Xiaoqiu Wang
Also known as: Xiaoqiu Churchill Wang
Works (52)
Updated: November 4th, 2024 01:45
2024 journal article
Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism
METABOLOMICS, 20(3).
author keywords: Metformin; Intestinal metabolism; Lipidomics; DIA
open access via doi.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 20, 2024
2023 article
Adrenomedullin Stimulates Proliferation, Migration and Adhesion of Porcine Trophectoderm Cells Via CALCRL-AKT-TSC2-MTORC1 Cell Signaling Pathway
Liu, B., Paudel, S., Flowers, W. L., Piedrahita, J. A., & Wang, X. (2023, May). JOURNAL OF ANIMAL SCIENCE, Vol. 101.
author keywords: adrenomedullin; peri-implantation; pig conceptus
TL;DR:
Results suggest that porcine ADM in histotroph act on its receptor component CALCRL to activate AKT-TSC2-MTOR, particularly MTORC1 signaling cascade, leading to elongation, migration and attachment of conceptuses.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024
2023 article
Adrenomedullin: A Novel Peptide Hormone for Uterine Receptivity and Conceptus Elongation in Pigs?
Paudel, S., Liu, B., Cummings, M. J., & Wang, X. (2023, May). JOURNAL OF ANIMAL SCIENCE, Vol. 101.
author keywords: conceptuses; implantation; pregnancy
TL;DR:
A significant role for ADM is indicated in uterine receptivity for implantation and conceptus growth and development in pigs, and a framework for future studies of ADM signaling to affect proliferation and migration of Tr cells, spacing of blastocysts, implantations and placentation in pigs is provided.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024
2023 article
Metabolomic Analysis of Uterine Luminal Fluid During the Peri-Implantation Period of Pregnancy in Pigs
Liu, B., Duan, L., Liu, X., & Wang, X. (2023, May). JOURNAL OF ANIMAL SCIENCE, Vol. 101.
author keywords: metabolomics; pig; pregnancy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024
2023 journal article
MicroRNA and mRNA sequencing analyses reveal key hepatic metabolic and signaling pathways responsive to maternal undernutrition in full-term fetal pigs
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 116.
author keywords: Maternal undernutrition; RNA sequencing; mRNA-miRNA correlation analysis; Ingenuity Pathways Analysis (IPA); Oxidative phosphorylation
MeSH headings : Pregnancy; Female; Animals; Swine; RNA, Messenger / metabolism; Fetus / metabolism; Liver / metabolism; Signal Transduction; Malnutrition / metabolism
TL;DR:
The correlation analyses showed that metabolic and signaling pathways such as oxidative phosphorylation, death receptor signaling, neuroinflammation signaling pathway, and estrogen receptor signaling pathways were significantly modified, and the gene modifications in these pathways were associated with the miRNA changes induced by the maternal undernutrition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 4, 2023
2023 journal article
Uterine histotroph and conceptus development: III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway
Amino Acids, 55(6), 743–756.
author keywords: Adrenomedullin; Trophectoderm cells; MTOR; Pigs; Implantation
MeSH headings : Pregnancy; Female; Swine; Animals; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Adrenomedullin / pharmacology; Signal Transduction; TOR Serine-Threonine Kinases / genetics; TOR Serine-Threonine Kinases / metabolism; Cell Proliferation; Sirolimus / pharmacology
TL;DR:
Results suggest that porcine ADM in histotroph acts on its receptor component CALCRL to activate AKT-TSC2-MTOR, particularly MTORC1 signaling cascade, leading to elongation, migration and attachment of conceptuses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 24, 2023
2022 journal article
Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC-MS/MS-based lipidomics analysis
METABOLOMICS, 18(8).
MeSH headings : Animals; Cardiolipins; Chromatography, Liquid / methods; Ions; Lipidomics; Metabolomics; Mice; Reproducibility of Results; Tandem Mass Spectrometry / methods
TL;DR:
A novel workflow using biologically relevant lipids to construct inclusion list for data-independent acquisition (DIA), named as BRI-DIA workflow, which is as efficient as traditional DDA method in profiling lipids, but offers better consistency of lipid identification, compared to D DA method.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2022
2022 journal article
Uterine-specific SIRT1 deficiency confers premature uterine aging and impairs invasion and spacing of blastocyst, and stromal cell decidualization, in mice
MOLECULAR HUMAN REPRODUCTION, 28(7).
author keywords: SIRT1; implantation; stromal cell decidualization; pregnancy; Sirtuin 1; progesterone receptor signaling
MeSH headings : Aging; Animals; Blastocyst; Decidua / metabolism; Embryo Implantation / physiology; Female; Hedgehog Proteins / metabolism; Mice; Pregnancy; Sirtuin 1 / genetics; Sirtuin 1 / metabolism; Stromal Cells / metabolism; Uterus / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022
2021 article
Amino Acids in Cell Signaling: Regulation and Function
AMINO ACIDS IN NUTRITION AND HEALTH: AMINO ACIDS IN GENE EXPRESSION, METABOLIC REGULATION, AND EXERCISING PERFORMANCE, Vol. 1332, pp. 17–33.
