You-Chen Lin

College of Sciences

Works (3)

Updated: July 5th, 2023 14:43

2021 review

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 54(8), 1866–1877.

By: M. Valdes-Pena n, N. Massaro n, Y. Lin n & J. Pierce n 

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / pharmacology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biological Products / chemical synthesis; Biological Products / chemistry; Biological Products / pharmacology; Drug Resistance, Multiple, Bacterial / drug effects; Guanidine / analogs & derivatives; Guanidine / chemical synthesis; Guanidine / pharmacology; Guanidines / chemical synthesis; Guanidines / pharmacology; Microbial Sensitivity Tests; Oxazolidinones / chemical synthesis; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Staphylococcus aureus / physiology; Stereoisomerism; Structure-Activity Relationship
TL;DR: These studies provide several distinct platforms for the development of novel therapeutics that can add to the arsenal of scaffolds for preclinical development and can provide insight into the biochemical processes and pathways that can be targeted by small molecules in the fight against antimicrobial-resistant and -tolerant infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 19, 2021

2021 journal article

Stereoselective Synthesis of the Spirocyclic gamma-Lactam Core of the Ansalactams

ORGANIC LETTERS, 23(24), 9559–9562.

By: Z. Liang n, Y. Lin n & J. Pierce n 

MeSH headings : Spiro Compounds
TL;DR: The development of a stereoselective formal [3+2] cycloaddition reaction for the construction of this key spiro-γ-lactam motif for the first time is reported, thereby enabling access to the northern domain of ansalactam A. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 1, 2021

2020 journal article

Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(21), 9850–9857.

By: Y. Lin n, A. Ribaucourt n, Y. Moazami n & J. Pierce n 

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / pharmacology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Microbial Sensitivity Tests; Molecular Conformation; Pyrimidines / chemical synthesis; Pyrimidines / chemistry; Pyrimidines / pharmacology; Staphylococcus aureus / drug effects; Stereoisomerism
TL;DR: The stereocontrolled synthesis allowed for the investigation of the antimicrobial activity of batzelladine D, demonstrating promising activity that is more potent for non-natural stereoisomers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 22, 2020

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