Works (43)

Updated: April 3rd, 2024 21:00

2024 journal article

The NLRP3 Inflammasome Is Dispensable in Methicillin-Resistant <i>Staphylococcus aureus</i> Urinary Tract Infection

PATHOGENS, 13(2).

author keywords: MRSA; UTI; NLRP3; inflammasome
TL;DR: It is suggested that MRSA-induced urinary NLRP3 activity does not play a role in the pathophysiology of the ascending UTI, and histopathological analysis of MRSA-infected bladder and kidney sections from Nlrp3−/− and WT mice showed similar inflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 18, 2024

2023 journal article

Acute and Repeated Ozone Exposures Differentially Affect Circadian Clock Gene Expression in Mice.

Advanced Biology, 5.

By: I. Sundar*, S. Duraisamy*, I. Choudhary*, Y. Saini* & P. Silveyra*

TL;DR: It is suggested that lung inflammation caused by O3 exposure affects clock genes which may regulate key signaling pathways. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2023 journal article

Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease.

Frontiers in Immunology.

By: Y. Mao*, S. Patial* & Y. Saini*

MeSH headings : Animals; Humans; Mice; Cystic Fibrosis / genetics; Epithelial Cells / metabolism; HMGB1 Protein / genetics; HMGB1 Protein / metabolism; Lung; Mice, Transgenic; Pulmonary Disease, Chronic Obstructive / pathology
TL;DR: The role of airway epithelium-specific HMGB1 in the pathogenesis of muco-obstructive lung disease in Scnn1b-transgenic (Tg+) mouse, a model of human cystic fibrosis (CF)-like lung disease, is investigated and novel insights are provided. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2023 journal article

Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury.

American Journal of Physiology. Lung Cellular and Molecular Physiology.

By: D. Das*, B. Puthusseri*, V. Gopu*, V. Krishnan*, A. Bhagavath*, S. Bolla*, Y. Saini*, G. Criner* ...

TL;DR: Treatment of patients with COPD or mice with CS-LI with a seven amino acid caveolin-1 scaffolding domain peptide (CSP7) reduced mucus hypersecretion in AECs and improved AT2 cell viability and significantly improved lung function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 15, 2023

2022 journal article

Activating transcription factor 6 protects against endothelial barrier dysfunction.

Cellular Signalling, 11.

By: K. Kubra*, . Akhter*, Y. Saini*, K. Kousoulas* & N. Barabutis*

MeSH headings : Actin Depolymerizing Factors / metabolism; Activating Transcription Factor 6 / metabolism; Activating Transcription Factor 6 / pharmacology; Animals; Cattle; Cells, Cultured; Dextrans / metabolism; Dextrans / pharmacology; Endothelial Cells / metabolism; Fluorescein-5-isothiocyanate / analogs & derivatives; Fluorescein-5-isothiocyanate / metabolism; Fluorescein-5-isothiocyanate / pharmacology; Lipopolysaccharides / metabolism; Lipopolysaccharides / pharmacology; RNA, Small Interfering / metabolism; Respiratory Distress Syndrome; Sepsis
TL;DR: ATF6 activation protects against endothelial barrier function, suggesting that this UPR sensor may serve as a therapeutic target for sepsis and ARDS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2022 journal article

Case report: <i>Mafb</i> promoter activity may define the alveolar macrophage dichotomy.

Frontiers in Immunology.

By: T. Vo* & Y. Saini*

MeSH headings : Mice; Animals; Macrophages, Alveolar / metabolism; Macrophages / metabolism; Lung / metabolism; Promoter Regions, Genetic; Proteins / metabolism; MafB Transcription Factor / genetics; MafB Transcription Factor / metabolism
TL;DR: A strain that expresses mTOM protein in all the cells of mouse body except for those that express Mafb-Cre-regulated mEGFP provides a unique tool to induce gene deletion in alveolar macrophages that encounter Th2 microenvironment in the lung airspaces. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2022 journal article

Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells.

Toxicology and Applied Pharmacology, 11.

By: R. Lamichhane*, S. Patial* & Y. Saini*

MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Bleomycin / toxicity; Chemokine CXCL10 / adverse effects; Cytokines; Female; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis / pathology; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / genetics; Interleukin-10; Interleukin-6; Interleukin-7; Lung; Lung Injury / pathology; Male; Mice; Mice, Inbred C57BL; Myeloid Cells; Pneumonia / chemically induced; RNA; Transcriptome
TL;DR: There are inherent transcriptomic differences between the male and female lung myeloid cells and that the pro-inflammatory nature of male myeloids cells is sufficient to increase the susceptibility of female mice to BLM-induced inflammation. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2022 journal article

In Vitro Screening Method for Characterization of Macrophage Activation Responses.