author keywords: Functional amino acids; Transceptor; Sensor; mTORC1; AMPK; MAPK
MeSH headings : Amino Acids; Animals; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1 / genetics; Signal Transduction
TL;DR:
This work will discuss functional amino acids in cell signaling pathways in mammals with a particular emphasis on mTORC1, AMPK, and MAPK pathways for protein synthesis, nutrient sensing, and anti-inflammatory responses, as well as cell survival, growth, and development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021
2021 journal article
Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses
BIOLOGY OF REPRODUCTION, 105(4), 876–891.
author keywords: adrenomedullin; conceptus; uterine fluid; uterus; pigs
MeSH headings : Adrenomedullin / genetics; Adrenomedullin / metabolism; Animals; Embryo, Mammalian / metabolism; Female; Receptors, Adrenomedullin / genetics; Receptors, Adrenomedullin / immunology; Spatio-Temporal Analysis; Sus scrofa / embryology; Sus scrofa / genetics; Uterus / metabolism
TL;DR:
It is suggested that adrenomedullin plays a significant role in uterine receptivity and conceptus growth and development, via the stimulation of cell proliferation and activation of MTORC1 signaling pathway in the porcine conceptus trophectoderm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 15, 2021
2019 article
ENDOMETRIAL EPITHELIAL FOXO1 DIRECTLY MODULATES SIGNALING PATHWAYS NECESSARY FOR UTERINE RECEPTIVITY.
Moustafa, S. M., Young, S. L., Wang, T., Wu, S., Li, R., Wang, X., … Demayo, F. (2019, September). FERTILITY AND STERILITY, Vol. 112, pp. E314–E315.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 28, 2019
2018 journal article
FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation
PLOS GENETICS, 14(11).
MeSH headings : Animals; Cell Nucleus / metabolism; Cell Polarity / genetics; Cell Polarity / physiology; Decidua / physiology; Embryo Implantation / genetics; Embryo Implantation / physiology; Endometrium / cytology; Endometrium / metabolism; Female; Forkhead Box Protein O1 / deficiency; Forkhead Box Protein O1 / genetics; Forkhead Box Protein O1 / metabolism; Gene Expression Profiling; Humans; Mice; Mice, Knockout; Pregnancy; Receptors, Progesterone / deficiency; Receptors, Progesterone / genetics; Receptors, Progesterone / metabolism; Signal Transduction
TL;DR:
It is demonstrated that expression of FOXO1 and the loss of PGR during the window of receptivity are interrelated and critical for embryo implantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 31, 2018
2018 journal article
Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep
Journal of Animal Science and Biotechnology, 9(1).
author keywords: Agmatine; Arginine; Interferon tau; Polyamines; Trophectoderm cells
TL;DR:
The double-knockdown of translation of ODC1 and ADC mRNAs was most detrimental to conceptus development and their production of interferon tau (IFNT).
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2018 journal article
Innate differences and colostrum-induced alterations of jejunal mucosal proteins in piglets with intra-uterine growth restriction
British Journal of Nutrition, 119(7), 734–747.
author keywords: Jejunum; Colostrum; Porcine neonates; Intra-uterine growth restriction; Proteomics
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Blood Glucose; Colostrum; Energy Metabolism; Female; Fetal Growth Retardation / immunology; Fetal Growth Retardation / metabolism; Fetal Growth Retardation / veterinary; Gene Expression Regulation / drug effects; Glucose / metabolism; Intestinal Mucosa / metabolism; Jejunum / drug effects; Jejunum / metabolism; Pregnancy; Proteomics; Swine; Swine Diseases / immunology; Swine Diseases / metabolism; Transcriptome
TL;DR:
These findings provide the first evidence in intestinal protein alterations of IUGR neonates in response to colostrum ingestion, and thus render new insights into the mechanisms responsible for impaired growth in IUGr neonates and into new nutritional intervention strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2018 journal article
SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh
NATURE COMMUNICATIONS, 9.
MeSH headings : Animals; CRISPR-Cas Systems / genetics; CRISPR-Cas Systems / physiology; Endometrium / metabolism; Female; GATA2 Transcription Factor / genetics; GATA2 Transcription Factor / metabolism; HMGB Proteins / genetics; HMGB Proteins / metabolism; Hedgehog Proteins / genetics; Hedgehog Proteins / metabolism; Hepatocyte Nuclear Factor 3-beta / genetics; Hepatocyte Nuclear Factor 3-beta / metabolism; Leukemia Inhibitory Factor / genetics; Leukemia Inhibitory Factor / metabolism; Mice; SOXF Transcription Factors / genetics; SOXF Transcription Factors / metabolism; Transcriptome / genetics; Uterus / metabolism
TL;DR:
The authors show that SOX17 is upstream of Indian hedgehog to regulate mouse uterine receptivity, and their analysis of uterine tissue from endometriosis patients suggests the same function in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 5, 2018
2017 journal article
Decidualisation and placentation defects are a major cause of age-related reproductive decline
Nature Communications, 8(1).
