Works (48)

Updated: May 11th, 2023 05:02

2023 journal article

MicroRNA and mRNA sequencing analyses reveal key hepatic metabolic and signaling pathways responsive to maternal undernutrition in full-term fetal pigs

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 116.

By: F. Wang, C. Man n, X. Wang, J. Odle, C. Maltecca & . Lin n

author keywords: Maternal undernutrition; RNA sequencing; mRNA-miRNA correlation analysis; Ingenuity Pathways Analysis (IPA); Oxidative phosphorylation
Sources: Web Of Science, ORCID
Added: March 4, 2023

2023 article

Uterine histotroph and conceptus development: III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway

Liu, B., Paudel, S., Flowers, W. L., Piedrahita, J. A., & Wang, X. (2023, April 10). AMINO ACIDS, Vol. 4.

author keywords: Adrenomedullin; Trophectoderm cells; MTOR; Pigs; Implantation
Sources: Web Of Science, ORCID
Added: April 24, 2023

2022 journal article

Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC-MS/MS-based lipidomics analysis

METABOLOMICS, 18(8).

By: L. Duan, G. Scheidemantle, M. Lodge, M. Cummings n, E. Pham, X. Wang, A. Kennedy, X. Liu

Sources: Web Of Science, ORCID
Added: July 26, 2022

2022 journal article

Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst, and stromal cell decidualization, in mice

MOLECULAR HUMAN REPRODUCTION, 28(7).

By: M. Cummings n, H. Yu*, S. Paudel, G. Hu*, X. Li*, M. Hemberger*, X. Wang

author keywords: SIRT1; implantation; stromal cell decidualization; pregnancy; Sirtuin 1; progesterone receptor signaling
Sources: Web Of Science, ORCID
Added: July 11, 2022

2021 article

Amino Acids in Cell Signaling: Regulation and Function

AMINO ACIDS IN NUTRITION AND HEALTH: AMINO ACIDS IN GENE EXPRESSION, METABOLIC REGULATION, AND EXERCISING PERFORMANCE, Vol. 1332, pp. 17–33.

By: S. Paudel, G. Wu & X. Wang

author keywords: Functional amino acids; Transceptor; Sensor; mTORC1; AMPK; MAPK
Sources: Web Of Science, ORCID
Added: October 26, 2021

2021 journal article

Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses

BIOLOGY OF REPRODUCTION, 105(4), 876–891.

By: S. Paudel, B. Liu, M. Cummings n, K. Quinn*, F. Bazer*, K. Caron*, X. Wang

author keywords: adrenomedullin; conceptus; uterine fluid; uterus; pigs
Sources: Web Of Science, ORCID
Added: November 15, 2021

2019 article

ENDOMETRIAL EPITHELIAL FOXO1 DIRECTLY MODULATES SIGNALING PATHWAYS NECESSARY FOR UTERINE RECEPTIVITY.

Moustafa, S. M., Young, S. L., Wang, T., Wu, S., Li, R., Wang, X., … Demayo, F. (2019, September). FERTILITY AND STERILITY, Vol. 112, pp. E314–E315.

By: S. Moustafa*, S. Young*, T. Wang*, S. Wu*, R. Li*, X. Wang, T. Spencer*, F. Demayo*

Sources: Web Of Science, ORCID
Added: October 28, 2019

2018 journal article

FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation

PLOS GENETICS, 14(11).

By: Y. Vasquez*, X. Wang, M. Wetendorf*, H. Franco*, Q. Mo*, T. Wang*, R. Lanz*, S. Young* ...

Sources: Web Of Science, ORCID
Added: December 31, 2018

2018 journal article

Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep

Journal of Animal Science and Biotechnology, 9(1).

By: Y. Lenis, G. Johnson, X. Wang, W. Tang, K. Dunlap, M. Satterfield, G. Wu, T. Hansen, F. Bazer

author keywords: Agmatine; Arginine; Interferon tau; Polyamines; Trophectoderm cells
Sources: Crossref, ORCID
Added: May 4, 2020

2018 journal article

Innate differences and colostrum-induced alterations of jejunal mucosal proteins in piglets with intra-uterine growth restriction

British Journal of Nutrition, 119(7), 734–747.