Methods and Protocols, 8.

By: B. Lewis*, S. Patial* & Y. Saini*

TL;DR: A high-throughput and stringent assay to determine macrophage activation markers developed in this article can be adapted for biomarker determination in pathological conditions and toxicant/drug safety screening. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2022 journal article

Induction of whole-body gene deletion <i>via</i> R26-regulated tamoxifen-inducible Cre recombinase activity.

Frontiers in Pharmacology.

By: R. Kumar*, Y. Mao*, S. Patial* & Y. Saini*

TL;DR: It is demonstrated that a combination of TAM-diet with either TAM-injections or TAM-oral gavage can be employed for the efficient deletion of a gene in the whole body and no recombination was evident in any of the tissues examined from the control mice. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2022 article

NLRP3 inflammasome is dispensable in methicillin resistant<i>Staphylococcus aureus</i>urinary tract infection

Paudel, S., Rogers, K. A., Kumar, R., Saini, Y., Patial, S., & Kulkarni, R. (2022, November).

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2022 journal article

Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2.

Scientific Reports, 1.

By: T. Vo*, K. Paudel*, I. Choudhary*, S. Patial* & Y. Saini*

MeSH headings : Animals; COVID-19 / chemically induced; COVID-19 / metabolism; Disease Susceptibility / chemically induced; Disease Susceptibility / metabolism; Macrophages, Alveolar / metabolism; Mice; Ozone / toxicity; SARS-CoV-2 / metabolism; Serine Endopeptidases / metabolism; Up-Regulation / drug effects
TL;DR: The data indicate that the unhealthy levels of ozone in the environment may predispose individuals to severe SARS-CoV-2 infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2022 journal article

Silencing of RNA binding protein, ZFP36L1, promotes epithelial-mesenchymal transition in liver cancer cells by regulating transcription factor ZEB2.

Cellular Signalling, 9.

By: J. Chen*, S. Patial* & Y. Saini*

TL;DR: The results demonstrate that ZFP36L1 suppresses EMT in hepatic cancer cells by down-regulating the expression of EMT-inducing transcription factor, ZEB2 and suggest an important role of ZFP 36L1 in the development, progression, and metastasis of hepatocellular cancer. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2021 journal article

Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs.

Scientific Reports, 7.

By: S. Patial*, B. Lewis*, T. Vo*, I. Choudhary*, K. Paudel*, Y. Mao*, D. Singamsetty*, F. Brombacher*, Y. Saini*

MeSH headings : Alleles; Animals; Bronchoalveolar Lavage Fluid; Eosinophils / metabolism; Immunity, Innate; Interleukin-13 / metabolism; Interleukin-33 / metabolism; Ligands; Lung / metabolism; Lymphocytes / cytology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myeloid Cells / metabolism; Pulmonary Eosinophilia; Receptors, Cell Surface / metabolism
TL;DR: It is established that myeloid-IL4Rα is an indispensable component of the IL-33-ILCsIL-13-IL 4Rα axis of eosinophil recruitment. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2021 journal article

Postnatal Ozone Exposure Disrupts Alveolar Development, Exaggerates Mucoinflammatory Responses, and Suppresses Bacterial Clearance in Developing <i>Scnn1b</i>-Tg<sup>+</sup> Mice Lungs.

Journal of Immunology (Baltimore, Md. : 1950), 8.

By: I. Choudhary*, T. Vo*, K. Paudel*, R. Yadav*, Y. Mao*, S. Patial*, Y. Saini*

MeSH headings : Animals; Bacteria / immunology; Cystic Fibrosis / immunology; Disease Models, Animal; Epithelial Sodium Channels / immunology; Inflammation / immunology; Lung / immunology; Macrophages / immunology; Mice; Mice, Transgenic; Mucus / immunology; Ozone / adverse effects; Postnatal Care
TL;DR: Ozone exposure results in alveolar space remodeling during active phases of lung development and markedly exaggerates the mucoinflammatory outcomes of pediatric-onset lung disease, including bacterial infections, granulocytic inflammation, mucus obstruction, and alveolars space enlargement. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2021 journal article

Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease.

Scientific Reports, 12.

