Dr. Yi Xiao acquired her Ph.D. in Chemistry from Nanjing University (China) in 2000 under the supervision of Professor Hongyuan Chen. In 2001, she began her first post-doctoral appointment in Professor Itamar Willner's group at The Hebrew University of Jerusalem (Israel) developing optical and electrochemical biosensors and bioelectronics. In 2004, she started her second post-doctoral appointment at the University of California at Santa Barbara (UCSB), working with Nobel Laureate Professor Alan Heeger and Professor Kevin Plaxco to develop electrochemical sensors based on oligonucleotide receptors (aptamers). In 2007, she joined Professor H.T. Soh's laboratory at UCSB as a Research Professor, developing new methods to generate aptamers via SELEX. Dr. Xiao joined Florida International University in 2011 as an Assistant Professor and was promoted to tenured Associate Professor in 2017. She recently moved to the NC State Department of Chemistry as a tenured Associate Professor.

Works (156)

Updated: August 7th, 2023 21:16

2023 journal article

Comparison of Aptamer Signaling Mechanisms Reveals Disparities in Sensor Response and Strategies to Eliminate False Signals

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145(22), 12407โ€“12422.

By: O. Alkhamis n, J. Canoura n, C. Willis n, L. Wang n, J. Perry n & Y. Xiao nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; DNA; DNA, Complementary; Sensitivity and Specificity; SELEX Aptamer Technique / methods; Biosensing Techniques / methods
Sources: Web Of Science, ORCID
Added: July 19, 2023

2023 article

Suite of Aptamer-Based Sensors for the Detection of Fentanyl and Its Analogues

Canoura, J., Liu, Y., Perry, J., Willis, C., & Xiao, Y. (2023, April 25). ACS SENSORS, Vol. 4.

By: J. Canoura n, Y. Liu n, J. Perry n, C. Willis n & Y. Xiao nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: aptamers; fentanyl; analogue; electrochemistry; colorimetry; fluorescence; bioanalytical; sensors
MeSH headings : Humans; United States; Fentanyl; Analgesics, Opioid; Illicit Drugs; Drug Overdose; Immunoassay
Sources: Web Of Science, ORCID
Added: May 30, 2023

2023 article

Using Exonucleases for Aptamer Characterization, Engineering, and Sensing

Alkhamis, O., Canoura, J., Ly, P. T., & Xiao, Y. (2023, June 14). ACCOUNTS OF CHEMICAL RESEARCH, Vol. 6.

By: O. Alkhamis n, J. Canoura n, P. Lyโ€‰ n & Y. Xiao nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Web Of Science, ORCID
Added: June 26, 2023

2022 journal article

DNA Aptamer-Cyanine Complexes as Generic Colorimetric Small-Molecule Sensors

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 61(3).

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: aptamers; colorimetric detection; cyanine dyes; dye-displacement; small-molecule targets
Sources: Web Of Science, ORCID
Added: April 18, 2022

2022 article

High-throughput quantitative binding analysis of DNA aptamers using exonucleases

Canoura, J., Alkhamis, O., Liu, Y., Willis, C., & Xiao, Y. (2022, December 30). NUCLEIC ACIDS RESEARCH, Vol. 12.

By: J. Canoura n, O. Alkhamis n, Y. Liu n, C. Willis n & Y. Xiao nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemical synthesis; Aptamers, Nucleotide / chemistry; Exonucleases; Ligands; Nucleic Acids; SELEX Aptamer Technique / methods; Fentanyl / analysis; Robotics
Sources: Web Of Science, ORCID
Added: January 17, 2023

2022 article

Near-Infrared Dye-Aptamer Assay for Small Molecule Detection in Complex Specimens

Jin, X., Liu, Y., Alkhamis, O., Canoura, J., Bacon, A., Xu, R., โ€ฆ Xiao, Y. (2022, July 7). ANALYTICAL CHEMISTRY, Vol. 7.

By: X. Jinโ€‰*, Y. Liu n, O. Alkhamis n, J. Canoura n, A. Bacon n, R. Xu*, F. Fuโ€‰*, Y. Xiao nโ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Biological Assay; Biosensing Techniques / methods
Sources: Web Of Science, ORCID
Added: July 26, 2022

2022 article

Systematic Study of in Vitro Selection Stringency Reveals How To Enrich High-Affinity Aptamers

Alkhamis, O., & Xiao, Y. (2022, December 27). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 12.

By: O. Alkhamis n & Y. Xiao nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; SELEX Aptamer Technique / methods; Ligands
Sources: Web Of Science, ORCID
Added: January 17, 2023

2021 journal article

Advances and Challenges in Smallโ€Molecule DNA Aptamer Isolation, Characterization, and Sensor Development

Angewandte Chemie International Edition, 60(31), 16800โ€“16923.

By: H. Yu*, O. Alkhamis*, J. Canoura*, Y. Liu* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: aptamers; biosensors; DNA; SELEX
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / isolation & purification; Biosensing Techniques; Equipment Design; SELEX Aptamer Technique
Sources: Crossref, ORCID
Added: July 27, 2021

2021 journal article

Aptamer-Integrated Multianalyte-Detecting Paper Electrochemical Device

ACS Applied Materials & Interfaces, 13(15), 17330โ€“17339.

By: Y. Liu*, O. Alkhamis*, X. Liuโ€‰*, H. Yuโ€‰*, J. Canoura* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: aptamer; small molecules; sensing; multianalyte detection; paper electrochemical device; ambient vacuum filtration
MeSH headings : Aptamers, Nucleotide / chemistry; Dimethylpolysiloxanes / chemistry; Electrochemistry / instrumentation; Nylons / chemistry; Paper; Vacuum
Sources: Crossref, ORCID
Added: July 27, 2021

2021 report

Aptamers that bind to natural and synthetic cannabinoids

(Patent No. US10907163B1).

By: H. Yu & Y. Xiaoโ€‰

Source: NC State University Libraries
Added: July 27, 2021

2021 conference paper

Development of Aptamer-Based Sensors for Sensitive and Specific Detection of Fentanyl Opioids

Presented at the Pittcon Conference and Expo.

By: J. Canoura, Y. Liu & Y. Xiaoโ€‰

Event: Pittcon Conference and Expo on March 11, 2021

Source: NC State University Libraries
Added: July 27, 2021

2021 journal article

Immobilization Strategies for Enhancing Sensitivity of Electrochemical Aptamer-Based Sensors

ACS Applied Materials & Interfaces, 13(8), 9491โ€“9499.

By: Y. Liu*, J. Canoura*, O. Alkhamis* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: aptamer; electrochemistry; sensing; target-assisted aptamer immobilization; small molecules; bundling effect
MeSH headings : Aptamers, Nucleotide / chemistry; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Cocaine / analysis; Cocaine / chemistry; DNA / chemistry; Electrochemical Techniques / instrumentation; Electrochemical Techniques / methods; Electrodes; Gold / chemistry; Hydrogen-Ion Concentration; Immobilized Nucleic Acids / chemistry; Osmolar Concentration; Signal-To-Noise Ratio
Sources: Crossref, ORCID
Added: July 11, 2021

2021 journal article

Isolation of Natural DNA Aptamers for Challenging Small-Molecule Targets, Cannabinoids

Analytical Chemistry, 93(6), 3172โ€“3180.

