William Polacheck
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Works (11)
Updated: August 12th, 2023 05:00
2023 journal article
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation
SCIENCE ADVANCES, 9(7).
MeSH headings : Humans; TOR Serine-Threonine Kinases / metabolism; Mechanistic Target of Rapamycin Complex 1 / metabolism; Sirolimus / pharmacology; Human Umbilical Vein Endothelial Cells / metabolism; Mitogen-Activated Protein Kinase Kinases / metabolism; Class I Phosphatidylinositol 3-Kinases / genetics; Class I Phosphatidylinositol 3-Kinases / metabolism; Vascular Malformations / metabolism; rac1 GTP-Binding Protein / metabolism
www.science.org (publisher PDF)
Source: Web Of Science
Added: March 27, 2023
2023 journal article
Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics
ACTA BIOMATERIALIA, 166, 346–359.
author keywords: Vascular Ehlers-Danlos syndrome; Cell derived matrix; Collagen III; Mechanotransduction; ECM mechanics; Viscoelasticity
Source: Web Of Science
Added: August 7, 2023
2022 journal article
A vascularized model of the human liver mimics regenerative responses
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(28).
author keywords: hepatocyte; regeneration; vascular
MeSH headings : Cell Culture Techniques, Three Dimensional; Cytokines; Endothelial Cells; Hepatocytes; Humans; Liver / blood supply; Liver Regeneration / physiology
Source: Web Of Science
Added: September 29, 2022
2022 journal article
Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow
BIOFABRICATION, 14(2).
author keywords: microfluidics; vascular biology; interstitial flow; hemodynamics; biofluid mechanics; mechanotransduction
MeSH headings : Lymphatic Vessels; Microfluidics / methods; Stress, Mechanical
Source: Web Of Science
Added: January 31, 2022
2021 journal article
Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter
ACTA BIOMATERIALIA, 135, 260–273.
author keywords: Angiogenesis; Cell migration; Cell proliferation; Microfluidics; ECM; Endothelial cells; Chemotaxis; Hydrogels; Microvasculature; Sprouting Morphogenesis; Matrix porosity
MeSH headings : Animals; Biocompatible Materials / pharmacology; Endothelial Cells; Extracellular Matrix; Hydrogels / pharmacology; Mice; Neovascularization, Physiologic; Porosity
Source: Web Of Science
Added: November 29, 2021
2021 review
Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response
[Review of ]. CANCERS, 13(17).
author keywords: malignant ascites; epithelial ovarian cancer; chemoresistance; mechanical stress; flow-induced shear stress; photodynamic therapy; tumor microenvironment; transcoelomic metastases; tumor heterogeneity; epithelial to mesenchymal transition
Source: Web Of Science
Added: September 20, 2021
2021 journal article
Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity
BIOMICROFLUIDICS, 15(5).
Source: Web Of Science
Added: October 4, 2021
2020 journal article
A Bile Duct-on-a-Chip With Organ-Level Functions
HEPATOLOGY, 71(4), 1350–1363.
MeSH headings : Animals; Bile Ducts / physiopathology; Cell Line; Epithelial Cells; Lab-On-A-Chip Devices; Mice; Mice, Inbred BALB C; Models, Animal
Source: Web Of Science
Added: November 11, 2019
2020 journal article
Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation
LAB ON A CHIP, 20(6), 1153–1166.
MeSH headings : Cell Movement; Cell Proliferation; Cues; Endothelial Cells; Humans; Neovascularization, Pathologic; Neovascularization, Physiologic
Source: Web Of Science
Added: April 20, 2020
2020 journal article
Microfluidics for the study of mechanotransduction
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 53(22).
author keywords: microfluidics; mechanotransduction; mechanobiology; microfabrication; cell adhesion; biofluids; microdevices
Source: Web Of Science
Added: April 20, 2020
2019 journal article
Microfabricated blood vessels for modeling the vascular transport barrier
NATURE PROTOCOLS, 14(5), 1425–1454.
MeSH headings : Capillary Permeability / physiology; Cell Culture Techniques / instrumentation; Cells, Cultured; Endothelial Cells / cytology; Equipment Design; Humans; Microfluidic Analytical Techniques / instrumentation; Microvessels / cytology; Microvessels / physiology; Models, Cardiovascular; Stromal Cells / cytology; Tissue Engineering / instrumentation
Source: Web Of Science
Added: June 4, 2019
