Will Barker

Works (1)

Updated: July 5th, 2023 15:35

2017 journal article

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria

BIOORGANIC & MEDICINAL CHEMISTRY, 25(20), 5749–5753.

By: W. Barker n, S. Martin n, C. Chandler *, T. Nguyen  n, T. Harris n, C. Goodell*, R. Melander n, Y. Doi *, R. Ernst *, C. Melander n

MeSH headings : Acinetobacter baumannii / drug effects; Adjuvants, Pharmaceutic / chemistry; Adjuvants, Pharmaceutic / pharmacology; Colistin / pharmacology; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Escherichia coli / drug effects; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Gram-Negative Bacteria / drug effects; Klebsiella pneumoniae / drug effects; Microbial Sensitivity Tests; Polymyxins / pharmacology; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
TL;DR: This work reports successful reversion of mcr-1-driven colistin resistance in Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli with adjuvants reported as modulators of chromosomally-encoded colistIn resistance. (via Semantic Scholar)
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