By: H. Yuโ€‰*, Y. Luoโ€‰*, O. Alkhamis*, J. Canoura*, B. Yuโ€‰* & Y. Xiao*โ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide; Cannabinoids; Gene Library; Ligands; SELEX Aptamer Technique
Sources: Crossref, ORCID
Added: July 11, 2021

2021 report

Materials and methods for colorimetric detection of small molecule targets

(Patent No. US10948504B2).

By: H. Yu, Y. Luo & Y. Xiaoโ€‰

Source: NC State University Libraries
Added: July 27, 2021

2021 report

Method for isolating cross-reactive aptamer and use thereof

(Patent No. US10907162B2).

By: W. Yang, H. Yu, Y. Liu & Y. Xiaoโ€‰

Source: NC State University Libraries
Added: July 27, 2021

2021 article

Platinum-Nanoparticle-Modified Single-Walled Carbon Nanotube-Laden Paper Electrodes for Electrocatalytic Oxidation of Methanol

Paudyal, J., Wang, P., Zhou, F., Liu, Y., Cai, Y., & Xiao, Y. (2021, December 15). ACS APPLIED NANO MATERIALS, Vol. 12.

By: J. Paudyalโ€‰*, P. Wangโ€‰*, F. Zhou*, Y. Liu*, Y. Caiโ€‰* & Y. Xiao nโ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: paper electrode; vacuum filtration; single-walled carbon nanotube; platinum nanoclusters; electrochemical deposition; sensor
Sources: Web Of Science, ORCID
Added: January 3, 2022

2020 journal article

Accelerating Post-SELEX Aptamer Engineering Using Exonuclease Digestion

Journal of the American Chemical Society, 143(2), 805โ€“816.

By: J. Canoura*, H. Yuโ€‰*, O. Alkhamis*, D. Roncancio*, R. Farhana* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / metabolism; Digestion; Escherichia coli / enzymology; Exodeoxyribonucleases / chemistry; Exodeoxyribonucleases / metabolism; SELEX Aptamer Technique
Sources: Crossref, ORCID
Added: July 11, 2021

2020 conference paper

Achieving Near-ideal Binding Spectra using Subideal Bioreceptors

Presented at the Pittcon 2020, Chicago, Illinois.

By: Y. Liu, H. Yu, O. Alkhamis, J. Moliver & Y. Xiaoโ€‰

Event: Pittcon 2020 at Chicago, Illinois on March 1-5, 2020

Source: NC State University Libraries
Added: July 27, 2021

2020 speech

Beauty Through Simplicity โ€“ Problem-Driven Aptamer Science

Invited talk presented at the NC State University, Raleigh, NC.

By: Y. Xiaoโ€‰

Event: at NC State University, Raleigh, NC on January 9-10, 2020

Source: NC State University Libraries
Added: July 27, 2021

2020 journal article

Fabrication of Aptamerโ€Modified Paper Electrochemical Devices for Onโ€Site Biosensing

Angewandte Chemie International Edition, 60(6), 2993โ€“3000.

By: H. Yu*, Z. Chenโ€‰*, Y. Liu*, O. Alkhamis*, Z. Song* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: aptamers; biosensors; nanomaterials; paper electrochemical devices; small molecules
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / metabolism; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Electrochemical Techniques / instrumentation; Electrodes; Gold / chemistry; Metal Nanoparticles / chemistry; Paper
Sources: Crossref, ORCID
Added: July 11, 2021

2020 conference paper

Isolation of Class-specific Aptamers and Development of Sensors for Instantaneous Detection of Synthetic Cathinones

Presented at the Pittcon, Chicago, IL.

By: Y. Xiaoโ€‰

Event: Pittcon at Chicago, IL on March 1-5, 2020

Source: NC State University Libraries
Added: July 27, 2021

2020 journal article

Label-free profiling of DNA aptamer-small molecule binding using T5 exonuclease

Nucleic Acids Research, 48(20), e120โ€“e120.

By: O. Alkhamis*, W. Yang*, R. Farhana*, H. Yuโ€‰* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; DNA / chemistry; Exodeoxyribonucleases / chemistry; Inverted Repeat Sequences; Ligands; Methamphetamine / analogs & derivatives; Methamphetamine / chemistry; Protein Binding; SELEX Aptamer Technique / methods
Sources: Crossref, ORCID
Added: July 11, 2021

2020 report

Materials and methods for colorimetric detection of small molecule targets

(Patent No. US10725058B2).

By: Y. Xiaoโ€‰, Y. Luo & H. Yu

Source: NC State University Libraries
Added: July 27, 2021

2020 report

Materials and methods for rapid and sensitive detection of small-molecule targets

(Patent No. US10550395B2).

By: Y. Xiaoโ€‰ & H. Yu

Source: NC State University Libraries
Added: July 27, 2021

2020 report

Materials and methods for rapid and specific detection of synthetic cathinones

(Patent No. US10683507B2).

By: Y. Xiaoโ€‰ & H. Yu

Source: NC State University Libraries
Added: July 27, 2021

2020 report

Method for isolating cross-reactive aptamer and use thereof

(Patent No. US10655132B1).

By: W. Yang, H. Yu, Y. Liu & Y. Xiaoโ€‰

Source: NC State University Libraries
Added: July 27, 2021

2020 conference paper

Screening of aptamer mutants for enhanced target specificity using a dual exonuclease digestion assay

Presented at the Pittcon 2020, Chicago, Illinois.

By: J. Canoura, R. Farhana, R. Roncancio & Y. Xiaoโ€‰

Event: Pittcon 2020 at Chicago, Illinois on March 1-5, 2020

Source: NC State University Libraries
Added: July 27, 2021

2020 journal article

Tuning Biosensor Cross-Reactivity Using Aptamer Mixtures

Analytical Chemistry, 92(7), 5041โ€“5047.

By: Y. Liu*, H. Yuโ€‰*, O. Alkhamis*, J. Moliver* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Alkaloids / analysis; Aptamers, Nucleotide / chemistry; Benzothiazoles / chemistry; Biosensing Techniques; Carbocyanines / chemistry; Electrochemical Techniques; SELEX Aptamer Technique
Sources: Crossref, ORCID
Added: July 11, 2021

2019 conference paper

A Cooperative-Binding Split Aptamer Assay for Rapid, Specific and Ultra-Sensitive Fluorescence Detection of Cocaine in Saliva

Presented at the Pittcon 2019, Philadelphia, Pennsylvania.

By: H. Yu, J. Canoura, B. Guntupalli & Y. Xiaoโ€‰

Event: Pittcon 2019 at Philadelphia, Pennsylvania on March 17-21, 2019

Source: NC State University Libraries
Added: July 27, 2021

2019 conference paper

Beauty Through Simplicity โ€“ Functionalized Aptamers for On-Site Small-Molecule Detection

Presented at the Pittcon 2019, Philadelphia, Pennsylvania.

By: Y. Xiaoโ€‰

Event: Pittcon 2019 at Philadelphia, Pennsylvania on March 17-21, 2019

Source: NC State University Libraries
Added: July 27, 2021

2019 conference paper

Development of Electrochemical Aptamer-Based Sensors for On-Site Synthetic Cathinone Detection

Presented at the Pittcon 2019, Philadelphia, Pennsylvanis.

By: Y. Liu, O. Alkhamis, H. Yu & Y. Xiaoโ€‰

Event: Pittcon 2019 at Philadelphia, Pennsylvanis on March 17-21, 2019

Source: NC State University Libraries
Added: July 27, 2021

2019 report

Highly conductive porous paper-based metal thin films

(Patent No. US10290386B2).

