Works (11)
Updated: July 19th, 2023 08:25
2018 journal article
Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity
American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(6), G966–G979.
author keywords: adherens junction; chloride channel ClC-2; colonic homeostasis; colonic tumorigenicity; colonoids
MeSH headings : Adherens Junctions / metabolism; Adherens Junctions / pathology; Animals; CLC-2 Chloride Channels; Carcinogenesis / genetics; Carcinogenesis / metabolism; Chloride Channels / genetics; Chloride Channels / metabolism; Colitis, Ulcerative / complications; Colonic Neoplasms / etiology; HT29 Cells; Homeostasis; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Mice; Mice, Inbred C57BL; Signal Transduction; beta Catenin / metabolism
TL;DR:
Disruption of adherens junctions in the absence of chloride channel protein-2 revealed critical functions of these junctional structures, including maintenance of colonic homeostasis and differentiation as well as driving tumorigenicity by regulating β-catenin signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 31, 2018
2016 journal article
Exploring Product Solution Differences Due to Choice Model Selection in the Presence of Noncompensatory Decisions With Conjunctive Screening Rules
JOURNAL OF MECHANICAL DESIGN, 139(2).
TL;DR:
It is demonstrated how respondents making noncompensatory choices with conjunctive rules can lead to compensatory model estimations with distinct respondent segmentation and relative, large absolute part-worth values.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury
American Journal of Physiology-Cell Physiology, 311(6), C996–C1004.
author keywords: intestinal anoxia/reoxygenation injury; tight junctions; myosin light chain kinase; Caco-2BBe1; intestinal barrier functions
MeSH headings : Animals; Caco-2 Cells; Cell Line, Tumor; Dextrans / metabolism; Endocytosis / physiology; Epithelial Cells / metabolism; Epithelial Cells / physiology; Humans; Hypoxia / metabolism; Hypoxia / physiopathology; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Myosin Light Chains / metabolism; Myosin-Light-Chain Kinase / metabolism; Occludin / metabolism; Permeability; Phosphorylation / physiology; Signal Transduction / physiology; Swine; Tight Junctions / metabolism; Tight Junctions / physiology
TL;DR:
It is suggested that MLCK-induced occludin endocytosis mediates intestinal epithelial barrier dysfunction during A/R injury and may be a target for the therapeutic treatment of ischemia/reperfusion injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Anticancer activity of TTAC-0001, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) monoclonal antibody, is associated with inhibition of tumor angiogenesis
MAbs, 7(6), 1195–1204.
author keywords: TTAC-0001; VEGF signaling; fully human neutralizing antibody; angiogenesis inhibitor; tumor growth inhibition; pharmacokinetics; glioblastoma; colorectal cancer
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Monoclonal / pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents / immunology; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Apoptosis / immunology; Area Under Curve; Cell Line, Tumor; Colorectal Neoplasms / drug therapy; Colorectal Neoplasms / immunology; Colorectal Neoplasms / metabolism; Glioblastoma / drug therapy; Glioblastoma / immunology; Glioblastoma / metabolism; HCT116 Cells; HT29 Cells; Humans; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / immunology; Neovascularization, Pathologic / immunology; Neovascularization, Pathologic / metabolism; Neovascularization, Pathologic / prevention & control; Treatment Outcome; Tumor Burden / drug effects; Tumor Burden / immunology; Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors; Vascular Endothelial Growth Factor Receptor-2 / immunology; Vascular Endothelial Growth Factor Receptor-2 / metabolism; Xenograft Model Antitumor Assays
TL;DR:
The data suggest that targeting VEGFR-2 with TTAC-0001 could be a promising approach for cancer treatment.
(via Semantic Scholar)
open access via www.tandfonline.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2015 journal article
Pharmaceutical Activation or Genetic Absence of ClC-2 Alters Tight Junctions During Experimental Colitis
Inflammatory Bowel Diseases, 21(12), 2747–2757.
