Wei Shen

Works (9)

Updated: April 5th, 2024 04:32

2020 journal article

SnRK1: a versatile plant protein kinase that limits geminivirus infection

CURRENT OPINION IN VIROLOGY, 47, 18–24.

By: W. Shen n & L. Hanley-Bowdoin n 

MeSH headings : Disease Resistance; Geminiviridae / genetics; Geminiviridae / metabolism; Geminiviridae / physiology; Host-Pathogen Interactions; Phosphorylation; Plant Diseases / virology; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Kinases / genetics; Protein Kinases / metabolism; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR: Data suggest that SnRK1 is involved in the co-evolution of plant hosts and geminiviruses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

2018 journal article

Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1-catalyzed phosphorylation

PLANT JOURNAL, 96(2), 287–299.

By: K. Caldo*, W. Shen n, Y. Xu *, L. Hanley-Bowdoin n , G. Chen *, R. Weselake *, M. Lemieux *

author keywords: triacylglycerol biosynthesis; DGAT; Brassica napus; biochemical regulation; allostery
MeSH headings : Acyl Coenzyme A / metabolism; Brassica napus / enzymology; Brassica napus / genetics; Carbohydrate Metabolism; Catalysis; Diacylglycerol O-Acyltransferase / genetics; Diacylglycerol O-Acyltransferase / metabolism; Energy Metabolism; Homeostasis; Lipids / physiology; Phosphatidic Acids / metabolism; Phosphorylation; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Triglycerides / biosynthesis
TL;DR: Phosphatidate (PA) was identified as a feed-forward activator of BnaDGAT1, enabling the final enzyme in the Kennedy pathway to adjust to the incoming flow of carbon leading to TAG, indicating that PA facilitates the transition of the enzyme into the more active state. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 22, 2018

2018 journal article

Sucrose Nonfermenting 1-Related Protein Kinase 1 Phosphorylates a Geminivirus Rep Protein to Impair Viral Replication and Infection

PLANT PHYSIOLOGY, 178(1), 372–389.

By: W. Shen n, B. Bobay *, L. Greeley  n, M. Reyes  n, C. Rajabu  n, R. Blackburn  n, M. Dallas n, M. Goshe n, J. Ascencio-Ibanez  n, L. Hanley-Bowdoin n 

MeSH headings : Amino Acid Sequence; Begomovirus / genetics; Begomovirus / metabolism; Begomovirus / physiology; Host-Pathogen Interactions; Solanum lycopersicum / enzymology; Solanum lycopersicum / virology; Mutation; Phosphorylation; Plant Diseases / virology; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Binding; Protein Domains; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Sequence Homology, Amino Acid; Serine / genetics; Serine / metabolism; Viral Proteins / chemistry; Viral Proteins / genetics; Viral Proteins / metabolism; Virus Replication
TL;DR: It is established that SnRK1 phosphorylates Rep and interferes with geminivirus replication and infection, underscoring the emerging role for SnRk1 in the host defense response against plant pathogens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018

2014 journal article

SnRK1 Phosphorylation of AL2 Delays Cabbage Leaf Curl Virus Infection in Arabidopsis

JOURNAL OF VIROLOGY, 88(18), 10598–10612.

By: W. Shen n, M. Dallas n, M. Goshe n & L. Hanley-Bowdoin n 

MeSH headings : Amino Acid Sequence; Arabidopsis / enzymology; Arabidopsis / genetics; Arabidopsis / virology; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Begomovirus / chemistry; Begomovirus / classification; Begomovirus / genetics; Begomovirus / metabolism; Host-Pathogen Interactions; Molecular Sequence Data; Phylogeny; Plant Diseases / virology; Protein Binding; Protein Kinases / genetics; Protein Kinases / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Viral Proteins / chemistry; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR: It is shown that the host protein kinase SnRK1, a central regulator of energy balance and nutrient metabolism in plants, phosphorylates serine-109 in AL2 proteins of three subgroups of New World begomoviruses, resulting in a delay in viral DNA accumulation and symptom appearance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Arabidopsis Protein Kinases GRIK1 and GRIK2 Specifically Activate SnRK1 by Phosphorylating Its Activation Loop

PLANT PHYSIOLOGY, 150(2), 996–1005.