By: Y. Xiaoโ€‰, B. Guntupalli & J. Paudyal

Source: NC State University Libraries
Added: July 27, 2021

2019 conference paper

In Vitro Isolation of Small-Molecule-Binding Aptamers with Intrinsic Dye-Displacement Functionality

Presented at the Pittcon 2019, Philadelphia, Pennsylvania.

By: H. Yu, W. Yang, O. Alkhamis, J. Canoura, K. Yang & Y. Xiaoโ€‰

Event: Pittcon 2019 at Philadelphia, Pennsylvania on March 17-21, 2019

Source: NC State University Libraries
Added: July 27, 2021

2019 journal article

In vitro isolation of class-specific oligonucleotide-based small-molecule receptors

Nucleic Acids Research, 47(12), e71โ€“e71.

By: W. Yang*, H. Yuโ€‰*, O. Alkhamis*, Y. Liu*, J. Canoura*, F. Fuโ€‰*, Y. Xiao*โ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Alkaloids / chemistry; Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / isolation & purification; Aptamers, Nucleotide / metabolism; High-Throughput Nucleotide Sequencing; SELEX Aptamer Technique / methods; Sequence Analysis, DNA
Sources: Crossref, ORCID
Added: July 11, 2021

2019 journal article

Innovative engineering and sensing strategies for aptamer-based small-molecule detection

TrAC Trends in Analytical Chemistry, 121, 115699.

By: O. Alkhamis*, J. Canoura*, H. Yu*, Y. Liu* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Crossref, ORCID
Added: July 11, 2021

2019 conference paper

Introducing Structure-Switching Functionality into Small-Molecule-Binding Aptamers via Nuclease-Directed Truncation

Presented at the Pittcon 2019, Philadelphia, Pennsylvania.

By: Z. Wang, H. Yu, J. Canoura, Y. Liu, O. Alkhamis, F. Fu, Y. Xiaoโ€‰

Event: Pittcon 2019 at Philadelphia, Pennsylvania on March 17-21, 2019

Source: NC State University Libraries
Added: July 27, 2021

2019 journal article

Label-Free, Visual Detection of Small Molecules Using Highly Target-Responsive Multimodule Split Aptamer Constructs

Analytical Chemistry, 91(11), 7199โ€“7207.

By: Y. Luoโ€‰*, H. Yuโ€‰*, O. Alkhamis*, Y. Liu*, X. Louโ€‰*, B. Yuโ€‰*, Y. Xiao*โ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / metabolism; Benzodioxoles / analysis; Biosensing Techniques; Cocaine / analysis; Colorimetry; DNA, Catalytic / chemistry; DNA, Catalytic / metabolism; Protein Engineering; Pyrrolidines / analysis; Small Molecule Libraries / analysis; Synthetic Cathinone
Sources: Crossref, ORCID
Added: July 11, 2021

2019 journal article

Perspective on the Future Role of Aptamers in Analytical Chemistry

Analytical Chemistry, 91(24), 15335โ€“15344.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Affinity Labels; Aptamers, Nucleotide / chemistry; Ligands; Nucleic Acids / chemistry; SELEX Aptamer Technique / methods; SELEX Aptamer Technique / trends
Sources: Crossref, ORCID
Added: July 11, 2021

2019 conference paper

Rapid, naked-eye screening for synthetic cathinones based on cross-reactive aptamers

Presented at the Pittcon 2019, Philadelphia, Pennsylvania.

By: W. Yang, H. Yu, O. Alkhamis, F. Fu & Y. Xiaoโ€‰

Event: Pittcon 2019 at Philadelphia, Pennsylvania on March 17-21, 2019

Source: NC State University Libraries
Added: July 27, 2021

2019 journal article

Universal Design of Structure-Switching Aptamers with Signal Reporting Functionality

Analytical Chemistry, 91(22), 14514โ€“14521.

By: H. Gaoโ€‰*, J. Zhao*, Y. Huangโ€‰*, X. Cheng*, S. Wangโ€‰*, Y. Hanโ€‰*, Y. Xiao*โ€‰, X. Louโ€‰*

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Benzothiazoles / chemistry; Biocatalysis; Biosensing Techniques / methods; Cocaine / analysis; Cocaine / chemistry; Colorimetry / methods; DNA, Catalytic / chemistry; DNA, Catalytic / genetics; Estradiol / analysis; Estradiol / chemistry; Fluorescent Dyes / chemistry; G-Quadruplexes; Limit of Detection; Mercury / analysis; Mercury / chemistry; Nucleic Acid Conformation; Peroxidase / chemistry; Spectrometry, Fluorescence / methods; Sulfadimethoxine / analysis; Sulfadimethoxine / chemistry; Thrombin / analysis; Thrombin / chemistry
Sources: Crossref, ORCID
Added: July 11, 2021

2018 conference paper

Aptamer-based Assays for On-site Drug Detection

Presented at the Pittcon 2018, Orlando, Florida.

By: Y. Xiaoโ€‰

Event: Pittcon 2018 at Orlando, Florida on February 26 - March 1, 2018

Source: NC State University Libraries
Added: July 27, 2021

2018 speech

Beauty through simplicity โ€“ functionalized aptamers for on-site small-molecule detection

Invited talk presented at the University of Notre Dame, South Bend, Indiana.

By: Y. Xiaoโ€‰

Event: at University of Notre Dame, South Bend, Indiana on September 17, 2018

Source: NC State University Libraries
Added: July 27, 2021

2018 journal article

Dithiothreitol-Regulated Coverage of Oligonucleotide-Modified Gold Nanoparticles To Achieve Optimized Biosensor Performance

ACS Applied Materials & Interfaces, 10(4), 4233โ€“4242.

By: P. Liang*, J. Canoura*, H. Yu*, O. Alkhamis* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: gold nanoparticles; DNA surface coverage; dithiothreitol; enzyme-assisted target recycling; DNA detection; cocaine detection
MeSH headings : Biosensing Techniques; Colorimetry; Dithiothreitol; Gold; Metal Nanoparticles
Sources: Crossref, ORCID
Added: July 11, 2021

2018 journal article

In vitro isolation of small-molecule-binding aptamers with intrinsic dye-displacement functionality

Nucleic Acids Research, 46(8), e43โ€“e43.

By: H. Yu*, W. Yang*, O. Alkhamis*, J. Canoura*, K. Yangโ€‰* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / genetics; Aptamers, Nucleotide / isolation & purification; Base Sequence; Benzodioxoles / analysis; Biosensing Techniques / methods; Carbocyanines / chemistry; Colorimetry / methods; Coloring Agents / chemistry; DNA / chemistry; DNA / genetics; Molecular Structure; Pyrrolidines / analysis; SELEX Aptamer Technique / methods; Synthetic Cathinone
Sources: Crossref, ORCID
Added: July 11, 2021

2018 journal article

Introducing structure-switching functionality into small-molecule-binding aptamers via nuclease-directed truncation

Nucleic Acids Research, 46(13), e81โ€“e81.