By: I. Choudhary*, T. Vo*, K. Paudel*, X. Wen*, R. Gupta*, M. Kesimer*, S. Patial*, Y. Saini*

MeSH headings : Animals; Bronchoalveolar Lavage Fluid / chemistry; Cytokines / analysis; Female; Inflammation Mediators / analysis; Male; Mice; Mice, Inbred C57BL; Ozone / adverse effects; Pneumonia / diagnosis; Proteins / analysis
TL;DR: Exosomal, secretory, and cell-specific proteins and biological pathways following repetitive exposure of mice to ozone are identified and significantly enhanced intracellular localization of mucoinflammatory proteins including MUC5B and FIZZ1 in ozone-exposed mice is revealed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: August 2, 2023

2021 journal article

ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice.

The American Journal of Pathology, 2.

By: C. Bathula*, J. Chen*, R. Kumar*, P. Blackshear*, Y. Saini* & S. Patial*

MeSH headings : 3' Untranslated Regions; Animals; Butyrate Response Factor 1 / genetics; Butyrate Response Factor 1 / metabolism; Fatty Liver, Alcoholic / genetics; Fatty Liver, Alcoholic / metabolism; Fatty Liver, Alcoholic / pathology; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / metabolism; Inflammation / genetics; Inflammation / metabolism; Inflammation / pathology; Liver / metabolism; Liver / pathology; Mice; Mice, Knockout; Mutation; RNA Stability
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2021 article

ZFP36L1 regulates <i>Fgf21</i> mRNA turnover and modulates alcoholic hepatic steatosis and inflammation in mice

Bathula, C. S., Chen, J., Blackshear, P. J., Saini, Y., & Patial, S. (2021, May).

By: C. Bathula*, J. Chen*, P. Blackshear*, Y. Saini* & S. Patial*

TL;DR: The results demonstrate that ZFP36L1 inactivation protects against alcohol-induced hepatic steatosis and liver injury, possibly by stabilizing Fgf21 mRNA and suggest that the modulation of ZFP 36L1 may be beneficial in the prevention or treatment of human alcoholic liver disease. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2020 journal article

Ablation of IL-33 Suppresses <i>Th2</i> Responses but Is Accompanied by Sustained Mucus Obstruction in the <i>Scnn1b</i> Transgenic Mouse Model.

Journal of Immunology (Baltimore, Md. : 1950), 3.

By: B. Lewis*, T. Vo*, I. Choudhary*, A. Kidder*, C. Bathula*, C. Ehre*, N. Wakamatsu*, S. Patial*, S. Patial, Y. Saini*

MeSH headings : Animals; Bronchoalveolar Lavage Fluid / cytology; Bronchoalveolar Lavage Fluid / immunology; Cystic Fibrosis / diagnosis; Cystic Fibrosis / genetics; Cystic Fibrosis / immunology; Cystic Fibrosis / pathology; Disease Models, Animal; Eosinophils / immunology; Eosinophils / metabolism; Epithelial Sodium Channels / genetics; Humans; Interleukin-33 / genetics; Interleukin-33 / metabolism; Lung / cytology; Lung / immunology; Lung / pathology; Mice; Mice, Knockout; Mice, Transgenic; Mucin 5AC / metabolism; Mucus / immunology; Mucus / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / immunology; Respiratory Mucosa / metabolism; Th2 Cells / immunology; Th2 Cells / metabolism
TL;DR: Although IL- 33 modulates Th2 inflammatory responses and MUC5AC protein production, mucus obstruction is not dependent on IL-33, and histological features, including subepithelial airway inflammation and alveolar space enlargement, were somewhat exaggerated inIL-33KO/Tg+ mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2020 journal article

Compartment-specific transcriptomics of ozone-exposed murine lungs reveals sex- and cell type-associated perturbations relevant to mucoinflammatory lung diseases.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 1.

By: I. Choudhary*, T. Vo*, K. Paudel*, S. Patial* & Y. Saini*

Source: ORCID
Added: August 2, 2023

2020 journal article

Lung macrophages: current understanding of their roles in Ozone-induced lung diseases.

Critical Reviews in Toxicology, 4.

By: S. Patial* & Y. Saini*

MeSH headings : Air Pollutants / toxicity; Air Pollution / statistics & numerical data; Animals; Humans; Lung / physiopathology; Lung Diseases / epidemiology; Lung Diseases / etiology; Macrophages / drug effects; Macrophages / physiology; Ozone / toxicity; United States
TL;DR: There is a vital need for additional policy-relevant scientific information, including mechanistic studies to further define the role of macrophages in response to O3, and a comprehensive list of currently known macrophage-specific roles in O3-induced lung diseases is included in this review. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2020 article

Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2

Vo, T., Paudel, K., Choudhary, I., Patial, S., & Saini, Y. (2020, November).

