Yogesh Saini

Paudel, S., Kumar, R., Rogers, K. A., Saini, Y., Patial, S., & Kulkarni, R. (2024). The NLRP3 Inflammasome Is Dispensable in Methicillin-Resistant <i>Staphylococcus aureus</i> Urinary Tract Infection. PATHOGENS, 13(2). https://doi.org/10.3390/pathogens13020106

Sundar, I. K., Duraisamy, S. K., Choudhary, I., Saini, Y., & Silveyra, P. (2023). Acute and Repeated Ozone Exposures Differentially Affect Circadian Clock Gene Expression in Mice. Advanced Biology, 5. https://doi.org/10.1002/adbi.202300045

Mao, Y., Patial, S., & Saini, Y. (2023). Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2022.944772

Das, D. N., Puthusseri, B., Gopu, V., Krishnan, V., Bhagavath, A. K., Bolla, S., … Shetty, S. (2023). Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.00178.2022

Kubra, K. T., Akhter, Saini, Y., Kousoulas, K. G., & Barabutis, N. (2022). Activating transcription factor 6 protects against endothelial barrier dysfunction. Cellular Signalling, 11. https://doi.org/10.1016/j.cellsig.2022.110432

Vo, T., & Saini, Y. (2022). Case report: <i>Mafb</i> promoter activity may define the alveolar macrophage dichotomy. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2022.1050494

Lamichhane, R., Patial, S., & Saini, Y. (2022). Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells. Toxicology and Applied Pharmacology, 11. https://doi.org/10.1016/j.taap.2022.116228

Lewis, B. W., Patial, S., & Saini, Y. (2022). In Vitro Screening Method for Characterization of Macrophage Activation Responses. Methods and Protocols, 8. https://doi.org/10.3390/mps5050068

Kumar, R., Mao, Y., Patial, S., & Saini, Y. (2022). Induction of whole-body gene deletion <i>via</i> R26-regulated tamoxifen-inducible Cre recombinase activity. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2022.1018798

Paudel, S., Rogers, K. A., Kumar, R., Saini, Y., Patial, S., & Kulkarni, R. (2022, November). NLRP3 inflammasome is dispensable in methicillin resistant<i>Staphylococcus aureus</i>urinary tract infection. https://doi.org/10.1101/2022.11.11.516235

Vo, T., Paudel, K., Choudhary, I., Patial, S., & Saini, Y. (2022). Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2. Scientific Reports, 1. https://doi.org/10.1038/s41598-022-04906-8

Chen, J., Patial, S., & Saini, Y. (2022). Silencing of RNA binding protein, ZFP36L1, promotes epithelial-mesenchymal transition in liver cancer cells by regulating transcription factor ZEB2. Cellular Signalling, 9. https://doi.org/10.1016/j.cellsig.2022.110462

Patial, S., Lewis, B. W., Vo, T., Choudhary, I., Paudel, K., Mao, Y., … Saini, Y. (2021). Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs. Scientific Reports, 7. https://doi.org/10.1038/s41598-021-94843-9

Choudhary, I., Vo, T., Paudel, K., Yadav, R., Mao, Y., Patial, S., & Saini, Y. (2021). Postnatal Ozone Exposure Disrupts Alveolar Development, Exaggerates Mucoinflammatory Responses, and Suppresses Bacterial Clearance in Developing <i>Scnn1b</i>-Tg<sup>+</sup> Mice Lungs. Journal of Immunology (Baltimore, Md. : 1950), 8. https://doi.org/10.4049/jimmunol.2001286

Choudhary, I., Vo, T., Paudel, K., Wen, X., Gupta, R., Kesimer, M., … Saini, Y. (2021). Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease. Scientific Reports, 12. https://doi.org/10.1038/s41598-021-02256-5

Bathula, C. S., Chen, J., Kumar, R., Blackshear, P. J., Saini, Y., & Patial, S. (2021). ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice. The American Journal of Pathology, 2. https://doi.org/10.1016/j.ajpath.2021.10.017

Bathula, C. S., Chen, J., Blackshear, P. J., Saini, Y., & Patial, S. (2021, May). ZFP36L1 regulates <i>Fgf21</i> mRNA turnover and modulates alcoholic hepatic steatosis and inflammation in mice. https://doi.org/10.1101/2021.05.11.443631

Lewis, B. W., Vo, T., Choudhary, I., Kidder, A., Bathula, C., Ehre, C., … Saini, Y. (2020). Ablation of IL-33 Suppresses <i>Th2</i> Responses but Is Accompanied by Sustained Mucus Obstruction in the <i>Scnn1b</i> Transgenic Mouse Model. Journal of Immunology (Baltimore, Md. : 1950), 3. https://doi.org/10.4049/jimmunol.1900234

Choudhary, I., Vo, T., Paudel, K., Patial, S., & Saini, Y. (2020). Compartment-specific transcriptomics of ozone-exposed murine lungs reveals sex- and cell type-associated perturbations relevant to mucoinflammatory lung diseases. American Journal of Physiology. Lung Cellular and Molecular Physiology, 1. https://doi.org/10.1152/ajplung.00381.2020

Patial, S., & Saini, Y. (2020). Lung macrophages: current understanding of their roles in Ozone-induced lung diseases. Critical Reviews in Toxicology, 4. https://doi.org/10.1080/10408444.2020.1762537

Vo, T., Paudel, K., Choudhary, I., Patial, S., & Saini, Y. (2020, November). Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2. https://doi.org/10.1101/2020.11.10.377408