By: Z. Wangโ€‰*, H. Yuโ€‰*, J. Canoura*, Y. Liu*, O. Alkhamis*, F. Fuโ€‰*, Y. Xiao*โ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Adenosine Triphosphate / analysis; Aptamers, Nucleotide / chemistry; Cocaine / analysis; Exodeoxyribonucleases; Mutation; Spectrometry, Fluorescence
Sources: Crossref, ORCID
Added: July 11, 2021

2018 report

Materials and methods for rapid visualization of NAD(P)H

(Patent No. US10000790B2).

By: P. Liang, H. Yu & Y. Xiaoโ€‰

Source: NC State University Libraries
Added: July 27, 2021

2018 journal article

No Structure-Switching Required: A Generalizable Exonuclease-Mediated Aptamer-Based Assay for Small-Molecule Detection

Journal of the American Chemical Society, 140(31), 9961โ€“9971.

By: J. Canoura*, Z. Wangโ€‰*, H. Yuโ€‰*, O. Alkhamis*, F. Fuโ€‰* & Y. Xiao*โ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Calorimetry / methods; Cocaine / chemistry; DNA / chemistry; Exodeoxyribonucleases / chemistry; Fluorescent Dyes / chemistry
Sources: Crossref, ORCID
Added: July 11, 2021

2018 conference paper

Rapid and sensitive detection of small-molecule targets via enzyme-assisted target recycling based on cooperative binding split aptamers

Presented at the Pittcon 2018, Orlando, Florida.

By: H. Yu, J. Canoura, B. Guntupalli, X. Lou & Y. Xiaoโ€‰

Event: Pittcon 2018 at Orlando, Florida on February 26 - March 1, 2018

Source: NC State University Libraries
Added: July 27, 2021

2018 journal article

Sensitive Detection of Small-Molecule Targets Using Cooperative Binding Split Aptamers and Enzyme-Assisted Target Recycling

Analytical Chemistry, 90(3), 1748โ€“1758.

By: H. Yuโ€‰*, J. Canoura*, B. Guntupalli*, O. Alkhamis* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Biosensing Techniques / methods; Colorimetry / methods; DNA / chemistry; Dehydroepiandrosterone Sulfate / analysis; Exodeoxyribonucleases / chemistry; Gold / chemistry; Limit of Detection; Metal Nanoparticles / chemistry; Nucleic Acid Amplification Techniques / methods
Sources: Crossref, ORCID
Added: July 11, 2021

2018 conference paper

Utilizing nuclease screening of ligand-aptamer complexes to enhance specificity of an aptamer-based cocaine assay

Presented at the 2017 Society of Forensic Toxicologists-International Association of Forensic Toxicologists (SOFT-TIAFT) Joint Meeting, Boca Raton, Florida.

By: Z. Wang, J. Canoura, H. Yu & Y. Xiaoโ€‰

Event: 2017 Society of Forensic Toxicologists-International Association of Forensic Toxicologists (SOFT-TIAFT) Joint Meeting at Boca Raton, Florida on January 7-11, 2018

Source: NC State University Libraries
Added: July 27, 2021

2017 journal article

A Broadly Applicable Assay for Rapidly and Accurately Quantifying DNA Surface Coverage on Diverse Particles

Bioconjugate Chemistry, 28(4), 933โ€“943.

By: H. Yuโ€‰*, X. Xuโ€‰*, P. Liang*, K. Lohโ€‰*, B. Guntupalli*, D. Roncancio*, Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Base Sequence; DNA Probes / analysis; DNA Probes / metabolism; Exodeoxyribonucleases / metabolism; Fluorescent Dyes / chemistry; Fluorescent Dyes / metabolism; Gold / chemistry; Immobilized Nucleic Acids / analysis; Immobilized Nucleic Acids / metabolism; Metal Nanoparticles / chemistry; Nucleic Acid Hybridization / methods; Static Electricity; Surface Properties
Sources: Crossref, ORCID
Added: July 11, 2021

2017 journal article

A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva

Chemical Science, 8(1), 131โ€“141.

By: H. Yu*, J. Canoura*, B. Guntupalli*, X. Louโ€‰* & Y. Xiao*โ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Crossref, ORCID
Added: July 11, 2021

2017 conference paper

A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva

Poster presented at the Gordon Research Conference: Nucleosides, Nucleotides & Oligonucleotides, Salve Regina University, Newport, RI.

By: H. Yu, J. Canoura, B. Guntupalli & Y. Xiaoโ€‰

Event: Gordon Research Conference: Nucleosides, Nucleotides & Oligonucleotides at Salve Regina University, Newport, RI on June 25-30, 2017

Source: NC State University Libraries
Added: September 6, 2021

2017 conference paper

A label-free aptamer-fluorophore assembly for highly sensitive and specific detection of cocaine

Presented at the Pittcon 2017, Chicago, Illinois.

By: D. Roncancio, H. Yu, X. Xu & Y. Xiaoโ€‰

Event: Pittcon 2017 at Chicago, Illinois on March 5-9, 2017

Source: NC State University Libraries
Added: September 11, 2021

2017 conference paper

Cooperative-binding split aptamer assays for rapid, specific and ultra-sensitive detection of small-molecule targets in biofluid samples

Invited talk presented at the 2017 American Chemical Society Florida Annual Meeting and Exposition, Tampa, FL.

By: H. Yu, J. Canoura, B. Guntupalli & Y. Xiaoโ€‰

Event: 2017 American Chemical Society Florida Annual Meeting and Exposition at Tampa, FL on May 5-6, 2017

Source: NC State University Libraries
Added: September 6, 2021

2017 conference paper

Gold nanoparticle-based assays for rapid and sensitive colorimetric and electrochemical biosensing

Presented at the Nano Florida 2017, Florida International University, Miami, FL.

By: Y. Xiaoโ€‰

Event: Nano Florida 2017 at Florida International University, Miami, FL on September 23-24, 2017

Source: NC State University Libraries
Added: August 27, 2021

2017 speech

Gold nanoparticle-based, paper devices for rapid and sensitive colorimetric and electrochemical biosensing

Invited talk presented at the 2017 American Chemical Society Florida Annual Meeting and Exposition, Tampa, FL.

By: P. Liang, B. Guntupalli, H. Yu & Y. Xiaoโ€‰

Event: 2017 American Chemical Society Florida Annual Meeting and Exposition at Tampa, FL on May 5-6, 2017

Source: NC State University Libraries
Added: September 6, 2021

2017 report

Materials and methods for rapid and specific detection of cocaine

(Patent No. US9804178B2).

By: D. Roncancio, H. Yu, X. Xu & Y. Xiaoโ€‰

Source: NC State University Libraries
Added: July 27, 2021

2017 conference paper

Rapid and sensitive detection of small-molecule targets via enzyme-assisted target recycling based on cooperative binding split aptamers

Poster presented at the Gordon Research Conference: Nucleosides, Nucleotides & Oligonucleotides, Salve Regina University, Newport, RI.

By: H. Yu, J. Canoura, B. Guntupalli, X. Lou & Y. Xiaoโ€‰

Event: Gordon Research Conference: Nucleosides, Nucleotides & Oligonucleotides at Salve Regina University, Newport, RI on June 25-30, 2017

Source: NC State University Libraries
Added: September 6, 2021

2017 conference paper

Utilizing dual-enzyme selectivity for the identification of aptamer binding domains and the development of sensitive fluorescence detection of small-molecule targets

Presented at the FIU Annual Scholarly Forum, Graduate Student Appreciation Week (GSAW), Florida International University, Miami, FL.