MeSH headings : Age Factors; Aging / genetics; Aging / physiology; Animals; Cells, Cultured; Decidua / metabolism; Decidua / physiopathology; Embryonic Development / genetics; Embryonic Development / physiology; Female; Gene Expression Profiling / methods; Humans; Male; Maternal Age; Mice, Inbred C57BL; Placenta / metabolism; Placenta / physiopathology; Placentation / genetics; Pregnancy; Pregnancy Complications / genetics; Pregnancy Complications / physiopathology; Reproduction / genetics; Reproduction / physiology; Uterus / metabolism; Uterus / physiopathology
TL;DR:
It is reported that abnormal embryonic development in aged female mice is associated with severe placentation defects, which result from major deficits in the decidualisation response of the uterine stroma, and rescued by transferring the embryo from an old to a young uterus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2017 journal article
Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment†
Biology of Reproduction, 96(2), 313–326.
author keywords: progesterone receptor; implantation; uterine receptivity; progesterone signaling; mouse models
MeSH headings : Alleles; Animals; Cloning, Molecular; Down-Regulation; Embryo Implantation; Endometrium; Female; Gene Expression Regulation / physiology; Hedgehog Proteins / genetics; Hedgehog Proteins / metabolism; Male; Mice, Transgenic; Progesterone / metabolism; Receptors, OSM-LIF / genetics; Receptors, OSM-LIF / metabolism; Receptors, Progesterone / genetics; Receptors, Progesterone / metabolism; Wnt Proteins / genetics; Wnt Proteins / metabolism
TL;DR:
Downregulation of the PGRA isoform at the window of receptivity is necessary for the attenuation of hedgehog signaling, transcriptional activation of LIF signaling, and modulation of solutes and fluid, producing a receptive environment for the attaching embryo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2017 chapter
Delivery of Morpholino Antisense Oligonucleotides to a Developing Ovine Conceptus via Luminal Injection into a Ligated Uterine Horn
In Morpholino Oligomers (pp. 241–250).
author keywords: Ovine; Conceptus; Peri-implantation; Uterine ligation; Morpholino antisense oligonucleotide; Endo-Porter
MeSH headings : Animals; Embryonic Development / genetics; Female; Gene Transfer Techniques; Morpholinos / administration & dosage; Morpholinos / genetics; Oligonucleotides, Antisense; Peptides; Uterus
TL;DR:
The method for preparation and surgical delivery of MAO-Endo-Porter complex to developing ovine conceptus on day 8 postmating is described and methods for posttreatment sample recovery on day 16 postmated are outlined.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2017 journal article
Hormone dependent uterine epithelial-stromal communication for pregnancy support
Placenta, 60, S20–S26.
author keywords: Progesterone; Pregnancy; Uterine receptivity
MeSH headings : Animals; Biomedical Research / methods; Biomedical Research / trends; Cell Communication; Cell Transdifferentiation; Embryo Implantation; Endometrium / cytology; Endometrium / physiology; Estrogens / metabolism; Estrogens / physiology; Female; Humans; Ovary / metabolism; Ovary / physiology; Pregnancy; Progesterone / metabolism; Progesterone / physiology; Stromal Cells / cytology; Stromal Cells / physiology; Uterus / cytology; Uterus / physiology
TL;DR:
The molecular mechanisms utilized by steroid hormones that regulate uterine receptivity, as well as the major hormones governing these processes, are discussed, to establish and maintain pregnancy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2016 journal article
Effects of agmatine on secretion of interferon tau and catecholamines and expression of genes related to production of polyamines by ovine trophectoderm cells
Amino Acids, 48(10), 2389–2399.
author keywords: Arginine; Agmatine; Polyamines; Trophectoderm cells; Interferon tau
MeSH headings : Agmatine / pharmacology; Animals; Biogenic Polyamines / biosynthesis; Catecholamines / metabolism; Cells, Cultured; Female; Gene Expression Regulation / drug effects; Interferon Type I / metabolism; Pregnancy Proteins / metabolism; Sheep; Trophoblasts / metabolism
TL;DR:
A role for Arg and Agm is suggested in the regulation of transport of basic amino acids (including Arg), polyamine synthesis, and secretion of catecholamines by oTr1 cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2016 journal article
Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells
Biology of Reproduction, 95(5), 102–102.
author keywords: fructose; O-linked glycosylation; phosphorylation; trophoblast
TL;DR:
Novel functional roles of fructose in promoting embryonic/fetal growth and development during pregnancy are revealed, and new insight is provided into understanding the relationship between excessive fructose intake and metabolic disorders.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2016 journal article
Uterine Histotroph and Conceptus Development. II. Arginine and Secreted Phosphoprotein 1 Cooperatively Stimulate Migration and Adhesion of Ovine Trophectoderm Cells via Focal Adhesion-MTORC2 Mediated Cytoskeleton Reorganization
Biology of Reproduction, 95(3), 71–71.
