William Marinello

neurodevelopment, brain, behavior, neuroendocrine, placenta, trophoblast, pregnancy, toxicology, endocrine disruptors, endocrine disrupting chemicals, EDC

Works (11)

Updated: April 23rd, 2025 20:48

2023 article

Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (Microtus ochrogaster)

Marinello, W. P., Gillera, S. E. A., Han, Y., Richardson, J. R., Armour, G. S., Horman, B. M., & Patisaul, H. B. (2023, August 8). Molecular and Cellular Endocrinology, Vol. 576.

By: W. Marinello n , S. Gillera n , Y. Han*, J. Richardson *, G. Armour n, B. Horman n, H. Patisaul n 

author keywords: Pregnancy; EDCs; Endocrine disruptors; Neurotoxicology; Developmental toxicology; Organophosphate
MeSH headings : Animals; Male; Humans; Female; Pregnancy; Grassland; Placenta; Brain; Arvicolinae
topics (OpenAlex): Neuroendocrine regulation and behavior; Toxic Organic Pollutants Impact; Neuroscience of respiration and sleep
TL;DR: Prairie voles are used, a monogamous and bi-parental rodent, leveraged for decades to decipher the underpinnings of social behaviors, to examine the impact of fetal FR exposure on gene targets in the mid-gestational placenta and fetal brain and provide insights on the mechanisms by which FRs impair neurodevelopment and later in life social behaviors. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023

2023 article

Uncovering the common factors of chemical exposure and behavior: Evaluating behavioral effects across a testing battery using factor analysis

Marinello, W. P., Gillera, S. E. A., Huang, L., Rollman, J., Reif, D. M., & Patisaul, H. B. (2023, October 31). NeuroToxicology, Vol. 99, pp. 264–273.

By: W. Marinello n , S. Gillera  n, L. Huang n, J. Rollman n, D. Reif n  & H. Patisaul n 

author keywords: EDCs; Endocrine disruptors; Neurodevelopment; Neurotoxicology; Organophosphate; Flame retardants; Vole; Behavior
MeSH headings : Animals; Pregnancy; Female; Humans; Organophosphates; Behavior, Animal; Environmental Exposure / analysis; Social Behavior; Flame Retardants / pharmacology
topics (OpenAlex): Olfactory and Sensory Function Studies; Child and Animal Learning Development; Memory and Neural Mechanisms
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2022 article

Effects of developmental exposure to FireMaster® 550 (FM 550) on microglia density, reactivity and morphology in a prosocial animal model

Marinello, W. P., Gillera, S. E. A., Fanning, M. J., Malinsky, L. B., Rhodes, C. L., Horman, B. M., & Patisaul, H. B. (2022, May 5). NeuroToxicology, Vol. 7.

By: W. Marinello n , S. Gillera n , M. Fanning n, L. Malinsky n, C. Rhodes n, B. Horman n, H. Patisaul n 

author keywords: Prefrontal cortex; Sex difference; Neurodevelopment; Endocrine disrupting chemicals; Flame retardants; Vole
MeSH headings : Animals; Arvicolinae; Female; Humans; Male; Mice; Microglia; Models, Animal; Organophosphates; Polybrominated Biphenyls; Pregnancy; Rats
topics (OpenAlex): Neuroinflammation and Neurodegeneration Mechanisms; Neuroendocrine regulation and behavior; Stress Responses and Cortisol
TL;DR: Overall, FM 550 exposure resulted in reduced numbers of microglia in most regions examined, with the 1000µg FM 550 exposed males particularly affected. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 20, 2022

2022 article

Individual and Combined Effects of Paternal Deprivation and Developmental Exposure to Firemaster 550 on Socio-Emotional Behavior in Prairie Voles

Gillera, S. E. A., Marinello, W. P., Nelson, M. A., Horman, B. M., & Patisaul, H. B. (2022, May 22). Toxics, Vol. 5.

By: S. Gillera n , W. Marinello n , M. Nelson n, B. Horman n & H. Patisaul n 

author keywords: endocrine disruptors; flame retardants; sexual differentiation; pair bond
topics (OpenAlex): Neuroendocrine regulation and behavior; Stress Responses and Cortisol; Memory and Neural Mechanisms
TL;DR: Evidence is provided that chemical and social stressors can have unique behavioral effects that differ by sex but may not produce worse outcomes in combination. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 13, 2022

2021 article

Endocrine disrupting chemicals (EDCs) and placental function: Impact on fetal brain development

Marinello, W. P., & Patisaul, H. B. (2021, January 1). Advances in Pharmacology, Vol. 92, pp. 347–400.