By: J. Canoura, Z. Wang, H. Yu & Y. Xiaoโ€‰

Event: FIU Annual Scholarly Forum, Graduate Student Appreciation Week (GSAW) at Florida International University, Miami, FL on March 27-28, 2017

Source: NC State University Libraries
Added: September 11, 2021

2017 conference paper

Utilizing nuclease screening of ligand-aptamer complexes to enhance specificity of an aptamer-based cocaine assay

Poster presented at the Gordon Research Conference: Nucleosides, Nucleotides & Oligonucleotides, Salve Regina University, Newport, RI.

By: J. Canoura, Z. Wang, H. Yu & Y. Xiaoโ€‰

Event: Gordon Research Conference: Nucleosides, Nucleotides & Oligonucleotides at Salve Regina University, Newport, RI on June 25-30, 2017

Source: NC State University Libraries
Added: September 6, 2021

2016 conference paper

A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva

Presented at the Pittcon 2017, Chicago, Illinois.

By: H. Yu, J. Canoura, B. Guntupalli & Y. Xiaoโ€‰

Event: Pittcon 2017 at Chicago, Illinois on March 5-9, 2017

Source: NC State University Libraries
Added: September 11, 2021

2016 conference paper

A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva

Presented at the 2016 Conference of Undergraduate Research at FIU (CURFIU), Miami, FL.

By: H. Yu, B. Guntupalli & Y. Xiaoโ€‰

Event: 2016 Conference of Undergraduate Research at FIU (CURFIU) at Miami, FL on March 30-31, 2016

Source: NC State University Libraries
Added: September 11, 2021

2016 conference paper

A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva

Presented at the FIU Annual Scholarly Forum, Graduate Student Appreciation Week (GSAW), Florida International University, Miami, FL.

By: Y. H.X., G. B. & X. Y

Event: FIU Annual Scholarly Forum, Graduate Student Appreciation Week (GSAW) at Florida International University, Miami, FL on March 28-29, 2016

Source: NC State University Libraries
Added: September 11, 2021

2016 conference paper

A label-free aptamer-fluorophore assembly for highly sensitive and specific detection of cocaine

Presented at the 2016 Conference of Undergraduate Research at FIU (CURFIU), Miami, FL.

By: D. Roncancio, H. Yu, X. Xu, S. Wu, R. Liu, J. Debord, X. Lou, Y. Xiaoโ€‰

Event: 2016 Conference of Undergraduate Research at FIU (CURFIU) at Miami, FL on March 30-31, 2016

Source: NC State University Libraries
Added: September 11, 2021

2016 conference paper

Ambient filtration method to rapidly prepare highly conductive, paper-based porous gold films for electrochemical biosensing

Presented at the 2016 Conference of Undergraduate Research at FIU (CURFIU), Miami, FL.

By: B. Guntupalli, P. Liang, J. Lee, Y. Yang, H. Yu, J. Canoura, J. He, W. Li, Y. Weizmann, Y. Xiaoโ€‰

Event: 2016 Conference of Undergraduate Research at FIU (CURFIU) at Miami, FL on March 30-31, 2016

Source: NC State University Libraries
Added: September 11, 2021

2016 speech

Bringing biosensors to the bedside

Invited talk presented at the University of Miami, Medical Campus - Batchelor Children's Research Institute, Miami, FL.

By: Y. Xiaoโ€‰

Event: at University of Miami, Medical Campus - Batchelor Children's Research Institute, Miami, FL on May 18, 2016

Source: NC State University Libraries
Added: September 11, 2021

2016 conference paper

Paper-based device for rapid visualization of NADH based on dissolution of gold nanoparticles

Poster presented at the 2016 Conference of Undergraduate Research at FIU (CURFIU), Miami, FL.

By: P. Liang, H. Yu, B. Guntupalli & Y. Xiaoโ€‰

Event: 2016 Conference of Undergraduate Research at FIU (CURFIU) at Miami, FL on March 30-31, 2016

Source: NC State University Libraries
Added: September 11, 2021

2016 conference paper

Paper-based devices for rapid and sensitive colorimetric and electrochemical biosensing

Invited talk presented at the 2016 ACS Florida Annual Meeting and Exposition, Tampa, FL.

By: Y. Xiaoโ€‰

Event: 2016 ACS Florida Annual Meeting and Exposition at Tampa, FL on May 5-7, 2016

Source: NC State University Libraries
Added: September 11, 2021

2016 journal article

Rapid, Surfactant-Free, and Quantitative Functionalization of Gold Nanoparticles with Thiolated DNA under Physiological pH and Its Application in Molecular Beacon-Based Biosensor

ACS Applied Materials & Interfaces, 8(40), 27298โ€“27304.

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: gold nanoparticle; thiolated DNA; DNA-gold nanoparticle conjugates; ethylene glycol spacer; physiological pH; adsorption kinetics; quantitative adsorption
MeSH headings : Biosensing Techniques; DNA; Gold; Hydrogen-Ion Concentration; Metal Nanoparticles; Surface-Active Agents
Sources: Crossref, ORCID
Added: July 11, 2021

2016 conference paper

Utilizing nuclease screening of ligand-aptamer complexes to enhance specificity of an aptamer-based cocaine assay

Poster presented at the 2016 ACS Florida Annual Meeting and Exposition, Tampa, FL.

By: J. Canoura, Z. Wang, H. Yu, B. Ng, D. Roncancio & Y. Xiaoโ€‰

Event: 2016 ACS Florida Annual Meeting and Exposition at Tampa, FL on May 5-7, 2016

Source: NC State University Libraries
Added: September 11, 2021

2015 conference paper

A paper-based device for rapid visualization of NADH based on dissolution of gold nanoparticles

Poster presented at the 2015 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts.

By: P. Liang, H. Yu & Y. Xiaoโ€‰

Event: 2015 Materials Research Society (MRS) Fall Meeting & Exhibit at Boston, Massachusetts on November 29 - December 4, 2015

Source: NC State University Libraries
Added: September 11, 2021

2015 journal article

Ambient Filtration Method To Rapidly Prepare Highly Conductive, Paper-Based Porous Gold Films for Electrochemical Biosensing

ACS Applied Materials & Interfaces, 7(49), 27049โ€“27058.

By: B. Guntupalli*, P. Liang*, J. Leeโ€‰*, Y. Yangโ€‰*, H. Yu*, J. Canoura*, J. Heโ€‰*, W. Liโ€‰*, Y. Weizmannโ€‰*, Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: gold nanoparticles; single-walled carbon nanotubes; paper-based hybrid porous gold film; vacuum filtration; electrocatalytic response; film conductivity
MeSH headings : Biosensing Techniques / methods; Filtration / methods; Gold / chemistry; Membranes, Artificial; Metal Nanoparticles / chemistry; Porosity
Sources: Crossref, ORCID
Added: July 11, 2021

2015 conference paper

Ambient filtration method to rapidly prepare highly conductive, paper-based porous gold films

Presented at the 2015 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts.

By: B. Guntupalli, P. Liang, Y. Yang, J. He, W. Li & Y. Xiaoโ€‰

Event: 2015 Materials Research Society (MRS) Fall Meeting & Exhibit at Boston, Massachusetts on November 29 - December 4, 2015

Source: NC State University Libraries
Added: September 11, 2021

2015 conference paper

Amplified colorimetric detection of cocaine in oral fluid based on exonuclease-assisted aptamer strand recycling

Poster presented at the Society of Forensic Toxicologists (SOFT) 2015 Annual Meeting, Atlanta, Georgia.