TL;DR:
Results suggest that arginine and SPP1 in histotroph affect cellular events required for rapid elongation of ovine conceptuses during the peri-implantation period of pregnancy.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2016 chapter
mTOR: The Master Regulator of Conceptus Development in Response to Uterine Histotroph During Pregnancy in Ungulates
In K. Maiese (Ed.), Molecules to Medicine with mTOR: Translating Critical Pathways Into Novel Therapeutic Strategies (pp. 23–35).
Ed(s): K. Maiese
TL;DR:
This review provides a framework for studies of constituents, including hexose sugars, extracellular matrix proteins, and their metabolites that independently and cooperatively activate nutrient-sensing cell signaling pathways, for growth, development, and survival of conceptuses, as well as for the optimization of culture media for in vitro studies of conceptus development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: April 4, 2021
2015 journal article
Functional Roles of Arginine During the Peri-Implantation Period of Pregnancy. III. Arginine Stimulates Proliferation and Interferon Tau Production by Ovine Trophectoderm Cells via Nitric Oxide and Polyamine-TSC2-MTOR Signaling Pathways
Biology of Reproduction, 92(3).
author keywords: arginine; interferon tau; mechanistic target of rapamycin; trophectoderm; tuberous sclerosis protein 2
MeSH headings : Animals; Arginine / pharmacology; Arginine / physiology; Cell Proliferation / drug effects; Cell Proliferation / physiology; Cells, Cultured; Dose-Response Relationship, Drug; Ectoderm / cytology; Ectoderm / drug effects; Ectoderm / metabolism; Embryo Implantation / physiology; Female; Interferon Type I / metabolism; Models, Animal; Nitric Oxide / metabolism; Phosphorylation; Polyamines / metabolism; Pregnancy; Pregnancy Proteins / metabolism; Pregnancy, Animal / physiology; Putrescine / metabolism; Repressor Proteins / metabolism; Sheep / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; TOR Serine-Threonine Kinases / metabolism
TL;DR:
It is indicated that arginine is essential for oTr1 cell proliferation and IFNT production via the NO/polyamine-TSC2-MTOR signaling pathways, particularly the pathway involving polyamine biosynthesis.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2015 journal article
Involvement of TLR7 and TLR8 in conceptus development and establishment of pregnancy in sheep
REPRODUCTION, 149(4), 305–316.
MeSH headings : Animals; Cells, Cultured; Embryo Implantation / drug effects; Embryo, Mammalian / cytology; Embryo, Mammalian / drug effects; Embryo, Mammalian / metabolism; Embryonic Development / drug effects; Endometrium / cytology; Endometrium / drug effects; Endometrium / metabolism; Estrous Cycle; Female; Fetal Development / drug effects; Immunoenzyme Techniques; Oligonucleotides, Antisense / pharmacology; Pregnancy; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sheep; Toll-Like Receptor 7 / antagonists & inhibitors; Toll-Like Receptor 7 / metabolism; Toll-Like Receptor 8 / antagonists & inhibitors; Toll-Like Receptor 8 / metabolism; Uterus / cytology; Uterus / drug effects; Uterus / metabolism
TL;DR:
Findings corroborate the hypothesis that TLR7 and TLR8 mediate pathways whereby enJSRV-Env regulates key peri-implantation events in conceptus development and differentiated functions of trophectoderm cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2015 journal article
Select nutrients and their effects on conceptus development in mammals
Animal Nutrition, 1(3), 85–95.
author keywords: Amino acids; Secreted phosphoprotein 1; Pregnancy; Interferon tau; Conceptus development; Trophectoderm
TL;DR:
Mechanisms whereby arginine regulates expression of genes via the mechanistic target of rapamycin cell signaling pathways critical to conceptus development, implantation and placentation are discussed in detail in this review.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2015 journal article
Synthesis of polyamines from L-proline in the porcine placenta and neonatal enterocytes
Amino Acids, 47(8), 1669.
Source: NC State University Libraries
Added: April 24, 2021
2015 journal article
The many faces of interferon tau
Amino Acids, 47(3), 449–460.
author keywords: Uterus; Amino acids; Proteins; Pregnancy; Uteroferrin; Interferon tau
MeSH headings : Animals; Arginine / metabolism; Biological Transport, Active / physiology; Embryo, Mammalian / metabolism; Female; Interferon Type I / metabolism; Pregnancy / metabolism; Pregnancy Proteins / metabolism; Ruminants / metabolism; Uterus / metabolism
TL;DR:
Interferon tau (IFNT) was discovered as the pregnancy recognition signal in ruminants, but is now known to have a plethora of physiological functions in the mammalian uterus, contributing to survival, growth and development of the ruminant conceptus.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2015 journal article
The many faces of interferon tau at the maternal-conceptus interface
American Journal of Reproductive Immunology, 73(S2), 21.