By: W. Marinello n  & H. Patisaul  n

Contributors: W. Marinello n  & H. Patisaul  n

MeSH headings : Animals; Brain; Endocrine Disruptors / toxicity; Female; Fetal Development; Fetus; Humans; Placenta; Pregnancy
topics (OpenAlex): Birth, Development, and Health; Pregnancy and preeclampsia studies; Pregnancy and Medication Impact
TL;DR: The importance of the placenta as a modulator of fetal brain development is illustrated and critical unexplored areas and possible vulnerabilities to environmental exposure are suggested. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: May 14, 2022

2021 article

Sex-specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture

Gillera, S. E. A., Marinello, W. P., Cao, K. T., Horman, B. M., Stapleton, H. M., & Patisaul, H. B. (2021, May 26). Endocrinology, Vol. 8.

By: S. Gillera n , W. Marinello n , K. Cao n, B. Horman n, H. Stapleton * & H. Patisaul n 

Contributors: S. Gillera n , W. Marinello n , K. Cao n, B. Horman n, H. Stapleton * & H. Patisaul n 

author keywords: Social; anxiety; neurodevelopment; neural; endocrine disruptors; endocrine disrupting chemicals; oxytocin; vasopressin; dopamine
MeSH headings : Animals; Arginine Vasopressin / metabolism; Arvicolinae; Endocrine Disruptors / toxicity; Female; Flame Retardants / toxicity; Male; Neurons / drug effects; Neurons / metabolism; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / drug effects; Sex Factors; Tyrosine 3-Monooxygenase / metabolism
topics (OpenAlex): Neuroendocrine regulation and behavior; Circadian rhythm and melatonin; Neuroscience of respiration and sleep
TL;DR: Results expand on previous work showing evidence of endocrine disruption of OT/AVP pathways, including to subpopulations of PVN AVP neurons that coordinate osmoregulatory functions in the periphery, by testing the hypothesis that FM 550 sex-specifically alters AVP and OT neuronal populations in critical nuclei. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 12, 2021

2020 article

Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes

Marinello, W. P., Mohseni, Z. S., Cunningham, S. J., Crute, C., Huang, R., Zhang, J. J., & Feng, L. (2020, September 9). The FASEB Journal, Vol. 34, pp. 14182–14199.

By: W. Marinello* , Z. Mohseni *, S. Cunningham *, C. Crute*, R. Huang *, J. Zhang*, L. Feng *

Contributors: W. Marinello* , Z. Mohseni *, S. Cunningham *, C. Crute*, R. Huang *, J. Zhang*, L. Feng *

author keywords: invasion; PFBS; placenta cytotrophoblast; preeclampsia; proliferation
MeSH headings : Apoptosis; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Female; Fluorocarbons / adverse effects; Gene Expression Profiling; Gene Expression Regulation / drug effects; Humans; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Phosphatidylinositol 3-Kinases / genetics; Phosphatidylinositol 3-Kinases / metabolism; Placenta / drug effects; Placenta / metabolism; Placenta / pathology; Pre-Eclampsia / chemically induced; Pre-Eclampsia / genetics; Pre-Eclampsia / metabolism; Pre-Eclampsia / pathology; Pregnancy; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Sulfonic Acids / adverse effects; Trophoblasts / drug effects; Trophoblasts / metabolism; Trophoblasts / pathology
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Birth, Development, and Health; Gestational Diabetes Research and Management
TL;DR: PBFS exposure altered trophoblast cell proliferation/invasion which might be mediated by preeclampsia‐related genes, suggesting a possible association between prenatal PFBS exposure and adverse placentation. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2022

2020 article

Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells

Marinello, W., Feng, L., & Allen, T. K. (2020, July 24). Frontiers in Physiology, Vol. 11.

By: W. Marinello* , L. Feng * & T. Allen *

Contributors: W. Marinello* , L. Feng * & T. Allen *

author keywords: progestins; preterm premature rupture of membranes; glucocorticoid receptor; progesterone receptor; interleukin-1 beta; Interleukin-8; matrix metalloproteinase 1
topics (OpenAlex): Preterm Birth and Chorioamnionitis; Pregnancy-related medical research; Reproductive System and Pregnancy
TL;DR: It is demonstrated that medroxyprogesterone acetate exerts its anti-inflammatory effect primarily through the glucocorticoid receptor in human amnion mesenchymal cells. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2022

2019 article

Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles

Gillera, S. E. A., Marinello, W. P., Horman, B. M., Phillips, A. L., Ruis, M. T., Stapleton, H. M., … Patisaul, H. B. (2019, November 12). Neurotoxicology and Teratology, Vol. 79, p. 106840.

