@article{rank_lynch_green_reed-jones_harrell_ueda_2023, title={Case report: Laryngospasm following ethanol ablation of a parathyroid nodule in a dog with primary hyperparathyroidism}, volume={10}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2023.1201663}, abstractNote={A 12-year-old female spayed dachshund was presented for emergency assessment of respiratory distress, characterized by inspiratory dyspnea with stridor. Percutaneous ultrasound-guided ethanol ablation of a functional parathyroid tumor was performed 72-h earlier for management of primary hyperparathyroidism. The dog was hypocalcemic (ionized calcium 0.7 mmol/L, reference interval: 0.9–1.3 mmol/L) at the time of presentation and had evidence of laryngospasm on a sedated oral exam. The dog was managed conservatively with supplemental oxygen, anxiolysis, and parenteral calcium administration. These interventions were associated with rapid and sustained improvement in clinical signs. The dog did not demonstrate any recurrence of signs afterwards. To the authors' knowledge, this is the first description of laryngospasm following ethanol ablation of a parathyroid nodule in a dog that developed hypocalcemia.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Rank, Kaitlyn and Lynch, Alex M. and Green, Randolph and Reed-Jones, Leslie and Harrell, Karyn and Ueda, Yu}, year={2023}, month={Jun} }
 @article{rank_lynch_ruterbories_li_ueda_2023, title={Evaluation of thrombin generation in dogs administered clopidogrel}, volume={10}, ISSN={2297-1769}, url={http://dx.doi.org/10.3389/fvets.2023.1194242}, DOI={10.3389/fvets.2023.1194242}, abstractNote={IntroductionThe antiplatelet effect of clopidogrel can vary between patients. A modified thromboelastography (TEG) protocol (TEG-Platelet Mapping assay® [TEG-PM]) can be used for clopidogrel monitoring but is not widely available. Thrombin generation (TG) assays could offer a novel alternative. The main objective of this pilot study was to assess TG assay variables (lag time, peak, endogenous thrombin potential [ETP]) in dogs before and after 7 days of clopidogrel administration and compare with TEG-PM variables (maximum amplitude [MA]-ADP and percentage (%) inhibition).}, journal={Frontiers in Veterinary Science}, publisher={Frontiers Media SA}, author={Rank, Kaitlyn and Lynch, Alex M. and Ruterbories, Laura K. and Li, Ronald H. L. and Ueda, Yu}, year={2023}, month={Aug} }
 @article{stern_rivas_kaplan_ueda_oldach_ontiveros_kooiker_dijk_harris_2023, title={Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C}, volume={13}, ISSN={["2045-2322"]}, url={https://publons.com/wos-op/publon/63367066/}, DOI={10.1038/s41598-023-36932-5}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Stern, Joshua A. and Rivas, Victor N. and Kaplan, Joanna L. and Ueda, Yu and Oldach, Maureen S. and Ontiveros, Eric S. and Kooiker, Kristina B. and Dijk, Sabine J. and Harris, Samantha P.}, year={2023}, month={Jun} }
 @article{rivas_ueda_stern_2023, title={Sex-specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta)}, volume={7}, ISSN={["1600-0684"]}, url={https://doi.org/10.1111/jmp.12662}, DOI={10.1111/jmp.12662}, abstractNote={Abstract}, journal={JOURNAL OF MEDICAL PRIMATOLOGY}, author={Rivas, Victor N. and Ueda, Yu and Stern, Joshua A.}, year={2023}, month={Jul} }
 @article{rivas_stern_ueda_2023, title={The Role of Personalized Medicine in Companion Animal Cardiology}, volume={53}, ISSN={["1878-1306"]}, url={https://publons.com/wos-op/publon/65523949/}, DOI={10.1016/j.cvsm.2023.05.016}, abstractNote={Cardiomyopathies remain one of the most common inherited cardiac diseases in both human and veterinary patients. To date, well over 100 mutated genes are known to cause cardiomyopathies in humans with only a handful known in cats and dogs. This review highlights the need and use of personalized one-health approaches to cardiovascular case management and advancement in pharmacogenetic-based therapy in veterinary medicine. Personalized medicine holds promise in understanding the molecular basis of disease and ultimately will unlock the next generation of targeted novel pharmaceuticals and aid in the reversal of detrimental effects at a molecular level.}, number={6}, journal={VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE}, author={Rivas, Victor N. and Stern, Joshua A. and Ueda, Yu}, year={2023}, month={Nov}, pages={1255–1276} }
