Works (42)

Updated: October 16th, 2023 05:00

2023 journal article

Acute and Repeated Ozone Exposures Differentially Affect Circadian Clock Gene Expression in Mice.

Advanced Biology, 5.

By: I. Sundar*, S. Duraisamy*, I. Choudhary*, Y. Saini* & P. Silveyra*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 2, 2023

2023 journal article

Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease.

Frontiers in Immunology.

By: Y. Mao*, S. Patial* & Y. Saini*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Humans; Mice; Cystic Fibrosis / genetics; Epithelial Cells / metabolism; HMGB1 Protein / genetics; HMGB1 Protein / metabolism; Lung; Mice, Transgenic; Pulmonary Disease, Chronic Obstructive / pathology
Source: ORCID
Added: August 2, 2023

2023 journal article

Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury.

American Journal of Physiology. Lung Cellular and Molecular Physiology.

By: D. Das*, B. Puthusseri*, V. Gopu*, V. Krishnan*, A. Bhagavath*, S. Bolla*, Y. Saini*, G. Criner* ...

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: October 15, 2023

2022 journal article

Activating transcription factor 6 protects against endothelial barrier dysfunction.

Cellular Signalling, 11.

By: K. Kubra*, . Akhter*, Y. Saini*, K. Kousoulas* & N. Barabutis*

co-author countries: United States of America 🇺🇸
MeSH headings : Actin Depolymerizing Factors / metabolism; Activating Transcription Factor 6 / metabolism; Activating Transcription Factor 6 / pharmacology; Animals; Cattle; Cells, Cultured; Dextrans / metabolism; Dextrans / pharmacology; Endothelial Cells / metabolism; Fluorescein-5-isothiocyanate / analogs & derivatives; Fluorescein-5-isothiocyanate / metabolism; Fluorescein-5-isothiocyanate / pharmacology; Lipopolysaccharides / metabolism; Lipopolysaccharides / pharmacology; RNA, Small Interfering / metabolism; Respiratory Distress Syndrome; Sepsis
Source: ORCID
Added: August 2, 2023

2022 journal article

Case report: Mafb promoter activity may define the alveolar macrophage dichotomy.

Frontiers in Immunology.

By: T. Vo* & Y. Saini*

co-author countries: United States of America 🇺🇸
MeSH headings : Mice; Animals; Macrophages, Alveolar / metabolism; Macrophages / metabolism; Lung / metabolism; Promoter Regions, Genetic; Proteins / metabolism; MafB Transcription Factor / genetics; MafB Transcription Factor / metabolism
Source: ORCID
Added: August 2, 2023

2022 journal article

Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells.

Toxicology and Applied Pharmacology, 11.

By: R. Lamichhane*, S. Patial* & Y. Saini*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Bleomycin / toxicity; Chemokine CXCL10 / adverse effects; Cytokines; Female; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis / pathology; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / genetics; Interleukin-10; Interleukin-6; Interleukin-7; Lung; Lung Injury / pathology; Male; Mice; Mice, Inbred C57BL; Myeloid Cells; Pneumonia / chemically induced; RNA; Transcriptome
Source: ORCID
Added: August 2, 2023

2022 journal article

In Vitro Screening Method for Characterization of Macrophage Activation Responses.

Methods and Protocols, 8.

By: B. Lewis*, S. Patial* & Y. Saini*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 2, 2023

2022 journal article

Induction of whole-body gene deletion via R26-regulated tamoxifen-inducible Cre recombinase activity.

Frontiers in Pharmacology.

By: R. Kumar*, Y. Mao*, S. Patial* & Y. Saini*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 2, 2023

2022 article

NLRP3 inflammasome is dispensable in methicillin resistantStaphylococcus aureusurinary tract infection

Paudel, S., Rogers, K. A., Kumar, R., Saini, Y., Patial, S., & Kulkarni, R. (2022, November).

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 2, 2023

2022 journal article

Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2.

Scientific Reports, 1.

