@article{jeong_premanandan_her_2024, title={A Retrospective Review of Morbidity and Mortality in ‘Good Samaritan’ Animals Admitted to a Tertiary Referral Veterinary Health Center From 2014 to 2022: Postmortem Examination}, url={https://doi.org/10.56771/jsmcah.v3.83}, DOI={10.56771/jsmcah.v3.83}, abstractNote={Introduction: Good Samaritan animals are frequently encountered at veterinary teaching hospitals and provide a useful indirect surveillance tool for monitoring major morbidity and mortality in unattended animals. Methods: Retrospective study. Good Samaritan animals’ medical and postmortem examination records were searched from the OSU VMC medical record database and the OSU CVM Anatomic pathology database and identified 100 cases from 2014 to 2022. Results: One hundred Good Samaritan animals that underwent postmortem examination were identified. These included 59 cats, 36 dogs, 2 raccoons, 1 squirrel, 1 bat, and 1 opossum with mean and median ages of 2.61 years and 1 year, respectively. The most predominant cause of death or major morbidity requiring euthanasia was euthanasia for rabies test (n = 19) in cats and vehicular trauma (n = 16) in dogs. Other mortality and significant morbidities include trauma (n = 15) followed by infectious disease (n = 5) in cats and infectious disease (n = 12) and neoplasia (n = 2) in dogs. Brain tissue from 51 animals was submitted to the Ohio Department of Health for rabies tests, and all had negative results. In 17 canines and felines with infectious diseases, dogs had viral (n = 6), parasitic (n = 5), and bacterial (n = 1) etiologies, while cats had bacterial (n = 2) and viral (n = 1), fungal (n = 1), and mixed (n = 1) etiologies. Conclusion: Epidemiological review of morbidity and mortality in Good Samaritan animals submitted for postmortem examination helps to characterize the types and severity of vehicular trauma and infectious diseases in stray animals. Young and intact animals were important demographic factors in Good Samaritan dogs and cats. The rabies test results tightly correlate with a trend of rabies test results in dogs and cats in Franklin County.}, journal={Journal of Shelter Medicine and Community Animal Health}, author={Jeong, Yea Ji and Premanandan, Christopher and Her, Jiwoong}, year={2024}, month={Sep} }
 @article{foster_newbold_miller_jeong_premanandan_husbands_2024, title={Periocular fibrosarcoma with lipogranulomatous conjunctivitis in a cat}, url={https://doi.org/10.1111/vop.13249}, DOI={10.1111/vop.13249}, abstractNote={A 9-year-old, female spayed domestic short-haired cat was presented with a 4-year history of bilateral lipogranulomatous conjunctivitis (LGC), which was confirmed via histopathology. Thirteen months following the initial biopsy, the cat was presented with a rapidly progressive mass lesion of the palpebral conjunctiva of the right eye. A surgical debulking, followed 1 month later by exenteration after marked regrowth of the mass confirmed fibrosarcoma. This case report is the first to describe a cat with chronic bilateral LGC that later developed a unilateral fibrosarcoma within the eyelid tissue of the right eye. Fibrosarcoma should be considered a differential in any cat with chronic LGC that develops a rapidly progressive mass in the eyelid.}, journal={Veterinary Ophthalmology}, author={Foster, T. M. and Newbold, G. M. and Miller, E. J. and Jeong, Y. J. and Premanandan, C. and Husbands, B. D.}, year={2024}, month={Jun} }