By: S. Gillera n , W. Marinello n , B. Horman  n, A. Phillips *, M. Ruis*, H. Stapleton *, D. Reif n , H. Patisaul  n

Contributors: S. Gillera n , W. Marinello n , B. Horman  n, A. Phillips *, M. Ruis*, H. Stapleton *, D. Reif n , H. Patisaul  n

author keywords: Social; Anxiety; Brain; Neurodevelopment; Neural; Endocrine disruptors; Endocrine disrupting chemicals; Flame retardants
MeSH headings : Animals; Anxiety / chemically induced; Arvicolinae; Behavior, Animal / drug effects; Exploratory Behavior / drug effects; Female; Flame Retardants / toxicity; Male; Organophosphates / toxicity; Polybrominated Biphenyls / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / psychology; Sex Characteristics; Social Behavior
topics (OpenAlex): Neuroendocrine regulation and behavior; Memory and Neural Mechanisms; Maternal Mental Health During Pregnancy and Postpartum
TL;DR: The utility of the prairie vole for investigating the impact of chemical exposures on social behavior is demonstrated and the hypothesis that developmental FR exposure impacts the social brain is supported. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Source: ORCID
Added: December 4, 2019

2018 article

Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM)

Feng, L., Allen, T. K., Marinello, W. P., & Murtha, A. P. (2018, April 13). American Journal of Obstetrics and Gynecology, Vol. 219, pp. 101.e1–101.e12.

By: L. Feng *, T. Allen *, W. Marinello*  & A. Murtha *

Contributors: L. Feng *, T. Allen *, W. Marinello*  & A. Murtha *

author keywords: amnion; chorion; decidua; endotoxin; lipopolysaccharide; preterm birth; prothrombin; Ureaplasma parvum
MeSH headings : Amnion / cytology; Blotting, Western; Chorion / cytology; Decidua / cytology; Epithelial Cells / metabolism; Extraembryonic Membranes / cytology; Extraembryonic Membranes / metabolism; Female; Fetal Membranes, Premature Rupture / genetics; Fetal Membranes, Premature Rupture / metabolism; Fetal Membranes, Premature Rupture / microbiology; Humans; In Vitro Techniques; Lipopolysaccharides; Pregnancy; Prothrombin / genetics; Prothrombin / metabolism; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells / metabolism; Thrombin / genetics; Thrombin / metabolism; Trophoblasts / metabolism; Ureaplasma; Ureaplasma Infections / genetics; Ureaplasma Infections / metabolism; Ureaplasma Infections / microbiology
topics (OpenAlex): Preterm Birth and Chorioamnionitis; Neonatal and Maternal Infections; Reproductive tract infections research
TL;DR: It is demonstrated that prothrombin can be produced directly by fetal membrane amnion, chorion, and decidua cells and by Ureaplasma parvum, but not lipopolysaccharide, treatments in a dose‐dependent manner. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 24, 2020

2018 article

Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress—Induced Aging in Chorion Cells

Feng, L., Allen, T. K., Marinello, W. P., & Murtha, A. P. (2018, May 22). Reproductive Sciences, Vol. 26, pp. 394–403.

By: L. Feng *, T. Allen *, W. Marinello*  & A. Murtha *

Contributors: L. Feng *, T. Allen *, W. Marinello*  & A. Murtha *

author keywords: fetal membranes and chorion cells; oxidative stress; PGRMC1; PPROM; SIRT3
MeSH headings : Cellular Senescence; Chorion / drug effects; Chorion / metabolism; Female; Fetal Membranes, Premature Rupture / metabolism; Humans; Hydrogen Peroxide / administration & dosage; Membrane Proteins / metabolism; Oxidative Stress; Pregnancy; Receptors, Progesterone / metabolism; Sirtuin 3 / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
topics (OpenAlex): Reproductive System and Pregnancy; Preterm Birth and Chorioamnionitis; Reproductive Biology and Fertility
TL;DR: Hydrogen peroxide significantly induced cell senescence and p38 MAPK phosphorylation, and it significantly decreased SIRT3 expression in full-thickness fetal membrane explants and chorion cells, which were enhanced by PGRMC1 knockdown. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 24, 2020

Employment

Updated: June 24th, 2020 09:55

2018 - present

North Carolina State University Raleigh, NC, US
Graduate Student Biological Sciences

2016 - 2018

Duke Medical Center Durham, North Carolina, US
Research Technician OBGYN

Education

Updated: June 25th, 2020 16:52

2018 - present

North Carolina State University Raleigh, NC, US
PhD Biological Sciences

2010 - 2014

University of North Carolina at Chapel Hill Chapel Hill, NC, US
Bachelor of Science Biology

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