By: T. Vo*, K. Paudel*, I. Choudhary*, S. Patial* & Y. Saini*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; COVID-19 / chemically induced; COVID-19 / metabolism; Disease Susceptibility / chemically induced; Disease Susceptibility / metabolism; Macrophages, Alveolar / metabolism; Mice; Ozone / toxicity; SARS-CoV-2 / metabolism; Serine Endopeptidases / metabolism; Up-Regulation / drug effects
Source: ORCID
Added: August 2, 2023

2022 journal article

Silencing of RNA binding protein, ZFP36L1, promotes epithelial-mesenchymal transition in liver cancer cells by regulating transcription factor ZEB2.

Cellular Signalling, 9.

By: J. Chen*, S. Patial* & Y. Saini*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 2, 2023

2021 journal article

Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs.

Scientific Reports, 7.

By: S. Patial*, B. Lewis*, T. Vo*, I. Choudhary*, K. Paudel*, Y. Mao*, D. Singamsetty*, F. Brombacher*, Y. Saini*

co-author countries: United States of America 🇺🇸 South Africa 🇿🇦
MeSH headings : Alleles; Animals; Bronchoalveolar Lavage Fluid; Eosinophils / metabolism; Immunity, Innate; Interleukin-13 / metabolism; Interleukin-33 / metabolism; Ligands; Lung / metabolism; Lymphocytes / cytology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myeloid Cells / metabolism; Pulmonary Eosinophilia; Receptors, Cell Surface / metabolism
Source: ORCID
Added: August 2, 2023

2021 journal article

Postnatal Ozone Exposure Disrupts Alveolar Development, Exaggerates Mucoinflammatory Responses, and Suppresses Bacterial Clearance in Developing Scnn1b-Tg+ Mice Lungs.

Journal of Immunology (Baltimore, Md. : 1950), 8.

By: I. Choudhary*, T. Vo*, K. Paudel*, R. Yadav*, Y. Mao*, S. Patial*, Y. Saini*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Bacteria / immunology; Cystic Fibrosis / immunology; Disease Models, Animal; Epithelial Sodium Channels / immunology; Inflammation / immunology; Lung / immunology; Macrophages / immunology; Mice; Mice, Transgenic; Mucus / immunology; Ozone / adverse effects; Postnatal Care
Source: ORCID
Added: August 2, 2023

2021 journal article

Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease.

Scientific Reports, 12.

By: I. Choudhary*, T. Vo*, K. Paudel*, X. Wen*, R. Gupta*, M. Kesimer*, S. Patial*, Y. Saini*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / chemistry; Cytokines / analysis; Female; Inflammation Mediators / analysis; Male; Mice; Mice, Inbred C57BL; Ozone / adverse effects; Pneumonia / diagnosis; Proteins / analysis
Source: ORCID
Added: August 2, 2023

2021 journal article

ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice.

The American Journal of Pathology, 2.

By: C. Bathula*, J. Chen*, R. Kumar*, P. Blackshear*, Y. Saini* & S. Patial*

co-author countries: United States of America 🇺🇸
MeSH headings : 3' Untranslated Regions; Animals; Butyrate Response Factor 1 / genetics; Butyrate Response Factor 1 / metabolism; Fatty Liver, Alcoholic / genetics; Fatty Liver, Alcoholic / metabolism; Fatty Liver, Alcoholic / pathology; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / metabolism; Inflammation / genetics; Inflammation / metabolism; Inflammation / pathology; Liver / metabolism; Liver / pathology; Mice; Mice, Knockout; Mutation; RNA Stability
Source: ORCID
Added: August 2, 2023

2021 article

ZFP36L1 regulates Fgf21 mRNA turnover and modulates alcoholic hepatic steatosis and inflammation in mice

Bathula, C. S., Chen, J., Blackshear, P. J., Saini, Y., & Patial, S. (2021, May).

By: C. Bathula*, J. Chen*, P. Blackshear*, Y. Saini* & S. Patial*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 2, 2023

2020 journal article

Ablation of IL-33 Suppresses Th2 Responses but Is Accompanied by Sustained Mucus Obstruction in the Scnn1b Transgenic Mouse Model.