By: Z. Wang, H. Yu, B. Ng, D. Roncancio, J. Canoura & Y. Xiaoโ€‰

Event: Society of Forensic Toxicologists (SOFT) 2015 Annual Meeting at Atlanta, Georgia on October 19-23, 2015

Source: NC State University Libraries
Added: September 11, 2021

2015 speech

Aptamer-based, exonuclease-amplified, paper device for point of collection screening of cocaine and methamphetamine in oral fluid

Invited talk presented at the Forensic Science R&D Grantees Meeting, Orlando, FL.

By: Y. Xiaoโ€‰

Event: Forensic Science R&D Grantees Meeting at Orlando, FL on February 17, 2015

Source: NC State University Libraries
Added: September 11, 2021

2015 conference paper

Base-pair mismatch detection

Invited talk presented at the FIU Biomolecular Sciences Institute Symposium on DNA Repair and Genome Stability: In honor of the 2015 Nobel Prize in Chemistry for DNA Repair, Miami, FL.

By: Y. Xiaoโ€‰

Event: FIU Biomolecular Sciences Institute Symposium on DNA Repair and Genome Stability: In honor of the 2015 Nobel Prize in Chemistry for DNA Repair at Miami, FL on December 16, 2015

Source: NC State University Libraries
Added: September 11, 2021

2015 speech

Bringing biosensors to the bedside

Recruitment talk presented at the Division of Health and Natural Sciences, Florida Memorial University, Miami, FL.

By: Y. Xiaoโ€‰

Event: at Division of Health and Natural Sciences, Florida Memorial University, Miami, FL on February 24, 2015

Source: NC State University Libraries
Added: September 11, 2021

2015 journal article

Nanoprobe-Enhanced, Split Aptamer-Based Electrochemical Sandwich Assay for Ultrasensitive Detection of Small Molecules

Analytical Chemistry, 87(15), 7712โ€“7719.

By: T. Zhaoโ€‰*, R. Liuโ€‰*, X. Dingโ€‰*, J. Zhao*, H. Yu*, L. Wangโ€‰*, Q. Xuโ€‰*, X. Wangโ€‰* ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Biosensing Techniques / methods; Cocaine / analysis; Electrochemical Techniques; Limit of Detection; Small Molecule Libraries / analysis
Sources: Crossref, ORCID
Added: July 11, 2021

2015 journal article

Paper-Based Device for Rapid Visualization of NADH Based on Dissolution of Gold Nanoparticles

ACS Applied Materials & Interfaces, 7(27), 15023โ€“15030.

By: P. Liang*, H. Yuโ€‰*, B. Guntupalli* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: dissolution of gold nanoparticles; dihydronicotinamide adenine dinucleotide; paper-based device; colorimetric screening; dehydrogenase inhibitors; NAD(+)-driven enzymatic reactions
MeSH headings : Colorimetry / instrumentation; Colorimetry / methods; Equipment Design; Equipment Failure Analysis; Gold / chemistry; Metal Nanoparticles / chemistry; Metal Nanoparticles / ultrastructure; NAD / analysis; NAD / chemistry; Paper; Reagent Strips; Reproducibility of Results; Sensitivity and Specificity
Sources: Crossref, ORCID
Added: July 11, 2021

2015 conference paper

Simple, rapid and ultra-sensitive fluorescence detection of cocaine in oral fluid based on cooperative binding split aptamer

Presented at the Society of Forensic Toxicologists (SOFT) 2015 Annual Meeting, Atlanta, Georgia.

By: H. Yu, Z. Wang, B. Ng, J. Canoura & Y. Xiaoโ€‰

Event: Society of Forensic Toxicologists (SOFT) 2015 Annual Meeting at Atlanta, Georgia on October 19-23, 2015

Source: NC State University Libraries
Added: September 11, 2021

2014 journal article

A Label-Free Aptamer-Fluorophore Assembly for Rapid and Specific Detection of Cocaine in Biofluids

Analytical Chemistry, 86(22), 11100โ€“11106.

By: D. Roncancio*, H. Yu*, X. Xuโ€‰*, S. Wuโ€‰*, R. Liuโ€‰*, J. Debord*, X. Louโ€‰*, Y. Xiao*โ€‰

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Body Fluids / chemistry; Cocaine / analysis; Fluorescence; Fluorescent Dyes / chemistry; Humans; Naphthyridines / chemistry; Time Factors
Sources: Crossref, ORCID
Added: July 11, 2021

2014 conference paper

A label-free aptamer-fluorophore assembly for highly sensitive and specific detection of cocaine

Poster presented at the 2014 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts.

By: D. Roncancio, S. Wu, H. Yu, X. Xu, R. Liu, J. Debord, X. Lou, Y. Xiaoโ€‰

Event: 2014 Materials Research Society (MRS) Fall Meeting & Exhibit at Boston, Massachusetts on November 30 - December 5, 2014

Source: NC State University Libraries
Added: September 11, 2021

2014 journal article

Amplified Single Base-Pair Mismatch Detection via Aggregation of Exonuclease-Sheared Gold Nanoparticles

Analytical Chemistry, 86(7), 3461โ€“3467.

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Base Pair Mismatch; Exonucleases / chemistry; Gold / chemistry; Metal Nanoparticles; Polymorphism, Single Nucleotide; Spectrophotometry, Ultraviolet
Sources: Crossref, ORCID
Added: July 11, 2021

2014 conference paper

Amplified single base-pair mismatch detection via the aggregation of exonuclease-sheared gold nanoparticles

Poster presented at the 2014 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts.

By: S. Wu, P. Liang, H. Yu, X. Xu, Y. Liu, X. Lou, Y. Xiaoโ€‰

Event: 2014 Materials Research Society (MRS) Fall Meeting & Exhibit at Boston, Massachusetts on November 30 - December 5, 2014

Source: NC State University Libraries
Added: September 11, 2021

2014 speech

Bringing biosensors to the bedside

Recruitment talk presented at the Department of Chemistry, St. Thomas University, Miami, FL.

By: Y. Xiaoโ€‰

Event: at Department of Chemistry, St. Thomas University, Miami, FL on November 5, 2014

Source: NC State University Libraries
Added: September 11, 2021

2014 conference paper

Target recycling-based assay for rapid and accurate determination of DNA surface coverage on gold nanoparticles

Presented at the 2014 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts.

By: X. Xu, B. Guntupalli, H. Yu & Y. Xiaoโ€‰

Event: 2014 Materials Research Society (MRS) Fall Meeting & Exhibit at Boston, Massachusetts on November 30 - December 5, 2014

Source: NC State University Libraries
Added: September 11, 2021

2013 conference paper

Ambient filtration method to prepare paper-based electroactive nanoporous gold thin film for detection of dopamine and serotonin

Presented at the 89th Florida Annual Meeting and Exposition, Palm Harbor, FL.

By: B. Guntupalli, P. Liang, J. Dai, Y. Yang, J. He, W. Li, Y. Xiaoโ€‰

Event: 89th Florida Annual Meeting and Exposition at Palm Harbor, FL on May 9-11, 2013

Source: NC State University Libraries
Added: September 11, 2021

2013 speech

Bringing biosensors to the bedside

Recruitment talk presented at the Department of Chemistry, University of Tampa, Tampa, FL.

