Yen-Hao Erik Lai
Radiation Biology, Radiation Oncology, Veterinary
Works (5)
Updated: October 2nd, 2024 05:07
2023 journal article
Acute radiotherapy-associated oral pain may promote tumor growth at distant sites
FRONTIERS IN ONCOLOGY, 13.
author keywords: pain; radiotherapy; sensory nerves; cancer; mouse; TRPV1
TL;DR:
This research points towards radiation-induced activation of capsaicin-responsive (TRPV1) neurons as the cause for accelerated growth of tumors at distant (unirradiated) sites.
(via Semantic Scholar)
open access via www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 12, 2023
2021 journal article
Behavioral phenotyping of cancer pain in domesticated cats with naturally occurring squamous cell carcinoma of the tongue: initial validation studies provide evidence for regional and widespread algoplasticity
PEERJ, 9.
author keywords: Comparative oncology; Comparative pain research; Animal models; Translational research; Feline
TL;DR:
Based on preliminary assessments, the assays described herein had reasonable inter-rater reliability, and they were able to both discriminate between cats with and without oral cancer, and respond in a predictable manner to analgesic therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 30, 2021
2021 journal article
Irradiation of the Normal Murine Tongue Causes Upregulation and Activation of Transient Receptor Potential (TRP) Ion Channels
RADIATION RESEARCH, 196(4), 331–344.
MeSH headings : Animals; Calcium; Female; Mice; Neurons; Transient Receptor Potential Channels; Trigeminal Ganglion; Up-Regulation
TL;DR:
The results intimate that various TRP channels, and TRPV1 in particular, should be explored as analgesic targets for patients experiencing pain after oral irradiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 18, 2021
2021 journal article
Minimally invasive ethyl cellulose ethanol ablation in domesticated cats with naturally occurring head and neck cancers: Six cats
VETERINARY AND COMPARATIVE ONCOLOGY, 19(3), 492–500.
author keywords: head and neck cancer; intratumoral injection; minimally invasive procedure; palliative; surgical alternative
MeSH headings : Animals; Carcinoma, Squamous Cell / drug therapy; Carcinoma, Squamous Cell / veterinary; Cat Diseases / drug therapy; Cats; Cellulose / analogs & derivatives; Cellulose / therapeutic use; Ethanol; Head and Neck Neoplasms / drug therapy; Head and Neck Neoplasms / veterinary; Pilot Projects; Quality of Life
TL;DR:
Ethyl cellulose ethanol ablation is not a viable treatment for feline lingual/sublingual SCC; tumor volume was effectively reduced in some cats, but the simultaneous loss of lingual function was poorly tolerated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: March 15, 2021
2020 journal article
Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment
VETERINARY RADIOLOGY & ULTRASOUND, 62(2), 255–263.
author keywords: glossitis; mucositis; TNF‐ α TRPV1; TRPV4
MeSH headings : Animals; Capsaicin / pharmacology; Histamine / pharmacology; Mice; Pain / prevention & control; Pain / veterinary; Pentoxifylline / therapeutic use; Pilot Projects; Prospective Studies; Radiation-Protective Agents / therapeutic use; Radiotherapy / adverse effects; Sensory System Agents / pharmacology; Signal Transduction / drug effects; Stomatitis / complications; Stomatitis / drug therapy; Stomatitis / etiology; Tumor Necrosis Factor-alpha / analysis; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Although PTX treatment did not reduce glossitis severity or mitigate weight loss in mice with RIM/RAP, it did inhibit the upregulation of TNF-α's receptor that normally accompanies RIM, and it also reduced neuronal responsiveness to each of the aforementioned chemical stimuli.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 11, 2021
Employment
Updated: September 30th, 2024 10:59
2024 - present
North Carolina State University Raleigh, US
Assistant Professor of Radiation Oncology
Clinical Sciences, College of Veterinary Medicine
2021 - 2024
Louisiana State University Baton Rouge, LA, US
Veterinary Radiation Oncology Resident
Clinical Sciences, School of Veterinary Medicine
2020 - 2021
Virginia Tech Blacksburg, Virginia, US
Veterinary oncology intern
College of Veterinary Medicine
2020 - 2020
North Carolina State University Raleigh, North Carolina, US
Post-doctoral fellow
Clinical Sciences, College of Veterinary Medicine
Education
Updated: April 18th, 2022 14:26
2016 - 2019
North Carolina State University Raleigh, North Carolina, US
Ph.D
Clinical Sciences, College of Veterinary Medicine
2013 - 2015
National Chung Hsing University Taichung, TW
Master
Veterinary Medicine
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