Younggeon Jin

Works (11)

Updated: April 25th, 2025 16:09

2018 journal article

Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity

American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(6), G966–G979.

By: Y. Jin n , D. Ibrahim  n, S. Magness n & A. Blikslager n 

author keywords: adherens junction; chloride channel ClC-2; colonic homeostasis; colonic tumorigenicity; colonoids
MeSH headings : Adherens Junctions / metabolism; Adherens Junctions / pathology; Animals; CLC-2 Chloride Channels; Carcinogenesis / genetics; Carcinogenesis / metabolism; Chloride Channels / genetics; Chloride Channels / metabolism; Colitis, Ulcerative / complications; Colonic Neoplasms / etiology; HT29 Cells; Homeostasis; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Mice; Mice, Inbred C57BL; Signal Transduction; beta Catenin / metabolism
topics (OpenAlex): Barrier Structure and Function Studies; Helicobacter pylori-related gastroenterology studies
TL;DR: Disruption of adherens junctions in the absence of chloride channel protein-2 revealed critical functions of these junctional structures, including maintenance of colonic homeostasis and differentiation as well as driving tumorigenicity by regulating β-catenin signaling. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 31, 2018

2016 article

Exploring Product Solution Differences Due to Choice Model Selection in the Presence of Noncompensatory Decisions With Conjunctive Screening Rules

Shin, J., & Ferguson, S. (2016, October 26). Journal of Mechanical Design, Vol. 139.

By: J. Shin n & S. Ferguson  n

topics (OpenAlex): Economic and Environmental Valuation; Consumer Market Behavior and Pricing; Decision-Making and Behavioral Economics
TL;DR: It is demonstrated how respondents making noncompensatory choices with conjunctive rules can lead to compensatory model estimations with distinct respondent segmentation and relative, large absolute part-worth values. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury

American Journal of Physiology-Cell Physiology, 311(6), C996–C1004.

By: Y. Jin n  & A. Blikslager n 

author keywords: intestinal anoxia/reoxygenation injury; tight junctions; myosin light chain kinase; Caco-2BBe1; intestinal barrier functions
MeSH headings : Animals; Caco-2 Cells; Cell Line, Tumor; Dextrans / metabolism; Endocytosis / physiology; Epithelial Cells / metabolism; Epithelial Cells / physiology; Humans; Hypoxia / metabolism; Hypoxia / physiopathology; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Myosin Light Chains / metabolism; Myosin-Light-Chain Kinase / metabolism; Occludin / metabolism; Permeability; Phosphorylation / physiology; Signal Transduction / physiology; Swine; Tight Junctions / metabolism; Tight Junctions / physiology
topics (OpenAlex): Barrier Structure and Function Studies; Gut microbiota and health; Connexins and lens biology
TL;DR: It is suggested that MLCK-induced occludin endocytosis mediates intestinal epithelial barrier dysfunction during A/R injury and may be a target for the therapeutic treatment of ischemia/reperfusion injury. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 article

Anticancer activity of TTAC-0001, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) monoclonal antibody, is associated with inhibition of tumor angiogenesis

Kim, D. G., Jin, Y., Jin, J., Yang, H., Joo, K. M., Lee, W. S., … Nam, D.-H. (2015, September 1). MAbs, Vol. 7, pp. 1195–1204.

By: D. Kim *, Y. Jin* , J. Jin*, H. Yang *, K. Joo *, W. Lee, S. Shim, S. Kim ...

author keywords: TTAC-0001; VEGF signaling; fully human neutralizing antibody; angiogenesis inhibitor; tumor growth inhibition; pharmacokinetics; glioblastoma; colorectal cancer
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Monoclonal / pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents / immunology; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Apoptosis / immunology; Area Under Curve; Cell Line, Tumor; Colorectal Neoplasms / drug therapy; Colorectal Neoplasms / immunology; Colorectal Neoplasms / metabolism; Glioblastoma / drug therapy; Glioblastoma / immunology; Glioblastoma / metabolism; HCT116 Cells; HT29 Cells; Humans; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / immunology; Neovascularization, Pathologic / immunology; Neovascularization, Pathologic / metabolism; Neovascularization, Pathologic / prevention & control; Treatment Outcome; Tumor Burden / drug effects; Tumor Burden / immunology; Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors; Vascular Endothelial Growth Factor Receptor-2 / immunology; Vascular Endothelial Growth Factor Receptor-2 / metabolism; Xenograft Model Antitumor Assays
topics (OpenAlex): Angiogenesis and VEGF in Cancer; Cancer Mechanisms and Therapy; Peptidase Inhibition and Analysis
TL;DR: The data suggest that targeting VEGFR-2 with TTAC-0001 could be a promising approach for cancer treatment. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 11, 2019

2015 journal article

Pharmaceutical Activation or Genetic Absence of ClC-2 Alters Tight Junctions During Experimental Colitis

Inflammatory Bowel Diseases, 21(12), 2747–2757.