 @article{jeong_knutsdottir_shojaeian_lerner_wissler_henriet_ng_datta_navarro-serer_chianchiano_et al._2023, title={Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion}, url={https://doi.org/10.1172/JCI162054}, DOI={10.1172/JCI162054}, abstractNote={Pancreatic ductal adenocarcinoma (PDAC) frequently presents with metastasis, but the molecular programs in human PDAC cells that drive invasion are not well understood. Using an experimental pipeline enabling PDAC organoid isolation and collection based on invasive phenotype, we assessed the transcriptomic programs associated with invasion in our organoid model. We identified differentially expressed genes in invasive organoids compared with matched noninvasive organoids from the same patients, and we confirmed that the encoded proteins were enhanced in organoid invasive protrusions. We identified 3 distinct transcriptomic groups in invasive organoids, 2 of which correlated directly with the morphological invasion patterns and were characterized by distinct upregulated pathways. Leveraging publicly available single-cell RNA-sequencing data, we mapped our transcriptomic groups onto human PDAC tissue samples, highlighting differences in the tumor microenvironment between transcriptomic groups and suggesting that non-neoplastic cells in the tumor microenvironment can modulate tumor cell invasion. To further address this possibility, we performed computational ligand-receptor analysis and validated the impact of multiple ligands (TGF-β1, IL-6, CXCL12, MMP9) on invasion and gene expression in an independent cohort of fresh human PDAC organoids. Our results identify molecular programs driving morphologically defined invasion patterns and highlight the tumor microenvironment as a potential modulator of these programs.}, journal={Journal of Clinical Investigation}, author={Jeong, Yea Ji and Knutsdottir, Hildur and Shojaeian, Fatemeh and Lerner, Michael G. and Wissler, Maria F. and Henriet, Elodie and Ng, Tammy and Datta, Shalini and Navarro-Serer, Bernat and Chianchiano, Peter and et al.}, year={2023}, month={Apr} }
 @article{felsenstein_trujillo_huang_nanda_jiang_jeong_pflüger_goggins_hruban_thompson_et al._2020, title={Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas}, volume={100}, url={http://dx.doi.org/10.1038/s41374-020-0372-0}, DOI={10.1038/s41374-020-0372-0}, number={7}, journal={Laboratory Investigation}, publisher={Elsevier BV}, author={Felsenstein, Matthäus and Trujillo, Maria A. and Huang, Bo and Nanda, Neha and Jiang, Zhengdong and Jeong, Yea Ji and Pflüger, Michael and Goggins, Michael G. and Hruban, Ralph H. and Thompson, Elizabeth D. and et al.}, year={2020}, month={Jul}, pages={1003–1013} }
 @article{huang_navarro-serer_jeong_chianchiano_xia_luchini_veronese_dowiak_ng_trujillo_et al._2020, title={Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome}, url={https://doi.org/10.1158/0008-5472.CAN-19-1523}, DOI={10.1158/0008-5472.CAN-19-1523}, abstractNote={Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by extensive local invasion and systemic spread. In this study, we employed a three-dimensional organoid model of human pancreatic cancer to characterize the molecular alterations critical for invasion. Time-lapse microscopy was used to observe invasion in organoids from 25 surgically resected human PDAC samples in collagen I. Subsequent lentiviral modification and small-molecule inhibitors were used to investigate the molecular programs underlying invasion in PDAC organoids. When cultured in collagen I, PDAC organoids exhibited two distinct, morphologically defined invasive phenotypes, mesenchymal and collective. Each individual PDAC gave rise to organoids with a predominant phenotype, and PDAC that generated organoids with predominantly mesenchymal invasion showed a worse prognosis. Collective invasion predominated in organoids from cancers with somatic mutations in the driver gene SMAD4 (or its signaling partner TGFBR2). Reexpression of SMAD4 abrogated the collective invasion phenotype in SMAD4-mutant PDAC organoids, indicating that SMAD4 loss is required for collective invasion in PDAC organoids. Surprisingly, invasion in passaged SMAD4-mutant PDAC organoids required exogenous TGFβ, suggesting that invasion in SMAD4-mutant organoids is mediated through noncanonical TGFβ signaling. The Rho-like GTPases RAC1 and CDC42 acted as potential mediators of TGFβ-stimulated invasion in SMAD4-mutant PDAC organoids, as inhibition of these GTPases suppressed collective invasion in our model. These data suggest that PDAC utilizes different invasion programs depending on SMAD4 status, with collective invasion uniquely present in PDAC with SMAD4 loss. Significance: Organoid models of PDAC highlight the importance of SMAD4 loss in invasion, demonstrating that invasion programs in SMAD4-mutant and SMAD4 wild-type tumors are different in both morphology and molecular mechanism.}, journal={Cancer Research}, author={Huang, Wenjie and Navarro-Serer, Bernat and Jeong, Yea Ji and Chianchiano, Peter and Xia, Limin and Luchini, Claudio and Veronese, Nicola and Dowiak, Cameron and Ng, Tammy and Trujillo, Maria A. and et al.}, year={2020}, month={Jul} }
