Xiaojing Liu


Works (18)

Updated: June 4th, 2024 05:00

2024 journal article

Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism


By: G. Scheidemantle n, L. Duan n, M. Lodge n, M. Cummings n, D. Hilovsky n, E. Pham n, X. Wang n, A. Kennedy n, X. Liu n

author keywords: Metformin; Intestinal metabolism; Lipidomics; DIA
Sources: Web Of Science, NC State University Libraries
Added: May 20, 2024

2024 journal article

Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells


By: M. Lodge n, G. Scheidemantle n, V. Adams n, M. Cottam*, D. Richard n, D. Breuer n, P. Thompson n, K. Shrestha n, X. Liu n, A. Kennedy n

TL;DR: It is demonstrated that chronic fructose diet decreased Kupffer cell populations while increasing transitioning monocytes and upregulating resolution and anti-inflammatory associated genes in Kupffer cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024

2024 journal article

Myeloid cell MHC I expression drives CD8<SUP>+</SUP> T cell activation in nonalcoholic steatohepatitis


By: V. Adams n, L. Collins n, T. Williams n, J. Holmes n, P. Hess n, H. Atkins*, G. Scheidemantle n, X. Liu n ...

Contributors: T. Williams n, V. Adams n, L. Collins n, J. Holmes n, P. Hess n, H. Atkins*, G. Scheidemantle n, X. Liu n ...

Ed(s): T. Williams n, L. Collins n & A. Kennedy n

author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
TL;DR: Activated hepatic CD8+ T cells are dependent on myeloid cell MHC class I expression in diet induced NASH to promote inflammation and fibrosis and a role of NADPH oxidase in the production of Ncf2 peptide generation is suggested. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 28, 2024

2024 article

Regulation of urea cycle by reversible high-stoichiometry lysine succinylation

Zhang, R., Fang, J., Xie, X., Carrico, C., Meyer, J. G., Wei, L., … Verdin, E. (2024, March 6). NATURE METABOLISM.

Source: Web Of Science
Added: April 1, 2024

2024 journal article

Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo


By: R. Patel*, D. Cooper*, K. Kadakia*, A. Allen*, L. Duan*, L. Luo*, N. Williams*, X. Liu n, J. Locasale*, D. Kirsch*

Source: Web Of Science
Added: June 3, 2024

2024 article

Variation in Biosynthesis and Metal-Binding Properties of Isonitrile-Containing Peptides Produced by Mycobacteria versus Streptomyces

Chen, T.-Y., Chen, J., Ruszczycky, M. W., Hilovsky, D., Hostetler, T., Liu, X., … Chang, W.-chen. (2024, March 19). ACS CATALYSIS, Vol. 3.

By: T. Chen n, J. Chen*, M. Ruszczycky*, D. Hilovsky n, T. Hostetler n, X. Liu n, J. Zhou*, W. Chang n

author keywords: isonitriles; Fe/2OG enzymes; metallophores; Mycobacterium; natural products
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024

2023 journal article

Excision of a Protein-Derived Amine for <i>p</i>-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD

BIOCHEMISTRY, 62(22), 3276–3282.

By: H. Phan n, O. Manley n, S. Skirboll n, L. Cha n, D. Hilovsky n, W. Chang n, P. Thompson n, X. Liu n, T. Makris n

TL;DR: Turnover studies using limiting O2 have identified a para-aminobenzaldehyde metabolic intermediate that is formed on the path to pABA formation and use of pABCHO and other probe substrates shows that the heterobimetallic Fe/Mn form of the enzyme is capable of oxygen insertion to generate the pA BA-carboxylate. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 12, 2023

2023 journal article

Histone malonylation is regulated by SIRT5 and KAT2A

ISCIENCE, 26(3).

TL;DR: The role of histone malonylation in ribosomal gene expression is highlighted by mass spectrometry and it is reported that availability of malonyl-co-enzyme A (malonyL-CoA), an endogenous provider ofmalonyl groups, affects lysinemalonylation, and that the deacylase SIRT5 selectively reduces malonylated of histones. (via Semantic Scholar)
Source: Web Of Science
Added: June 12, 2023

2023 journal article

Immunoediting instructs tumor metabolic reprogramming to support immune evasion

CELL METABOLISM, 35(1), 118-+.

