Wei Shen

Works (10)

Updated: January 23rd, 2026 07:16

2025 article

A TIR ‐ NLR gene from Arabidopsis Pla‐1 confers resistance to geminivirus infection

Shen, W., Ruhel, R., Reyes, M. I., Wheeler, E., Deppong, D., Mickelson‐Young, L., … Ascencio‐Ibáñez, J. T. (2025, December 1). The Plant Journal.

By: W. Shen n, R. Ruhel  n, M. Reyes n, E. Wheeler n, D. Deppong  n, L. Mickelson‐Young n, J. Ndunguru *, L. Hanley‐Bowdoin n , J. Ascencio‐Ibáñez  n

MeSH headings : Arabidopsis / genetics; Arabidopsis / virology; Arabidopsis / immunology; Plant Diseases / virology; Plant Diseases / genetics; Plant Diseases / immunology; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Disease Resistance / genetics; Geminiviridae / physiology; NLR Proteins / genetics; NLR Proteins / metabolism; Gene Expression Regulation, Plant; Begomovirus
topics (OpenAlex): Plant Virus Research Studies; Plant-Microbe Interactions and Immunity; Insect-Plant Interactions and Control
Sources: NC State University Libraries, NC State University Libraries
Added: December 7, 2025

2020 article

SnRK1: a versatile plant protein kinase that limits geminivirus infection

Shen, W., & Hanley-Bowdoin, L. (2020, December 25). Current Opinion in Virology, Vol. 47, pp. 18–24.

By: W. Shen n & L. Hanley-Bowdoin n 

MeSH headings : Disease Resistance; Geminiviridae / genetics; Geminiviridae / metabolism; Geminiviridae / physiology; Host-Pathogen Interactions; Phosphorylation; Plant Diseases / virology; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Kinases / genetics; Protein Kinases / metabolism; Viral Proteins / genetics; Viral Proteins / metabolism
topics (OpenAlex): Plant Virus Research Studies; Plant tissue culture and regeneration; Plant Molecular Biology Research
TL;DR: Data suggest that SnRK1 is involved in the co-evolution of plant hosts and geminiviruses. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

2018 article

Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1‐catalyzed phosphorylation

Caldo, K. M. P., Shen, W., Xu, Y., Hanley‐Bowdoin, L., Chen, G., Weselake, R. J., & Lemieux, M. J. (2018, July 13). The Plant Journal, Vol. 96, pp. 287–299.

By: K. Caldo*, W. Shen n, Y. Xu *, L. Hanley‐Bowdoin n , G. Chen *, R. Weselake *, M. Lemieux*

author keywords: triacylglycerol biosynthesis; DGAT; Brassica napus; biochemical regulation; allostery
MeSH headings : Acyl Coenzyme A / metabolism; Brassica napus / enzymology; Brassica napus / genetics; Carbohydrate Metabolism; Catalysis; Diacylglycerol O-Acyltransferase / genetics; Diacylglycerol O-Acyltransferase / metabolism; Energy Metabolism; Homeostasis; Lipids / physiology; Phosphatidic Acids / metabolism; Phosphorylation; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Triglycerides / biosynthesis
topics (OpenAlex): Lipid metabolism and biosynthesis; Plant nutrient uptake and metabolism; Plant Molecular Biology Research
TL;DR: Phosphatidate (PA) was identified as a feed-forward activator of BnaDGAT1, enabling the final enzyme in the Kennedy pathway to adjust to the incoming flow of carbon leading to TAG, indicating that PA facilitates the transition of the enzyme into the more active state. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 22, 2018

2018 article

Sucrose Nonfermenting 1-Related Protein Kinase 1 Phosphorylates a Geminivirus Rep Protein to Impair Viral Replication and Infection

Shen, W., Bobay, B. G., Greeley, L. A., Reyes, M. I., Rajabu, C. A., Blackburn, R. K., … Hanley-Bowdoin, L. (2018, July 13). PLANT PHYSIOLOGY, Vol. 178, pp. 372–389.