By: T. Vo*, K. Paudel*, I. Choudhary*, S. Patial* & Y. Saini*

TL;DR: The data indicate that the unhealthy levels of ozone in the environment may predispose individuals to severe SARS-CoV-2 infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2020 journal article

The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.

Journal of Immunology (Baltimore, Md. : 1950), 9.

By: B. Lewis*, I. Choudhary*, K. Paudel*, Y. Mao*, R. Sharma*, Y. Wang*, J. Deshane*, R. Boucher*, S. Patial*, Y. Saini*

MeSH headings : Animals; Cells, Cultured; Cystic Fibrosis / immunology; Disease Models, Animal; Epithelial Cells / metabolism; Epithelial Cells / pathology; Epithelial Sodium Channels / genetics; Homeodomain Proteins / genetics; Humans; Immunity, Innate; Inflammation / immunology; Metaplasia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mucin-5B / genetics; Mucin-5B / metabolism; Respiratory Tract Diseases / immunology; Up-Regulation
TL;DR: Collectively, these data indicate that, in the context of airway mucus obstruction, the adaptive immune system suppresses antibacterial macrophage activation, whereas the innate lymphoid system contributes to MCM, mucin production, and mucus obstruct. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2020 journal article

The Tristetraprolin Family of RNA-Binding Proteins in Cancer: Progress and Future Prospects.

Cancers, 6.

By: Y. Saini*, J. Chen* & S. Patial*

TL;DR: The various hallmark molecular traits of cancers that are reported to be regulated by the tristetraprolin family of RNA-binding proteins are summarized and the role of the TTP family RBPs in the regulation of trait-associated mRNA targets in relevant cancer types/cell lines is emphasized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2020 journal article

Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice.

Frontiers in Immunology.

By: I. Choudhary*, T. Vo*, C. Bathula*, R. Lamichhane*, B. Lewis*, J. Looper*, S. Jeyaseelan*, P. Blackshear*, Y. Saini*, S. Patial*

MeSH headings : Acute Lung Injury / chemically induced; Acute Lung Injury / prevention & control; Alveolar Epithelial Cells / metabolism; Animals; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Chemotaxis, Leukocyte; Cytokines / physiology; Endothelial Cells / metabolism; Female; Fibroblasts / metabolism; Lipopolysaccharides / toxicity; Male; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils / immunology; Radiation Chimera; Tristetraprolin / biosynthesis; Tristetraprolin / deficiency; Tristetraprolin / genetics; Tristetraprolin / physiology; Up-Regulation
TL;DR: It is suggested that non-HPCs-specific overexpression of TTP within the lungs protects against ALI via downregulation of neutrophil chemoattractants and reduction in neutrophilic infiltration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2020 article

Vesicular and Extravesicular Protein Signatures From the Airspaces of Ozone-Exposed Mice Reflect Muco-Inflammatory Disturbances.

Choudhary, I., Vo, T., Paudel, K., Gupta, R., Kesimer, M., Patial, S., & Saini, Y. (2020, December).

By: I. Choudhary*, T. Vo*, K. Paudel*, R. Gupta*, M. Kesimer*, S. Patial*, Y. Saini*

TL;DR: This study identified exosomal, secretory, and cell-specific proteins and biological pathways following sub-chronic exposure of mice to ozone, indicating the cellular sources of the proteins that are ferried in the exosomes upon ozone-induced lung injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: August 2, 2023

2019 journal article

Immunopathology of Airway Surface Liquid Dehydration Disease.

Journal of Immunology Research.

By: B. Lewis*, S. Patial* & Y. Saini*

MeSH headings : Airway Obstruction / immunology; Airway Obstruction / metabolism; Airway Obstruction / microbiology; Airway Obstruction / physiopathology; Animals; Cystic Fibrosis / genetics; Cystic Fibrosis / immunology; Cystic Fibrosis / microbiology; Cystic Fibrosis / physiopathology; Cystic Fibrosis Transmembrane Conductance Regulator / metabolism; Dehydration / metabolism; Dehydration / physiopathology; Disease Models, Animal; Epithelial Sodium Channels / genetics; Ion Channels / deficiency; Ion Channels / genetics; Leukocytes / immunology; Lung / immunology; Lung / physiopathology; Macrophages / immunology; Mice; Mice, Transgenic; Mucociliary Clearance / genetics; Mucociliary Clearance / immunology; Respiratory Tract Infections / immunology; Respiratory Tract Infections / physiopathology
TL;DR: The Scnn1b-Tg+ mouse model exhibits airway surface liquid (ASL) dehydration, impaired MCC, increased mucus production, and early spontaneous pulmonary bacterial infections and various unanswered questions on the initiation and progression of mucobstruction and bacterial infections are analyzed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2018 journal article

Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis.