Source: NC State University Libraries
Added: April 24, 2021
2014 journal article
Analysis of polyamines in biological samples by HPLC involving pre-column derivatization with o-phthalaldehyde and N-acetyl-l-cysteine
Amino Acids, 46(6), 1557–1564.
author keywords: Polyamines; Derivatization; o-Phthalaldehyde; N-Acetyl-L-cysteine; HPLC
MeSH headings : Acetylcysteine / chemistry; Animals; Cells, Cultured / chemistry; Chromatography, High Pressure Liquid / methods; Plants / chemistry; Polyamines / analysis; Reproducibility of Results; Spectrometry, Fluorescence / methods; o-Phthalaldehyde / chemistry
TL;DR:
The HPLC method is highly sensitive, specific, accurate, easily automated, and capable for the analysis of samples with different characteristics and small volume/amount, and provides a useful research tool for studying the biochemistry, physiology, and pharmacology of polyamines and related substances.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2014 journal article
Arginine Decarboxylase and Agmatinase: An Alternative Pathway for De Novo Biosynthesis of Polyamines for Development of Mammalian Conceptuses
Biology of Reproduction, 90(4).
author keywords: agmatine; development; polyamines; sheep; trophectoderm
MeSH headings : Agmatine / metabolism; Animals; Carboxy-Lyases / metabolism; Cationic Amino Acid Transporter 1 / genetics; Cationic Amino Acid Transporter 1 / metabolism; Citrulline / metabolism; Embryo Implantation / physiology; Embryonic Development / physiology; Female; Mammals; Nitric Oxide Synthase Type III / genetics; Nitric Oxide Synthase Type III / metabolism; Ornithine / metabolism; Ornithine Decarboxylase / genetics; Ornithine Decarboxylase / metabolism; Pregnancy; Pregnancy, Animal / physiology; Putrescine / biosynthesis; Sheep; Spermidine / biosynthesis; Spermine / biosynthesis; Ureohydrolases / metabolism
TL;DR:
It is concluded that the majority of polyamine synthesis is by the conventional ODC1-dependent pathway (arginine-ornithine-putrescine) and that deficiencies in O DC1 result in increased activity of the rescue ADC/AGMAT-dependent route for production of polyamines.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2014 journal article
Environmental factors affecting pregnancy: Endocrine disrupters, nutrients and metabolic pathways
Molecular and Cellular Endocrinology, 398(1-2), 53–68.
author keywords: Arginine; Glucose; Secreted phosphoprotein 1; Pregnancy; Endocrine Disrupter
MeSH headings : Agmatine / metabolism; Animals; Arginine / metabolism; Embryo Implantation; Embryonic Development; Endocrine Disruptors / adverse effects; Environment; Environmental Exposure / adverse effects; Estrogens / adverse effects; Female; Gene Expression Regulation, Developmental; High Fructose Corn Syrup / adverse effects; Humans; Infertility / chemically induced; Insulin Resistance; Metabolic Diseases / chemically induced; Nitric Oxide / biosynthesis; Phosphoproteins / metabolism; Polyamines / metabolism; Pregnancy; Prenatal Exposure Delayed Effects; Progestins / adverse effects
TL;DR:
Uterine adenogenesis, a unique post-natal event in mammals, is vulnerable to endocrine disruption by estrogens and progestins resulting in infertility or reduced prolificacy, and novel pathways for nutrient metabolism during pregnancy can improve survival and growth.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2014 journal article
Exosomes, endogenous retroviruses and toll-like receptors: pregnancy recognition in ewes
REPRODUCTION, 149(3), 281–291.
MeSH headings : Animals; Cytokines / metabolism; Embryo Implantation / physiology; Endogenous Retroviruses / metabolism; Endometrium / metabolism; Exosomes / metabolism; Female; Pregnancy; Pregnancy, Animal / physiology; Sheep / physiology; Signal Transduction / physiology; Toll-Like Receptors / genetics; Toll-Like Receptors / metabolism; Uterus / metabolism
TL;DR:
The hypothesis that free and/or exosomal enJSRV act on the trophectoderm via TLR to induce the secretion of IFNT in a manner similar to that for innate immune responses of macrophages and plasmacytoid dendritic cells to viral pathogens is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2014 journal article
Functional Role of Arginine During the Peri-implantation Period of Pregnancy. II. Consequences of Loss of Function of Nitric Oxide Synthase NOS3 mRNA in Ovine Conceptus Trophectoderm
Biology of Reproduction, 91(3).