By: W. Shen n, B. Bobay *, L. Greeley  n, M. Reyes  n, C. Rajabu  n, R. Blackburn  n, M. Dallas n, M. Goshe n, J. Ascencio-Ibáñez n, L. Hanley-Bowdoin n 

MeSH headings : Amino Acid Sequence; Begomovirus / genetics; Begomovirus / metabolism; Begomovirus / physiology; Host-Pathogen Interactions; Solanum lycopersicum / enzymology; Solanum lycopersicum / virology; Mutation; Phosphorylation; Plant Diseases / virology; Plant Proteins / genetics; Plant Proteins / metabolism; Protein Binding; Protein Domains; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Sequence Homology, Amino Acid; Serine / genetics; Serine / metabolism; Viral Proteins / chemistry; Viral Proteins / genetics; Viral Proteins / metabolism; Virus Replication
topics (OpenAlex): Plant Virus Research Studies; Plant-Microbe Interactions and Immunity; Legume Nitrogen Fixing Symbiosis
TL;DR: It is established that SnRK1 phosphorylates Rep and interferes with geminivirus replication and infection, underscoring the emerging role for SnRk1 in the host defense response against plant pathogens. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018

2014 article

SnRK1 Phosphorylation of AL2 Delays Cabbage Leaf Curl Virus Infection in Arabidopsis

Shen, W., Dallas, M. B., Goshe, M. B., & Hanley-Bowdoin, L. (2014, July 3). Journal of Virology, Vol. 88, pp. 10598–10612.

By: W. Shen n, M. Dallas n, M. Goshe n & L. Hanley-Bowdoin n 

MeSH headings : Amino Acid Sequence; Arabidopsis / enzymology; Arabidopsis / genetics; Arabidopsis / virology; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Begomovirus / chemistry; Begomovirus / classification; Begomovirus / genetics; Begomovirus / metabolism; Host-Pathogen Interactions; Molecular Sequence Data; Phylogeny; Plant Diseases / virology; Protein Binding; Protein Kinases / genetics; Protein Kinases / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Viral Proteins / chemistry; Viral Proteins / genetics; Viral Proteins / metabolism
topics (OpenAlex): Plant Virus Research Studies; Plant tissue culture and regeneration; Plant-Microbe Interactions and Immunity
TL;DR: It is shown that the host protein kinase SnRK1, a central regulator of energy balance and nutrient metabolism in plants, phosphorylates serine-109 in AL2 proteins of three subgroups of New World begomoviruses, resulting in a delay in viral DNA accumulation and symptom appearance. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Arabidopsis Protein Kinases GRIK1 and GRIK2 Specifically Activate SnRK1 by Phosphorylating Its Activation Loop    

Shen, W., Reyes, M. I., & Hanley-Bowdoin, L. (2009, April 1). PLANT PHYSIOLOGY, Vol. 150, pp. 996–1005.

By: W. Shen n, M. Reyes n & L. Hanley-Bowdoin n 

MeSH headings : Adenosine Monophosphate / pharmacology; Amino Acid Sequence; Arabidopsis / drug effects; Arabidopsis / enzymology; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / metabolism; Benzimidazoles / pharmacology; Cations / pharmacology; Conserved Sequence; Enzyme Activation / drug effects; Molecular Sequence Data; Naphthalimides / pharmacology; Phosphorylation / drug effects; Phosphothreonine / metabolism; Protein Binding / drug effects; Protein Serine-Threonine Kinases / chemistry; Protein Serine-Threonine Kinases / metabolism; Substrate Specificity / drug effects
topics (OpenAlex): Plant nutrient uptake and metabolism; Metabolism, Diabetes, and Cancer; Plant Molecular Biology Research
TL;DR: The GRIK-SnRK1 cascade may function in a developmentally regulated fashion and coordinate the unique metabolic requirements of rapidly growing cells and geminivirus-infected cells that have been induced to reenter the cell cycle. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
7. Affordable and Clean Energy (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Overexpression of a directed mutant of 14-3-3ω in Arabidopsis leaves affects phosphorylation and protein content of nitrate reductaseThis paper is one of a selection published in a Special Issue comprising papers presented at the 50th Annual Meeting of the Canadian Society of Plant Physiologists (CSPP) held at the University of Ottawa, Ontario, in June 2008.

Oh, M.-H., Huber, J. L., Shen, W., Athwal, G. S., Wu, X., & Huber, S. C. (2009, July 1). Botany.

By: M. Oh *, J. Huber*, W. Shen*, G. Athwal*, X. Wu * & S. Huber *

author keywords: Arabidopsis thaliana; 14-3-3 protein; beta-glucosidase; glutathione S-transferase; two-dimensional difference gel electrophoresis; site-directed mutagenesis
topics (OpenAlex): 14-3-3 protein interactions; Photosynthetic Processes and Mechanisms; Ubiquitin and proteasome pathways
TL;DR: This work generated transgenic Arabidopsis plants constitutively overexpressing a directed mutant of 14-3-3 isoform ω that inhibits phosphorylated nitrate reductase (pNR) in a largely divalent-cation-independent manner in vitro. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Geminivirus-induced gene silencing of the tobacco retinoblastoma-related gene results in cell death and altered development

Jordan, C. V., Shen, W., Hanley-Bowdoin, L. K., & Robertson, D. (2007, July 17). Plant Molecular Biology, Vol. 65, pp. 163–175.