Journal of Immunology (Baltimore, Md. : 1950), 3.

By: B. Lewis*, T. Vo*, I. Choudhary*, A. Kidder*, C. Bathula*, C. Ehre*, N. Wakamatsu*, S. Patial*, S. Patial, Y. Saini*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / cytology; Bronchoalveolar Lavage Fluid / immunology; Cystic Fibrosis / diagnosis; Cystic Fibrosis / genetics; Cystic Fibrosis / immunology; Cystic Fibrosis / pathology; Disease Models, Animal; Eosinophils / immunology; Eosinophils / metabolism; Epithelial Sodium Channels / genetics; Humans; Interleukin-33 / genetics; Interleukin-33 / metabolism; Lung / cytology; Lung / immunology; Lung / pathology; Mice; Mice, Knockout; Mice, Transgenic; Mucin 5AC / metabolism; Mucus / immunology; Mucus / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / immunology; Respiratory Mucosa / metabolism; Th2 Cells / immunology; Th2 Cells / metabolism
Source: ORCID
Added: August 2, 2023

2020 journal article

Compartment-specific transcriptomics of ozone-exposed murine lungs reveals sex- and cell type-associated perturbations relevant to mucoinflammatory lung diseases.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 1.

By: I. Choudhary*, T. Vo*, K. Paudel*, S. Patial* & Y. Saini*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 2, 2023

2020 journal article

Lung macrophages: current understanding of their roles in Ozone-induced lung diseases.

Critical Reviews in Toxicology, 4.

By: S. Patial* & Y. Saini*

co-author countries: United States of America 🇺🇸
MeSH headings : Air Pollutants / toxicity; Air Pollution / statistics & numerical data; Animals; Humans; Lung / physiopathology; Lung Diseases / epidemiology; Lung Diseases / etiology; Macrophages / drug effects; Macrophages / physiology; Ozone / toxicity; United States
Source: ORCID
Added: August 2, 2023

2020 article

Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2

Vo, T., Paudel, K., Choudhary, I., Patial, S., & Saini, Y. (2020, November).

By: T. Vo, K. Paudel, I. Choudhary, S. Patial & Y. Saini*

Source: ORCID
Added: August 2, 2023

2020 journal article

The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.

Journal of Immunology (Baltimore, Md. : 1950), 9.

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cells, Cultured; Cystic Fibrosis / immunology; Disease Models, Animal; Epithelial Cells / metabolism; Epithelial Cells / pathology; Epithelial Sodium Channels / genetics; Homeodomain Proteins / genetics; Humans; Immunity, Innate; Inflammation / immunology; Metaplasia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mucin-5B / genetics; Mucin-5B / metabolism; Respiratory Tract Diseases / immunology; Up-Regulation
Source: ORCID
Added: August 2, 2023

2020 journal article

The Tristetraprolin Family of RNA-Binding Proteins in Cancer: Progress and Future Prospects.

Cancers, 6.

By: Y. Saini*, J. Chen* & S. Patial*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 2, 2023

2020 journal article

Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice.

Frontiers in Immunology.

By: I. Choudhary*, T. Vo*, C. Bathula*, R. Lamichhane*, B. Lewis*, J. Looper*, S. Jeyaseelan*, P. Blackshear*, Y. Saini*, S. Patial*

co-author countries: United States of America 🇺🇸
MeSH headings : Acute Lung Injury / chemically induced; Acute Lung Injury / prevention & control; Alveolar Epithelial Cells / metabolism; Animals; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Chemotaxis, Leukocyte; Cytokines / physiology; Endothelial Cells / metabolism; Female; Fibroblasts / metabolism; Lipopolysaccharides / toxicity; Male; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils / immunology; Radiation Chimera; Tristetraprolin / biosynthesis; Tristetraprolin / deficiency; Tristetraprolin / genetics; Tristetraprolin / physiology; Up-Regulation
Source: ORCID
Added: August 2, 2023

2020 article

Vesicular and Extravesicular Protein Signatures From the Airspaces of Ozone-Exposed Mice Reflect Muco-Inflammatory Disturbances.