author keywords: development; morpholino; nitric oxide; nitric oxide synthase
MeSH headings : Animals; Animals, Inbred Strains; Arginine / metabolism; Blastocyst / cytology; Blastocyst / drug effects; Blastocyst / metabolism; Blastocyst / pathology; Cationic Amino Acid Transporter 1 / metabolism; Embryo Implantation / drug effects; Embryo, Mammalian / cytology; Embryo, Mammalian / drug effects; Embryo, Mammalian / metabolism; Embryo, Mammalian / pathology; Embryonic Development / drug effects; Extraembryonic Membranes / cytology; Extraembryonic Membranes / drug effects; Extraembryonic Membranes / metabolism; Extraembryonic Membranes / pathology; Female; Fetal Growth Retardation / chemically induced; Fetal Growth Retardation / metabolism; Fetal Growth Retardation / pathology; Immunohistochemistry; Interferon Type I / metabolism; Morpholinos / pharmacology; Nitric Oxide Synthase Type III / antagonists & inhibitors; Nitric Oxide Synthase Type III / genetics; Nitric Oxide Synthase Type III / metabolism; Pregnancy; Pregnancy Maintenance / drug effects; Pregnancy Proteins / metabolism; RNA, Messenger / antagonists & inhibitors; RNA, Messenger / metabolism; Sheep, Domestic; Texas
TL;DR:
The data suggest that NOS3 is the key enzyme for NO production by conceptus Tr and that this protein also regulates the availability of arginine in conceptus tissues for synthesis of polyamines that are essential for conceptus survival and development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2014 journal article
Functional role of arginine during the peri‐implantation period of pregnancy. I. Consequences of loss of function of arginine transporter SLC7A1 mRNA in ovine conceptus trophectoderm
The FASEB Journal, 28(7), 2852–2863.
author keywords: development; sheep; morpholino
MeSH headings : Amino Acids / genetics; Amino Acids / metabolism; Animals; Arginine / genetics; Arginine / metabolism; Cationic Amino Acid Transporter 1 / genetics; Cationic Amino Acid Transporter 1 / metabolism; Embryo Implantation / genetics; Embryo Implantation / physiology; Endometrium / metabolism; Endometrium / physiology; Female; Gene Expression Regulation, Developmental / genetics; Nitric Oxide Synthase Type III / genetics; Nitric Oxide Synthase Type III / metabolism; Ornithine Decarboxylase / genetics; Ornithine Decarboxylase / metabolism; Polyamines / metabolism; Pregnancy; RNA, Messenger / genetics; Sheep / genetics; Sheep / metabolism; Uterus / metabolism; Uterus / physiology
TL;DR:
An in vivo morpholino antisense oligonucleotide (MAO)‐mediated knockdown of SLC7A1 mRNA, the arginine transporter in ovine conceptus trophectoderm (Tr), resulted in retarded conceptus development and abnormal function compared to MAO control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2014 journal article
Improving amino acid nutrition to prevent intrauterine growth restriction in mammals
Amino Acids, 46(7), 1605–1623.
author keywords: Amino acids; Fetus; Intervention; IUGR; Nutrition; Placenta; Pregnancy
MeSH headings : Amino Acids / metabolism; Amino Acids / pharmacology; Animals; Arginine / metabolism; Arginine / pharmacology; Female; Fetal Growth Retardation / metabolism; Fetal Growth Retardation / prevention & control; Fetal Growth Retardation / veterinary; Mammals; Maternal Nutritional Physiological Phenomena; Placental Circulation; Pregnancy
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2014 journal article
Putrescine Stimulates the mTOR Signaling Pathway and Protein Synthesis in Porcine Trophectoderm Cells
Biology of Reproduction, 91(5).
author keywords: mTOR; placental cells; protein synthesis; putrescine
MeSH headings : Animals; Cell Proliferation / drug effects; Cells, Cultured; Ectoderm / drug effects; Ectoderm / metabolism; Eflornithine / pharmacology; Female; Pregnancy; Protein Biosynthesis / drug effects; Putrescine / pharmacology; Signal Transduction / drug effects; Swine; TOR Serine-Threonine Kinases / metabolism; Trophoblasts / drug effects; Trophoblasts / metabolism; Up-Regulation / drug effects
TL;DR:
Results indicate that putrescine promotes cell proliferation and protein synthesis in a dose- and time-dependent manner, which was inhibited by difluoro-methylornithine (an inhibitor of ornithine decarboxylase), and reveals a novel and important role for putresCine in regulating the mTOR signaling pathway in porcine placental cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2014 journal article
Temporal proteomic analysis reveals defects in small-intestinal development of porcine fetuses with intrauterine growth restriction
The Journal of Nutritional Biochemistry, 25(7), 785–795.
