William Marinello

https://orcid.org/0000-0002-7248-3908

neurodevelopment, brain, behavior, neuroendocrine, placenta, trophoblast, pregnancy, toxicology, endocrine disruptors, endocrine disrupting chemicals, EDC

Works (9)

Updated: July 29th, 2023 21:16
Download BibTeX Download Plain Text View JSON

2022 journal article

Effects of developmental exposure to FireMaster (R) 550 (FM 550) on microglia density, reactivity and morphology in a prosocial animal model

NEUROTOXICOLOGY, 91, 140–154.

By: W. Marinello n , S. Gillera n , M. Fanning n, L. Malinsky n, C. Rhodes n, B. Horman n, H. Patisaul n 

author keywords: Prefrontal cortex; Sex difference; Neurodevelopment; Endocrine disrupting chemicals; Flame retardants; Vole
MeSH headings : Animals; Arvicolinae; Female; Humans; Male; Mice; Microglia; Models, Animal; Organophosphates; Polybrominated Biphenyls; Pregnancy; Rats
Sources: Web Of Science, ORCID
Added: June 20, 2022

2022 journal article

Individual and Combined Effects of Paternal Deprivation and Developmental Exposure to Firemaster 550 on Socio-Emotional Behavior in Prairie Voles

TOXICS, 10(5).

By: S. Gillera n , W. Marinello n , M. Nelson n, B. Horman n & H. Patisaul n 

author keywords: endocrine disruptors; flame retardants; sexual differentiation; pair bond
Sources: Web Of Science, ORCID
Added: June 13, 2022

2021 chapter

Endocrine disrupting chemicals (EDCs) and placental function: Impact on fetal brain development

In Advances in Pharmacology (Vol. 92, pp. 347–400).

By: W. Marinello n  & H. Patisaul  n

MeSH headings : Animals; Brain; Endocrine Disruptors / toxicity; Female; Fetal Development; Fetus; Humans; Placenta; Pregnancy
Source: ORCID
Added: May 14, 2022

2021 journal article

Sex-specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture

ENDOCRINOLOGY, 162(8).

By: S. Gillera n , W. Marinello n , K. Cao n, B. Horman n, H. Stapleton * & H. Patisaul n 

author keywords: Social; anxiety; neurodevelopment; neural; endocrine disruptors; endocrine disrupting chemicals; oxytocin; vasopressin; dopamine
MeSH headings : Animals; Arginine Vasopressin / metabolism; Arvicolinae; Endocrine Disruptors / toxicity; Female; Flame Retardants / toxicity; Male; Neurons / drug effects; Neurons / metabolism; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / drug effects; Sex Factors; Tyrosine 3-Monooxygenase / metabolism
Sources: Web Of Science, ORCID
Added: July 12, 2021

2020 journal article

Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes

FASEB Journal, 34(11), 14182–14199.

By: W. Marinello* , Z. Mohseni*, S. Cunningham *, C. Crute*, R. Huang *, J. Zhang*, L. Feng *

author keywords: invasion; PFBS; placenta cytotrophoblast; preeclampsia; proliferation
MeSH headings : Apoptosis; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Female; Fluorocarbons / adverse effects; Gene Expression Profiling; Gene Expression Regulation / drug effects; Humans; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Phosphatidylinositol 3-Kinases / genetics; Phosphatidylinositol 3-Kinases / metabolism; Placenta / drug effects; Placenta / metabolism; Placenta / pathology; Pre-Eclampsia / chemically induced; Pre-Eclampsia / genetics; Pre-Eclampsia / metabolism; Pre-Eclampsia / pathology; Pregnancy; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Sulfonic Acids / adverse effects; Trophoblasts / drug effects; Trophoblasts / metabolism; Trophoblasts / pathology
Source: ORCID
Added: May 14, 2022

2020 journal article

Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells

Frontiers in Physiology, 11.

By: W. Marinello* , L. Feng * & T. Allen *

author keywords: progestins; preterm premature rupture of membranes; glucocorticoid receptor; progesterone receptor; interleukin-1 beta; Interleukin-8; matrix metalloproteinase 1
Source: ORCID
Added: May 14, 2022

2020 journal article

Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles

Neurotoxicology and Teratology, 79, 106840.

By: S. Gillera n , W. Marinello n , B. Horman n, A. Phillips *, M. Ruis*, H. Stapleton *, D. Reif n , H. Patisaul  n

author keywords: Social; Anxiety; Brain; Neurodevelopment; Neural; Endocrine disruptors; Endocrine disrupting chemicals; Flame retardants
MeSH headings : Animals; Anxiety / chemically induced; Arvicolinae; Behavior, Animal / drug effects; Exploratory Behavior / drug effects; Female; Flame Retardants / toxicity; Male; Organophosphates / toxicity; Polybrominated Biphenyls / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / psychology; Sex Characteristics; Social Behavior
Source: ORCID
Added: December 4, 2019

2019 journal article

Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress–Induced Aging in Chorion Cells

Reproductive Sciences, 26(3), 394–403.

By: L. Feng *, T. Allen *, W. Marinello*  & A. Murtha*

author keywords: fetal membranes and chorion cells; oxidative stress; PGRMC1; PPROM; SIRT3
MeSH headings : Cellular Senescence; Chorion / drug effects; Chorion / metabolism; Female; Fetal Membranes, Premature Rupture / metabolism; Humans; Hydrogen Peroxide / administration & dosage; Membrane Proteins / metabolism; Oxidative Stress; Pregnancy; Receptors, Progesterone / metabolism; Sirtuin 3 / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
Source: ORCID
Added: June 24, 2020

2018 journal article

Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM)

American Journal of Obstetrics and Gynecology, 219(1), 101.e1–101.e12.

By: L. Feng *, T. Allen *, W. Marinello*  & A. Murtha*

author keywords: amnion; chorion; decidua; endotoxin; lipopolysaccharide; preterm birth; prothrombin; Ureaplasma parvum
MeSH headings : Amnion / cytology; Blotting, Western; Chorion / cytology; Decidua / cytology; Epithelial Cells / metabolism; Extraembryonic Membranes / cytology; Extraembryonic Membranes / metabolism; Female; Fetal Membranes, Premature Rupture / genetics; Fetal Membranes, Premature Rupture / metabolism; Fetal Membranes, Premature Rupture / microbiology; Humans; In Vitro Techniques; Lipopolysaccharides; Pregnancy; Prothrombin / genetics; Prothrombin / metabolism; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells / metabolism; Thrombin / genetics; Thrombin / metabolism; Trophoblasts / metabolism; Ureaplasma; Ureaplasma Infections / genetics; Ureaplasma Infections / metabolism; Ureaplasma Infections / microbiology
Source: ORCID
Added: June 24, 2020

Employment

Updated: June 24th, 2020 09:55

2018 - present

North Carolina State University Raleigh, NC, US
Graduate Student Biological Sciences

2016 - 2018

Duke Medical Center Durham, North Carolina, US
Research Technician OBGYN

Education

Updated: June 25th, 2020 16:52

2018 - present

North Carolina State University Raleigh, NC, US
PhD Biological Sciences

2010 - 2014

University of North Carolina at Chapel Hill Chapel Hill, NC, US
Bachelor of Science Biology