Choudhary, I., Vo, T., Paudel, K., Gupta, R., Kesimer, M., Patial, S., & Saini, Y. (2020, December).

By: I. Choudhary*, T. Vo*, K. Paudel*, R. Gupta*, M. Kesimer*, S. Patial*, Y. Saini*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 2, 2023

2019 journal article

Immunopathology of Airway Surface Liquid Dehydration Disease.

Journal of Immunology Research.

By: B. Lewis*, S. Patial* & Y. Saini*

co-author countries: United States of America 🇺🇸
MeSH headings : Airway Obstruction / immunology; Airway Obstruction / metabolism; Airway Obstruction / microbiology; Airway Obstruction / physiopathology; Animals; Cystic Fibrosis / genetics; Cystic Fibrosis / immunology; Cystic Fibrosis / microbiology; Cystic Fibrosis / physiopathology; Cystic Fibrosis Transmembrane Conductance Regulator / metabolism; Dehydration / metabolism; Dehydration / physiopathology; Disease Models, Animal; Epithelial Sodium Channels / genetics; Ion Channels / deficiency; Ion Channels / genetics; Leukocytes / immunology; Lung / immunology; Lung / physiopathology; Macrophages / immunology; Mice; Mice, Transgenic; Mucociliary Clearance / genetics; Mucociliary Clearance / immunology; Respiratory Tract Infections / immunology; Respiratory Tract Infections / physiopathology
Source: ORCID
Added: August 2, 2023

2018 journal article

Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis.

Physiological Reports, 4.

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Bronchitis, Chronic / pathology; Disease Models, Animal; Lung / pathology; Macrophages / pathology; Mice; Mice, Transgenic
Source: ORCID
Added: August 2, 2023

2017 journal article

Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease.

Journal of Immunology (Baltimore, Md. : 1950), 8.

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Animals, Newborn; Bacterial Infections / immunology; Bacterial Infections / physiopathology; Bacterial Load; Cell Movement; Cystic Fibrosis / immunology; Cystic Fibrosis / microbiology; Cystic Fibrosis / physiopathology; Disease Models, Animal; Down-Regulation; Epithelial Cells / immunology; Epithelial Cells / pathology; Epithelial Sodium Channels / deficiency; Epithelial Sodium Channels / genetics; Epithelial Sodium Channels / metabolism; Female; Goblet Cells / pathology; Humans; Immunoglobulin A / immunology; Interleukin-33 / genetics; Interleukin-33 / immunology; Interleukin-33 / metabolism; Lung / cytology; Lung / immunology; Lung / pathology; Lung Diseases, Obstructive / immunology; Lung Diseases, Obstructive / physiopathology; Mice; Mice, Transgenic; Mucin-5B; Mucus / metabolism; Neutrophils / immunology; Neutrophils / pathology; Neutrophils / physiology; Signal Transduction; Th2 Cells / immunology; Th2 Cells / pathology; Tobacco Smoke Pollution / adverse effects
Source: ORCID
Added: August 2, 2023

2017 journal article

Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.

The American Journal of Pathology, 1.

By: D. Yu*, Y. Saini*, G. Chen*, A. Ghio*, H. Dang*, K. Burns*, Y. Wang*, R. Davis* ...

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Animals; Cell Proliferation; Disease Models, Animal; Epithelial Sodium Channels / genetics; Epithelial Sodium Channels / metabolism; Female; Male; Meibomian Glands / metabolism; Mice; Mice, Knockout; Phenotype; Pseudohypoaldosteronism / genetics; Pseudohypoaldosteronism / metabolism; Sex Factors; Tears / metabolism
Source: ORCID
Added: August 2, 2023

2016 journal article

Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses.

American Journal of Respiratory Cell and Molecular Biology, 2.

