Activating Proteins / chemistry; GTPase-Activating Proteins / metabolism; GTPase-Activating Proteins / physiology; Gene Expression Regulation, Developmental; Green Fluorescent Proteins / metabolism; In Situ Hybridization; Mutation; Phenotype; Protein Binding; Proto-Oncogene Proteins / biosynthesis; RNA / metabolism; Repressor Proteins / genetics; Signal Transduction; Trans-Activators / biosynthesis; Transgenes; Wings, Animal / embryology; Wnt1 Protein

TL;DR: Two mutant lines that modify wg-mediated epidermal patterning represent the first loss-of-function mutations in the RacGap50C gene, which suggests that the mutant embryos suffer from ectopic Wg pathway activation. (via Semantic Scholar)

MeSH headings : Animals; Down-Regulation; Drosophila / embryology; Drosophila Proteins / physiology; Morphogenesis; Proto-Oncogene Proteins / physiology; Signal Transduction; Wnt1 Protein

TL;DR: New findings in Drosophila reveal a novel mechanism for down-regulating the activity of the Wingless/Wnt pathway that is needed for tumor suppression in adult tissues. (via Semantic Scholar)