By: C. Tsai*, Y. Chuang*, X. Li*, Y. Yu*, S. Tzeng*, S. Teoh*, K. Lindblad*, M. Di Matteo* ...

MeSH headings : Humans; Immune Evasion; Neoplasms / pathology; Interferon-gamma / metabolism; T-Lymphocytes / metabolism; Carcinogenesis; Cell Transformation, Neoplastic; Tumor Microenvironment
TL;DR: The findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells to empower them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 20, 2023

2023 article

Metabolomic Analysis of Uterine Luminal Fluid During the Peri-Implantation Period of Pregnancy in Pigs

Liu, B., Duan, L., Liu, X., & Wang, X. (2023, May). JOURNAL OF ANIMAL SCIENCE, Vol. 101.

By: B. Liu n, L. Duan n, X. Liu n & X. Wang n

author keywords: metabolomics; pig; pregnancy
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024

2022 journal article

C-13 tracer analysis suggests extensive recycling of endogenous CO2 in vivo


By: L. Duan n, D. Cooper*, G. Scheidemantle n, J. Locasale*, D. Kirsch* & X. Liu n

author keywords: C-13 tracing; High-resolution mass spectrometry; Anaplerotic metabolism; CO2 recycling
TL;DR: The results show that recycling of endogenous CO2 is substantial in vivo and incorporation of endogenous 13CO2 into M’+ 1 metabolites is substantial and should be considered, and provide a new paradigm to understand carbon atom transformations in vivo. (via Semantic Scholar)
Source: Web Of Science
Added: July 18, 2022

2022 article

MNK2 deficiency potentiates beta-cell regeneration via translational regulation

Karampelias, C., Watt, K., Mattsson, C. L., Ruiz, A. F., Rezanejad, H., Mi, J., … Andersson, O. (2022, June 13). NATURE CHEMICAL BIOLOGY.

By: C. Karampelias*, K. Watt*, C. Mattsson*, A. Ruiz*, H. Rezanejad*, J. Mi*, X. Liu*, L. Chu* ...

MeSH headings : Animals; Cell Line; Eukaryotic Initiation Factor-4E / chemistry; Eukaryotic Initiation Factor-4E / genetics; Eukaryotic Initiation Factor-4E / metabolism; Eukaryotic Initiation Factor-4G; Humans; Infant, Newborn; Intracellular Signaling Peptides and Proteins / metabolism; Phosphorylation; Protein Serine-Threonine Kinases / genetics; Zebrafish / metabolism
TL;DR: Screening 257 million yeast clones determined that CID661578 targets MAP kinase-interacting serine/threonine kinase 2 (MNK2) and demonstrates a targetable role of MNK2-controlled translation in β-cell regeneration, a role that warrants further investigation in diabetes. (via Semantic Scholar)
Source: Web Of Science
Added: June 20, 2022

2022 journal article

Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC-MS/MS-based lipidomics analysis


By: L. Duan n, G. Scheidemantle n, M. Lodge n, M. Cummings n, E. Pham n, X. Wang n, A. Kennedy n, X. Liu n

MeSH headings : Animals; Cardiolipins; Chromatography, Liquid / methods; Ions; Lipidomics; Metabolomics; Mice; Reproducibility of Results; Tandem Mass Spectrometry / methods
TL;DR: A novel workflow using biologically relevant lipids to construct inclusion list for data-independent acquisition (DIA), named as BRI-DIA workflow, which is as efficient as traditional DDA method in profiling lipids, but offers better consistency of lipid identification, compared to D DA method. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2022

2021 journal article

Primary saturation of alpha, beta-unsaturated carbonyl containing fatty acids does not abolish electrophilicity


By: N. Snyder*, J. O'Brien*, B. Singh*, G. Buchan*, A. Arroyo*, X. Liu n, A. Bostwick*, E. Varner* ...

author keywords: Eicosanoids; Dehydrogenase; Fatty acid/metabolism; Fatty acid/oxidation; Mass spectrometry; oxoETE; KETE; Prostaglandin reductase
MeSH headings : A549 Cells; Alcohol Oxidoreductases / antagonists & inhibitors; Alcohol Oxidoreductases / genetics; Alcohol Oxidoreductases / metabolism; Arachidonic Acids / chemistry; Arachidonic Acids / metabolism; Chromatography, Liquid; Docosahexaenoic Acids / chemistry; Docosahexaenoic Acids / metabolism; Electrochemistry; Fatty Acids, Monounsaturated / chemistry; Fatty Acids, Monounsaturated / metabolism; Fatty Acids, Unsaturated / chemistry; Fatty Acids, Unsaturated / metabolism; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Oxidation-Reduction; Signal Transduction; Tandem Mass Spectrometry; Up-Regulation
Source: Web Of Science
Added: November 8, 2021

2021 journal article

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes beta-cell differentiation


By: C. Karampelias*, H. Rezanejad*, M. Rosko*, L. Duan n, J. Lu*, L. Pazzagli*, P. Bertolino*, C. Cesta* ...