By: X. Wang, Y. Zhu*, C. Feng*, G. Lin*, G. Wu, D. Li*, J. Wang*

author keywords: Jejunum; Colostrum; Porcine neonates; Intra-uterine growth restriction; Proteomics
Sources: Crossref, ORCID
Added: May 4, 2020

2018 journal article

SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh

NATURE COMMUNICATIONS, 9.

By: X. Wang, X. Li*, T. Wang*, S. Wu*, J. Jeong*, T. Kim*, S. Young*, B. Lessey* ...

Sources: Web Of Science, ORCID
Added: November 5, 2018

2017 journal article

Decidualisation and placentation defects are a major cause of age-related reproductive decline

Nature Communications, 8(1).

By: L. Woods*, V. Perez-Garcia*, J. Kieckbusch*, X. Wang, F. DeMayo*, F. Colucci*, M. Hemberger*

Sources: Crossref, ORCID
Added: May 4, 2020

2017 journal article

Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment†

Biology of Reproduction, 96(2), 313–326.

author keywords: progesterone receptor; implantation; uterine receptivity; progesterone signaling; mouse models
Sources: Crossref, ORCID
Added: May 4, 2020

2017 chapter

Delivery of Morpholino Antisense Oligonucleotides to a Developing Ovine Conceptus via Luminal Injection into a Ligated Uterine Horn

In Morpholino Oligomers (pp. 241–250).

By: X. Wang & K. Dunlap*

author keywords: Ovine; Conceptus; Peri-implantation; Uterine ligation; Morpholino antisense oligonucleotide; Endo-Porter
Sources: Crossref, ORCID
Added: May 4, 2020

2017 journal article

Hormone dependent uterine epithelial-stromal communication for pregnancy support

Placenta, 60, S20–S26.

By: X. Wang, S. Wu* & F. DeMayo*

author keywords: Progesterone; Pregnancy; Uterine receptivity
Sources: Crossref, ORCID
Added: May 4, 2020

2016 journal article

Effects of agmatine on secretion of interferon tau and catecholamines and expression of genes related to production of polyamines by ovine trophectoderm cells

Amino Acids, 48(10), 2389–2399.

By: Y. Lenis*, X. Wang, W. Tang*, G. Wu & F. Bazer*

author keywords: Arginine; Agmatine; Polyamines; Trophectoderm cells; Interferon tau
Sources: Crossref, ORCID
Added: May 4, 2020

2016 journal article

Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells

Biology of Reproduction, 95(5), 102–102.

By: X. Wang, D. Li*, G. Wu* & F. Bazer*

author keywords: fructose; O-linked glycosylation; phosphorylation; trophoblast
Sources: Crossref, ORCID
Added: May 4, 2020

2016 journal article

Uterine Histotroph and Conceptus Development. II. Arginine and Secreted Phosphoprotein 1 Cooperatively Stimulate Migration and Adhesion of Ovine Trophectoderm Cells via Focal Adhesion-MTORC2 Mediated Cytoskeleton Reorganization

Biology of Reproduction, 95(3), 71–71.

By: X. Wang, G. Johnson*, R. Burghardt*, G. Wu & F. Bazer*

Sources: Crossref, ORCID
Added: May 4, 2020

2016 chapter

mTOR: The Master Regulator of Conceptus Development in Response to Uterine Histotroph During Pregnancy in Ungulates

In K. Maiese (Ed.), Molecules to Medicine with mTOR: Translating Critical Pathways Into Novel Therapeutic Strategies (pp. 23–35).

By: X. Wang, G. Wu & F. Bazer*

Ed(s): K. Maiese

Sources: NC State University Libraries, ORCID
Added: April 4, 2021

2015 journal article

Exosomes, endogenous retroviruses and toll-like receptors: pregnancy recognition in ewes

REPRODUCTION, 149(3), 281–291.

By: I. Ruiz-González*, J. Xu*, X. Wang, R. Burghardt*, K. Dunlap* & F. Bazer*

Sources: Crossref, ORCID
Added: May 4, 2020

2015 journal article

Functional Roles of Arginine During the Peri-Implantation Period of Pregnancy. III. Arginine Stimulates Proliferation and Interferon Tau Production by Ovine Trophectoderm Cells via Nitric Oxide and Polyamine-TSC2-MTOR Signaling Pathways

Biology of Reproduction, 92(3).

