Yen-Hao Erik Lai

Radiation Biology, Radiation Oncology, Veterinary

Works (26)

Updated: November 15th, 2024 16:00

2024 conference paper

Long-term survival of adrenal tumors treated with stereotactic body radiation therapy

Veterinary Cancer Society Annual Conference. Presented at the Veterinary Cancer Society Annual Conference, Orlando, FL.

By: Y. Lai, M. Kent, M. Nolan, D. Fu & J. Looper

Event: Veterinary Cancer Society Annual Conference at Orlando, FL

Source: NC State University Libraries
Added: October 20, 2024

2023 journal article

Acute radiotherapy-associated oral pain may promote tumor growth at distant sites

FRONTIERS IN ONCOLOGY, 13.

By: C. Meneses n, E. Gidcumb n, K. Marcus n, Y. Gonzalez n, Y. Lai n, S. Mishra n, B. Lascelles n, M. Nolan n

author keywords: pain; radiotherapy; sensory nerves; cancer; mouse; TRPV1
TL;DR: This research points towards radiation-induced activation of capsaicin-responsive (TRPV1) neurons as the cause for accelerated growth of tumors at distant (unirradiated) sites. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 12, 2023

2023 conference paper

Effects of half body irradiation on remission and survival for dogs with high grade lymphoma

American College of Veterinary Radiology Annual Scientific Meeting. Presented at the American College of Veterinary Radiology Annual Scientific Meeting, New Orleans, LA.

By: Y. Lai, S. Lyles, M. Mitchell & J. Looper

Event: American College of Veterinary Radiology Annual Scientific Meeting at New Orleans, LA

Source: NC State University Libraries
Added: October 20, 2024

2023 conference paper

The management of canine thymoma with intensity-modulated radiation therapy (IMRT)

House Officer Seminar, Louisiana State University. Presented at the House Officer Seminar, Louisiana State University, Baton Rouge, LA.

By: Y. Lai & J. Looper

Event: House Officer Seminar, Louisiana State University at Baton Rouge, LA

Source: NC State University Libraries
Added: October 20, 2024

2022 conference paper

Canine adrenal gland tumors treated with radiation therapy

House Officer Seminar. Louisiana State University. Presented at the House Officer Seminar. Louisiana State University, Baton Rouge, LA.

By: Y. Lai & J. Looper

Event: House Officer Seminar. Louisiana State University at Baton Rouge, LA

Source: NC State University Libraries
Added: October 20, 2024

2022 conference paper

Strontium-90, a unique radiation modality treating cancers in dogs and cats

House Officer Seminar. Louisiana State University, Presented at the House Officer Seminar. Louisiana State University, Baton Rouge, LA.

By: Y. Lai & J. Looper

Event: House Officer Seminar. Louisiana State University, at Baton Rouge, LA

Source: NC State University Libraries
Added: October 20, 2024

2021 journal article

Behavioral phenotyping of cancer pain in domesticated cats with naturally occurring squamous cell carcinoma of the tongue: initial validation studies provide evidence for regional and widespread algoplasticity

PEERJ, 9.

By: Y. Lai n, B. Lascelles n & M. Nolan n

author keywords: Comparative oncology; Comparative pain research; Animal models; Translational research; Feline
TL;DR: Based on preliminary assessments, the assays described herein had reasonable inter-rater reliability, and they were able to both discriminate between cats with and without oral cancer, and respond in a predictable manner to analgesic therapy. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 30, 2021

2021 conference paper

Half body irradiation in lymphoma patients

House Officer Seminar. Louisiana State University. Presented at the House Officer Seminar. Louisiana State University, Baton Rouge, LA.

By: Y. Lai & J. Looper

Event: House Officer Seminar. Louisiana State University at Baton Rouge, LA

Source: NC State University Libraries
Added: October 20, 2024

2021 journal article

Irradiation of the Normal Murine Tongue Causes Upregulation and Activation of Transient Receptor Potential (TRP) Ion Channels

RADIATION RESEARCH, 196(4), 331–344.

By: Y. Lai*, W. Baumer, C. Meneses*, D. Roback*, J. Robertson*, S. Mishra n, B. Lascelles*, M. Nolan n

MeSH headings : Animals; Calcium; Female; Mice; Neurons; Transient Receptor Potential Channels; Trigeminal Ganglion; Up-Regulation
TL;DR: The results intimate that various TRP channels, and TRPV1 in particular, should be explored as analgesic targets for patients experiencing pain after oral irradiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 18, 2021

2021 journal article

Minimally invasive ethyl cellulose ethanol ablation in domesticated cats with naturally occurring head and neck cancers: Six cats

VETERINARY AND COMPARATIVE ONCOLOGY, 19(3), 492–500.