By: Y. Saini*, K. Wilkinson, K. Terrell, K. Burns, A. Livraghi-Butrico*, C. Doerschuk*, W. O'Neal*, R. Boucher*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Animals, Newborn; Cytokines / immunology; Cytokines / metabolism; Diphtheria Toxin / genetics; Diphtheria Toxin / metabolism; Disease Models, Animal; Epithelial Sodium Channels / genetics; Epithelial Sodium Channels / metabolism; Genetic Predisposition to Disease; Inflammation Mediators / immunology; Inflammation Mediators / metabolism; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Lung / immunology; Lung / metabolism; Lung / microbiology; Macrophages / immunology; Macrophages / metabolism; Mice, Inbred C57BL; Mice, Transgenic; Mucociliary Clearance; Muramidase / genetics; Pasteurella Infections / genetics; Pasteurella Infections / immunology; Pasteurella Infections / metabolism; Pasteurella Infections / microbiology; Pasteurella pneumotropica / immunology; Pasteurella pneumotropica / pathogenicity; Peptide Fragments / genetics; Peptide Fragments / metabolism; Phenotype; Pneumonia, Bacterial / genetics; Pneumonia, Bacterial / immunology; Pneumonia, Bacterial / metabolism; Pneumonia, Bacterial / microbiology; Promoter Regions, Genetic
Source: ORCID
Added: August 2, 2023

2015 journal article

Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells.

Experimental Cell Research, 7.

By: A. Nair*, P. Ebenezer*, Y. Saini* & J. Francis*

co-author countries: United States of America 🇺🇸
MeSH headings : Angiotensin II; Animals; Antihypertensive Agents / pharmacology; Cell Line; Epithelial Cells / immunology; Epithelial Cells / metabolism; HMGB1 Protein / metabolism; Hypertension / chemically induced; Hypertension / complications; Hypertension / metabolism; Kidney Failure, Chronic / etiology; Kidney Failure, Chronic / immunology; Kidney Failure, Chronic / metabolism; Kidney Tubules / pathology; Losartan / pharmacology; NF-kappa B / metabolism; Rats; Signal Transduction; Toll-Like Receptor 4 / metabolism
Source: ORCID
Added: August 2, 2023

2015 journal article

Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.

Biochemistry, 6.

By: H. Hwang*, S. Lynn*, A. Vengellur*, Y. Saini*, E. Grier*, S. Ferguson-Miller*, J. LaPres*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cell Hypoxia; Cells, Cultured; Clone Cells; Electron Transport Complex IV / antagonists & inhibitors; Electron Transport Complex IV / genetics; Electron Transport Complex IV / metabolism; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Enzyme Induction / drug effects; Enzyme Inhibitors / pharmacology; Gene Expression Profiling; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Mice; Mice, Transgenic; Mitochondria / drug effects; Mitochondria / enzymology; Mitochondria / metabolism; Oxidative Phosphorylation / drug effects; Oxygen Consumption / drug effects; RNA, Messenger / metabolism; Recombinant Proteins / metabolism; Transcriptional Activation / drug effects
Source: ORCID
Added: August 2, 2023

2015 journal article

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.

PloS One.

By: Y. Saini*, S. Proper*, P. Dornbos*, K. Greenwood*, A. Kopec*, S. Lynn*, E. Grier*, L. Burgoon* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors / deficiency; Basic Helix-Loop-Helix Transcription Factors / genetics; Gene Deletion; Gene Regulatory Networks; Genotype; Hypoxia-Inducible Factor 1, alpha Subunit / deficiency; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Lung / metabolism; Lung / pathology; Mice; Phenotype; Respiratory Distress Syndrome, Newborn / genetics; Respiratory Distress Syndrome, Newborn / metabolism; Respiratory Distress Syndrome, Newborn / pathology; Signal Transduction; Survival Analysis; Transcription, Genetic
Source: ORCID
Added: August 2, 2023

2014 journal article

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration.

BMC Genomics, 9.

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Dehydration; Down-Regulation; Epithelial Sodium Channels / genetics; Epithelial Sodium Channels / metabolism; Gene Expression Profiling; Humans; Inflammation / genetics; Longitudinal Studies; Lung / metabolism; Macrophage Activation; Macrophages, Alveolar / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mucus / metabolism; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; Up-Regulation
Source: ORCID
Added: August 2, 2023

2013 journal article

Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.

