William Polacheck

The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress

Singh, T., Jacobs, K. A., Polacheck, W. J., & Kutys, M. L. (2026, January 24). Life Science Alliance.

Colloidal-Fibrillar Composite Gels Demonstrate Structural Reinforcement, Secondary Fibrillar Alignment, and Improved Vascular Healing Outcomes

Communications Engineering, 4, 67.

Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations

Aw, W. Y., Sawhney, A., Rathod, M., Whitworth, C. P., Doherty, E. L., Madden, E., … Polacheck, W. J. (2025, February 5). APL Bioengineering.

Endothelial-smooth muscle microgauges for modeling pulmonary arterial vasoregulation

Sawhney, A., Piatt, R., Rathod, M., Stack, R., Whitworth, C., & Polacheck, W. (2025, January 1). Lab on a Chip.

Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction

Rathod, M., Stack, R. N., Kubik, S. E., Huang, S. A., Whitworth, C. P., Aw, W. Y., … Polacheck, W. J. (2025, June 20). Advanced Science.

New Approach Methodologies: What Clinical Pharmacologists Should Prepare For

Cao, Y., & Polacheck, W. (2025, August 24). Clinical Pharmacology & Therapeutics.

The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress

Singh, T., Jacobs, K. A., Polacheck, W. J., & Kutys, M. L. (2025, July 14).

Understanding the Lymphatic System: Tissue-on-Chip Modeling

Polacheck, W. J., Dixon, J. B., & Aw, W. Y. (2025, January 22). Annual Review of Biomedical Engineering.

A nanoporous hydrogel-based model to study chemokine gradient-driven angiogenesis under luminal flow

Mote, N., Kubik, S., Polacheck, W. J., Baker, B. M., & Trappmann, B. (2024, January 1). Lab on a Chip.

Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg

Farber, G., Dong, Y., Wang, Q., Rathod, M., Wang, H., Dixit, M., … Qian, L. (2024, May 16). Nature Communications.

Donor‐Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure

Rathod, M. L., Aw, W. Y., Huang, S., Lu, J., Doherty, E. L., Whithworth, C. P., … Polacheck, W. J. (2024, January 7). Small.

P300 Modulates Endothelial Mechanotransduction of Fluid Shear Stress

Whitworth, C. P., Aw, W. Y., Doherty, E. L., Handler, C., Ambekar, Y., Sawhney, A., … Polacheck, W. J. (2024, June 11). Cellular and Molecular Bioengineering.

Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation

Aw, W. Y., Cho, C., Wang, H., Cooper, A. H., Doherty, E. L., Rocco, D., … Polacheck, W. J. (2023, February 15). Science Advances.

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics

Doherty, E. L., Aw, W. Y., Warren, E. C., Hockenberry, M., Whitworth, C. P., Krohn, G., … Polacheck, W. J. (2023, May 13). Acta Biomaterialia.

Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling

Whitworth, C. P., & Polacheck, W. J. (2023, December 20). Expert Opinion on Drug Discovery.

A vascularized model of the human liver mimics regenerative responses

Chhabra, A., Song, H.-H. G., Grzelak, K. A., Polacheck, W. J., Fleming, H. E., Chen, C. S., & Bhatia, S. N. (2022, June 28). Proceedings of the National Academy of Sciences.

Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow

Lee, G.-hun, Huang, S. A., Aw, W. Y., Rathod, M. L., Cho, C., Ligler, F. S., & Polacheck, W. J. (2022, January 6). Biofabrication.

Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter

Wang, W. Y., Kent, R. N., Huang, S. A., Jarman, E. H., Shikanov, E. H., Davidson, C. D., … Baker, B. M. (2021, August 29). Acta Biomaterialia.

Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response

Rickard, B. P., Conrad, C., Sorrin, A. J., Ruhi, M. K., Reader, J. C., Huang, S. A., … Rizvi, I. (2021, August 26). Cancers, Vol. 13, p. 4318.

Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity

Pérez-Rodríguez, S., Huang, S. A., Borau, C., García-Aznar, J. M., & Polacheck, W. J. (2021, September 1). Biomicrofluidics.

Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation

Wang, W. Y., Lin, D., Jarman, E. H., Polacheck, W. J., & Baker, B. M. (2020, January 1). Lab on a Chip.

Microfluidics for the study of mechanotransduction

Griffith, C. M., Huang, S. A., Cho, C., Khare, T. M., Rich, M., Lee, G.-hun, … Polacheck, W. J. (2020, February 21). Journal of Physics D Applied Physics.

A Bile Duct‐on‐a‐Chip With Organ‐Level Functions

Du, Y., Khandekar, G., Llewellyn, J., Polacheck, W., Chen, C. S., & Wells, R. G. (2019, August 29). Hepatology.

Microfabricated blood vessels for modeling the vascular transport barrier

Polacheck, W. J., Kutys, M. L., Tefft, J. B., & Chen, C. S. (2019, April 5). Nature Protocols.