Works (11)

Updated: August 12th, 2023 05:00

2023 journal article

Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation


By: W. Aw n, C. Cho n, H. Wang n, A. Cooper n, E. Doherty n, D. Rocco*, S. Huang n, S. Kubik n ...

MeSH headings : Humans; TOR Serine-Threonine Kinases / metabolism; Mechanistic Target of Rapamycin Complex 1 / metabolism; Sirolimus / pharmacology; Human Umbilical Vein Endothelial Cells / metabolism; Mitogen-Activated Protein Kinase Kinases / metabolism; Class I Phosphatidylinositol 3-Kinases / genetics; Class I Phosphatidylinositol 3-Kinases / metabolism; Vascular Malformations / metabolism; rac1 GTP-Binding Protein / metabolism
Source: Web Of Science
Added: March 27, 2023

2023 journal article

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics


By: E. Doherty n, W. Aw n, E. Warren n, M. Hockenberry*, C. Whitworth*, G. Krohn n, S. Howell*, B. Diekman n ...

author keywords: Vascular Ehlers-Danlos syndrome; Cell derived matrix; Collagen III; Mechanotransduction; ECM mechanics; Viscoelasticity
Source: Web Of Science
Added: August 7, 2023

2022 journal article

A vascularized model of the human liver mimics regenerative responses


By: A. Chhabra*, H. Song*, K. Grzelak*, W. Polacheck n, H. Fleming*, C. Chen*, S. Bhatia*

author keywords: hepatocyte; regeneration; vascular
MeSH headings : Cell Culture Techniques, Three Dimensional; Cytokines; Endothelial Cells; Hepatocytes; Humans; Liver / blood supply; Liver Regeneration / physiology
Source: Web Of Science
Added: September 29, 2022

2022 journal article

Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow


By: G. Lee n, S. Huang n, W. Aw n, M. Rathod n, C. Cho n, F. Ligler n, W. Polacheck n

author keywords: microfluidics; vascular biology; interstitial flow; hemodynamics; biofluid mechanics; mechanotransduction
MeSH headings : Lymphatic Vessels; Microfluidics / methods; Stress, Mechanical
Source: Web Of Science
Added: January 31, 2022

2021 journal article

Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter


By: W. Wang*, R. Kent*, S. Huang n, E. Jarman*, E. Shikanov*, C. Davidson*, H. Hiraki*, D. Lin* ...

author keywords: Angiogenesis; Cell migration; Cell proliferation; Microfluidics; ECM; Endothelial cells; Chemotaxis; Hydrogels; Microvasculature; Sprouting Morphogenesis; Matrix porosity
MeSH headings : Animals; Biocompatible Materials / pharmacology; Endothelial Cells; Extracellular Matrix; Hydrogels / pharmacology; Mice; Neovascularization, Physiologic; Porosity
Source: Web Of Science
Added: November 29, 2021

2021 review

Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response

[Review of ]. CANCERS, 13(17).

By: B. Rickard n, C. Conrad*, A. Sorrin*, M. Ruhi n, J. Reader*, S. Huang n, W. Franco*, G. Scarcelli* ...

author keywords: malignant ascites; epithelial ovarian cancer; chemoresistance; mechanical stress; flow-induced shear stress; photodynamic therapy; tumor microenvironment; transcoelomic metastases; tumor heterogeneity; epithelial to mesenchymal transition
Source: Web Of Science
Added: September 20, 2021

2021 journal article

Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity


By: S. Perez-Rodriguez*, S. Huang n, C. Borau*, J. Manuel Garcia-Aznar & W. Polacheck n

Source: Web Of Science
Added: October 4, 2021

2020 journal article

A Bile Duct-on-a-Chip With Organ-Level Functions

HEPATOLOGY, 71(4), 1350–1363.

By: Y. Du*, G. Khandekar*, J. Llewellyn*, W. Polacheck n, C. Chen* & R. Wells*

MeSH headings : Animals; Bile Ducts / physiopathology; Cell Line; Epithelial Cells; Lab-On-A-Chip Devices; Mice; Mice, Inbred BALB C; Models, Animal
Source: Web Of Science
Added: November 11, 2019

2020 journal article

Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation

LAB ON A CHIP, 20(6), 1153–1166.

By: W. Wang*, D. Lin*, E. Jarman*, W. Polacheck n & B. Baker*

MeSH headings : Cell Movement; Cell Proliferation; Cues; Endothelial Cells; Humans; Neovascularization, Pathologic; Neovascularization, Physiologic
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Microfluidics for the study of mechanotransduction


By: C. Griffith, S. Huang*, C. Cho, T. Khare, M. Rich, G. Lee*, F. Ligler*, B. Diekman*, W. Polacheck*

author keywords: microfluidics; mechanotransduction; mechanobiology; microfabrication; cell adhesion; biofluids; microdevices
Source: Web Of Science
Added: April 20, 2020

2019 journal article

Microfabricated blood vessels for modeling the vascular transport barrier

NATURE PROTOCOLS, 14(5), 1425–1454.

By: W. Polacheck*, M. Kutys*, J. Tefft* & C. Chen*

MeSH headings : Capillary Permeability / physiology; Cell Culture Techniques / instrumentation; Cells, Cultured; Endothelial Cells / cytology; Equipment Design; Humans; Microfluidic Analytical Techniques / instrumentation; Microvessels / cytology; Microvessels / physiology; Models, Cardiovascular; Stromal Cells / cytology; Tissue Engineering / instrumentation
Source: Web Of Science
Added: June 4, 2019