By: W. Shen n, M. Reyes n & L. Hanley-Bowdoin n 

MeSH headings : Adenosine Monophosphate / pharmacology; Amino Acid Sequence; Arabidopsis / drug effects; Arabidopsis / enzymology; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / metabolism; Benzimidazoles / pharmacology; Cations / pharmacology; Conserved Sequence; Enzyme Activation / drug effects; Molecular Sequence Data; Naphthalimides / pharmacology; Phosphorylation / drug effects; Phosphothreonine / metabolism; Protein Binding / drug effects; Protein Serine-Threonine Kinases / chemistry; Protein Serine-Threonine Kinases / metabolism; Substrate Specificity / drug effects
TL;DR: The GRIK-SnRK1 cascade may function in a developmentally regulated fashion and coordinate the unique metabolic requirements of rapidly growing cells and geminivirus-infected cells that have been induced to reenter the cell cycle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Overexpression of a directed mutant of 14-3-3 omega in Arabidopsis leaves affects phosphorylation and protein content of nitrate reductase

Oh, M.-H., Huber, J. L., Shen, W., Athwal, G. S., Wu, X., & Huber, S. C. (2009, July). BOTANY, Vol. 87, pp. 691–701.

By: M. Oh *, J. Huber*, W. Shen*, G. Athwal*, X. Wu * & S. Huber *

author keywords: Arabidopsis thaliana; 14-3-3 protein; beta-glucosidase; glutathione S-transferase; two-dimensional difference gel electrophoresis; site-directed mutagenesis
TL;DR: This work generated transgenic Arabidopsis plants constitutively overexpressing a directed mutant of 14-3-3 isoform ω that inhibits phosphorylated nitrate reductase (pNR) in a largely divalent-cation-independent manner in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Geminivirus-induced gene silencing of the tobacco retinoblastoma-related gene results in cell death and altered development

PLANT MOLECULAR BIOLOGY, 65(1-2), 163–175.

By: C. Jordan n , W. Shen n, L. Hanley-Bowdoin n  & D. Robertson n

author keywords: DNA VIGS; retinoblastoma-related protein; cell death; geminivirus; hyperplasia; cell differentiation
MeSH headings : Cell Death; DNA, Viral / genetics; Geminiviridae / genetics; Gene Expression Regulation, Plant / genetics; Gene Silencing; Genetic Vectors / genetics; Plant Leaves / genetics; Plant Leaves / growth & development; Plant Leaves / metabolism; Retinoblastoma / genetics; Retinoblastoma / metabolism; Tobacco / cytology; Tobacco / genetics; Tobacco / growth & development
TL;DR: The results suggest that either inappropriate activation of the cell cycle is lethal in plants or that RBR has other functions, unrelated to the cell Cycle, and demonstrate that continual transcription of RBR is necessary for cell survival. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1-and mammalian AMPK-activating kinases

PLANT PHYSIOLOGY, 142(4), 1642–1655.

By: W. Shen n & L. Hanley-Bowdoin n 

MeSH headings : AMP-Activated Protein Kinase Kinases; Amino Acid Sequence; Animals; Arabidopsis / enzymology; Arabidopsis / genetics; Arabidopsis / virology; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Flowers / genetics; Flowers / metabolism; Flowers / virology; Fungal Proteins / chemistry; Geminiviridae / physiology; Gene Expression Regulation, Plant; Genetic Complementation Test; Molecular Sequence Data; Phylogeny; Plant Diseases / virology; Plant Leaves / genetics; Plant Leaves / metabolism; Plant Leaves / virology; Plant Shoots / genetics; Plant Shoots / metabolism; Plant Shoots / virology; Protein Kinases / chemistry; Protein Serine-Threonine Kinases / chemistry; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; RNA, Messenger / metabolism; Sequence Alignment; Two-Hybrid System Techniques; Up-Regulation; Viral Proteins / metabolism
TL;DR: Both full-length GRIK1 and GRIk2 interact with AL1 in yeast two-hybrid studies, suggesting that the Arabidopsis kinases mediate one or more processes during early plant development and geminivirus infection by activating SNF1-related kinases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Polycations globally enhance binding of 14-3-3 omega to target proteins in spinach leaves

PLANT AND CELL PHYSIOLOGY, 47(6), 764–771.

By: W. Shen n & S. Huber  n

author keywords: divalent cations; far-Western overlay; nitrate reductase; 14-3-3 protein; spermine; Spinacia oleracea
MeSH headings : 14-3-3 Proteins / analysis; 14-3-3 Proteins / metabolism; Adenosine Monophosphate / pharmacology; Arabidopsis Proteins / analysis; Arabidopsis Proteins / metabolism; Digoxigenin; Light; Magnesium / pharmacology; Nitrate Reductase / analysis; Nitrate Reductase / metabolism; Phosphorylation; Photoperiod; Plant Leaves / chemistry; Plant Leaves / metabolism; Plant Proteins / analysis; Plant Proteins / metabolism; Polyamines / pharmacology; Polyelectrolytes; Protein Binding; Spermine / pharmacology; Spinacia oleracea / chemistry; Spinacia oleracea / metabolism
TL;DR: The results suggest that the binding of 14-3-3s to targets in addition to pNR may also be regulated by polycations and 5'-AMP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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