 @article{sullivan_brill_mangus_jeong_solis_knight_colantuoni_keceli_paolocci_queen_et al._2020, title={Upregulation of Superoxide Dismutase 2 by Astrocytes in the SIV/Macaque Model of HIV-Associated Neurologic Disease}, volume={79}, url={http://dx.doi.org/10.1093/jnen/nlaa084}, DOI={10.1093/jnen/nlaa084}, abstractNote={Abstract HIV-associated neurocognitive disorders (HAND) remain prevalent despite implementation of antiretroviral therapy (ART). Development of HAND is linked to mitochondrial dysfunction and oxidative stress in the brain; therefore, upregulation of antioxidant defenses is critical to curtail neuronal damage. Superoxide dismutase 2 (SOD2) is a mitochondrial antioxidant enzyme essential for maintaining cellular viability. We hypothesized that SOD2 was upregulated during retroviral infection. Using a simian immunodeficiency virus (SIV)-infected macaque model of HIV, quantitative PCR showed elevated SOD2 mRNA in cortical gray ([GM], 7.6-fold for SIV vs uninfected) and white matter ([WM], 77-fold for SIV vs uninfected) during SIV infection. Further, SOD2 immunostaining was enhanced in GM and WM from SIV-infected animals. Double immunofluorescence labeling illustrated that SOD2 primarily colocalized with astrocyte marker glial fibrillary acidic protein (GFAP) in SIV-infected animals. Interestingly, in ART-treated SIV-infected animals, brain SOD2 RNA levels were similar to uninfected animals. Additionally, using principal component analysis in a transcriptomic approach, SOD2 and GFAP expression separated SIV-infected from uninfected brain tissue. Projection of these data into a HIV dataset revealed similar expression changes, thereby validating the clinical relevance. Together, our findings suggest that novel SOD2-enhancing therapies may reduce neuroinflammation in ART-treated HIV-infected patients.}, number={9}, journal={Journal of Neuropathology & Experimental Neurology}, publisher={Oxford University Press (OUP)}, author={Sullivan, Michelle N and Brill, Samuel A and Mangus, Lisa M and Jeong, Yea Ji and Solis, Clarisse V and Knight, Audrey C and Colantuoni, Carlo and Keceli, Gizem and Paolocci, Nazareno and Queen, Suzanne E and et al.}, year={2020}, month={Sep}, pages={986–997} }
 @article{jeong_jung_her_baek_lee_lee_yoon_2015, title={Congenital systemic melanosis in a black mongrel pig}, volume={55}, url={http://dx.doi.org/10.14405/kjvr.2015.55.2.145}, DOI={10.14405/kjvr.2015.55.2.145}, abstractNote={(Received: January 9, 2015; Revised: May 4, 2015; Accepted: May 11, 2015)Abstract : Four 3-day-old piglets with retarded growth were submitted to the Animal and Plant Quarantine Agencyfor diagnosis. Necropsy showed that one piglet had black spots ranging from 2 mm to 1 cm in diameter in thecerebellum, lungs, regional lymph nodes, and cecum. Histological findings were consistent with the gross appearancein which melanin pigmentation was observed in the organs mentioned above. Based on Fontana-Masson staining, wediagnosed this animal with systemic melanosis. To the best of our knowledge, this is the first case of systemic melanosisin black breeds of swine in Korea. Keywords: black pig, Fontana-Masson staining, melanosis, melanin}, number={2}, journal={Korean Journal of Veterinary Research}, publisher={The Korean Society of Veterinary Science (KJVR)}, author={Jeong, Yea-Ji and Jung, Ji-Youl and Her, Ji-Woong and Baek, Kang-Hyun and Lee, Jong-Hyeong and Lee, Myoung-Heon and Yoon, Soon-Seek}, year={2015}, month={Jun}, pages={145–148} }