author keywords: Intrauterine growth restriction; Fetus; Intestine; Development; Pig
MeSH headings : Animals; Animals, Newborn; Female; Fetal Growth Retardation / metabolism; Gestational Age; Intestinal Mucosa / metabolism; Intestine, Small / embryology; Intestine, Small / metabolism; Pregnancy; Proteome / metabolism; Swine
TL;DR:
These findings provide the first evidence for altered proteomes in the small intestine of IUGR fetuses, thereby predisposing the gut to metabolic defects during gestation and neonatal periods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2014 journal article
Uterine Histotroph and Conceptus Development. I. Cooperative Effects of Arginine and Secreted Phosphoprotein 1 on Proliferation of Ovine Trophectoderm Cells via Activation of the PDK1-Akt/PKB-TSC2-MTORC1 Signaling Cascade
Biology of Reproduction, 92(2).
author keywords: arginine; MTORC1; sheep; SPP1; trophectoderm
MeSH headings : Animals; Arginine / pharmacology; Cell Line; Cell Proliferation / drug effects; Cell Proliferation / physiology; Embryonic Development / drug effects; Female; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes / metabolism; Osteopontin / pharmacology; Pregnancy; Protein Serine-Threonine Kinases / metabolism; Proto-Oncogene Proteins c-akt / metabolism; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Sheep; Signal Transduction / drug effects; Signal Transduction / physiology; TOR Serine-Threonine Kinases / metabolism; Uterus / drug effects; Uterus / metabolism
TL;DR:
Results suggest that arginine and SPP1 in histotroph act cooperatively to enhance survival, growth, and development of ovine conceptuses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2013 journal article
Impacts of arginine nutrition on embryonic and fetal development in mammals
Amino Acids, 45(2), 241–256.
author keywords: Arginine; Cell signaling; Embryos; Nutrition; Reproduction
MeSH headings : Animals; Arginine / administration & dosage; Arginine / metabolism; Dietary Supplements; Embryo, Mammalian; Embryonic Development; Female; Fetal Growth Retardation / metabolism; Humans; Mice; Nutritional Status; Polyamines / metabolism; Pregnancy; Rats; Sheep, Domestic / embryology; Signal Transduction
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2013 journal article
T Cells Development Is Different between Thymus from Normal and Intrauterine Growth Restricted Pig Fetus at Different Gestational Stage
Asian-Australasian Journal of Animal Sciences, 26(3), 343–348.
author keywords: Intrauterine Growth Retardation; T Cell Development; Immunity; Notch Signaling; Pig Fetus
TL;DR:
The results suggested that normal fetuses had a greater proportion of T-cell subsets at earlier gestation periods, and the Notch signaling pathway was likely partially responsible for these differences to some degree.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2012 journal article
IUGR alters muscle fiber development and proteome in fetal pigs
Frontiers in Bioscience, 18(2), 598–607.
author keywords: IUGR; Muscle; Fetal Pigs; Proteome; Review
MeSH headings : Animals; Animals, Newborn; Female; Fetal Growth Retardation / metabolism; Fetal Weight; Muscle Development; Muscle Fibers, Skeletal / metabolism; Muscle Proteins / metabolism; Muscle, Skeletal / embryology; Muscle, Skeletal / metabolism; Pregnancy; Proteome; Sus scrofa
TL;DR:
Proteomic analysis has shown that 37 proteins involved in energy supply and protein metabolism, structure and type of muscle fiber, proliferation and differentiation of muscle fibers, nutrient transport, intracellular environment, and tissue integrity were differentially expressed between IUGR and NBW fetal pigs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2012 journal article
Intrauterine growth restriction alters the hepatic proteome in fetal pigs
The Journal of Nutritional Biochemistry, 24(6), 954–959.
author keywords: Fetus; Intrauterine growth restriction; Liver; Pigs; Proteome
MeSH headings : Animals; Animals, Newborn; Aspartate Aminotransferases / metabolism; Fetal Growth Retardation / metabolism; Fetal Weight; Fetus; Lipoprotein Lipase / metabolism; Liver / metabolism; Oxidative Stress; Proteome / metabolism; Proteomics; Swine
TL;DR:
Results indicate altered metabolism of nutrients, abnormal ammonia utilization, and reduced capacity for detoxification in the liver of IUGR fetus, which has important implication for explaining low food efficiency and understanding the mechanism responsible for impaired growth in IugR neonates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2011 journal article
Dietary Supplementation with the Probiotic Lactobacillus fermentum I5007 and the Antibiotic Aureomycin Differentially Affects the Small Intestinal Proteomes of Weanling Piglets
The Journal of Nutrition, 142(1), 7–13.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Blotting, Western; Chlortetracycline / pharmacology; Dietary Supplements; Intestine, Small / drug effects; Intestine, Small / metabolism; Limosilactobacillus fermentum; Probiotics; Proteome; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Weaning
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2010 journal article
Differential composition of proteomes in sow colostrum and milk from anterior and posterior mammary glands1
Journal of Animal Science, 88(8), 2657–2664.