By: X. Wang, R. Burghardt*, J. Romero*, T. Hansen*, G. Wu* & F. Bazer*

author keywords: arginine; interferon tau; mechanistic target of rapamycin; trophectoderm; tuberous sclerosis protein 2
Sources: Crossref, ORCID
Added: May 4, 2020

2015 journal article

Involvement of TLR7 and TLR8 in conceptus development and establishment of pregnancy in sheep

REPRODUCTION, 149(4), 305–316.

By: I. Ruiz-González*, M. Minten*, X. Wang, K. Dunlap* & F. Bazer*

Sources: Crossref, ORCID
Added: May 4, 2020

2015 journal article

Select nutrients and their effects on conceptus development in mammals

Animal Nutrition, 1(3), 85–95.

By: F. Bazer*, X. Wang, G. Johnson* & G. Wu

author keywords: Amino acids; Secreted phosphoprotein 1; Pregnancy; Interferon tau; Conceptus development; Trophectoderm
Sources: Crossref, ORCID
Added: May 4, 2020

2015 journal article

Synthesis of polyamines from L-proline in the porcine placenta and neonatal enterocytes

Amino Acids, 47(8), 1669.

By: G. Wu, F. Bazer, X. Wang, G. Johnson, Y. Hou, Z. Dai, J. Wang, Z. Wu

Source: NC State University Libraries
Added: April 24, 2021

2015 journal article

The many faces of interferon tau

Amino Acids, 47(3), 449–460.

By: F. Bazer*, W. Ying*, X. Wang, K. Dunlap*, B. Zhou*, G. Johnson*, G. Wu*

author keywords: Uterus; Amino acids; Proteins; Pregnancy; Uteroferrin; Interferon tau
Sources: Crossref, ORCID
Added: May 4, 2020

2015 journal article

The many faces of interferon tau at the maternal-conceptus interface

American Journal of Reproductive Immunology, 73(S2), 21.

By: F. Bazer, I. Ruiz-Gonzalez, J. Xu, X. Wang & K. Dunlap

Source: NC State University Libraries
Added: April 24, 2021

2015 journal article

Uterine Histotroph and Conceptus Development. I. Cooperative Effects of Arginine and Secreted Phosphoprotein 1 on Proliferation of Ovine Trophectoderm Cells via Activation of the PDK1-Akt/PKB-TSC2-MTORC1 Signaling Cascade

Biology of Reproduction, 92(2).

By: X. Wang, G. Johnson*, R. Burghardt*, G. Wu & F. Bazer*

author keywords: arginine; MTORC1; sheep; SPP1; trophectoderm
Sources: Crossref, ORCID
Added: May 4, 2020

2014 journal article

Analysis of polyamines in biological samples by HPLC involving pre-column derivatization with o-phthalaldehyde and N-acetyl-l-cysteine

Amino Acids, 46(6), 1557–1564.

By: Z. Dai*, Z. Wu*, J. Wang*, X. Wang, S. Jia*, F. Bazer*, G. Wu

author keywords: Polyamines; Derivatization; o-Phthalaldehyde; N-Acetyl-L-cysteine; HPLC
Sources: Crossref, ORCID
Added: May 4, 2020

2014 journal article

Arginine Decarboxylase and Agmatinase: An Alternative Pathway for De Novo Biosynthesis of Polyamines for Development of Mammalian Conceptuses

Biology of Reproduction, 90(4).

By: X. Wang, W. Ying*, K. Dunlap*, G. Lin*, M. Satterfield*, R. Burghardt*, G. Wu, F. Bazer*

author keywords: agmatine; development; polyamines; sheep; trophectoderm
Sources: Crossref, ORCID
Added: May 4, 2020

2014 journal article

Environmental factors affecting pregnancy: Endocrine disrupters, nutrients and metabolic pathways

Molecular and Cellular Endocrinology, 398(1-2), 53–68.