 @article{walker_ueda_crofton_harris_stern_2022, title={Ambulatory electrocardiography, heart rate variability, and pharmacologic stress testing in cats with subclinical hypertrophic cardiomyopathy}, volume={12}, ISSN={["2045-2322"]}, DOI={10.1038/s41598-022-05999-x}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Walker, Ashley L. and Ueda, Yu and Crofton, Amanda E. and Harris, Samantha P. and Stern, Joshua A.}, year={2022}, month={Feb} }
 @article{salmelin_ueda_gilbert_martinez_2022, title={Comparison of Trauma in Dogs due to Direct Motor Vehicle Collision or Fall from Open Pick-up Truck Bed during Transportation (2002-2020)}, volume={12}, ISSN={["2567-6911"]}, DOI={10.1055/s-0042-1756516}, abstractNote={Abstract}, journal={VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY}, author={Salmelin, Bettina R. M. and Ueda, Yu and Gilbert, Peter J. and Martinez, Steven A.}, year={2022}, month={Dec} }
 @article{chalifoux_butty_mauro_moyle_ehrhardt_robertson_labato_culler_londono_vigani_et al._2022, title={Outcomes of 434 dogs with non-steroidal anti-inflammatory drug toxicosis treated with fluid therapy, lipid emulsion, or therapeutic plasma exchange}, volume={12}, ISSN={["1939-1676"]}, url={http://dx.doi.org/10.1111/jvim.16603}, DOI={10.1111/jvim.16603}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, publisher={Wiley}, author={Chalifoux, Nolan V. and Butty, Emmanuelle M. and Mauro, Katie D. and Moyle, Rachel B. and Ehrhardt, Caryn M. and Robertson, James B. and Labato, Mary A. and Culler, Christine A. and Londono, Leonel A. and Vigani, Alessio and et al.}, year={2022}, month={Dec} }
 @article{butty_suter_chalifoux_lynch_mauro_moyle_ehrhardt_robertson_culler_londono_et al._2022, title={Outcomes of nonsteroidal anti-inflammatory drug toxicosis treated with therapeutic plasma exchange in 62 dogs}, volume={8}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.16507}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Butty, Emmanuelle M. and Suter, Steven E. and Chalifoux, Nolan V and Lynch, Alex M. and Mauro, Katie D. and Moyle, Rachel B. and Ehrhardt, Caryn M. and Robertson, James B. and Culler, Christine A. and Londono, Leonel A. and et al.}, year={2022}, month={Aug} }
 @article{tan_li_ueda_stern_hussain_haginoya_sharpe_gunther-harrington_epstein_nguyen_2022, title={Platelet Priming and Activation in Naturally Occurring Thermal Burn Injuries and Wildfire Smoke Exposure Is Associated With Intracardiac Thrombosis and Spontaneous Echocardiographic Contrast in Feline Survivors}, volume={9}, ISSN={2297-1769}, url={http://dx.doi.org/10.3389/fvets.2022.892377}, DOI={10.3389/fvets.2022.892377}, abstractNote={Wildfires pose a major health risk for humans, wildlife, and domestic animals. We previously discovered pathophysiologic parallels between domestic cats with naturally occurring smoke inhalation and thermal burn injuries and human beings with similar injuries; these were characterized by transient myocardial thickening, cardiac troponin I elevation and formation of intracardiac thrombosis. While the underlying mechanisms remain unclear, results from murine models suggest that platelet priming and activation may contribute to a global hypercoagulable state and thrombosis. Herein, we evaluated and compared the degree of platelet activation, platelet response to physiologic agonists and levels of platelet-derived microvesicles (PDMV) in 29 cats with naturally occurring wildfire thermal injuries (WF), 21 clinically healthy cats with subclinical hypertrophic cardiomyopathy (HCM) and 11 healthy cats without HCM (CC). We also quantified and compared