Xuying Zhang

Works (8)

Updated: July 13th, 2023 21:19

2023 journal article

Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain

IScience, 26(3), 106242.

By: X. Zhang n, G. Xiao n, C. Johnson n, Y. Cai  n, Z. Horowitz n, C. Mennicke n, R. Coffey *, M. Haider*  ...

topics (OpenAlex): MicroRNA in disease regulation; Neurogenesis and neuroplasticity mechanisms; RNA Research and Splicing
TL;DR: Subtractive bulk ventral and dorsal forebrain deletions of Egfr uncovered significant and permanent decreases in oligodendrogenesis and myelination in the cortex and corpus callosum, and a regenerative population of gliogenic progenitors in the mouse forebrain may compensate for the missing EGFR-dependent dorsal glia in the bulk Egfr-deleted forebrain. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 5, 2023

2023 article

COMBINe enables automated detection and classification of neurons and astrocytes in tissue-cleared mouse brains

Cai, Y., Zhang, X., Li, C., Ghashghaei, H. T., & Greenbaum, A. (2023, April 1). Cell Reports Methods.

By: Y. Cai  n, X. Zhang n, C. Li n, H. Ghashghaei n & A. Greenbaum n

MeSH headings : Animals; Mice; Astrocytes; Excipients; Microscopy, Fluorescence; Neurons; Prosencephalon
topics (OpenAlex): Cell Image Analysis Techniques; Single-cell and spatial transcriptomics; Advanced Fluorescence Microscopy Techniques
TL;DR: An automated workflow to map sparsely labeled neurons and astrocytes in genetically distinct mouse forebrains using mosaic analysis with double markers (MADM) is presented and the regional and subregional effects of MADM-based deletion of the epidermal growth factor receptor (EGFR) are quantitatively analyzed. (via Semantic Scholar)
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Source: Web Of Science
Added: May 30, 2023

2021 article

Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy

Li, C., Moatti, A., Zhang, X., Ghashghaei, H. T., & Greenbaum, A. (2021, July 7). Biomedical Optics Express, Vol. 12, p. 5214.

By: C. Li n, A. Moatti n , X. Zhang n, H. Ghashghaei n & A. Greenbaum  n

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Image Processing Techniques and Applications; Cell Image Analysis Techniques
TL;DR: A deep learning-based autofocus framework that can estimate the position of the objective-lens focal plane relative to the light-sheet, based on two defocused images is presented, which outperforms or provides comparable results with the best traditional aut ofocus method on small and large image patches respectively. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: August 16, 2021

2021 article

Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy: publisher’s note

Li, C., Moatti, A., Zhang, X., Ghashghaei, H. T., & Greenbaum, A. (2021, December 8). Biomedical Optics Express.

By: C. Li n, A. Moatti n , X. Zhang n, H. Ghashghaei n & A. Greenbaum n

topics (OpenAlex): Advanced Fluorescence Microscopy Techniques; Cell Image Analysis Techniques; Image Processing Techniques and Applications
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Source: Web Of Science
Added: January 10, 2022

2021 article

Detection and classification of neurons and glial cells in the MADM mouse brain using RetinaNet

Cai, Y., Zhang, X., Kovalsky, S. Z., Ghashghaei, H. T., & Greenbaum, A. (2021, September 24). PLoS ONE.

By: Y. Cai  n, X. Zhang n, S. Kovalsky *, H. Ghashghaei n & A. Greenbaum n

MeSH headings : Animals; Brain; Cell Differentiation; Mice; Neuroglia; Neurons
topics (OpenAlex): Cell Image Analysis Techniques; Single-cell and spatial transcriptomics; Advanced Fluorescence Microscopy Techniques
TL;DR: Object detection networks (neural networks) are utilized to detect and classify targets in complex microscopy images, while simplifying data annotation, and merging the predictions of the two computational models significantly improved the automated cell counting of glial clusters. (via Semantic Scholar)
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8. Decent Work and Economic Growth (OpenAlex)
Source: Web Of Science
Added: February 28, 2022

2018 article

Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain

Muthusamy, N., Brumm, A., Zhang, X., Carmichael, S. T., & Ghashghaei, H. T. (2018, January 23). Scientific Reports.

By: N. Muthusamy n, A. Brumm*, X. Zhang n, S. Carmichael * & H. Ghashghaei n

MeSH headings : Animals; Cell Differentiation / physiology; Ependyma / metabolism; Forkhead Transcription Factors / metabolism; Mice; Neurogenesis / physiology; Neuroglia / metabolism; Neurons / metabolism; Prosencephalon / metabolism; Stem Cells / metabolism; Stroke / metabolism
topics (OpenAlex): Neurogenesis and neuroplasticity mechanisms; MicroRNA in disease regulation; FOXO transcription factor regulation
TL;DR: Using a cell specific genetic approach, Foxj1+ ependymal cells are ruled out as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Muthusamy, N., Zhang, X., Johnson, C. A., Yadav, P. N., & Ghashghaei, H. T. (2016, December 5). Nature Neuroscience.

By: N. Muthusamy n, X. Zhang n, C. Johnson n, P. Yadav * & H. Ghashghaei n

MeSH headings : Animals; Appetitive Behavior / physiology; Avoidance Learning / physiology; Behavior, Animal / physiology; Conditioning, Classical / physiology; Male; Mice; Neurogenesis / physiology; Neurons / physiology; Olfactory Cortex / physiology; Smell / physiology
topics (OpenAlex): Olfactory and Sensory Function Studies; Neurobiology and Insect Physiology Research; Photoreceptor and optogenetics research
TL;DR: It is demonstrated that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 article

Transplantation of GABAergic Interneurons into the Neonatal Primary Visual Cortex Reduces Absence Seizures in Stargazer Mice

Hammad, M., Schmidt, S. L., Zhang, X., Bray, R., Frohlich, F., & Ghashghaei, H. T. (2014, May 8). Cerebral Cortex.

By: M. Hammad*, S. Schmidt *, X. Zhang*, R. Bray, F. Frohlich * & H. Ghashghaei n

author keywords: absence seizure; MGE transplantation; network activity; Stargazer; visual cortex
MeSH headings : Animals; Calcium Channels / genetics; Calcium Channels / metabolism; Disease Models, Animal; Embryo, Mammalian; Epilepsy, Absence / genetics; Epilepsy, Absence / surgery; GABAergic Neurons / physiology; GABAergic Neurons / transplantation; Glutamate Decarboxylase / metabolism; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; In Vitro Techniques; Median Eminence / cytology; Membrane Potentials / drug effects; Membrane Potentials / physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neocortex / cytology; Nerve Tissue Proteins / metabolism; Proto-Oncogene Proteins c-fos / metabolism; Treatment Outcome; Visual Cortex / transplantation; gamma-Aminobutyric Acid / metabolism
topics (OpenAlex): Neuroscience and Neuropharmacology Research; Neurogenesis and neuroplasticity mechanisms; Neuroscience and Neural Engineering
TL;DR: It is reported that transplantation of MGE cells into the primary visual cortex (V1) of Stg mice significantly reduces AE episodes and lowers mortality and presents MGE grafting in the V1 as a possible clinical approach in the treatment of AE. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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