Contributors: n , T. Pridgen n & A. Blikslager n
author keywords: ClC-2 chloride channel; lubiprostone; tight junctions; inflammatory bowel diseases; intestinal barrier function
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Chloride Channel Agonists / pharmacology; Chloride Channels / deficiency; Chloride Channels / drug effects; Colitis / chemically induced; Colitis / drug therapy; Colitis / genetics; Dextran Sulfate; Fluorescent Antibody Technique; Intestinal Mucosa / metabolism; Intestines / drug effects; Lubiprostone / pharmacology; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Permeability / drug effects; Tight Junction Proteins / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism; Trinitrobenzenes
TL;DR:
A central role for ClC-2 in restoration of barrier function and tight junction architecture in experimental murine colitis is suggested, which can be therapeutically targeted with lubiprostone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
TTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis
MAbs, 7(5), 957–968.
author keywords: TTAC-0001; anti-VEGFR2 monoclonal antibody; angiogenesis; cross species reactivity; VEGFR-2(KDR); VEGF
MeSH headings : Angiogenesis Inhibitors / pharmacology; Animals; Antibodies, Monoclonal / pharmacology; Antibodies, Monoclonal, Humanized; Cell Movement / drug effects; Cell Proliferation / drug effects; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Human Umbilical Vein Endothelial Cells / drug effects; Humans; Immunohistochemistry; Mice; Neovascularization, Pathologic; Rats; Surface Plasmon Resonance; Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors
TL;DR:
The data indicates that TTAC-0001 blocks the binding of VEGFs to VEG FR-2/KDR and inhibits VEGFR-induced signaling pathways and angiogenesis, which strongly support the further development of TTac-0001 as an anti-cancer agent in the clinic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2014 journal article
Tu2028 Lubiprostone reduces murine colitis principally in a ClC-2-dependent manner.
Gastroenterology, 146(5), S-901.
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019
2013 journal article
Gene silencing of c-Met leads to brain metastasis inhibitory effects
Clin Exp Metastasis, 30(7), 845–854.
author keywords: c-Met; Brain metastasis; Epithelial-mesenchymal transition; Migration; ShRNA
TL;DR:
The data reveal the novel function of c-Met in the process of brain metastasis and its potential as a preventive and/or therapeutic target in this disease.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2011 journal article
Abstract 647: TTAC-0001, anti-VEGFR2/KDR monoclonal antibody, inhibits VEGFR signaling and tumor growth in preclinical models
Cancer Res, 71(8 Supplement), 647–647.
Source: ORCID
Added: February 11, 2019
2010 journal article
Abstract LB-326: Synergistic therapeutic effects of cytokine-induced killer (CIK) cell and temozolomide against glioblastoma
Cancer Res, 70(8 Supplement), LB-326-LB-326.
Source: ORCID
Added: February 11, 2019
2010 journal article
Functional neural stem cell isolation from brains of adult mutant SOD1 (SOD1 G93A ) transgenic amyotrophic lateral sclerosis (ALS) mice
Neurological Research, 33(1), 33–37.
author keywords: Amyotrophic lateral sclerosis; In vitro expansion; Mutant SOD1 transgenic mouse; Neural stem cell; Hippocampus; Primary culture
MeSH headings : Amyotrophic Lateral Sclerosis / genetics; Animals; Cell Culture Techniques; Cell Differentiation; Dentate Gyrus / cytology; Disease Models, Animal; Hippocampus / cytology; Humans; Mice; Mice, Transgenic; Mutant Proteins; Neural Stem Cells / cytology; Superoxide Dismutase / genetics
TL;DR:
The results would suggest that increased neuroregeneration in early phase of ALS could be translated to regenerative approaches; however, long-term exposure to ALS microenvironments could abolish functional capacities of NSCs.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
Employment
Updated: May 9th, 2023 12:58
2019 - present
University of Maryland, College Park College Park, Maryland, US
Assistant Professor
Department of Animal and Avian Sciences
2014 - 2019
North Carolina State University College of Veterinary Medicine Raleigh, NC, US
Postdoctoral Research Scholar
Clinical Sciences
2011 - 2014
North Carolina State University College of Veterinary Medicine Raleigh, NC, US
Postdoctoral Graduate Research Assistant
Clinical Sciences
2009 - 2011
Samsung Medical Center Seoul, Seoul, KR
Postdoctoral Research Scholar
Cancer Stem Cell Research Center and Laboratory of Neurosurgery
2003 - 2009
Jeju National University College of Veterinary Medicine Jeju, Jeju, KR
Pre-doctoral Research Assistant
Laboratory of Toxicological Biochemistry
Education
Updated: November 11th, 2015 15:05
2011 - 2014
North Carolina State University, Comparative Biomedical Sciences Raleigh, NC, US
Doctor of Philosophy
Clinical Sciences
2005 - 2009
Jeju National University, College of Veterinary Medicine Jeju, Jeju, KR
Doctor of Veterinary Medicine
Veterinary Medicine
2003 - 2005
Jeju National University Jeju, Jeju, KR
Certificate
Preveterinary Medical Science
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