Lewis, B. W., Choudhary, I., Paudel, K., Mao, Y., Sharma, R., Wang, Y., … Saini, Y. (2020). The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice. Journal of Immunology (Baltimore, Md. : 1950), 9. https://doi.org/10.4049/jimmunol.2000530

Saini, Y., Chen, J., & Patial, S. (2020). The Tristetraprolin Family of RNA-Binding Proteins in Cancer: Progress and Future Prospects. . Cancers, 6. https://doi.org/10.3390/cancers12061539

Choudhary, I., Vo, T., Bathula, C. S., Lamichhane, R., Lewis, B. W., Looper, J., … Patial, S. (2020). Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.02164

Choudhary, I., Vo, T., Paudel, K., Gupta, R., Kesimer, M., Patial, S., & Saini, Y. (2020, December). Vesicular and Extravesicular Protein Signatures From the Airspaces of Ozone-Exposed Mice Reflect Muco-Inflammatory Disturbances. https://doi.org/10.21203/rs.3.rs-132766/v1

Lewis, B. W., Patial, S., & Saini, Y. (2019). Immunopathology of Airway Surface Liquid Dehydration Disease. Journal of Immunology Research. https://doi.org/10.1155/2019/2180409

Saini, Y., Lewis, B. W., Yu, D., Dang, H., Livraghi-Butrico, A., Del, P. F., … Boucher, R. C. (2018). Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis. Physiological Reports, 4. https://doi.org/10.14814/phy2.13677

Lewis, B. W., Sultana, R., Sharma, R., Noël, A., Langohr, I., Patial, S., … Saini, Y. (2017). Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease. Journal of Immunology (Baltimore, Md. : 1950), 8. https://doi.org/10.4049/jimmunol.1700144

Yu, D., Saini, Y., Chen, G., Ghio, A. J., Dang, H., Burns, K. A., … Boucher, R. C. (2017). Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice. The American Journal of Pathology, 1. https://doi.org/10.1016/j.ajpath.2017.09.016

Saini, Y., Wilkinson, K. J., Terrell, K. A., Burns, K. A., Livraghi-Butrico, A., Doerschuk, C. M., … Boucher, R. C. (2016). Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses. American Journal of Respiratory Cell and Molecular Biology, 2. https://doi.org/10.1165/rcmb.2014-0111oc

Nair, A. R., Ebenezer, P. J., Saini, Y., & Francis, J. (2015). Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells. Experimental Cell Research, 7. https://doi.org/10.1016/j.yexcr.2015.05.011

Hwang, H. J., Lynn, S. G., Vengellur, A., Saini, Y., Grier, E. A., Ferguson-Miller, S. M., & LaPres, J. J. (2015). Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes. Biochemistry, 6. https://doi.org/10.1021/bi5012892

Saini, Y., Proper, S. P., Dornbos, P., Greenwood, K. K., Kopec, A. K., Lynn, S. G., … LaPres, J. J. (2015). Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice. PloS One. https://doi.org/10.1371/journal.pone.0139270

Saini, Y., Dang, H., Livraghi-Butrico, A., Kelly, E. J., Jones, L. C., O'Neal, W. K., & Boucher, R. C. (2014). Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration. BMC Genomics, 9. https://doi.org/10.1186/1471-2164-15-726

Proper, S. P., Saini, Y., Greenwood, K. K., Bramble, L. A., Downing, N. J., & Lapres, J. J. (2013). Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicological Sciences : an Official Journal of the Society of Toxicology, 2. https://doi.org/10.1093/toxsci/kft253

Patial, S., Shahi, S., Saini, Y., Lee, T., Packiriswamy, N., Appledorn, D. M., … Parameswaran, N. (2011). G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice. Journal of Cellular Physiology, 5. https://doi.org/10.1002/jcp.22460

Patial, S., Saini, Y., Parvataneni, S., Appledorn, D. M., Dorn, G. W., Lapres, J. J., … Parameswaran, N. (2011). Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice. Journal of Cellular Physiology, 3. https://doi.org/10.1002/jcp.22384

Greenwood, K. K., Proper, S. P., Saini, Y., Bramble, L. A., Jackson-Humbles, D. N., Wagner, J. G., & LaPres, J. J. (2011). Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma. American Journal of Physiology. Lung Cellular and Molecular Physiology, 3. https://doi.org/10.1152/ajplung.00193.2011

Sparkenbaugh, E. M., Saini, Y., Greenwood, K. K., LaPres, J. J., Luyendyk, J. P., Copple, B. L., … Roth, R. A. (2011). The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity. The Journal of Pharmacology and Experimental Therapeutics, 8. https://doi.org/10.1124/jpet.111.180521

Saini, Y., Greenwood, K. K., Merrill, C., Kim, K. Y., Patial, S., Parameswaran, N., & LaPres, J. J. (2010). Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation. Toxicological Sciences : an Official Journal of the Society of Toxicology, 8. https://doi.org/10.1093/toxsci/kfq155

Saini, Y., Kim, K. Y., Lewandowski, R., Bramble, L. A., & Lapres, J. J. (2009). Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. American Journal of Physiology. Lung Cellular and Molecular Physiology, 2. https://doi.org/10.1152/ajplung.00252.2009

Saini, Y., & LaPres, J. J. (2008). HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. The Journal of Biological Chemistry, 11. https://doi.org/10.1074/jbc.m805927200

Patial, S., Chaturvedi, V. K., Rai, A., Saini, M., Chandra, R., Saini, Y., & Gupta, P. K. (2007). Virus neutralizing antibody response in mice and dogs with a bicistronic DNA vaccine encoding rabies virus glycoprotein and canine parvovirus VP2. Vaccine, 5. https://doi.org/10.1016/j.vaccine.2007.02.051