By: F. Bazer*, G. Wu, G. Johnson* & X. Wang

author keywords: Arginine; Glucose; Secreted phosphoprotein 1; Pregnancy; Endocrine Disrupter
Sources: Crossref, ORCID
Added: May 4, 2020

2014 journal article

Functional Role of Arginine During the Peri-implantation Period of Pregnancy. II. Consequences of Loss of Function of Nitric Oxide Synthase NOS3 mRNA in Ovine Conceptus Trophectoderm

Biology of Reproduction, 91(3).

By: X. Wang, J. Frank*, J. Xu*, K. Dunlap*, M. Satterfield*, R. Burghardt*, J. Romero*, T. Hansen*, G. Wu, F. Bazer*

author keywords: development; morpholino; nitric oxide; nitric oxide synthase
Sources: Crossref, ORCID
Added: May 4, 2020

2014 journal article

Functional role of arginine during the peri‐implantation period of pregnancy. I. Consequences of loss of function of arginine transporter SLC7A1 mRNA in ovine conceptus trophectoderm

The FASEB Journal, 28(7), 2852–2863.

By: X. Wang, J. Frank*, D. Little*, K. Dunlap*, M. Satterfield*, R. Burghardt*, T. Hansen*, G. Wu, F. Bazer*

author keywords: development; sheep; morpholino
Sources: Crossref, ORCID
Added: May 4, 2020

2014 journal article

Improving amino acid nutrition to prevent intrauterine growth restriction in mammals

Amino Acids, 46(7), 1605–1623.

By: G. Lin*, X. Wang, G. Wu, C. Feng*, H. Zhou*, D. Li*, J. Wang*

author keywords: Amino acids; Fetus; Intervention; IUGR; Nutrition; Placenta; Pregnancy
Sources: Crossref, ORCID
Added: May 4, 2020

2014 journal article

Putrescine Stimulates the mTOR Signaling Pathway and Protein Synthesis in Porcine Trophectoderm Cells

Biology of Reproduction, 91(5).

By: X. Kong*, X. Wang, Y. Yin*, X. Li*, H. Gao*, F. Bazer*, G. Wu

author keywords: mTOR; placental cells; protein synthesis; putrescine
Sources: Crossref, ORCID
Added: May 4, 2020

2014 journal article

Temporal proteomic analysis reveals defects in small-intestinal development of porcine fetuses with intrauterine growth restriction

The Journal of Nutritional Biochemistry, 25(7), 785–795.

By: X. Wang, G. Lin*, C. Liu*, C. Feng*, H. Zhou*, T. Wang*, D. Li*, G. Wu, J. Wang*

author keywords: Intrauterine growth restriction; Fetus; Intestine; Development; Pig
Sources: Crossref, ORCID
Added: May 4, 2020

2013 journal article

IUGR alters muscle fiber development and proteome in fetal pigs 

Frontiers in Bioscience, 18(2), 598–607.

By: T. Wang*, C. Liu, C. Feng, X. Wang, G. Lin, Y. Zhu, J. Yin, D. Li, J. Wang

author keywords: IUGR; Muscle; Fetal Pigs; Proteome; Review
Sources: Crossref, ORCID
Added: January 21, 2021

2013 journal article

Impacts of arginine nutrition on embryonic and fetal development in mammals

Amino Acids, 45(2), 241–256.

By: G. Wu*, F. Bazer*, M. Satterfield*, X. Li*, X. Wang, G. Johnson*, R. Burghardt*, Z. Dai*, J. Wang*, Z. Wu*

author keywords: Arginine; Cell signaling; Embryos; Nutrition; Reproduction
Sources: Crossref, ORCID
Added: May 4, 2020

2013 journal article

Intrauterine growth restriction alters the hepatic proteome in fetal pigs

The Journal of Nutritional Biochemistry, 24(6), 954–959.

By: C. Liu*, G. Lin*, X. Wang, T. Wang*, G. Wu, D. Li*, J. Wang*

author keywords: Fetus; Intrauterine growth restriction; Liver; Pigs; Proteome
Sources: Crossref, ORCID
Added: May 4, 2020

2013 journal article

T Cells Development Is Different between Thymus from Normal and Intrauterine Growth Restricted Pig Fetus at Different Gestational Stage

Asian-Australasian Journal of Animal Sciences, 26(3), 343–348.