Toxicological Sciences : an Official Journal of the Society of Toxicology, 2.

By: S. Proper*, Y. Saini*, K. Greenwood*, L. Bramble, N. Downing & J. Lapres*

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / deficiency; Basic Helix-Loop-Helix Transcription Factors / genetics; Bronchoalveolar Lavage Fluid / cytology; Cobalt / toxicity; Cytokines / genetics; Cytokines / immunology; Disease Models, Animal; Doxycycline / pharmacology; Gene Expression Profiling; Immunohistochemistry; Lung Injury / chemically induced; Lung Injury / complications; Lung Injury / immunology; Lung Injury / pathology; Mice; Mice, Knockout; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / immunology; Pulmonary Alveoli / pathology; Pulmonary Eosinophilia / chemically induced; Pulmonary Eosinophilia / etiology; Pulmonary Eosinophilia / immunology; Pulmonary Eosinophilia / pathology; Respiratory Mucosa / drug effects; Respiratory Mucosa / immunology; Respiratory Mucosa / pathology
Source: ORCID
Added: August 2, 2023

2011 journal article

G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice.

Journal of Cellular Physiology, 5.

By: S. Patial*, S. Shahi*, Y. Saini*, T. Lee*, N. Packiriswamy*, D. Appledorn*, J. Lapres*, A. Amalfitano*, N. Parameswaran*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cells, Cultured; Cytokines / metabolism; Female; G-Protein-Coupled Receptor Kinase 5 / deficiency; G-Protein-Coupled Receptor Kinase 5 / drug effects; G-Protein-Coupled Receptor Kinase 5 / genetics; G-Protein-Coupled Receptor Kinase 5 / metabolism; I-kappa B Proteins / metabolism; Inflammation / chemically induced; Inflammation / enzymology; Inflammation / immunology; Inflammation Mediators / metabolism; Lipopolysaccharides / pharmacology; Lung / drug effects; Lung / enzymology; Lung / immunology; Macrophages, Peritoneal / drug effects; Macrophages, Peritoneal / enzymology; Macrophages, Peritoneal / immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-KappaB Inhibitor alpha; NF-kappa B / metabolism; Neutrophil Infiltration / drug effects; Phosphorylation; Signal Transduction / drug effects; Time Factors; Toll-Like Receptor 4 / agonists; Toll-Like Receptor 4 / metabolism
Source: ORCID
Added: August 2, 2023

2011 journal article

Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice.

Journal of Cellular Physiology, 3.

By: S. Patial*, Y. Saini*, S. Parvataneni*, D. Appledorn*, G. Dorn*, J. Lapres*, A. Amalfitano*, P. Senagore*, N. Parameswaran*

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: August 2, 2023

2011 journal article

Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 3.

By: K. Greenwood*, S. Proper*, Y. Saini*, L. Bramble, D. Jackson-Humbles, J. Wagner*, J. LaPres*

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Airway Resistance / drug effects; Animals; Animals, Newborn; Asthma / chemically induced; Asthma / immunology; Asthma / metabolism; Bronchoalveolar Lavage Fluid / chemistry; Bronchoconstrictor Agents / pharmacology; Cell Count; Cytokines / metabolism; Eosinophil Major Basic Protein / metabolism; Eosinophils / metabolism; Eosinophils / pathology; Female; Gene Expression; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit / deficiency; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Immunity, Innate; Inflammation / immunology; Inflammation / metabolism; Inflammation / pathology; Lung / metabolism; Lung / pathology; Methacholine Chloride / pharmacology; Mice; Mice, Transgenic; Ovalbumin; Random Allocation
Source: ORCID
Added: August 2, 2023

2011 journal article

The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.

The Journal of Pharmacology and Experimental Therapeutics, 8.

