Works (13)

Updated: January 31st, 2024 05:01

2024 article

Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure

Rathod, M. L., Aw, W. Y., Huang, S., Lu, J., Doherty, E. L., Whithworth, C. P., … Polacheck, W. J. (2024, January 7). SMALL.

By: M. Rathod n, W. Aw n, S. Huang n, J. Lu n, E. Doherty n, C. Whithworth*, G. Xi, P. Roy-Chaudhury*, W. Polacheck n

co-author countries: United States of America 🇺🇸
author keywords: blood-derived endothelial cell; cardiovascular; chronic kidney disease; indoxyl sulfate; microfluidics; organs-on-chip; uremic toxin
Source: Web Of Science
Added: January 29, 2024

2023 journal article

Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation

SCIENCE ADVANCES, 9(7).

By: W. Aw n, C. Cho n, H. Wang n, A. Cooper n, E. Doherty n, D. Rocco*, S. Huang n, S. Kubik n ...

co-author countries: United States of America 🇺🇸
MeSH headings : Humans; TOR Serine-Threonine Kinases / metabolism; Mechanistic Target of Rapamycin Complex 1 / metabolism; Sirolimus / pharmacology; Human Umbilical Vein Endothelial Cells / metabolism; Mitogen-Activated Protein Kinase Kinases / metabolism; Class I Phosphatidylinositol 3-Kinases / genetics; Class I Phosphatidylinositol 3-Kinases / metabolism; Vascular Malformations / metabolism; rac1 GTP-Binding Protein / metabolism
Source: Web Of Science
Added: March 27, 2023

2023 journal article

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics

ACTA BIOMATERIALIA, 166, 346–359.

By: E. Doherty n, W. Aw n, E. Warren n, M. Hockenberry*, C. Whitworth*, G. Krohn n, S. Howell*, B. Diekman n ...

co-author countries: United States of America 🇺🇸
author keywords: Vascular Ehlers-Danlos syndrome; Cell derived matrix; Collagen III; Mechanotransduction; ECM mechanics; Viscoelasticity
Source: Web Of Science
Added: August 7, 2023

2023 article

Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling

Whitworth, C. P., & Polacheck, W. J. (2023, December 22). EXPERT OPINION ON DRUG DISCOVERY.

By: C. Whitworth* & W. Polacheck n

co-author countries: United States of America 🇺🇸
author keywords: Blood outgrowth endothelial cell; induced pluripotent stem cells; disease modeling; drug discovery; endothelial colony forming cell; organ-on-chip; Vascular disease
Source: Web Of Science
Added: January 8, 2024

2022 journal article

A vascularized model of the human liver mimics regenerative responses

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(28).

By: A. Chhabra*, H. Song*, K. Grzelak*, W. Polacheck n, H. Fleming*, C. Chen*, S. Bhatia*

co-author countries: United States of America 🇺🇸
author keywords: hepatocyte; regeneration; vascular
MeSH headings : Cell Culture Techniques, Three Dimensional; Cytokines; Endothelial Cells; Hepatocytes; Humans; Liver / blood supply; Liver Regeneration / physiology
Source: Web Of Science
Added: September 29, 2022

2022 journal article

Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow

BIOFABRICATION, 14(2).

By: G. Lee n, S. Huang n, W. Aw n, M. Rathod n, C. Cho n, F. Ligler n, W. Polacheck n

co-author countries: United States of America 🇺🇸
author keywords: microfluidics; vascular biology; interstitial flow; hemodynamics; biofluid mechanics; mechanotransduction
MeSH headings : Lymphatic Vessels; Microfluidics / methods; Stress, Mechanical
Source: Web Of Science
Added: January 31, 2022

2021 journal article

Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter

ACTA BIOMATERIALIA, 135, 260–273.

By: W. Wang*, R. Kent*, S. Huang n, E. Jarman*, E. Shikanov*, C. Davidson*, H. Hiraki*, D. Lin* ...

co-author countries: United States of America 🇺🇸
author keywords: Angiogenesis; Cell migration; Cell proliferation; Microfluidics; ECM; Endothelial cells; Chemotaxis; Hydrogels; Microvasculature; Sprouting Morphogenesis; Matrix porosity
MeSH headings : Animals; Biocompatible Materials / pharmacology; Endothelial Cells; Extracellular Matrix; Hydrogels / pharmacology; Mice; Neovascularization, Physiologic; Porosity
Source: Web Of Science
Added: November 29, 2021

2021 review

Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response

[Review of ]. CANCERS, 13(17).

By: B. Rickard n, C. Conrad*, A. Sorrin*, M. Ruhi n, J. Reader*, S. Huang n, W. Franco*, G. Scarcelli* ...

co-author countries: United States of America 🇺🇸
author keywords: malignant ascites; epithelial ovarian cancer; chemoresistance; mechanical stress; flow-induced shear stress; photodynamic therapy; tumor microenvironment; transcoelomic metastases; tumor heterogeneity; epithelial to mesenchymal transition
Source: Web Of Science
Added: September 20, 2021

2021 journal article

Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity

BIOMICROFLUIDICS, 15(5).

By: S. Perez-Rodriguez*, S. Huang n, C. Borau*, J. Manuel Garcia-Aznar & W. Polacheck n

co-author countries: Spain 🇪🇸 United States of America 🇺🇸
Source: Web Of Science
Added: October 4, 2021

2020 journal article

A Bile Duct-on-a-Chip With Organ-Level Functions

HEPATOLOGY, 71(4), 1350–1363.

By: Y. Du*, G. Khandekar*, J. Llewellyn*, W. Polacheck n, C. Chen* & R. Wells*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Bile Ducts / physiopathology; Cell Line; Epithelial Cells; Lab-On-A-Chip Devices; Mice; Mice, Inbred BALB C; Models, Animal
Source: Web Of Science
Added: November 11, 2019

2020 journal article

Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation

LAB ON A CHIP, 20(6), 1153–1166.

By: W. Wang*, D. Lin*, E. Jarman*, W. Polacheck n & B. Baker*

co-author countries: United States of America 🇺🇸
MeSH headings : Cell Movement; Cell Proliferation; Cues; Endothelial Cells; Humans; Neovascularization, Pathologic; Neovascularization, Physiologic
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Microfluidics for the study of mechanotransduction

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 53(22).

By: C. Griffith, S. Huang*, C. Cho, T. Khare, M. Rich, G. Lee*, F. Ligler*, B. Diekman*, W. Polacheck*

author keywords: microfluidics; mechanotransduction; mechanobiology; microfabrication; cell adhesion; biofluids; microdevices
Source: Web Of Science
Added: April 20, 2020

2019 journal article

Microfabricated blood vessels for modeling the vascular transport barrier

NATURE PROTOCOLS, 14(5), 1425–1454.

By: W. Polacheck n, M. Kutys*, J. Tefft* & C. Chen*

co-author countries: United States of America 🇺🇸
MeSH headings : Capillary Permeability / physiology; Cell Culture Techniques / instrumentation; Cells, Cultured; Endothelial Cells / cytology; Equipment Design; Humans; Microfluidic Analytical Techniques / instrumentation; Microvessels / cytology; Microvessels / physiology; Models, Cardiovascular; Stromal Cells / cytology; Tissue Engineering / instrumentation
Source: Web Of Science
Added: June 4, 2019

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