By: Y. Lai n, R. Morhard*, N. Ramanujam* & M. Nolan n

author keywords: head and neck cancer; intratumoral injection; minimally invasive procedure; palliative; surgical alternative
MeSH headings : Animals; Carcinoma, Squamous Cell / drug therapy; Carcinoma, Squamous Cell / veterinary; Cat Diseases / drug therapy; Cats; Cellulose / analogs & derivatives; Cellulose / therapeutic use; Ethanol; Head and Neck Neoplasms / drug therapy; Head and Neck Neoplasms / veterinary; Pilot Projects; Quality of Life
TL;DR: Ethyl cellulose ethanol ablation is not a viable treatment for feline lingual/sublingual SCC; tumor volume was effectively reduced in some cats, but the simultaneous loss of lingual function was poorly tolerated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: March 15, 2021

2020 journal article

Early radiation‐induced oral pain signaling responses are reduced with pentoxifylline treatment

Veterinary Radiology & Ultrasound, 62(2), 255–263.

By: M. Price n, Y. Lai n, K. Marcus n, J. Robertson n, B. Lascelles n & M. Nolan n

author keywords: glossitis; mucositis; TNF‐ α TRPV1; TRPV4
MeSH headings : Animals; Capsaicin / pharmacology; Histamine / pharmacology; Mice; Pain / prevention & control; Pain / veterinary; Pentoxifylline / therapeutic use; Pilot Projects; Prospective Studies; Radiation-Protective Agents / therapeutic use; Radiotherapy / adverse effects; Sensory System Agents / pharmacology; Signal Transduction / drug effects; Stomatitis / complications; Stomatitis / drug therapy; Stomatitis / etiology; Tumor Necrosis Factor-alpha / analysis; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Although PTX treatment did not reduce glossitis severity or mitigate weight loss in mice with RIM/RAP, it did inhibit the upregulation of TNF-α's receptor that normally accompanies RIM, and it also reduced neuronal responsiveness to each of the aforementioned chemical stimuli. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: January 11, 2021

2019 conference paper

Cellular and molecular mechanisms of pain caused by acute radiation injuries

American College of Veterinary Radiology Annual Scientific Meeting. Presented at the American College of Veterinary Radiology Annual Scientific Meeting, Baltimore, MD.

By: Y. Lai, B. Duncan, X. Lascelles & M. Nolan

Event: American College of Veterinary Radiology Annual Scientific Meeting at Baltimore, MD

Source: NC State University Libraries
Added: October 20, 2024

2019 thesis

Mechanisms and Models of Pain in Head and Neck Cancer Irradiation

(PhD dissertation). Comparative Biomedical Sciences, North Carolina State University.

By: Y. Lai

Source: NC State University Libraries
Added: October 20, 2024

2019 conference paper

Orofacial pain assessment in cats with tongue cancers

College of Veterinary Medicine Research Forum. Presented at the College of Veterinary Medicine Research Forum, NC State University, Raliegh, NC.

By: Y. Lai, B. Duncan, X. Lascelles & M. Nolan

Event: College of Veterinary Medicine Research Forum at NC State University, Raliegh, NC

Source: NC State University Libraries
Added: October 20, 2024

2019 journal article

Preclinical optimization of an enhanced ethanol ablation technique in a large animal spontaneous disease model of human head and neck cancer

Consortium for Canine Comparative Oncology. Presented at the Consortium for Canine Comparative Oncology, Durham, NC.

By: E. Lai, R. Morhard, N. Ramanujam, B. Duncan, X. Lascelles & M. Nolan

Event: Consortium for Canine Comparative Oncology at Durham, NC

Source: NC State University Libraries
Added: October 20, 2024

2019 conference paper

Quantify orofacial pain in feline head and neck cancer

Pain in Animal Workshop. Presented at the Pain in Animal Workshop, Bethesda, MD.

By: Y. Lai, B. Duncan, X. Lascelles & M. Nolan

Event: Pain in Animal Workshop at Bethesda, MD

Source: NC State University Libraries
Added: October 20, 2024

2018 conference paper

Irradiation triggers trpv1 and trpv4 activation that is related to discomfort and pain

Consortium for Canine Comparative Oncology. Presented at the Consortium for Canine Comparative Oncology, Durham, NC.

By: Y. Lai, J. Washburn, K. Marcus & M. Nolan

Event: Consortium for Canine Comparative Oncology at Durham, NC

Source: NC State University Libraries
Added: October 20, 2024

2018 conference paper

Radiotherapy-induced mucositis and pain are associated with TRPV1 and TRPV4 activation

Radiation Research Society Annual International Meeting. Presented at the Radiation Research Society Annual International Meeting, Chicago, IL.