By: C. Jordan n , W. Shen n, L. Hanley-Bowdoin n  & D. Robertson n

author keywords: DNA VIGS; retinoblastoma-related protein; cell death; geminivirus; hyperplasia; cell differentiation
MeSH headings : Cell Death; DNA, Viral / genetics; Geminiviridae / genetics; Gene Expression Regulation, Plant / genetics; Gene Silencing; Genetic Vectors / genetics; Plant Leaves / genetics; Plant Leaves / growth & development; Plant Leaves / metabolism; Retinoblastoma / genetics; Retinoblastoma / metabolism; Tobacco / cytology; Tobacco / genetics; Tobacco / growth & development
topics (OpenAlex): Plant Virus Research Studies; Plant-Microbe Interactions and Immunity; Plant tissue culture and regeneration
TL;DR: The results suggest that either inappropriate activation of the cell cycle is lethal in plants or that RBR has other functions, unrelated to the cell Cycle, and demonstrate that continual transcription of RBR is necessary for cell survival. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Geminivirus Infection Up-Regulates the Expression of Two Arabidopsis Protein Kinases Related to Yeast SNF1- and Mammalian AMPK-Activating Kinases

Shen, W., & Hanley-Bowdoin, L. (2006, October 13). PLANT PHYSIOLOGY, Vol. 142, pp. 1642–1655.

By: W. Shen n & L. Hanley-Bowdoin n 

MeSH headings : AMP-Activated Protein Kinase Kinases; Amino Acid Sequence; Animals; Arabidopsis / enzymology; Arabidopsis / genetics; Arabidopsis / virology; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Flowers / genetics; Flowers / metabolism; Flowers / virology; Fungal Proteins / chemistry; Geminiviridae / physiology; Gene Expression Regulation, Plant; Genetic Complementation Test; Molecular Sequence Data; Phylogeny; Plant Diseases / virology; Plant Leaves / genetics; Plant Leaves / metabolism; Plant Leaves / virology; Plant Shoots / genetics; Plant Shoots / metabolism; Plant Shoots / virology; Protein Kinases / chemistry; Protein Serine-Threonine Kinases / chemistry; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; RNA, Messenger / metabolism; Sequence Alignment; Two-Hybrid System Techniques; Up-Regulation; Viral Proteins / metabolism
topics (OpenAlex): Plant Virus Research Studies; Plant nutrient uptake and metabolism; Fungal and yeast genetics research
TL;DR: Both full-length GRIK1 and GRIk2 interact with AL1 in yeast two-hybrid studies, suggesting that the Arabidopsis kinases mediate one or more processes during early plant development and geminivirus infection by activating SNF1-related kinases. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Polycations Globally Enhance Binding of 14-3-3ω to Target Proteins in Spinach Leaves

Shen, W., & Huber, S. C. (2006, April 19). Plant and Cell Physiology.

By: W. Shen n & S. Huber  n

author keywords: divalent cations; far-Western overlay; nitrate reductase; 14-3-3 protein; spermine; Spinacia oleracea
MeSH headings : 14-3-3 Proteins / analysis; 14-3-3 Proteins / metabolism; Adenosine Monophosphate / pharmacology; Arabidopsis Proteins / analysis; Arabidopsis Proteins / metabolism; Digoxigenin; Light; Magnesium / pharmacology; Nitrate Reductase / analysis; Nitrate Reductase / metabolism; Phosphorylation; Photoperiod; Plant Leaves / chemistry; Plant Leaves / metabolism; Plant Proteins / analysis; Plant Proteins / metabolism; Polyamines / pharmacology; Polyelectrolytes; Protein Binding; Spermine / pharmacology; Spinacia oleracea / chemistry; Spinacia oleracea / metabolism
topics (OpenAlex): 14-3-3 protein interactions; Ubiquitin and proteasome pathways; Microbial Natural Products and Biosynthesis
TL;DR: The results suggest that the binding of 14-3-3s to targets in addition to pNR may also be regulated by polycations and 5'-AMP. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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