circulating PDMVs in WF cats to CC cats. In addition, we examined the association between thrombotic events, severity of burn injuries, myocardial changes, and the degree of platelet activation in cats exposed to wildfires. Flow cytometric detection of platelet surface P-selectin expression showed that WF cats had increased platelet response to adenosine diphosphate (ADP) and thrombin compared to the two control groups indicating the presence of primed platelets in circulation. In addition, cats in the WF group had increased circulating levels of PDMV, characterized by increased phosphatidylserine on the external leaflet. Cats in the WF group with documented intracardiac thrombosis had elevated platelet activation and platelet priming in the presence of ADP. While high dose arachidonic acid (AA) mostly resulted in platelet inhibition, persistent response to AA was noted among cats in the WF group with intracardiac thrombosis. Univariate and multiple logistic regression analyses demonstrated that increased platelet response to AA was independently associated with thrombotic events. This is the first study reporting the significant association between platelet priming and intracardiac thrombosis in domestic cats with naturally occurring wildfire-related injuries and smoke inhalation. Further studies are required to delineate additional mechanisms between inflammation and thrombosis, especially regarding platelet primers and the cyclooxygenase pathway.}, journal={Frontiers in Veterinary Science}, publisher={Frontiers Media SA}, author={Tan, Avalene W. K. and Li, Ronald H. L. and Ueda, Yu and Stern, Joshua A. and Hussain, Mehrab and Haginoya, Satoshi and Sharpe, Ashely N. and Gunther-Harrington, Catherine T. and Epstein, Steven E. and Nguyen, Nghi}, year={2022}, month={Jul} }
 @article{ueda_li_nguyen_ontiveros_kovacs_oldach_vernau_court_stern_2021, title={A genetic polymorphism in P2RY(1) impacts response to clopidogrel in cats with hypertrophic cardiomyopathy}, volume={11}, ISSN={["2045-2322"]}, url={https://europepmc.org/articles/PMC8206363}, DOI={10.1038/s41598-021-91372-3}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Ueda, Yu and Li, Ronald H. L. and Nguyen, Nghi and Ontiveros, Eric S. and Kovacs, Samantha L. and Oldach, Maureen S. and Vernau, Karen M. and Court, Michael H. and Stern, Joshua A.}, year={2021}, month={Jun} }
 @article{oldach_ueda_ontiveros_fousse_visser_stern_2021, title={Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy}, volume={17}, ISSN={["1746-6148"]}, DOI={10.1186/s12917-021-02799-9}, abstractNote={Abstract}, number={1}, journal={BMC VETERINARY RESEARCH}, author={Oldach, Maureen S. and Ueda, Yu and Ontiveros, Eric S. and Fousse, Samantha L. and Visser, Lance C. and Stern, Joshua A.}, year={2021}, month={Feb} }
 @article{grigg_ueda_walker_hart_simas_stern_2021, title={Comparative Assessment of Heart Rate Variability Obtained via Ambulatory ECG and Polar Heart Rate Monitors in Healthy Cats: A Pilot Study}, volume={8}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2021.741583}, abstractNote={Chronic exposure to stressful environments can negatively impact cats' health and welfare, affecting behavioral, autonomic, endocrine, and immune function, as with cats in shelters. Low-stress handling practices likely improve shelter cat welfare, but data supporting improved outcomes remain limited. Cardiac activity, particularly heart rate variability (HRV), is an indicator of stress and emotional state in humans and non-human animals, tracking important body functions associated with stress responsiveness, environmental adaptability, mental, and physical health. HRV studies in cats are limited, involving mainly anesthetized or restrained cats. This pilot study tested the feasibility of obtaining HRV data from unrestrained cats, using a commercially available cardiac monitoring system (Polar H10 with chest strap), compared with data from a traditional ambulatory electrocardiogram. Simultaneous data for the two systems were obtained for five adult cats. Overall, the Polar H10 monitor assessments of HRV were lower than the true HRV assessment by ambulatory ECG, except for SDNN. Correlation between the two systems was weak. Possible reasons for the lack of agreement between the two methods are discussed. At this time, our results do not support the use of Polar H10 heart rate monitors for studies of HRV in cats.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Grigg, Emma K. and Ueda, Yu and Walker, Ashley L. and Hart, Lynette A. and Simas, Samany and Stern, Joshua A.}, year={2021}, month={Nov} }