By: Y. Lin*, J. Wang*, X. Wang, W. Wu* & C. Lai*

author keywords: Intrauterine Growth Retardation; T Cell Development; Immunity; Notch Signaling; Pig Fetus
Sources: Crossref, ORCID
Added: May 4, 2020

2011 journal article

Dietary Supplementation with the Probiotic Lactobacillus fermentum I5007 and the Antibiotic Aureomycin Differentially Affects the Small Intestinal Proteomes of Weanling Piglets

The Journal of Nutrition, 142(1), 7–13.

By: X. Wang, F. Yang*, C. Liu*, H. Zhou*, G. Wu, S. Qiao*, D. Li*, J. Wang*

Sources: Crossref, ORCID
Added: May 4, 2020

2010 journal article

Differential composition of proteomes in sow colostrum and milk from anterior and posterior mammary glands1

Journal of Animal Science, 88(8), 2657–2664.

By: W. Wu*, X. Wang, G. Wu*, S. Kim, F. Chen* & J. Wang*

author keywords: anterior mammary gland; colostrum; milk; posterior mammary gland; proteome; sow
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018

2010 journal article

Temporal Proteomic Analysis Reveals Continuous Impairment of Intestinal Development in Neonatal Piglets with Intrauterine Growth Restriction

Journal of Proteome Research, 9(2), 924–935.

By: X. Wang, W. Wu*, G. Lin*, D. Li*, G. Wu & J. Wang*

author keywords: Intrauterine growth restriction; Piglets; Intestine; Development; Temporal proteomic analysis; Histological analysis
Sources: Crossref, ORCID
Added: May 4, 2020

2009 journal article

Advance in maternal bioactive compounds in promoting growth and development of piglets

Chinese Journal of Animal Science, 45(9), 61–64.

By: W. Wu, X. Wang & J. Wang

Source: NC State University Libraries
Added: April 24, 2021

2009 journal article

Dietary L-arginine Supplementation Improves Intestinal Function in Weaned Pigs after an Escherichia coli Lipopolysaccharide Challenge

Asian-Australasian Journal of Animal Sciences, 22(12), 1667–1675.

By: Y. Liu, J. Han, J. Huang, X. Wang, F. Wang & J. Wang

Sources: Crossref, ORCID
Added: May 4, 2020

2009 journal article

Progress in proteome research of breast milk

Chinese Journal of Animal Nutrition, 21(6), 809–815.

By: W. Wu, X. Wang & J. Wang

Source: NC State University Libraries
Added: April 24, 2021

2009 journal article

Proteomic analysis reveals altered expression of proteins related to glutathione metabolism and apoptosis in the small intestine of zinc oxide-supplemented piglets

Amino Acids, 37(1), 209–218.

By: X. Wang, D. Ou*, J. Yin*, G. Wu & J. Wang*

author keywords: Apoptosis; Small intestine; Proteomics; Redox; ZnO
Sources: Crossref, ORCID
Added: May 4, 2020

2009 journal article

The development of T lymphocytes in intrauterine growth retardation piglets

Chinese Journal of Animal Science, 45(21), 13–15.

By: Y. Lin, J. Wang, X. Wang, W. Wu & C. Lai

Source: NC State University Libraries
Added: April 24, 2021

2008 journal article

Intrauterine Growth Restriction Affects the Proteomes of the Small Intestine, Liver, and Skeletal Muscle in Newborn Pigs

The Journal of Nutrition, 138(1), 60–66.

By: J. Wang*, L. Chen*, D. Li*, Y. Yin*, X. Wang, P. Li*, L. Dangott*, W. Hu*, G. Wu

Sources: Crossref, ORCID
Added: May 4, 2020

Employment

Updated: September 7th, 2018 11:46

2018 - present

North Carolina State University Raleigh, NC, US
Assistant Professor Animal Science

2016 - 2018

National Institute of Environmental Health Sciences Durham, NC, US
Postdoctoral Fellow Reproductive and Development Biology Laboratory

Education

Updated: December 10th, 2019 13:40

2011 - 2015

Texas A&M University College Station, TX, US
Ph.D. in Physiology of Reproduction Animal Science

2007 - 2013

China Agricultural University Beijing, CN
Ph.D. in Animal Nutrition Animal Science and Technology

2003 - 2007

China Agricultural University Beijing, CN
B.Sc. in Animal Science Animal Science and Technology