By: Y. Jin n , T. Pridgen n & A. Blikslager n 

Contributors: Y. Jin n , T. Pridgen n & A. Blikslager n 

author keywords: ClC-2 chloride channel; lubiprostone; tight junctions; inflammatory bowel diseases; intestinal barrier function
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Chloride Channel Agonists / pharmacology; Chloride Channels / deficiency; Chloride Channels / drug effects; Colitis / chemically induced; Colitis / drug therapy; Colitis / genetics; Dextran Sulfate; Fluorescent Antibody Technique; Intestinal Mucosa / metabolism; Intestines / drug effects; Lubiprostone / pharmacology; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Permeability / drug effects; Tight Junction Proteins / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism; Trinitrobenzenes
topics (OpenAlex): Barrier Structure and Function Studies; Gut microbiota and health; Drug Transport and Resistance Mechanisms
TL;DR: A central role for ClC-2 in restoration of barrier function and tight junction architecture in experimental murine colitis is suggested, which can be therapeutically targeted with lubiprostone. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 article

TTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis

Lee, W. S., Pyun, B.-J., Kim, S.-W., Shim, S. R., Nam, J. R., Yoo, J. Y., … Yoo, J.-S. (2015, May 5). MAbs, Vol. 7, pp. 957–968.

By: W. Lee*, B. Pyun*, S. Kim *, S. Shim *, J. Nam*, J. Yoo *, Y. Jin n , J. Jin* ...

author keywords: TTAC-0001; anti-VEGFR2 monoclonal antibody; angiogenesis; cross species reactivity; VEGFR-2(KDR); VEGF
MeSH headings : Angiogenesis Inhibitors / pharmacology; Animals; Antibodies, Monoclonal / pharmacology; Antibodies, Monoclonal, Humanized; Cell Movement / drug effects; Cell Proliferation / drug effects; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Human Umbilical Vein Endothelial Cells / drug effects; Humans; Immunohistochemistry; Mice; Neovascularization, Pathologic; Rats; Surface Plasmon Resonance; Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors
topics (OpenAlex): Angiogenesis and VEGF in Cancer; Protein Degradation and Inhibitors; Cancer Mechanisms and Therapy
TL;DR: The data indicates that TTAC-0001 blocks the binding of VEGFs to VEG FR-2/KDR and inhibits VEGFR-induced signaling pathways and angiogenesis, which strongly support the further development of TTac-0001 as an anti-cancer agent in the clinic. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 11, 2019

2014 journal article

Tu2028 Lubiprostone reduces murine colitis principally in a ClC-2-dependent manner.

Gastroenterology, 146(5), S-901.

By: Y. Jin* , T. Pridgen & A. Blikslager* 

topics (OpenAlex): Microscopic Colitis
Sources: ORCID, Crossref, NC State University Libraries
Added: February 11, 2019

2013 article

Gene silencing of c-Met leads to brain metastasis inhibitory effects

Lee, S. J., Seol, H. J., Lee, H. W., Kang, W. Y., Kang, B. G., Jin, J., … Nam, D.-H. (2013, April 27). Clinical & Experimental Metastasis, Vol. 30, pp. 845–854.

By: S. Lee *, H. Seol *, H. Lee *, W. Kang*, B. Kang *, J. Jin*, M. Jo*, Y. Jin*  ...

author keywords: c-Met; Brain metastasis; Epithelial-mesenchymal transition; Migration; ShRNA
MeSH headings : Animals; Base Sequence; Brain Neoplasms / genetics; Brain Neoplasms / pathology; Brain Neoplasms / prevention & control; Brain Neoplasms / secondary; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Proliferation; DNA Primers; Epithelial-Mesenchymal Transition; Female; Gene Silencing; Humans; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-met / genetics; Reverse Transcriptase Polymerase Chain Reaction
topics (OpenAlex): Lung Cancer Treatments and Mutations; Liver physiology and pathology; Cancer Cells and Metastasis
TL;DR: The data reveal the novel function of c-Met in the process of brain metastasis and its potential as a preventive and/or therapeutic target in this disease. (via Semantic Scholar)
Source: ORCID
Added: February 11, 2019

2011 article

Abstract 647: TTAC-0001, anti-VEGFR2/KDR monoclonal antibody, inhibits VEGFR signaling and tumor growth in preclinical models

Jin, Y., Jin, J., Yang, H., Park, M., Lee, W. S., Kim, S.-W., … Nam, D.-H. (2011, April 1). Cancer Research, Vol. 71, pp. 647–647.