 @article{ueda_kovacs_reader_roberts_stern_2021, title={Heritability and Pedigree Analyses of Hypertrophic Cardiomyopathy in Rhesus Macaques (Macaca Mulatta)}, volume={8}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2021.540493}, abstractNote={In a colony of rhesus macaques at California National Primate Research Center (CNPRC), naturally occurring hypertrophic cardiomyopathy (HCM) classified by left ventricular hypertrophy without obvious underlying diseases has been identified during necropsy over the last two decades. A preliminary pedigree analysis suggested a strong genetic predisposition of this disease with a founder effect. However, the mode of inheritance was undetermined due to insufficient pedigree data. Since 2015, antemortem examination using echocardiographic examination as well as other cardiovascular analyses have been performed on large numbers of rhesus macaques at the colony. Based on antemortem examination, HCM was diagnosed in additional 65 rhesus macaques. Using HCM cases diagnosed based on antemortem and postmortem examinations, the heritability (h2) was estimated to determine the degree of genetic and environmental contributions to the development of HCM in rhesus macaques at the CNPRC. The calculated mean and median heritability (h2) of HCM in this colony of rhesus macaques were 0.5 and 0.51 (95% confidence interval; 0.14–0.82), respectively. This suggests genetics influence development of HCM in the colony of rhesus macaques. However, post-translational modifications and environmental factors are also likely to contribute the variability of phenotypic expression. Based on the pedigree analysis, an autosomal recessive trait was suspected, but an autosomal dominant mode of inheritance with incomplete penetrance was also possible. Further investigation with more data from siblings, offspring, and parents of HCM-affected rhesus macaques are warranted. Importantly, the findings of the present study support conducting genetic investigations such as whole genome sequencing to identify the causative variants of inherited HCM in rhesus macaques.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Ueda, Yu and Kovacs, Samantha and Reader, Rachel and Roberts, Jeffrey A. and Stern, Joshua A.}, year={2021}, month={Jun} }
 @article{kielb basile_lynch_ruterbories_castaneda_griffith_ueda_2021, title={Influence of long-stay jugular catheters on hemostatic variables in healthy dogs}, volume={7}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.13085}, DOI={10.1111/vec.13085}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Kielb Basile, Jessica L. and Lynch, Alex M. and Ruterbories, Laura and Castaneda, Kady and Griffith, Emily and Ueda, Yu}, year={2021}, month={Jul} }
 @article{gunther-harrington_sharpe_vernau_ueda_montgomery_surmick_fernandez_ontiveros_walker_stern_2021, title={Reference intervals for radiographic, echocardiographic and N-terminal pro B-type natriuretic peptide values in healthy kittens}, volume={23}, ISSN={["1532-2750"]}, DOI={10.1177/1098612X20946461}, abstractNote={Objectives Assessment of heart size in kittens is important, and there is a need for reference intervals (RIs) to prevent misinterpretation of cardiomegaly in this patient population. The purpose of this study was to generate RIs for echocardiographic and radiographic quantification of cardiac size in healthy kittens. }, number={4}, journal={JOURNAL OF FELINE MEDICINE AND SURGERY}, author={Gunther-Harrington, Catherine T. and Sharpe, Ashley N. and Vernau, Karen M. and Ueda, Yu and Montgomery, Elizabeth A. and Surmick, Jennifer D. and Fernandez, Nicole and Ontiveros, Eric and Walker, Ashley L. and Stern, Joshua A.}, year={2021}, month={Apr}, pages={293–301} }