By: E. Lai & M. Nolan

Event: Radiation Research Society Annual International Meeting at Chicago, IL

Source: NC State University Libraries
Added: October 20, 2024

2018 conference paper

Upregulation of TRPV1 and TRPV4 in Radiation-induced Mucositis and Pain

American Society for Radiation Oncology, Tumor Microenvironment Workshop. Presented at the American Society for Radiation Oncology, Tumor Microenvironment Workshop, Washington, DC.

By: E. Lai & M. Nolan

Event: American Society for Radiation Oncology, Tumor Microenvironment Workshop at Washington, DC

Source: NC State University Libraries
Added: October 20, 2024

2017 conference paper

Improvement on a murine model for studying radiation-induced oral mucositis and associated discomfort

Radiation Research Society Annual International Meeting. Presented at the Radiation Research Society Annual International Meeting, Cancun, Mexico.

By: Y. Lai & M. Nolan

Event: Radiation Research Society Annual International Meeting at Cancun, Mexico

Source: NC State University Libraries
Added: October 20, 2024

2017 conference paper

Low-dose total body irradiation alters the sensitivity of sensory trigeminal ganglia neurons to chemical stimuli

College of Veterinary Medicine Research Forum. Presented at the College of Veterinary Medicine Research Forum, NC State University, Raleigh, NC.

By: Y. Lai & M. Nolan

Event: College of Veterinary Medicine Research Forum at NC State University, Raleigh, NC

Source: NC State University Libraries
Added: October 20, 2024

2015 conference paper

Detection of MAGE-A in Normal Canine Tissues by Real-time Polymerase Chain Reaction

Spring Conference of Chinese Society of Veterinary Medicine. Presented at the Spring Conference of Chinese Society of Veterinary Medicine, Taiwan.

By: Y. Lai, Y. Chen, W. Hsu & S. Chang

Event: Spring Conference of Chinese Society of Veterinary Medicine at Taiwan

Source: NC State University Libraries
Added: October 20, 2024

2015 thesis

Detection of MAGE-A in Normal Canine Tissues by Reverse Transcription-Polymerase Chain Reaction

(Master of Veterinary Medicine thesis). National Chung-Hsing University.

By: Y. Lai, W. Hsu & S. Chang

Source: NC State University Libraries
Added: October 20, 2024

2014 conference paper

Detection of MAGE-A in Normal Mammalian Tissues

Seminar of Veterinary Medicine Master Program, College of Veterinary Medicine. Presented at the Seminar of Veterinary Medicine Master Program, College of Veterinary Medicine, National Chung Hsing University.

By: Y. Lai & S. Chang

Event: Seminar of Veterinary Medicine Master Program, College of Veterinary Medicine at National Chung Hsing University

Source: NC State University Libraries
Added: October 20, 2024

2013 conference paper

Thoracolumbar Spinal Intervertebral Disk Disease in Two Dachshunds

Clinical Conference, College of Veterinary Medicine. Presented at the Clinical Conference, College of Veterinary Medicine, National Chung Hsing University.

By: Y. Lai & W. Lee

Event: Clinical Conference, College of Veterinary Medicine at National Chung Hsing University

Source: NC State University Libraries
Added: October 20, 2024

2012 conference paper

Conjunctival Squamous Cell Carcinoma and Phlebothrombosis in a Hanoverian Horse

Clinical Conference, College of Veterinary Medicine. Presented at the Clinical Conference, College of Veterinary Medicine, National Chung Hsing University.

By: Y. Lai & J. Chan

Event: Clinical Conference, College of Veterinary Medicine at National Chung Hsing University

Source: NC State University Libraries
Added: October 20, 2024

Employment

Updated: September 30th, 2024 10:59

2024 - present

North Carolina State University Raleigh, US
Assistant Professor of Radiation Oncology Clinical Sciences, College of Veterinary Medicine

2021 - 2024

Louisiana State University Baton Rouge, LA, US
Veterinary Radiation Oncology Resident Clinical Sciences, School of Veterinary Medicine

2020 - 2021

Virginia Tech Blacksburg, Virginia, US
Veterinary oncology intern College of Veterinary Medicine

2020 - 2020

North Carolina State University Raleigh, North Carolina, US
Post-doctoral fellow Clinical Sciences, College of Veterinary Medicine

Education

Updated: April 18th, 2022 14:26

2016 - 2019

North Carolina State University Raleigh, North Carolina, US
Ph.D Clinical Sciences, College of Veterinary Medicine

2013 - 2015

National Chung Hsing University Taichung, TW
Master Veterinary Medicine

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