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Myeloid cell-specific HMGB1 deficiency exaggerates mucoinflammatory response in Scnn1b-Tg+ mice. https://doi.org/10.21203/rs.3.rs-5510137/v1 Chauhan, N., Xiong, Y., Ren, S., Dwivedy, A., Magazine, N., Zhou, L., … Wang, X. (2024). Net-Shaped DNA Nanostructures Designed for Rapid/Sensitive Detection and Potential Inhibition of the SARS-CoV-2 Virus. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.4c12780 Vo, T., Kumar, R., Lamichhane, R., Choudhary, I., Rekha, K. C., Mao, Y., … Saini, Y. (2025). Protocol for X-ray irradiation of C57BL/6J recipient mice followed by the transplantation of mTomato-expressing bone marrow cells. STAR PROTOCOLS, 6(1). https://doi.org/10.1016/j.xpro.2024.103504 Hu, Y., Patial, S., Saini, Y., & Yoshimura, M. (2024). Role of Myeloid Cell-Specific Adenylyl Cyclase Type 7 in Lipopolysaccharide- and Alcohol-Induced Immune Responses. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms252312831 Paudel, S., Kumar, R., Rogers, K. A., Saini, Y., Patial, S., & Kulkarni, R. (2024). The NLRP3 Inflammasome Is Dispensable in Methicillin-Resistant Staphylococcus aureus Urinary Tract Infection. PATHOGENS, 13(2). https://doi.org/10.3390/pathogens13020106 Sundar, I. K., Duraisamy, S. K., Choudhary, I., Saini, Y., & Silveyra, P. (2023). Acute and Repeated Ozone Exposures Differentially Affect Circadian Clock Gene Expression in Mice. Advanced Biology, 5. https://doi.org/10.1002/adbi.202300045 Mao, Y., Patial, S., & Saini, Y. (2023). Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2022.944772 Das, D. N., Puthusseri, B., Gopu, V., Krishnan, V., Bhagavath, A. K., Bolla, S., … Shetty, S. (2023). Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00178.2022 Kubra, K. T., Akhter, Saini, Y., Kousoulas, K. G., & Barabutis, N. (2022). Activating transcription factor 6 protects against endothelial barrier dysfunction. Cellular Signalling, 11. https://doi.org/10.1016/j.cellsig.2022.110432 Vo, T., & Saini, Y. (2022). Case report: Mafb promoter activity may define the alveolar macrophage dichotomy. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2022.1050494 Patial, S., Kumar, R., & Saini, Y. (2022). Diagnostic Veterinary Pathology and its relevance to animal and human health. In G. Mal, R. Sharma, B. Singh, U. S. Pati, D. Gopinath, G. Jairath, & R. (Eds.), Current Scenario and Future Challenges of Animal Health and Production in the North-Western Himalayan Region (pp. 39–41). A: ICAR- Indian Veterinary Research Institute, Regional Station. Lamichhane, R., Patial, S., & Saini, Y. (2022). Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells. Toxicology and Applied Pharmacology, 11. https://doi.org/10.1016/j.taap.2022.116228 Lewis, B. W., Patial, S., & Saini, Y. (2022). In Vitro Screening Method for Characterization of Macrophage Activation Responses. Methods and Protocols, 8. https://doi.org/10.3390/mps5050068 Kumar, R., Mao, Y., Patial, S., & Saini, Y. (2022). Induction of whole-body gene deletion via R26-regulated tamoxifen-inducible Cre recombinase activity. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2022.1018798 Paudel, S., Rogers, K. A., Kumar, R., Saini, Y., Patial, S., & Kulkarni, R. (2022, November). NLRP3 inflammasome is dispensable in methicillin resistantStaphylococcus aureusurinary tract infection. https://doi.org/10.1101/2022.11.11.516235 Vo, T., Paudel, K., Choudhary, I., Patial, S., & Saini, Y. (2022). Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2. Scientific Reports, 1. https://doi.org/10.1038/s41598-022-04906-8 Chen, J., Patial, S., & Saini, Y. (2022). Silencing of RNA binding protein, ZFP36L1, promotes epithelial-mesenchymal transition in liver cancer cells by regulating transcription factor ZEB2. Cellular Signalling, 9. https://doi.org/10.1016/j.cellsig.2022.110462 Patial, S., Lewis, B. W., Vo, T., Choudhary, I., Paudel, K., Mao, Y., … Saini, Y. (2021). Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs. Scientific Reports, 7. https://doi.org/10.1038/s41598-021-94843-9 Choudhary, I., Vo, T., Paudel, K., Yadav, R., Mao, Y., Patial, S., & Saini, Y. (2021). Postnatal Ozone Exposure Disrupts Alveolar Development, Exaggerates Mucoinflammatory Responses, and Suppresses Bacterial Clearance in Developing Scnn1b-Tg+ Mice Lungs. Journal of Immunology (Baltimore, Md. : 1950), 8. https://doi.org/10.4049/jimmunol.2001286 Choudhary, I., Vo, T., Paudel, K., Wen, X., Gupta, R., Kesimer, M., … Saini, Y. (2021). Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease. Scientific Reports, 12. https://doi.org/10.1038/s41598-021-02256-5 Bathula, C. S., Chen, J., Kumar, R., Blackshear, P. J., Saini, Y., & Patial, S. (2021). ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice. The American Journal of Pathology, 2. https://doi.org/10.1016/j.ajpath.2021.10.017 Bathula, C. S., Chen, J., Blackshear, P. J., Saini, Y., & Patial, S. (2021, May). ZFP36L1 regulates Fgf21 mRNA turnover and modulates alcoholic hepatic steatosis and inflammation in mice. https://doi.org/10.1101/2021.05.11.443631 Lewis, B. W., Vo, T., Choudhary, I., Kidder, A., Bathula, C., Ehre, C., … Saini, Y. (2020). Ablation of IL-33 Suppresses Th2 Responses but Is Accompanied by Sustained Mucus Obstruction in the Scnn1b Transgenic Mouse Model. Journal of Immunology (Baltimore, Md. : 1950), 3. https://doi.org/10.4049/jimmunol.1900234 Choudhary, I., Vo, T., Paudel, K., Patial, S., & Saini, Y. (2020). Compartment-specific transcriptomics of ozone-exposed murine lungs reveals sex- and cell type-associated perturbations relevant to mucoinflammatory lung diseases. American Journal of Physiology. Lung Cellular and Molecular Physiology, 1. https://doi.org/10.1152/ajplung.00381.2020 Patial, S., & Saini, Y. (2020). Lung macrophages: current understanding of their roles in Ozone-induced lung diseases. Critical Reviews in Toxicology, 4. https://doi.org/10.1080/10408444.2020.1762537 Vo, T., Paudel, K., Choudhary, I., Patial, S., & Saini, Y. (2020, November). Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2. https://doi.org/10.1101/2020.11.10.377408 Lewis, B. W., Choudhary, I., Paudel, K., Mao, Y., Sharma, R., Wang, Y., … Saini, Y. (2020). The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice. Journal of Immunology (Baltimore, Md. : 1950), 9. https://doi.org/10.4049/jimmunol.2000530 Saini, Y., Chen, J., & Patial, S. (2020). The Tristetraprolin Family of RNA-Binding Proteins in Cancer: Progress and Future Prospects. . Cancers, 6. https://doi.org/10.3390/cancers12061539 Choudhary, I., Vo, T., Bathula, C. S., Lamichhane, R., Lewis, B. W., Looper, J., … Patial, S. (2020). Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.02164 Choudhary, I., Vo, T., Paudel, K., Gupta, R., Kesimer, M., Patial, S., & Saini, Y. (2020, December). Vesicular and Extravesicular Protein Signatures From the Airspaces of Ozone-Exposed Mice Reflect Muco-Inflammatory Disturbances. https://doi.org/10.21203/rs.3.rs-132766/v1 Lewis, B. W., Patial, S., & Saini, Y. (2019). Immunopathology of Airway Surface Liquid Dehydration Disease. Journal of Immunology Research. https://doi.org/10.1155/2019/2180409 Saini, Y., Lewis, B. W., Yu, D., Dang, H., Livraghi-Butrico, A., Del, P. F., … Boucher, R. C. (2018). Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis. Physiological Reports, 4. https://doi.org/10.14814/phy2.13677 Lewis, B., Sharma, R., Langohr, I., Noel, A., Patial, S., Penn, A., & Saini, Y. (2017). Early Postnatal Secondhand Smoke (SHS) Exposure Disrupts Bacterial Clearance and Abolishes Th2 Responses in Muco-Obstructive Lung Disease. Society of Toxicology. Poster Presentation. Lewis, B. W., Sultana, R., Sharma, R., Noël, A., Langohr, I., Patial, S., … Saini, Y. (2017). Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease. Journal of Immunology (Baltimore, Md. : 1950), 8. https://doi.org/10.4049/jimmunol.1700144 Yu, D., Saini, Y., Chen, G., Ghio, A. J., Dang, H., Burns, K. A., … Boucher, R. C. (2017). Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice. The American Journal of Pathology, 1. https://doi.org/10.1016/j.ajpath.2017.09.016 Lewis, L., Sultana, R., & Saini, Y. (2016). In Vitro Screening Method for Characterization of Macrophage Activation Responses to Environmental Stress. The Toxicologist. Poster Presentation. Alexis, N., Wells, H., Miller, S., Goldstein, B., Saini, Y., Donaldson, S., & Peden, D. (2016). M1 M2 Sputum Macrophage Profiles in Healthy Individuals, Airway Disease, Tobacco Smokers and Alternative Tobacco Users. . AAI meeting in American Journal of Respiratory and Critical Care Medicine, 193:A4347. Poster Presentation. Saini, Y. (2016). Understanding macrophage recruitment to the stressed airspaces. AAI meeting abstract published in J Immunoll, 196(1 Supplement). Poster Presentation. Nair, A. R., Ebenezer, P. J., Saini, Y., & Francis, J. (2015). Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells. Experimental Cell Research, 7. https://doi.org/10.1016/j.yexcr.2015.05.011 J. Sesma, A. L.-B. (2015). Blockage of the P2y14-receptor inhibits neutrophil infiltration in chronic lung diseases. . ATS meeting abstract published in Am J Respir Crit Care Med. Hwang, H. J., Lynn, S. G., Vengellur, A., Saini, Y., Grier, E. A., Ferguson-Miller, S. M., & LaPres, J. J. (2015). Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes. Biochemistry, 6. https://doi.org/10.1021/bi5012892 Saini, Y., Proper, S. P., Dornbos, P., Greenwood, K. K., Kopec, A. K., Lynn, S. G., … LaPres, J. J. (2015). Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice. PloS One. https://doi.org/10.1371/journal.pone.0139270 Saini, Y., Wilkinson, K. J., Terrell, K. A., Burns, K. A., Livraghi-Butrico, A., Doerschuk, C. M., … Boucher, R. C. (2016). Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses. American Journal of Respiratory Cell and Molecular Biology, 2. https://doi.org/10.1165/rcmb.2014-0111oc Alexis, N., Wells, H., Yogesh Saini, L. B., Allbritton, N., & Muhlebach, M. (2014). Application of isoraft single cell isolation for analysis of pediatric BAL macrophages. AAAAI meeting. Abstract published in the Journal of Allergy and Clinical Immunology, 133) supplement (page AB142. Saini, Y., Dang, H., Livraghi-Butrico, A., Kelly, E. J., Jones, L. C., O'Neal, W. K., & Boucher, R. C. (2014). Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration. BMC Genomics, 9. https://doi.org/10.1186/1471-2164-15-726 KK Greenwood, S. P. P. (2013). Epithelial-Derived Hypoxia Inducible Factor-1/2α Plays a Role in Programming the Innate Immune Response of the Lung. Society of Toxicology, 256. Proper, S. P., Saini, Y., Greenwood, K. K., Bramble, L. A., Downing, N. J., & Lapres, J. J. (2013). Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicological Sciences : an Official Journal of the Society of Toxicology, 2. https://doi.org/10.1093/toxsci/kft253 Sesma, J., Yogesh Saini, J. M., Claire Doerschuk, A. L., Kreda, S., Harden, T., & Lazarowski, E. (2013). UDP-glucose Contributes to Neutrophil Infiltration in CF Lung Disease. . North American Cystic Fibrosis Conference abstract published in Pediatric Pulmonology, 48) supplement S36. Yogesh Saini, H. D. (2012). Macrophage activation patterns and development of airway inflammation in Scnn1b transgenic mic. North American Cystic Fibrosis Conference abstract published in Pediatric Pulmonology, 47) supplement S35. Thakur, S. D., Vaid, R. K., Panda, A. K., & Saini, Y. (2012). Marine mammal brucellosis: A new dimension to an old zoonosis. CURRENT SCIENCE, 103(8), 17391817. A Livraghi-Butrico, E. A. D. (2012). Mechanisms of host defense during airway mucus obstruction in Scnn1b transgenic mice, a mouse model of COPD. . Proc Am Thorac Soc., 9(2), 82–83. Yogesh Saini, K. T. (2012). The role of macrophages in lung inflammation in a mouse model of chronic bronchitis. Experimental Biology Meeting abstract published in FASEB Journa, 26(697). Greenwood, K. K., Proper, S. P., Saini, Y., Bramble, L. A., Jackson-Humbles, D. N., Wagner, J. G., & LaPres, J. J. (2011). Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma. American Journal of Physiology. Lung Cellular and Molecular Physiology, 3. https://doi.org/10.1152/ajplung.00193.2011 Sparkenbaugh, E. M., Saini, Y., Greenwood, K. K., LaPres, J. J., Luyendyk, J. P., Copple, B. L., … Roth, R. A. (2011). The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity. The Journal of Pharmacology and Experimental Therapeutics, 8. https://doi.org/10.1124/jpet.111.180521 Yogesh Saini, K. T. (2011). The roles of macrophages in determining the initiation, progression and resolution of lung inflammation in a mouse model of chronic bronchitis. North American Cystic Fibrosis Conference, 134) supplement 34. Saini, Y., Greenwood, K. K., Merrill, C., Kim, K. Y., Patial, S., Parameswaran, N., & LaPres, J. J. (2010). Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation. Toxicological Sciences : an Official Journal of the Society of Toxicology, 8. https://doi.org/10.1093/toxsci/kfq155 Patial, S., Shahi, S., Saini, Y., Lee, T., Packiriswamy, N., Appledorn, D. M., … Parameswaran, N. (2011). G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice. Journal of Cellular Physiology, 5. https://doi.org/10.1002/jcp.22460 Patial, S., Saini, Y., Parvataneni, S., Appledorn, D. M., Dorn, G. W., Lapres, J. J., … Parameswaran, N. (2011). Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice. Journal of Cellular Physiology, 3. https://doi.org/10.1002/jcp.22384 The role of hypoxia inducible factors 1 alpha (HIF1α) in cobalt-induced acute and sub-chronic lung inflammation. . (2010). Society of Toxicology, The Toxicologist, 1569 (325), 2010. Hypoxia inducible factor 1 alpha (HIF1α) mediates ozone-induced lung injury in mice. (2009). Society of Toxicology, The Toxicologist, 2087 (434), 2009. Hypoxia inducible factor 1 alpha (HIF1α) mediates ozone-induced lung injury in mice. . (2009). Hypoxia and Consequences: From Molecule and Malady, The New York Academy of Sciences, 2009. Hypoxia inducible factor 1 alpha (HIF1α) protects mice lungs from cobalt-induced injury. (2009). 105. Society of Toxicology, The Toxicologist, 1569 (325), 2009. Hypoxia inducible factor 1 alpha (HIF1α) protects mice lungs from cobalt-induced injury. . (2009). Hypoxia and Consequences: From Molecule and Malady, The New York Academy of Sciences, 2009. Saini, Y., Kim, K. Y., Lewandowski, R., Bramble, L. A., & Lapres, J. J. (2009). Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. American Journal of Physiology. Lung Cellular and Molecular Physiology, 2. https://doi.org/10.1152/ajplung.00252.2009 Saini, Y., & LaPres, J. J. (2008). HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. The Journal of Biological Chemistry, 11. https://doi.org/10.1074/jbc.m805927200 Understanding Cobalt Chloride-Induced Lung Injury through Cytometric, Metabolomics, Proteomic, and Histological Analysis of Bronchioalveolar Lavage Fluid (BALF). (2008). Society of Toxicology, The Toxicologist, 2092 (430), 2008. Patial, S., Chaturvedi, V. K., Rai, A., Saini, M., Chandra, R., Saini, Y., & Gupta, P. K. (2007). Virus neutralizing antibody response in mice and dogs with a bicistronic DNA vaccine encoding rabies virus glycoprotein and canine parvovirus VP2. Vaccine, 5. https://doi.org/10.1016/j.vaccine.2007.02.051 G-protein coupled receptor kinase-5 mediates Toll-like receptor-4-induced NF-kB activation in primary macrophages and in vivo in mice. . AAI Annual Meeting, J. Immunol., Apr 2010; 184: 94.11.