By: Y. Xiaoโ€‰

Event: at Department of Chemistry, University of Tampa, Tampa, FL on November 22, 2013

Source: NC State University Libraries
Added: September 11, 2021

2013 journal article

Controlling the function of DNA nanostructures with specific trigger sequences

Chem. Commun., 49(4), 397โ€“399.

By: S. Deborggraeveโ€‰*, J. Dai*, Y. Xiao*โ€‰ & H. Sohโ€‰*

co-author countries: Belgium ๐Ÿ‡ง๐Ÿ‡ช United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Base Pair Mismatch; Base Sequence; DNA / chemistry; DNA / genetics; DNA, Catalytic / chemistry; DNA, Catalytic / genetics; Models, Molecular; Molecular Sequence Data; Nanostructures / chemistry; Nucleic Acid Hybridization; Optical Imaging
Sources: Crossref, ORCID
Added: July 11, 2021

2013 journal article

In Vitro Selection of Shape-Changing DNA Nanostructures Capable of Binding-Induced Cargo Release

ACS Nano, 7(11), 9675โ€“9683.

By: S. Ohโ€‰*, K. Plakos*, Y. Xiao*โ€‰, M. Eisenstein* & H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: allostery; microfluidics; in vitro selection; functional aptamer; ATP; ATMND; structure-switching
MeSH headings : Adenosine Triphosphate / chemistry; Allosteric Site; Base Sequence; Binding Sites; Cloning, Molecular; DNA / chemistry; Microfluidics; Molecular Conformation; Molecular Sequence Data; Nanostructures / chemistry; Nanotechnology / methods; Nucleic Acid Conformation; Nucleotides; Spectrometry, Fluorescence
Sources: Crossref, ORCID
Added: July 11, 2021

2013 conference paper

Paper-based single-walled carbon nanotube thin film for catalytic detection of nicotinamide adenine dinucleotide in human blood

Invited talk presented at the 89th Florida Annual Meeting and Exposition, Palm Harbor, FL.

By: Y. Xiaoโ€‰, J. Dai, J. Paudyal, B. Guntupalli, P. Liang, F. Pubillones, Y. Yang, W. Li, X. Wang

Event: 89th Florida Annual Meeting and Exposition at Palm Harbor, FL on May 9-11, 2013

Source: NC State University Libraries
Added: September 11, 2021

2013 journal article

Self-Assembled DNA Monolayer Buffered Dynamic Ranges of Mercuric Electrochemical Sensor

Analytical Chemistry, 85(15), 7574โ€“7580.

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Biosensing Techniques / methods; Buffers; DNA Probes / chemistry; Electric Conductivity; Electrochemistry; Feasibility Studies; Limit of Detection; Mercury / analysis; Mercury / chemistry; Nucleic Acid Hybridization; Surface Properties
Sources: Crossref, ORCID
Added: July 11, 2021

2012 conference paper

Biosensors, biotechnologies and biomaterials

Presented at the 9th International Symposium on Persistent Toxic Substances, Miami, FL.

By: Y. Xiaoโ€‰

Event: 9th International Symposium on Persistent Toxic Substances at Miami, FL on October 23-27, 2012

Source: NC State University Libraries
Added: September 11, 2021

2012 journal article

Electrochemical DNA three-way junction based sensor for distinguishing chiral metallo-supramolecular complexes

Chemical Communications, 48(55), 6900.

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Coordination Complexes / chemistry; DNA / chemistry; Electrochemical Techniques; Electrodes; Ferric Compounds / chemistry; Stereoisomerism
Sources: Crossref, ORCID
Added: July 11, 2021

2012 journal article

Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution

Nucleic Acids Research, 40(22), 11777โ€“11783.

By: K. Ahmad*, Y. Xiao*โ€‰ & H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; DNA, Single-Stranded / chemistry; Directed Molecular Evolution / methods; Ligands; Microfluidic Analytical Techniques; Nucleic Acid Conformation; Thrombin / antagonists & inhibitors
Sources: Crossref, ORCID
Added: July 11, 2021

2011 speech

Bringing biosensors to the bedside

Recruitment talk presented at the Department of Chemistry, Barry University, Miami, FL.

By: Y. Xiaoโ€‰

Event: at Department of Chemistry, Barry University, Miami, FL on November 21, 2011

Source: NC State University Libraries
Added: September 11, 2021

2011 journal article

Genetic Analysis of H1N1 Influenza Virus from Throat Swab Samples in a Microfluidic System for Point-of-Care Diagnostics

Journal of the American Chemical Society, 133(23), 9129โ€“9135.

By: B. Ferguson, S. Buchsbaum, T. Wuโ€‰*, K. Hsieh, Y. Xiao*โ€‰, R. Sunโ€‰*, H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : DNA, Single-Stranded / genetics; DNA, Single-Stranded / isolation & purification; Electrochemistry / instrumentation; Influenza A Virus, H1N1 Subtype / genetics; Influenza A Virus, H1N1 Subtype / isolation & purification; Limit of Detection; Magnetics; Microfluidic Analytical Techniques; Pharynx / virology; Point-of-Care Systems; Protein Denaturation; RNA, Viral / genetics; RNA, Viral / isolation & purification; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleoproteins / chemistry; Specimen Handling
Sources: Crossref, ORCID
Added: July 11, 2021

2011 journal article

Improving Aptamer Selection Efficiency through Volume Dilution, Magnetic Concentration, and Continuous Washing in Microfluidic Channels

Analytical Chemistry, 83(17), 6883โ€“6889.

By: S. Ohโ€‰*, K. Ahmad*, M. Cho*, S. Kimโ€‰*, Y. Xiao*โ€‰ & H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Magnetics; Microfluidic Analytical Techniques / methods; SELEX Aptamer Technique; Streptavidin / analysis
Sources: Crossref, ORCID
Added: July 11, 2021

2011 journal article

Measurement of Aptamerโ€“Protein Interactions with Back-Scattering Interferometry

Analytical Chemistry, 83(23), 8867โ€“8870.

By: I. Olmsted*, Y. Xiao*โ€‰, M. Cho*, A. Csordas*, J. Sheehan*, J. Meilerโ€‰*, H. Sohโ€‰*, D. Bornhop*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / metabolism; Humans; Interferometry; Light; Protein Binding; Solutions / chemistry; Thrombin / chemistry; Thrombin / metabolism
Sources: Crossref, ORCID
Added: July 11, 2021

2011 journal article

Polarity-Switching Electrochemical Sensor for Specific Detection of Single-Nucleotide Mismatches

Angewandte Chemie International Edition, 50(47), 11176โ€“11180.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: DNA; electrochemistry; sensors; single-nucleotide mismatch
MeSH headings : Base Pair Mismatch; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; DNA / analysis; DNA / genetics; DNA Probes; Electrochemistry / instrumentation; Electrochemistry / methods; Electrodes; Polymorphism, Single Nucleotide
Sources: Crossref, ORCID
Added: July 11, 2021

2011 journal article

Probing the Limits of Aptamer Affinity with a Microfluidic SELEX Platform

PLoS ONE, 6(11), e27051.