By: E. Sparkenbaugh*, Y. Saini*, K. Greenwood*, J. LaPres, J. Luyendyk*, B. Copple*, J. Maddox*, P. Ganey*, R. Roth*

co-author countries: Czechia 🇨🇿 United States of America 🇺🇸
MeSH headings : Acetaminophen / toxicity; Animals; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Chemical and Drug Induced Liver Injury / prevention & control; Hepatocytes / drug effects; Hepatocytes / metabolism; Hepatocytes / pathology; Hypoxia-Inducible Factor 1, alpha Subunit / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Oxidative Stress / drug effects; Oxidative Stress / physiology
Source: ORCID
Added: August 2, 2023

2010 journal article

Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation.

Toxicological Sciences : an Official Journal of the Society of Toxicology, 8.

By: Y. Saini*, K. Greenwood*, C. Merrill, K. Kim, S. Patial*, N. Parameswaran*, J. LaPres*

co-author countries: France 🇫🇷 Russian Federation 🇷🇺 United States of America 🇺🇸
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Cobalt / toxicity; Cytokines / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / physiology; Immunity, Innate / drug effects; Inflammation / etiology; Lung / drug effects; Lung / immunology; Lung / pathology; Mice; Neutrophil Infiltration / drug effects
Source: ORCID
Added: August 2, 2023

2009 journal article

Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 2.

By: Y. Saini*, K. Kim, R. Lewandowski, L. Bramble & J. Lapres*

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Animals; Asthma / chemically induced; Asthma / immunology; Body Weight; Bronchoalveolar Lavage Fluid / cytology; Cobalt / immunology; Cobalt / pharmacology; Cytokines / immunology; Gene Expression Profiling; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Inflammation / chemically induced; Inflammation / immunology; Lung / cytology; Lung / drug effects; Lung / immunology; Lung / pathology; Mice; Mice, Knockout; Mice, Transgenic; Th2 Cells / immunology
Source: ORCID
Added: August 2, 2023

2008 journal article

HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice.

The Journal of Biological Chemistry, 11.

By: Y. Saini* & J. LaPres*

co-author countries: United States of America 🇺🇸
MeSH headings : Adaptation, Physiological / genetics; Animals; Animals, Newborn; Cell Differentiation / genetics; Disease Models, Animal; Female; Fetal Development / genetics; Fetus / metabolism; Fetus / pathology; Gene Knockdown Techniques / methods; Glycogen / genetics; Glycogen / metabolism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Infant, Newborn; Male; Mice; Mice, Transgenic; Oxygen / metabolism; Pregnancy; Pulmonary Alveoli / embryology; Pulmonary Alveoli / pathology; Pulmonary Surfactant-Associated Proteins / genetics; Pulmonary Surfactant-Associated Proteins / metabolism; Respiratory Distress Syndrome, Newborn / genetics; Respiratory Distress Syndrome, Newborn / metabolism; Respiratory Distress Syndrome, Newborn / pathology; Respiratory Distress Syndrome, Newborn / physiopathology; Respiratory Mucosa / embryology; Respiratory Mucosa / pathology; Signal Transduction / genetics
Source: ORCID
Added: August 2, 2023

2007 journal article

Virus neutralizing antibody response in mice and dogs with a bicistronic DNA vaccine encoding rabies virus glycoprotein and canine parvovirus VP2.

Vaccine, 5.

By: S. Patial, V. Chaturvedi, A. Rai, M. Saini, R. Chandra, Y. Saini*, P. Gupta

MeSH headings : Animals; Antibodies, Viral / biosynthesis; Antibodies, Viral / immunology; Antigens, Surface / genetics; Antigens, Surface / immunology; Capsid Proteins / genetics; Capsid Proteins / immunology; Cattle; Cell Line; Cricetinae; Dogs; Glycoproteins / genetics; Glycoproteins / immunology; Mice; Parvovirus, Canine / genetics; Parvovirus, Canine / immunology; Rabies / immunology; Rabies / prevention & control; Rabies / veterinary; Rabies Vaccines / genetics; Rabies Vaccines / immunology; Rabies Vaccines / pharmacology; Rabies virus / genetics; Rabies virus / immunology; Vaccines, DNA / genetics; Vaccines, DNA / immunology; Vaccines, DNA / pharmacology; Viral Proteins / genetics; Viral Proteins / immunology
Source: ORCID
Added: August 2, 2023

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