Works (3)

Updated: July 5th, 2023 15:41

2016 journal article

Quantitative analysis of B-lymphocyte migration directed by CXCL13


By: X. Liu n, S. Asokan*, J. Bear* & J. Haugh n

MeSH headings : Adsorption; Animals; B-Lymphocytes / cytology; Cell Movement; Chemokine CXCL13 / metabolism; Computational Biology; Computer Simulation; Intercellular Adhesion Molecule-1 / metabolism; Mice; Mice, Inbred C57BL; Microfluidics; Microscopy, Fluorescence; Phenotype
TL;DR: TIRF microscopy was used to characterize the changes in shape (morphodynamics) of primary, murine B cells as they migrated on surfaces with adsorbed chemokine, CXCL13, and the adhesive ligand, ICAM-1, and showed that B-cell migration is more persistent when the direction of migration is better aligned with the gradient. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Linking morphodynamics and directional persistence of T lymphocyte migration


By: X. Liu n, E. Welf n & J. Haugh n

author keywords: cell migration; chemokine; TIRF microscopy; image analysis
MeSH headings : Actins / physiology; Animals; Cell Movement / physiology; Cell Polarity / physiology; Cell Size; Cells, Cultured; Computer Simulation; Humans; Membrane Fluidity / physiology; Mice; Models, Biological; Models, Statistical; Molecular Motor Proteins / physiology; Stochastic Processes; T-Lymphocytes / cytology; T-Lymphocytes / physiology
TL;DR: This study uses total internal reflection fluorescence microscopy to monitor T lymphocytes' areas of contact with a surface presenting adhesive ICAM-1 and the chemokine, and suggests that switching of the dominant protrusion between the two sides of the migration axis is associated with persistent migration, whereas the opposite is true of cell turning. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration


By: V. Vernekar*, C. Wallace*, M. Wu*, J. Chao*, . Shannon K. O'Connor, A. Raleigh*, X. Liu n, J. Haugh n, W. Reichert*

author keywords: Chemotaxis; Chemokine; Cell adhesion molecule; Surface immobilization; Surface gradients; B lymphocyte
MeSH headings : Animals; B-Lymphocytes / cytology; Cell Movement / physiology; Cells, Cultured; Chemokine CXCL12 / chemistry; Intercellular Adhesion Molecule-1 / chemistry; Mice; Mice, Transgenic; Ultraviolet Rays
TL;DR: This test platform can be especially valuable for investigators interested in studying the influence of surface-immobilized factors on cell behavior and may also be used as a cell migration enabling platform for testing the effects of various diffusible agents. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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