Xiao Cheng

Dept Molecular Biomedical Scie

Works (8)

Updated: April 25th, 2025 17:55

2024 article

Anticancer Therapy Targeting Cancer-Derived Extracellular Vesicles

Cheng, X., Henick, B. S., & Cheng, K. (2024, February 23). ACS Nano.

By: X. Cheng n, B. Henick * & K. Cheng*

author keywords: Extracellular vesicles; Cancer therapy; Nanomedicine; Cancer metastasis; Biomaterials; Drug delivery; Cancer Vaccine; Immunotherapy
MeSH headings : Humans; Neoplasms / pathology; Extracellular Vesicles / metabolism; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / metabolism; Biological Transport
topics (OpenAlex): Extracellular vesicles in disease; Nanoplatforms for cancer theranostics; MicroRNA in disease regulation
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 1, 2024

2024 article

Optimizing cell therapy by sorting cells with high extracellular vesicle secretion

Koo, D., Cheng, X., Udani, S., Baghdasarian, S., Zhu, D., Li, J., … Carlo, D. D. (2024, June 7). Nature Communications.

By: D. Koo *, X. Cheng n, S. Udani *, S. Baghdasarian*, D. Zhu* , J. Li*, B. Hall, N. Tsubamoto* ...

MeSH headings : Extracellular Vesicles / metabolism; Extracellular Vesicles / transplantation; Animals; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / therapy; Myocardial Infarction / metabolism; Humans; Cell- and Tissue-Based Therapy / methods; Mesenchymal Stem Cell Transplantation / methods; Disease Models, Animal; Mice, Inbred C57BL; Cell Separation / methods; Male
topics (OpenAlex): Extracellular vesicles in disease; Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 8, 2024

2023 article

Microneedle Patch Delivery of PROTACs for Anti-Cancer Therapy

Cheng, X., Hu, S., & Cheng, K. (2023, June 9). ACS Nano, Vol. 6.

By: X. Cheng n, S. Hu n  & K. Cheng n

author keywords: PROTAC; estrogen receptor; microneedle patch; hyaluronic acid gel; ER-positive breast cancer
MeSH headings : Humans; Female; Estrogen Receptor alpha / metabolism; Proteolysis Targeting Chimera; Breast Neoplasms / pathology; Drug Delivery Systems / methods; Proteolysis
topics (OpenAlex): Protein Degradation and Inhibitors; Multiple Myeloma Research and Treatments; Ubiquitin and proteasome pathways
TL;DR: The work demonstrates the feasibility and proof-of-concept therapeutic potential of using microneedle patches to directly deliver PROTACs into tumors and can sufficiently degrade ERα in MCF7 cells. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 26, 2023

2022 article

Gecko-Inspired Adhesives with Asymmetrically Tilting-Oriented Micropillars

Shi, W., Cheng, X., & Cheng, K. (2022, July 13). Langmuir.

By: W. Shi  n, X. Cheng n & K. Cheng n

MeSH headings : Adhesiveness; Adhesives; Animals; Finite Element Analysis; Lizards; Locomotion
topics (OpenAlex): Adhesion, Friction, and Surface Interactions; Surface Modification and Superhydrophobicity; Force Microscopy Techniques and Applications
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 1, 2022

2022 journal article

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Matter, 5(9), 2960–2974.

By: K. Popowski n , A. Moatti n , G. Scull n, D. Silkstone n, H. Lutz  n, B. López de Juan Abad  n, A. George n , E. Belcher  n ...

topics (OpenAlex): Extracellular vesicles in disease; RNA Interference and Gene Delivery; Inhalation and Respiratory Drug Delivery
TL;DR: The results suggest that extracellular vesicles can serve as an inhaled mRNA drug-delivery system that is superior to synthetic liposomes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 17, 2022

2021 article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

Hu, S., Wang, X., Li, Z., Zhu, D., Cores, J., Wang, Z., … Cheng, K. (2021, June 8). Nano Today, Vol. 8.

By: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

Contributors: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
topics (OpenAlex): Extracellular vesicles in disease; Cardiovascular Effects of Exercise
TL;DR: It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021

2020 article

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

Xie, M., Li, J., Zhang, S., Zhu, D., Mei, X., Wang, Z., … Cheng, K. (2020, December 3). Bioactive Materials, Vol. 6, pp. 1777–1788.

By: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

Contributors: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
topics (OpenAlex): Ovarian function and disorders; Reproductive Biology and Fertility; Sperm and Testicular Function
TL;DR: A novel TGN contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN) yielded a higher contraceptive success rate than that of the commercial contraceptive gel (Contragel®), and has the added benefits to prevent sexually transmitted diseases and improve male libido and erection function during sexual intercourse. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2020 article

Visualizing cancer extravasation: from mechanistic studies to drug development

Cheng, X., & Cheng, K. (2020, November 6). Cancer and Metastasis Reviews.

By: X. Cheng n & K. Cheng n

author keywords: Cancer metastasis; Cancer cell extravasation; Cancer models; Cancer therapies
MeSH headings : Drug Development; Humans; Neoplasm Metastasis; Neoplastic Cells, Circulating / pathology; Transendothelial and Transepithelial Migration
topics (OpenAlex): 3D Printing in Biomedical Research; Cancer Research and Treatments; Nanoplatforms for cancer theranostics
TL;DR: This review focuses on recent progress in cancer extravasation visualization techniques, including the development of both in vitro and in vivo cancerExtravasation models, that shed light on the underlying mechanisms. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 24, 2020

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