By: Y. Jin* , J. Jin*, H. Yang *, M. Park *, W. Lee, S. Kim, S. Shim, Y. Kim ...

topics (OpenAlex): Protein Degradation and Inhibitors; Angiogenesis and VEGF in Cancer; Histone Deacetylase Inhibitors Research
Source: ORCID
Added: February 11, 2019

2010 article

Abstract LB-326: Synergistic therapeutic effects of cytokine-induced killer (CIK) cell and temozolomide against glioblastoma

Jin, Y., Jin, J., Joo, K. M., Lee, S. J., Jo, M.-young, Kim, Y., & Nam, D.-H. (2010, April 1). Cancer Research, Vol. 70, pp. LB-326-LB-326.

By: Y. Jin* , J. Jin*, K. Joo *, S. Lee *, M. Jo*, Y. Kim *, D. Nam *

topics (OpenAlex): CAR-T cell therapy research; Immune Cell Function and Interaction; Immune cells in cancer
Source: ORCID
Added: February 11, 2019

2010 article

Functional neural stem cell isolation from brains of adult mutant SOD1 (SOD1G93A) transgenic amyotrophic lateral sclerosis (ALS) mice

Lee, J. C., Jin, Y., Jin, J., Kang, B. G., Nam, D.-H., Joo, K. M., & Cha, C. I. (2010, September 2). Neurological Research, Vol. 33, pp. 33–37.

By: J. Lee *, Y. Jin* , J. Jin, B. Kang, D. Nam, K. Joo, C. Cha*

author keywords: Amyotrophic lateral sclerosis; In vitro expansion; Mutant SOD1 transgenic mouse; Neural stem cell; Hippocampus; Primary culture
MeSH headings : Amyotrophic Lateral Sclerosis / genetics; Animals; Cell Culture Techniques; Cell Differentiation; Dentate Gyrus / cytology; Disease Models, Animal; Hippocampus / cytology; Humans; Mice; Mice, Transgenic; Mutant Proteins; Neural Stem Cells / cytology; Superoxide Dismutase / genetics
topics (OpenAlex): Amyotrophic Lateral Sclerosis Research; Neurogenetic and Muscular Disorders Research; Neurogenesis and neuroplasticity mechanisms
TL;DR: The results would suggest that increased neuroregeneration in early phase of ALS could be translated to regenerative approaches; however, long-term exposure to ALS microenvironments could abolish functional capacities of NSCs. (via Semantic Scholar)
Source: ORCID
Added: February 11, 2019

Employment

Updated: May 9th, 2023 12:58

2019 - present

University of Maryland, College Park College Park, Maryland, US
Assistant Professor Department of Animal and Avian Sciences

2014 - 2019

North Carolina State University College of Veterinary Medicine Raleigh, NC, US
Postdoctoral Research Scholar Clinical Sciences

2011 - 2014

North Carolina State University College of Veterinary Medicine Raleigh, NC, US
Postdoctoral Graduate Research Assistant Clinical Sciences

2009 - 2011

Samsung Medical Center Seoul, Seoul, KR
Postdoctoral Research Scholar Cancer Stem Cell Research Center and Laboratory of Neurosurgery

2003 - 2009

Jeju National University College of Veterinary Medicine Jeju, Jeju, KR
Pre-doctoral Research Assistant Laboratory of Toxicological Biochemistry

Education

Updated: November 11th, 2015 15:05

2011 - 2014

North Carolina State University, Comparative Biomedical Sciences Raleigh, NC, US
Doctor of Philosophy Clinical Sciences

2005 - 2009

Jeju National University, College of Veterinary Medicine Jeju, Jeju, KR
Doctor of Veterinary Medicine Veterinary Medicine

2003 - 2005

Jeju National University Jeju, Jeju, KR
Certificate Preveterinary Medical Science

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