 @article{ueda_duler_elliot_sosa_roberts_stern_2020, title={Echocardiographic reference intervals with allometric scaling of 823 clinically healthy rhesus macaques (Macaca mulatta)}, volume={16}, ISSN={["1746-6148"]}, DOI={10.1186/s12917-020-02578-y}, abstractNote={Abstract}, number={1}, journal={BMC VETERINARY RESEARCH}, author={Ueda, Yu and Duler, Laetitia M. M. and Elliot, Kami J. and Sosa, Paul-Michael D. and Roberts, Jeffrey A. and Stern, Joshua A.}, year={2020}, month={Sep} }
 @article{willcox_belanger_burton_yu_ueda_visser_skorupski_stern_2020, title={Intramuscular Diphenhydramine Does Not Affect Acute Doxorubicin Infusion-Related Arrhythmia Number or Severity in a Prospective Crossover Study in Canine Lymphoma: A Pilot Study}, volume={7}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2020.00368}, abstractNote={Background: Doxorubicin (DOX) is one of the most effective chemotherapeutics for canine high-grade lymphoma. In addition to dose-dependent chronic cardiotoxicity, DOX can trigger acute cardiac arrhythmias during drug infusion. Diphenhydramine premedication is commonly used, as histamine release is a proposed mechanism for DOX-associated arrhythmogenesis. Hypothesis/Objectives: The study objectives were to evaluate the incidence and severity of DOX infusion-related cardiac arrhythmias in dogs with high-grade lymphoma and evaluate the effect of diphenhydramine premedication on arrhythmia frequency and severity during and after DOX infusion. Animals: Twenty-two client-owned dogs with cytologically/histopathologically confirmed high-grade lymphoma were recruited, of which 19 were enrolled and 9 completed the study. Methods: Dogs were screened by echocardiogram and concurrent electrocardiogram for this randomized prospective crossover study. Group A received no premedication for DOX #1 and was premedicated with diphenhydramine for DOX #2; Group B received diphenhydramine with DOX #1 and no premedication for DOX #2. For both visits, Holter monitor data were collected for 1 h pre-DOX and 3 h post-DOX administration. Results: Nineteen dogs were enrolled and 9 dogs [Group A (5), Group B (4)] completed the protocol. There was no statistical difference between the DOX alone and DOX + diphenhydramine when evaluating the total number of ventricular premature complexes (VPCs, P = 0.34), change in VPCs/hour (P = 0.25), total number of atrial premature complexes (APCs, P = 0.5), change in APCs/hour (P = 0.06), or ventricular arrhythmia severity score (P > 0.99). Conclusions and clinical importance: This study demonstrates that in these dogs with rigorous pretreatment cardiovascular screening, DOX infusion did not induce significant arrhythmias. Furthermore, these data suggest that, with this screening approach, diphenhydramine may not alter the arrhythmia number or severity in canine DOX recipients.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Willcox, Jennifer Lindley and Belanger, Catherine and Burton, Jenna Hart and Yu, Lydia and Ueda, Yu and Visser, Lance C. and Skorupski, Katherine and Stern, Joshua A.}, year={2020}, month={Jul} }
 @article{morimoto_hyodo_kamata_kadoba_itoh_fukushima_chiba_takenaka_mochizuki_ueda_et al._2020, title={Navigator-triggered and breath-hold 3D MRCP using compressed sensing: image quality and method selection factor assessment}, url={https://doi.org/10.1007/s00261-020-02403-y}, DOI={10.1007/s00261-020-02403-y}, journal={Abdominal Radiology}, author={Morimoto, Daisuke and Hyodo, Tomoko and Kamata, Ken and Kadoba, Tomoya and Itoh, Makoto and Fukushima, Hiroyuki and Chiba, Yasutaka and Takenaka, Mamoru and Mochizuki, Tomohiro and Ueda, Yu and et al.}, year={2020}, month={Oct} }