Works (3)

Updated: July 5th, 2023 15:42

2018 journal article

NMDA Receptor-Dependent Cholinergic Modulation of Mesolimbic Dopamine Cell Bodies: Neurochemical and Behavioral Studies

ACS Chemical Neuroscience, 10(3), 1497–1505.

By: M. Spanos n, X. Xie n, J. Gras-Najjar n, S. White n & L. Sombers n

author keywords: Glutamate; acetylcholine; dopamine; sensory stimuli; ventral tegmental area
MeSH headings : Animals; Cell Body / drug effects; Cell Body / metabolism; Cholinergic Agonists / administration & dosage; Dopamine / metabolism; Male; Microinjections / methods; N-Methylaspartate / administration & dosage; Photic Stimulation / methods; Psychomotor Performance / drug effects; Psychomotor Performance / physiology; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate / agonists; Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate / metabolism; Ventral Tegmental Area / drug effects; Ventral Tegmental Area / metabolism
TL;DR: It is suggested that acetylcholine and glutamate synergistically act at dopamine cells in the VTA to modulate VTA-NAc shell dopaminergic output, and this underlies motivation to lever press for a motivationally neutral visual stimulus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 9, 2019

2016 journal article

Contribution of an SFK-Mediated Signaling Pathway in the Dorsal Hippocampus to Cocaine-Memory Reconsolidation in Rats


By: A. Wells*, X. Xie n, J. Higginbotham*, A. Arguello*, K. Healey*, M. Blanton*, R. Fuchs*

MeSH headings : Animals; Cocaine / administration & dosage; Dopamine Uptake Inhibitors / administration & dosage; Drug-Seeking Behavior / drug effects; Drug-Seeking Behavior / physiology; Enzyme Inhibitors / pharmacology; Excitatory Amino Acid Antagonists / pharmacology; Extinction, Psychological / drug effects; Extinction, Psychological / physiology; Hippocampus / drug effects; Hippocampus / enzymology; Male; Memory Consolidation / drug effects; Memory Consolidation / physiology; Pyrimidines / pharmacology; Quinoxalines / pharmacology; Rats, Sprague-Dawley; Receptors, AMPA / metabolism; Receptors, N-Methyl-D-Aspartate / metabolism; Self Administration; Signal Transduction / drug effects; src-Family Kinases / antagonists & inhibitors; src-Family Kinases / metabolism
TL;DR: It is suggested that hippocampal SFKs contribute to the long-term stability of cocaine-related memories that underlie contextual stimulus control over cocaine-seeking behavior. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Cocaine seeking and taking: role of hippocampal dopamine D1-like receptors


By: X. Xie n, A. Wells* & R. Fuchs*

author keywords: Cocaine; context; dopamine D1-like receptor; hippocampus; reinstatement
MeSH headings : Animals; Benzazepines / pharmacology; Cocaine / administration & dosage; Conditioning, Operant / drug effects; Dopamine Antagonists / pharmacology; Dopamine Uptake Inhibitors / administration & dosage; Drug-Seeking Behavior / drug effects; Extinction, Psychological / drug effects; Functional Laterality; Hippocampus / drug effects; Hippocampus / metabolism; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1 / antagonists & inhibitors; Receptors, Dopamine D1 / metabolism; Reinforcement, Psychology; Self Administration
TL;DR: It is suggested that D1-like receptor stimulation in the DH is critical for the incentive motivational effects and/or memory of cocaine-paired contextual stimuli that contribute to drug-seeking behaviour. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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