MeSH headings : Animals; Animals, Genetically Modified; Animals, Newborn; Carbon / metabolism; Carnitine / metabolism; Cell Differentiation / drug effects; Cell Differentiation / genetics; Cells, Cultured; Folate Receptor 1 / genetics; Folate Receptor 1 / metabolism; Gene Expression Regulation / drug effects; Humans; Insulin-Secreting Cells / cytology; Insulin-Secreting Cells / metabolism; Larva / genetics; Larva / metabolism; Leucovorin / pharmacology; Metabolic Networks and Pathways / drug effects; Mice; Pyrimidines / metabolism; Swine; Zebrafish / genetics; Zebrafish / metabolism
TL;DR: It is found that both folate receptor 1 (folr1) overexpression and treatment with folinic acid, stimulated β-cell differentiation in zebrafish, suggesting evolutionarily conserved and previously unknown roles for folic acid and one-carbon metabolism in the generation of β-cells. (via Semantic Scholar)
Source: Web Of Science
Added: July 19, 2021

2020 journal article

SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease


By: P. Gut*, S. Matilainen*, J. Meyer*, P. Pallijeff*, J. Richard*, C. Carroll*, L. Euro*, C. Jackson* ...

MeSH headings : Acyl Coenzyme A / metabolism; Animals; Cells, Cultured; Female; Humans; Infant; Lysine / metabolism; Male; Mice; Mice, Knockout; Mitochondria / metabolism; Mitochondrial Diseases / genetics; Mitochondrial Diseases / metabolism; Mitochondrial Diseases / pathology; Mutation; Proteomics; Sirtuins / deficiency; Sirtuins / genetics; Sirtuins / metabolism; Succinate-CoA Ligases / deficiency; Succinate-CoA Ligases / genetics; Succinate-CoA Ligases / metabolism; Survival Analysis; Zebrafish
TL;DR: Increased succinyl-CoA levels contribute to SCL pathology by causing global protein hyper-succinylation, and a zebrafish model of the SCL deficiency is developed and finds that SIRT5 gain-of-function reduces global protein succinylation and improves survival. (via Semantic Scholar)
Source: Web Of Science
Added: January 4, 2021

2019 article

Acetate production from glucose and coupling to mitochondrial metabolism in mammals

Liu, X., Cooper, D. E., Cluntun, A. A., Warmoes, M. O., Zhao, S., Reid, M. A., … Locasale, J. W. (2019, July). CANCER RESEARCH, Vol. 79.

By: X. Liu n, D. Cooper*, A. Cluntun*, M. Warmoes*, S. Zhao*, M. Reid*, J. Liu*, P. Lund* ...

TL;DR: Direct evidence is provided that acetate arises from endogenous metabolism of glucose in mammalian cells, but the regulatory mechanisms, which involve ROS and mitochondrial functions are identified. (via Semantic Scholar)
Source: Web Of Science
Added: October 21, 2019

2019 journal article

Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8(+) T Cells in Early Life

JOURNAL OF IMMUNOLOGY, 203(10), 2571–2576.

MeSH headings : Adoptive Transfer / methods; Animals; Animals, Newborn; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Cells, Cultured; Deoxyglucose / pharmacology; Glycolysis / drug effects; Glycolysis / immunology; Immunologic Memory / drug effects; Immunologic Memory / immunology; Interleukin-2 / pharmacology; Listeria monocytogenes / immunology; Listeriosis / immunology; Listeriosis / microbiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA-Binding Proteins / genetics; RNA-Binding Proteins / metabolism
TL;DR: It is shown that neonatal CD8+ T cells exhibit higher glycolytic activity than adult CD8- T cells postinfection, which may be due to age-related differences in Lin28b expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: November 25, 2019

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