William Marinello
neurodevelopment, brain, behavior, neuroendocrine, placenta, trophoblast, pregnancy, toxicology, endocrine disruptors, endocrine disrupting chemicals, EDC
Works (11)
Updated: December 19th, 2023 05:02
2023 journal article
Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (<i>Microtus ochrogaster</i>)
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 576.
author keywords: Pregnancy; EDCs; Endocrine disruptors; Neurotoxicology; Developmental toxicology; Organophosphate
TL;DR:
Prairie voles are used, a monogamous and bi-parental rodent, leveraged for decades to decipher the underpinnings of social behaviors, to examine the impact of fetal FR exposure on gene targets in the mid-gestational placenta and fetal brain and provide insights on the mechanisms by which FRs impair neurodevelopment and later in life social behaviors.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023
2023 journal article
Uncovering the common factors of chemical exposure and behavior: Evaluating behavioral effects across a testing battery using factor analysis
NEUROTOXICOLOGY, 99, 264–273.
author keywords: EDCs; Endocrine disruptors; Neurodevelopment; Neurotoxicology; Organophosphate; Flame retardants; Vole; Behavior
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023
2022 journal article
Effects of developmental exposure to FireMaster (R) 550 (FM 550) on microglia density, reactivity and morphology in a prosocial animal model
NEUROTOXICOLOGY, 91, 140–154.
author keywords: Prefrontal cortex; Sex difference; Neurodevelopment; Endocrine disrupting chemicals; Flame retardants; Vole
MeSH headings : Animals; Arvicolinae; Female; Humans; Male; Mice; Microglia; Models, Animal; Organophosphates; Polybrominated Biphenyls; Pregnancy; Rats
TL;DR:
Overall, FM 550 exposure resulted in reduced numbers of microglia in most regions examined, with the 1000µg FM 550 exposed males particularly affected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 20, 2022
2022 journal article
Individual and Combined Effects of Paternal Deprivation and Developmental Exposure to Firemaster 550 on Socio-Emotional Behavior in Prairie Voles
TOXICS, 10(5).
author keywords: endocrine disruptors; flame retardants; sexual differentiation; pair bond
TL;DR:
Evidence is provided that chemical and social stressors can have unique behavioral effects that differ by sex but may not produce worse outcomes in combination.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 13, 2022
2021 chapter
Endocrine disrupting chemicals (EDCs) and placental function: Impact on fetal brain development
In Advances in Pharmacology (Vol. 92, pp. 347–400).
Contributors: n & H. Patisaul n
MeSH headings : Animals; Brain; Endocrine Disruptors / toxicity; Female; Fetal Development; Fetus; Humans; Placenta; Pregnancy
TL;DR:
The importance of the placenta as a modulator of fetal brain development is illustrated and critical unexplored areas and possible vulnerabilities to environmental exposure are suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: May 14, 2022
2021 journal article
Sex-specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture
ENDOCRINOLOGY, 162(8).
Contributors: S. Gillera n, n , K. Cao n, B. Horman n, H. Stapleton * & H. Patisaul n
author keywords: Social; anxiety; neurodevelopment; neural; endocrine disruptors; endocrine disrupting chemicals; oxytocin; vasopressin; dopamine
MeSH headings : Animals; Arginine Vasopressin / metabolism; Arvicolinae; Endocrine Disruptors / toxicity; Female; Flame Retardants / toxicity; Male; Neurons / drug effects; Neurons / metabolism; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / drug effects; Sex Factors; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
Results expand on previous work showing evidence of endocrine disruption of OT/AVP pathways, including to subpopulations of PVN AVP neurons that coordinate osmoregulatory functions in the periphery, by testing the hypothesis that FM 550 sex-specifically alters AVP and OT neuronal populations in critical nuclei.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 12, 2021
2020 journal article
Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes
FASEB Journal, 34(11), 14182–14199.
Contributors: * , Z. Mohseni*, S. Cunningham *, C. Crute*, R. Huang *, J. Zhang*, L. Feng *
author keywords: invasion; PFBS; placenta cytotrophoblast; preeclampsia; proliferation
MeSH headings : Apoptosis; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Female; Fluorocarbons / adverse effects; Gene Expression Profiling; Gene Expression Regulation / drug effects; Humans; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Phosphatidylinositol 3-Kinases / genetics; Phosphatidylinositol 3-Kinases / metabolism; Placenta / drug effects; Placenta / metabolism; Placenta / pathology; Pre-Eclampsia / chemically induced; Pre-Eclampsia / genetics; Pre-Eclampsia / metabolism; Pre-Eclampsia / pathology; Pregnancy; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Sulfonic Acids / adverse effects; Trophoblasts / drug effects; Trophoblasts / metabolism; Trophoblasts / pathology
TL;DR:
PBFS exposure altered trophoblast cell proliferation/invasion which might be mediated by preeclampsia‐related genes, suggesting a possible association between prenatal PFBS exposure and adverse placentation.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2022
2020 journal article
Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells
Frontiers in Physiology, 11.