Physiological Reports, 4.

MeSH headings : Animals; Bronchitis, Chronic / pathology; Disease Models, Animal; Lung / pathology; Macrophages / pathology; Mice; Mice, Transgenic
TL;DR: Dynamic roles of MΦ are identified in moderating, rather than exacerbating, the severity of lung disease in a model of CB, as indicated by an increased incidence of mucus plugging, mucous cells, airway inflammation, higher levels of cytokines/chemokines, and worsened alveolar airspace enlargement. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: August 2, 2023

2017 journal article

Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease.

Journal of Immunology (Baltimore, Md. : 1950), 8.

MeSH headings : Animals; Animals, Newborn; Bacterial Infections / immunology; Bacterial Infections / physiopathology; Bacterial Load; Cell Movement; Cystic Fibrosis / immunology; Cystic Fibrosis / microbiology; Cystic Fibrosis / physiopathology; Disease Models, Animal; Down-Regulation; Epithelial Cells / immunology; Epithelial Cells / pathology; Epithelial Sodium Channels / deficiency; Epithelial Sodium Channels / genetics; Epithelial Sodium Channels / metabolism; Female; Goblet Cells / pathology; Humans; Immunoglobulin A / immunology; Interleukin-33 / genetics; Interleukin-33 / immunology; Interleukin-33 / metabolism; Lung / cytology; Lung / immunology; Lung / pathology; Lung Diseases, Obstructive / immunology; Lung Diseases, Obstructive / physiopathology; Mice; Mice, Transgenic; Mucin-5B; Mucus / metabolism; Neutrophils / immunology; Neutrophils / pathology; Neutrophils / physiology; Signal Transduction; Th2 Cells / immunology; Th2 Cells / pathology; Tobacco Smoke Pollution / adverse effects
TL;DR: The data indicate that household smoking may predispose neonates with muco-obstructive lung disease to bacterial exacerbations and that early postnatal SHS exposure reversibly suppresses IL-33 levels in airspaces which results in reduced neutrophil recruitment and diminished Th2 response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2017 journal article

Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.

The American Journal of Pathology, 1.

By: D. Yu*, Y. Saini*, G. Chen*, A. Ghio*, H. Dang*, K. Burns*, Y. Wang*, R. Davis* ...

MeSH headings : Animals; Cell Proliferation; Disease Models, Animal; Epithelial Sodium Channels / genetics; Epithelial Sodium Channels / metabolism; Female; Male; Meibomian Glands / metabolism; Mice; Mice, Knockout; Phenotype; Pseudohypoaldosteronism / genetics; Pseudohypoaldosteronism / metabolism; Sex Factors; Tears / metabolism
TL;DR: Human subjects with pseudohypoaldosteronism-1 because of loss-of-function mutations in epithelial sodium channel (ENaC) subunits exhibit meibomian gland (MG) dysfunction and cell proliferation assays revealed lower proliferation rates of MG cells derived from β ENaC MG KO than control mice, suggesting that βEN aC plays a role in cell renewal of mouse MG. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2016 journal article

Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses.

American Journal of Respiratory Cell and Molecular Biology, 2.

By: Y. Saini*, K. Wilkinson*, K. Terrell*, K. Burns*, A. Livraghi-Butrico*, C. Doerschuk*, W. O'Neal*, R. Boucher*

MeSH headings : Animals; Animals, Newborn; Cytokines / immunology; Cytokines / metabolism; Diphtheria Toxin / genetics; Diphtheria Toxin / metabolism; Disease Models, Animal; Epithelial Sodium Channels / genetics; Epithelial Sodium Channels / metabolism; Genetic Predisposition to Disease; Inflammation Mediators / immunology; Inflammation Mediators / metabolism; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Lung / immunology; Lung / metabolism; Lung / microbiology; Macrophages / immunology; Macrophages / metabolism; Mice, Inbred C57BL; Mice, Transgenic; Mucociliary Clearance; Muramidase / genetics; Pasteurella Infections / genetics; Pasteurella Infections / immunology; Pasteurella Infections / metabolism; Pasteurella Infections / microbiology; Pasteurella pneumotropica / immunology; Pasteurella pneumotropica / pathogenicity; Peptide Fragments / genetics; Peptide Fragments / metabolism; Phenotype; Pneumonia, Bacterial / genetics; Pneumonia, Bacterial / immunology; Pneumonia, Bacterial / metabolism; Pneumonia, Bacterial / microbiology; Promoter Regions, Genetic
TL;DR: Key MΦ-mucus clearance interactions with respect to both infectious and inflammatory components of muco-obstructive lung disease are identified. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2015 journal article

Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells.

