Works (8)
Updated: July 13th, 2023 21:19
2023 journal article
Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain
ISCIENCE, 26(3).
TL;DR:
Subtractive bulk ventral and dorsal forebrain deletions of Egfr uncovered significant and permanent decreases in oligodendrogenesis and myelination in the cortex and corpus callosum, and a regenerative population of gliogenic progenitors in the mouse forebrain may compensate for the missing EGFR-dependent dorsal glia in the bulk Egfr-deleted forebrain.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 5, 2023
2023 journal article
COMBINe enables automated detection and classification of neurons and astrocytes in tissue-cleared mouse brains
CELL REPORTS METHODS, 3(4).
MeSH headings : Animals; Mice; Astrocytes; Excipients; Microscopy, Fluorescence; Neurons; Prosencephalon
TL;DR:
An automated workflow to map sparsely labeled neurons and astrocytes in genetically distinct mouse forebrains using mosaic analysis with double markers (MADM) is presented and the regional and subregional effects of MADM-based deletion of the epidermal growth factor receptor (EGFR) are quantitatively analyzed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 30, 2023
2022 article
Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy: publishers note (vol 12, pg 5214, 2021)
LI, C., Moatti, A., Zhang, X., Ghashghaei, H. T., & Greenbaum, A. (2022, January 1). BIOMEDICAL OPTICS EXPRESS, Vol. 13, pp. 373–373.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 10, 2022
2021 journal article
Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy
BIOMEDICAL OPTICS EXPRESS, 12(8), 5214–5226.
TL;DR:
A deep learning-based autofocus framework that can estimate the position of the objective-lens focal plane relative to the light-sheet, based on two defocused images is presented, which outperforms or provides comparable results with the best traditional aut ofocus method on small and large image patches respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 16, 2021
2021 journal article
Detection and classification of neurons and glial cells in the MADM mouse brain using RetinaNet
PLOS ONE, 16(9).
MeSH headings : Animals; Brain; Cell Differentiation; Mice; Neuroglia; Neurons
TL;DR:
Object detection networks (neural networks) are utilized to detect and classify targets in complex microscopy images, while simplifying data annotation, and merging the predictions of the two computational models significantly improved the automated cell counting of glial clusters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
8. Decent Work and Economic Growth
(OpenAlex)
Source: Web Of Science
Added: February 28, 2022
2018 journal article
Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain
SCIENTIFIC REPORTS, 8.
MeSH headings : Animals; Cell Differentiation / physiology; Ependyma / metabolism; Forkhead Transcription Factors / metabolism; Mice; Neurogenesis / physiology; Neuroglia / metabolism; Neurons / metabolism; Prosencephalon / metabolism; Stem Cells / metabolism; Stroke / metabolism
TL;DR:
Using a cell specific genetic approach, Foxj1+ ependymal cells are ruled out as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning
NATURE NEUROSCIENCE, 20(1), 20–23.
MeSH headings : Animals; Appetitive Behavior / physiology; Avoidance Learning / physiology; Behavior, Animal / physiology; Conditioning, Classical / physiology; Male; Mice; Neurogenesis / physiology; Neurons / physiology; Olfactory Cortex / physiology; Smell / physiology
TL;DR:
It is demonstrated that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Transplantation of GABAergic Interneurons into the Neonatal Primary Visual Cortex Reduces Absence Seizures in Stargazer Mice
CEREBRAL CORTEX, 25(9), 2970–2979.
author keywords: absence seizure; MGE transplantation; network activity; Stargazer; visual cortex
MeSH headings : Animals; Calcium Channels / genetics; Calcium Channels / metabolism; Disease Models, Animal; Embryo, Mammalian; Epilepsy, Absence / genetics; Epilepsy, Absence / surgery; GABAergic Neurons / physiology; GABAergic Neurons / transplantation; Glutamate Decarboxylase / metabolism; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; In Vitro Techniques; Median Eminence / cytology; Membrane Potentials / drug effects; Membrane Potentials / physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neocortex / cytology; Nerve Tissue Proteins / metabolism; Proto-Oncogene Proteins c-fos / metabolism; Treatment Outcome; Visual Cortex / transplantation; gamma-Aminobutyric Acid / metabolism
TL;DR:
It is reported that transplantation of MGE cells into the primary visual cortex (V1) of Stg mice significantly reduces AE episodes and lowers mortality and presents MGE grafting in the V1 as a possible clinical approach in the treatment of AE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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