Xiao Cheng

Dept Molecular Biomedical Scie

Works (7)

Updated: April 6th, 2024 05:01

2024 article

Anticancer Therapy Targeting Cancer-Derived Extracellular Vesicles

Cheng, X., Henick, B. S., & Cheng, K. (2024, February 23). ACS NANO.

By: X. Cheng n, B. Henick * & K. Cheng*

author keywords: Extracellular vesicles; Cancer therapy; Nanomedicine; Cancer metastasis; Biomaterials; Drug delivery; Cancer Vaccine; Immunotherapy
Source: Web Of Science
Added: April 1, 2024

2023 article

Microneedle Patch Delivery of PROTACs for Anti-Cancer Therapy

Cheng, X., Hu, S., & Cheng, K. (2023, June 9). ACS NANO, Vol. 6.

By: X. Cheng n, S. Hu n  & K. Cheng n

author keywords: PROTAC; estrogen receptor; microneedle patch; hyaluronic acid gel; ER-positive breast cancer
MeSH headings : Humans; Female; Estrogen Receptor alpha / metabolism; Proteolysis Targeting Chimera; Breast Neoplasms / pathology; Drug Delivery Systems / methods; Proteolysis
TL;DR: The work demonstrates the feasibility and proof-of-concept therapeutic potential of using microneedle patches to directly deliver PROTACs into tumors and can sufficiently degrade ERα in MCF7 cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 26, 2023

2022 journal article

Gecko-Inspired Adhesives with Asymmetrically Tilting-Oriented Micropillars

LANGMUIR, 38(29).

By: W. Shi  n, X. Cheng n & K. Cheng n

MeSH headings : Adhesiveness; Adhesives; Animals; Finite Element Analysis; Lizards; Locomotion
Source: Web Of Science
Added: August 1, 2022

2022 journal article

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Matter, 5(9), 2960–2974.

By: K. Popowski n , A. Moatti n , G. Scull n, D. Silkstone n, H. Lutz n, B. López de Juan Abad  n, A. George n , E. Belcher  n ...

TL;DR: The results suggest that extracellular vesicles can serve as an inhaled mRNA drug-delivery system that is superior to synthetic liposomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 17, 2022

2021 journal article

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

BIOACTIVE MATERIALS, 6(6), 1777–1788.

By: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

Contributors: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
TL;DR: A novel TGN contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN) yielded a higher contraceptive success rate than that of the commercial contraceptive gel (Contragel®), and has the added benefits to prevent sexually transmitted diseases and improve male libido and erection function during sexual intercourse. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2021 journal article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

NANO TODAY, 39.

By: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

Contributors: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
TL;DR: It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021

2021 review

Visualizing cancer extravasation: from mechanistic studies to drug development

[Review of ]. CANCER AND METASTASIS REVIEWS, 40(1), 71–88.

By: X. Cheng n & K. Cheng n

author keywords: Cancer metastasis; Cancer cell extravasation; Cancer models; Cancer therapies
MeSH headings : Drug Development; Humans; Neoplasm Metastasis; Neoplastic Cells, Circulating / pathology; Transendothelial and Transepithelial Migration
TL;DR: This review focuses on recent progress in cancer extravasation visualization techniques, including the development of both in vitro and in vivo cancerExtravasation models, that shed light on the underlying mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 24, 2020

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