Experimental Cell Research, 7.

By: A. Nair*, P. Ebenezer*, Y. Saini* & J. Francis*

MeSH headings : Angiotensin II; Animals; Antihypertensive Agents / pharmacology; Cell Line; Epithelial Cells / immunology; Epithelial Cells / metabolism; HMGB1 Protein / metabolism; Hypertension / chemically induced; Hypertension / complications; Hypertension / metabolism; Kidney Failure, Chronic / etiology; Kidney Failure, Chronic / immunology; Kidney Failure, Chronic / metabolism; Kidney Tubules / pathology; Losartan / pharmacology; NF-kappa B / metabolism; Rats; Signal Transduction; Toll-Like Receptor 4 / metabolism
TL;DR: A key role for HMGB1-TLR4 signaling is indicated in AngII-mediated inflammation in the renal epithelial cells, suggesting this pathway as a potential therapeutic target for hypertensive renal dysfunctions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2015 journal article

Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.

Biochemistry, 6.

By: H. Hwang*, S. Lynn*, A. Vengellur*, Y. Saini*, E. Grier*, S. Ferguson-Miller*, J. LaPres*

MeSH headings : Animals; Cell Hypoxia; Cells, Cultured; Clone Cells; Electron Transport Complex IV / antagonists & inhibitors; Electron Transport Complex IV / genetics; Electron Transport Complex IV / metabolism; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Enzyme Induction / drug effects; Enzyme Inhibitors / pharmacology; Gene Expression Profiling; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Mice; Mice, Transgenic; Mitochondria / drug effects; Mitochondria / enzymology; Mitochondria / metabolism; Oxidative Phosphorylation / drug effects; Oxygen Consumption / drug effects; RNA, Messenger / metabolism; Recombinant Proteins / metabolism; Transcriptional Activation / drug effects
TL;DR: It is proposed that adaptation to hypoxic stress of CcO as the main cellular oxygen consumer is mediated by induction of hypoxia-sensitive tissue-specific isoforms, and it is suggested that HIF1 plays a central role in maintaining homeostasis in cellular respiration duringhypoxic stress via regulation of C c oxidase activity. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2015 journal article

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.

PloS One.

By: Y. Saini*, S. Proper*, P. Dornbos*, K. Greenwood*, A. Kopec*, S. Lynn*, E. Grier*, L. Burgoon* ...

MeSH headings : Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors / deficiency; Basic Helix-Loop-Helix Transcription Factors / genetics; Gene Deletion; Gene Regulatory Networks; Genotype; Hypoxia-Inducible Factor 1, alpha Subunit / deficiency; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Lung / metabolism; Lung / pathology; Mice; Phenotype; Respiratory Distress Syndrome, Newborn / genetics; Respiratory Distress Syndrome, Newborn / metabolism; Respiratory Distress Syndrome, Newborn / pathology; Signal Transduction; Survival Analysis; Transcription, Genetic
TL;DR: Investigation of the independent role of Hif-2α in lung epithelium and its ability to alter H IF-1α-mediated lung maturation suggests that modulation of hormone-mediated, NF-κB, C/EBPα, and c-MYC signaling are central to HIF-mediated changes in lung development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2014 journal article

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration.

BMC Genomics, 9.

MeSH headings : Animals; Dehydration; Down-Regulation; Epithelial Sodium Channels / genetics; Epithelial Sodium Channels / metabolism; Gene Expression Profiling; Humans; Inflammation / genetics; Longitudinal Studies; Lung / metabolism; Macrophage Activation; Macrophages, Alveolar / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mucus / metabolism; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; Up-Regulation
TL;DR: The robust signatures observed in Scnn1b-Tg lung macrophages highlight their critical role in disease pathogenesis and emphasize the importance of region-, cell-type-, and time-dependent analyses to fully dissect the natural history of disease and the consequences of disease on normal lung development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2013 journal article

Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.

Toxicological Sciences : an Official Journal of the Society of Toxicology, 2.