Contributors: * , L. Feng * & T. Allen *
author keywords: progestins; preterm premature rupture of membranes; glucocorticoid receptor; progesterone receptor; interleukin-1 beta; Interleukin-8; matrix metalloproteinase 1
TL;DR:
It is demonstrated that medroxyprogesterone acetate exerts its anti-inflammatory effect primarily through the glucocorticoid receptor in human amnion mesenchymal cells.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2022
2020 journal article
Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles
Neurotoxicology and Teratology, 79, 106840.
Contributors: S. Gillera n, n , B. Horman n, A. Phillips *, M. Ruis*, H. Stapleton *, D. Reif n , H. Patisaul n
author keywords: Social; Anxiety; Brain; Neurodevelopment; Neural; Endocrine disruptors; Endocrine disrupting chemicals; Flame retardants
MeSH headings : Animals; Anxiety / chemically induced; Arvicolinae; Behavior, Animal / drug effects; Exploratory Behavior / drug effects; Female; Flame Retardants / toxicity; Male; Organophosphates / toxicity; Polybrominated Biphenyls / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / psychology; Sex Characteristics; Social Behavior
TL;DR:
The utility of the prairie vole for investigating the impact of chemical exposures on social behavior is demonstrated and the hypothesis that developmental FR exposure impacts the social brain is supported.
(via Semantic Scholar)
Source: ORCID
Added: December 4, 2019
2019 journal article
Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress–Induced Aging in Chorion Cells
Reproductive Sciences, 26(3), 394–403.
Contributors: L. Feng *, T. Allen *, * & A. Murtha*
author keywords: fetal membranes and chorion cells; oxidative stress; PGRMC1; PPROM; SIRT3
MeSH headings : Cellular Senescence; Chorion / drug effects; Chorion / metabolism; Female; Fetal Membranes, Premature Rupture / metabolism; Humans; Hydrogen Peroxide / administration & dosage; Membrane Proteins / metabolism; Oxidative Stress; Pregnancy; Receptors, Progesterone / metabolism; Sirtuin 3 / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
Hydrogen peroxide significantly induced cell senescence and p38 MAPK phosphorylation, and it significantly decreased SIRT3 expression in full-thickness fetal membrane explants and chorion cells, which were enhanced by PGRMC1 knockdown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 24, 2020
2018 journal article
Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM)
American Journal of Obstetrics and Gynecology, 219(1), 101.e1–101.e12.
Contributors: L. Feng *, T. Allen *, * & A. Murtha*
author keywords: amnion; chorion; decidua; endotoxin; lipopolysaccharide; preterm birth; prothrombin; Ureaplasma parvum
MeSH headings : Amnion / cytology; Blotting, Western; Chorion / cytology; Decidua / cytology; Epithelial Cells / metabolism; Extraembryonic Membranes / cytology; Extraembryonic Membranes / metabolism; Female; Fetal Membranes, Premature Rupture / genetics; Fetal Membranes, Premature Rupture / metabolism; Fetal Membranes, Premature Rupture / microbiology; Humans; In Vitro Techniques; Lipopolysaccharides; Pregnancy; Prothrombin / genetics; Prothrombin / metabolism; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells / metabolism; Thrombin / genetics; Thrombin / metabolism; Trophoblasts / metabolism; Ureaplasma; Ureaplasma Infections / genetics; Ureaplasma Infections / metabolism; Ureaplasma Infections / microbiology
TL;DR:
It is demonstrated that prothrombin can be produced directly by fetal membrane amnion, chorion, and decidua cells and by Ureaplasma parvum, but not lipopolysaccharide, treatments in a dose‐dependent manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 24, 2020
Employment
Updated: June 24th, 2020 09:55
2018 - present
North Carolina State University Raleigh, NC, US
Graduate Student
Biological Sciences
2016 - 2018
Duke Medical Center Durham, North Carolina, US
Research Technician
OBGYN
Education
Updated: June 25th, 2020 16:52
2018 - present
North Carolina State University Raleigh, NC, US
PhD
Biological Sciences
2010 - 2014
University of North Carolina at Chapel Hill Chapel Hill, NC, US
Bachelor of Science
Biology
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