author keywords: anterior mammary gland; colostrum; milk; posterior mammary gland; proteome; sow
MeSH headings : Animals; Animals, Suckling / growth & development; Blotting, Western / veterinary; Colostrum / chemistry; Electrophoresis, Gel, Two-Dimensional / veterinary; Female; Mammary Glands, Animal / physiology; Mass Spectrometry / veterinary; Milk / chemistry; Milk Proteins / analysis; Proteome / chemistry; Swine / metabolism
TL;DR:
Investigation of differential proteomes of colostrum and milk secreted by anterior and posterior mammary glands indicates that in comparison with posterior MG, anterior MG are more active in protein synthesis and produce more immunoglobulins and lactoferrin in colostrums and milk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Advance in maternal bioactive compounds in promoting growth and development of piglets
Chinese Journal of Animal Science, 45(9), 61–64.
Source: NC State University Libraries
Added: April 24, 2021
2009 journal article
Dietary L-arginine Supplementation Improves Intestinal Function in Weaned Pigs after an Escherichia coli Lipopolysaccharide Challenge
Asian-Australasian Journal of Animal Sciences, 22(12), 1667–1675.
TL;DR:
Results indicate that Arg supplementation has beneficial effects in alleviating the impairment of gut function induced by LPS challenge.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2009 journal article
Progress in proteome research of breast milk
Chinese Journal of Animal Nutrition, 21(6), 809–815.
Source: NC State University Libraries
Added: April 24, 2021
2009 journal article
Proteomic analysis reveals altered expression of proteins related to glutathione metabolism and apoptosis in the small intestine of zinc oxide-supplemented piglets
Amino Acids, 37(1), 209–218.
author keywords: Apoptosis; Small intestine; Proteomics; Redox; ZnO
MeSH headings : Animals; Apoptosis / drug effects; Diarrhea / chemically induced; Diet; Dietary Supplements; Down-Regulation / physiology; Enzymes / biosynthesis; Glutathione / metabolism; Jejunum / cytology; Jejunum / drug effects; Jejunum / metabolism; Oxidative Stress / physiology; Proteomics; Swine; Up-Regulation / physiology; Zinc Oxide / administration & dosage
TL;DR:
Results indicate that ZnO supplementation improves the redox state and prevents apoptosis in the jejunum of weaning piglets, thereby alleviating weaning-associated intestinal dysfunction and malabsorption of nutrients (including amino acids).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2009 journal article
Temporal Proteomic Analysis Reveals Continuous Impairment of Intestinal Development in Neonatal Piglets with Intrauterine Growth Restriction
Journal of Proteome Research, 9(2), 924–935.
author keywords: Intrauterine growth restriction; Piglets; Intestine; Development; Temporal proteomic analysis; Histological analysis
MeSH headings : Amino Acids / metabolism; Animals; Animals, Newborn; Apoptosis; Energy Metabolism; Fetal Growth Retardation / physiopathology; Homeostasis; Jejunum / embryology; Lipid Metabolism; Mass Spectrometry; Minerals / metabolism; Oxidation-Reduction; Proteome; Swine; Vitamins / metabolism
TL;DR:
The results of the temporal proteomics analysis reveal continuous impairment of intestinal development in neonatal piglets with IUGR and are expected to provide new strategies to improve their survival and growth.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2009 journal article
The development of T lymphocytes in intrauterine growth retardation piglets
Chinese Journal of Animal Science, 45(21), 13–15.
Source: NC State University Libraries
Added: April 24, 2021
2008 journal article
Intrauterine Growth Restriction Affects the Proteomes of the Small Intestine, Liver, and Skeletal Muscle in Newborn Pigs
The Journal of Nutrition, 138(1), 60–66.
MeSH headings : Animals; Animals, Newborn; Birth Weight; Female; Fetal Growth Retardation / metabolism; Gene Expression Profiling; Intestine, Small / growth & development; Intestine, Small / metabolism; Liver / growth & development; Liver / metabolism; Muscle Proteins / metabolism; Muscle, Skeletal / growth & development; Muscle, Skeletal / metabolism; Pregnancy; Proteome / metabolism; Swine / growth & development
TL;DR:
The novel findings suggest that cellular signaling defects, redox imbalance, reduced protein synthesis, and enhanced proteolysis may be the major mechanisms responsible for abnormal absorption and metabolism of nutrients, as well as reduced growth and impaired development of the small intestine, liver, and muscle in IUGR neonates.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
Employment
Updated: September 7th, 2018 11:46
2018 - present
North Carolina State University Raleigh, NC, US
Assistant Professor
Animal Science
2016 - 2018
National Institute of Environmental Health Sciences Durham, NC, US
Postdoctoral Fellow
Reproductive and Development Biology Laboratory
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