By: S. Proper*, Y. Saini*, K. Greenwood*, L. Bramble, N. Downing & J. Lapres*

MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / deficiency; Basic Helix-Loop-Helix Transcription Factors / genetics; Bronchoalveolar Lavage Fluid / cytology; Cobalt / toxicity; Cytokines / genetics; Cytokines / immunology; Disease Models, Animal; Doxycycline / pharmacology; Gene Expression Profiling; Immunohistochemistry; Lung Injury / chemically induced; Lung Injury / complications; Lung Injury / immunology; Lung Injury / pathology; Mice; Mice, Knockout; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / immunology; Pulmonary Alveoli / pathology; Pulmonary Eosinophilia / chemically induced; Pulmonary Eosinophilia / etiology; Pulmonary Eosinophilia / immunology; Pulmonary Eosinophilia / pathology; Respiratory Mucosa / drug effects; Respiratory Mucosa / immunology; Respiratory Mucosa / pathology
TL;DR: Results show that loss of HIF2α leads to enhanced eosinophilic inflammation and increased goblet cell metaplasia, and suggest that epithelial Hif2α signaling does play an important role in modulating the inflammatory and repair response in the lung. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2011 journal article

G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice.

Journal of Cellular Physiology, 5.

By: S. Patial*, S. Shahi*, Y. Saini*, T. Lee*, N. Packiriswamy*, D. Appledorn*, J. Lapres*, A. Amalfitano*, N. Parameswaran*

MeSH headings : Animals; Cells, Cultured; Cytokines / metabolism; Female; G-Protein-Coupled Receptor Kinase 5 / deficiency; G-Protein-Coupled Receptor Kinase 5 / drug effects; G-Protein-Coupled Receptor Kinase 5 / genetics; G-Protein-Coupled Receptor Kinase 5 / metabolism; I-kappa B Proteins / metabolism; Inflammation / chemically induced; Inflammation / enzymology; Inflammation / immunology; Inflammation Mediators / metabolism; Lipopolysaccharides / pharmacology; Lung / drug effects; Lung / enzymology; Lung / immunology; Macrophages, Peritoneal / drug effects; Macrophages, Peritoneal / enzymology; Macrophages, Peritoneal / immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-KappaB Inhibitor alpha; NF-kappa B / metabolism; Neutrophil Infiltration / drug effects; Phosphorylation; Signal Transduction / drug effects; Time Factors; Toll-Like Receptor 4 / agonists; Toll-Like Receptor 4 / metabolism
TL;DR: It is demonstrated that GRK5 is an important positive regulator of lipopolysaccharide (LPS, a TLR4 agonist)‐induced inflammatory cytokine and chemokine production in vivo and a key modulator of LPS‐inducedinflammatory response in vitro. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2011 journal article

Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice.

Journal of Cellular Physiology, 3.

By: S. Patial*, Y. Saini*, S. Parvataneni*, D. Appledorn*, G. Dorn*, J. Lapres*, A. Amalfitano*, P. Senagore*, N. Parameswaran*

TL;DR: Previously undescribed negative regulatory role for GRK2 is revealed in TLR4‐induced p105‐ERK pathway as well as in the consequent inflammatory cytokine/chemokine production and endotoxemia in mice. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2011 journal article

Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 3.

By: K. Greenwood*, S. Proper*, Y. Saini*, L. Bramble, D. Jackson-Humbles, J. Wagner*, J. LaPres*

MeSH headings : Airway Resistance / drug effects; Animals; Animals, Newborn; Asthma / chemically induced; Asthma / immunology; Asthma / metabolism; Bronchoalveolar Lavage Fluid / chemistry; Bronchoconstrictor Agents / pharmacology; Cell Count; Cytokines / metabolism; Eosinophil Major Basic Protein / metabolism; Eosinophils / metabolism; Eosinophils / pathology; Female; Gene Expression; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit / deficiency; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Immunity, Innate; Inflammation / immunology; Inflammation / metabolism; Inflammation / pathology; Lung / metabolism; Lung / pathology; Methacholine Chloride / pharmacology; Mice; Mice, Transgenic; Ovalbumin; Random Allocation
TL;DR: The results suggest that epithelial hypoxia inducible factor-1α plays an important role in establishing the innate immunity of the lung and epithelial-specific deficiency in the transcription factor, during early postnatal development, increases the severity of inflammation and functional airway resistance, following ovalbumin challenge. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2011 journal article

The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.

The Journal of Pharmacology and Experimental Therapeutics, 8.

By: E. Sparkenbaugh*, Y. Saini*, K. Greenwood, J. LaPres, J. Luyendyk, B. Copple, J. Maddox, P. Ganey, R. Roth

MeSH headings : Acetaminophen / toxicity; Animals; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Chemical and Drug Induced Liver Injury / prevention & control; Hepatocytes / drug effects; Hepatocytes / metabolism; Hepatocytes / pathology; Hypoxia-Inducible Factor 1, alpha Subunit / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Oxidative Stress / drug effects; Oxidative Stress / physiology
TL;DR: Hypoxia-inducible factor-1α contributes to hemostasis, sterile inflammation, and early hepatocellular necrosis during the pathogenesis of APAP toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2010 journal article

Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation.

Toxicological Sciences : an Official Journal of the Society of Toxicology, 8.

By: Y. Saini*, K. Greenwood*, C. Merrill, K. Kim, S. Patial*, N. Parameswaran*, J. LaPres*

MeSH headings : Animals; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Cobalt / toxicity; Cytokines / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / physiology; Immunity, Innate / drug effects; Inflammation / etiology; Lung / drug effects; Lung / immunology; Lung / pathology; Mice; Neutrophil Infiltration / drug effects
TL;DR: The timing of these results suggests that the loss of epithelial-derived HIF1alpha alters the lung's innate immune response and biases the tissue toward a Th2-mediated inflammation, which is linked to disease progression. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2009 journal article

Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 2.

By: Y. Saini*, K. Kim, R. Lewandowski, L. Bramble & J. Lapres*

MeSH headings : Animals; Asthma / chemically induced; Asthma / immunology; Body Weight; Bronchoalveolar Lavage Fluid / cytology; Cobalt / immunology; Cobalt / pharmacology; Cytokines / immunology; Gene Expression Profiling; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Inflammation / chemically induced; Inflammation / immunology; Lung / cytology; Lung / drug effects; Lung / immunology; Lung / pathology; Mice; Mice, Knockout; Mice, Transgenic; Th2 Cells / immunology
TL;DR: The results suggest that epithelial-derived HIF signaling has a critical role in establishing a tissue's inflammatory response, and compromised HIF1alpha signaling biases the tissue towards a Th2-mediated reaction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

2008 journal article

HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice.

The Journal of Biological Chemistry, 11.

By: Y. Saini* & J. LaPres*

MeSH headings : Adaptation, Physiological / genetics; Animals; Animals, Newborn; Cell Differentiation / genetics; Disease Models, Animal; Female; Fetal Development / genetics; Fetus / metabolism; Fetus / pathology; Gene Knockdown Techniques / methods; Glycogen / genetics; Glycogen / metabolism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Infant, Newborn; Male; Mice; Mice, Transgenic; Oxygen / metabolism; Pregnancy; Pulmonary Alveoli / embryology; Pulmonary Alveoli / pathology; Pulmonary Surfactant-Associated Proteins / genetics; Pulmonary Surfactant-Associated Proteins / metabolism; Respiratory Distress Syndrome, Newborn / genetics; Respiratory Distress Syndrome, Newborn / metabolism; Respiratory Distress Syndrome, Newborn / pathology; Respiratory Distress Syndrome, Newborn / physiopathology; Respiratory Mucosa / embryology; Respiratory Mucosa / pathology; Signal Transduction / genetics
TL;DR: Ulastructural analysis of lungs from HIF1α deletion pups had high levels of glycogen, aberrant septal development, and decreased expression of several factors necessary for proper lung development, including HIF2α, β-catenin, and vascular endothelial growth factor. (via Semantic Scholar)
Source: ORCID
Added: August 2, 2023

2007 journal article

Virus neutralizing antibody response in mice and dogs with a bicistronic DNA vaccine encoding rabies virus glycoprotein and canine parvovirus VP2.

Vaccine, 5.

By: S. Patial*, V. Chaturvedi, A. Rai, M. Saini, R. Chandra, Y. Saini*, P. Gupta

MeSH headings : Animals; Antibodies, Viral / biosynthesis; Antibodies, Viral / immunology; Antigens, Surface / genetics; Antigens, Surface / immunology; Capsid Proteins / genetics; Capsid Proteins / immunology; Cattle; Cell Line; Cricetinae; Dogs; Glycoproteins / genetics; Glycoproteins / immunology; Mice; Parvovirus, Canine / genetics; Parvovirus, Canine / immunology; Rabies / immunology; Rabies / prevention & control; Rabies / veterinary; Rabies Vaccines / genetics; Rabies Vaccines / immunology; Rabies Vaccines / pharmacology; Rabies virus / genetics; Rabies virus / immunology; Vaccines, DNA / genetics; Vaccines, DNA / immunology; Vaccines, DNA / pharmacology; Viral Proteins / genetics; Viral Proteins / immunology
TL;DR: It is indicated that bicistronic DNA vaccine can be used in dogs to induce virus neutralizing immune responses against both rabies and CPV. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 2, 2023

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