By: K. Ahmad*, S. Ohโ€‰*, S. Kimโ€‰*, F. McClellen*, Y. Xiao*โ€‰ & H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Ed(s): M. Antopolsky

MeSH headings : Animals; Aptamers, Nucleotide / genetics; Aptamers, Nucleotide / metabolism; Base Sequence; Becaplermin; Microfluidic Analytical Techniques / methods; Protein Binding; Proto-Oncogene Proteins c-sis / metabolism; SELEX Aptamer Technique / instrumentation
Sources: Crossref, ORCID
Added: July 11, 2021

2011 journal article

Selection of phage-displayed peptides on live adherent cells in microfluidic channels

Proceedings of the National Academy of Sciences, 108(17), 6909โ€“6914.

By: J. Wangโ€‰*, Y. Liu, T. Teesaluโ€‰*, K. Sugahara*, V. Kotamrajua*, J. Adams*, B. Fergusonโ€‰*, Q. Gongโ€‰* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Bacteriophage T7 / genetics; Cell Line, Tumor; Humans; Microfluidic Analytical Techniques / methods; Neuropilin-1 / antagonists & inhibitors; Neuropilin-1 / genetics; Neuropilin-1 / metabolism; Peptide Library
Sources: Crossref, ORCID
Added: July 11, 2021

2011 journal article

Two-Step, PCR-Free Telomerase Detection by Using Exonuclease III-Aided Target Recycling

ChemBioChem, 12(18), 2745โ€“2747.

By: X. Zuoโ€‰*, F. Xiaโ€‰*, A. Patterson*, H. Sohโ€‰*, Y. Xiao*โ€‰ & K. Plaxcoโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: cancer; nucleic acid detection; signal amplification; telomerase
MeSH headings : Base Sequence; Cell Line; Chromatography, High Pressure Liquid; DNA Probes; Exodeoxyribonucleases / metabolism; Humans; Mass Spectrometry; Polymerase Chain Reaction / methods; Telomerase / metabolism
Sources: Crossref, ORCID
Added: July 11, 2021

2010 journal article

An Electrochemical Supersandwich Assay for Sensitive and Selective DNA Detection in Complex Matrices

Journal of the American Chemical Society, 132(41), 14346โ€“14348.

By: F. Xiaโ€‰*, R. Whiteโ€‰*, X. Zuoโ€‰*, A. Patterson*, Y. Xiao*โ€‰, D. Kang*, X. Gongโ€‰*, K. Plaxcoโ€‰*, A. Heeger*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : DNA / analysis; Electrochemistry / methods; Limit of Detection; Nucleic Acid Hybridization
Sources: Crossref, ORCID
Added: August 3, 2021

2010 journal article

Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes

Proceedings of the National Academy of Sciences, 107(24), 10837โ€“10841.

By: F. Xiaโ€‰*, X. Zuoโ€‰*, R. Yangโ€‰*, Y. Xiao*โ€‰, D. Kang*, A. Vallee-Belisleโ€‰*, X. Gongโ€‰*, J. Yuen* ...

co-author countries: Bulgaria ๐Ÿ‡ง๐Ÿ‡ฌ China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: biosensor; aptamer; visual detection; thrombin detection; cocaine detection
MeSH headings : Biosensing Techniques / methods; Cocaine / analysis; Colorimetry / methods; DNA / analysis; Fluorenes; Gold; Humans; Ions / analysis; Metal Nanoparticles; Polymers; Proteins / analysis; Quaternary Ammonium Compounds
Sources: Crossref, ORCID
Added: August 3, 2021

2010 journal article

Detection of Proteins in Serum by Micromagnetic Aptamer PCR (MAP) Technology

Angewandte Chemie International Edition, 49(2), 355โ€“358.

By: A. Csordas*, A. Gerdonโ€‰*, J. Adams*, J. Qian*, S. Ohโ€‰*, Y. Xiao*โ€‰, H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: analytical methods; aptamers; growth factors; polymerase chain reaction; proteins
MeSH headings : Aptamers, Nucleotide / chemistry; Becaplermin; Biomarkers; Blood Proteins / chemistry; Calibration; DNA / chemistry; Electromagnetic Fields; Humans; Indicators and Reagents; Magnetics; Microfluidic Analytical Techniques; Platelet-Derived Growth Factor / analysis; Platelet-Derived Growth Factor / metabolism; Protein Array Analysis; Proto-Oncogene Proteins c-sis; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction / methods
Sources: Crossref, ORCID
Added: August 3, 2021

2010 journal article

Detection of Telomerase Activity in High Concentration of Cell Lysates Using Primer-Modified Gold Nanoparticles

Journal of the American Chemical Society, 132(43), 15299โ€“15307.

By: Y. Xiao*โ€‰, K. Dane*, T. Uzawaโ€‰*, A. Csordas*, J. Qian*, H. Sohโ€‰*, P. Daugherty*, E. Lagally*, A. Heeger*, K. Plaxcoโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Artifacts; Base Sequence; Cell Extracts; Cell Line, Tumor; Citric Acid / chemistry; DNA Primers / genetics; Gold / chemistry; Humans; Mammary Glands, Human / enzymology; Metal Nanoparticles / chemistry; Osmolar Concentration; Polymerase Chain Reaction / methods; Repetitive Sequences, Nucleic Acid; Telomerase / metabolism; Telomere / genetics; Time Factors
Sources: Crossref, ORCID
Added: July 11, 2021

2010 journal article

Electrochemical DNA Detection via Exonuclease and Target-Catalyzed Transformation of Surface-Bound Probes

Langmuir, 26(12), 10392โ€“10396.

By: K. Hsieh, Y. Xiao*โ€‰ & H. Tom Sohโ€‰*

co-author countries: Belgium ๐Ÿ‡ง๐Ÿ‡ช
MeSH headings : Catalysis; DNA / analysis; Electrochemical Techniques / methods; Electrochemical Techniques / standards; Exonucleases / metabolism; Molecular Probe Techniques; Molecular Probes
Sources: Crossref, ORCID
Added: August 3, 2021

2010 journal article

In vitro selection of structure-switching, self-reporting aptamers

Proceedings of the National Academy of Sciences, 107(32), 14053โ€“14058.

By: S. Ohโ€‰*, K. Plakos*, X. Louโ€‰*, Y. Xiao*โ€‰ & H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: G-quadruplex; systematic evolution of ligands by exponential enrichment; sensor; binding induced folding; molecular recognition
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / isolation & purification; DNA, Catalytic / metabolism; Fluorescence; Fluorescent Dyes; Gene Library; Humans; Mesoporphyrins; Nucleic Acid Conformation; Thrombin / genetics
Sources: Crossref, ORCID
Added: July 11, 2021

2010 journal article

Label-Free, Dual-Analyte Electrochemical Biosensors: A New Class of Molecular-Electronic Logic Gates

Journal of the American Chemical Society, 132(25), 8557โ€“8559.

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Biosensing Techniques / methods; Cocaine / analysis; Computers, Molecular; DNA, Bacterial / genetics; DNA, Complementary / analysis; DNA, Complementary / genetics; Electricity; Electrochemistry; Logic; Salmonella typhimurium; Transistors, Electronic
Sources: Crossref, ORCID
Added: July 11, 2021

2010 journal article

On the Binding of Cationic, Water-Soluble Conjugated Polymers to DNA: Electrostatic and Hydrophobic Interactions

Journal of the American Chemical Society, 132(4), 1252โ€“1254.

By: F. Xia, X. Zuo, R. Yang, Y. Xiao*โ€‰, D. Kang, A. Valleฬe-Beฬlisle, X. Gong, A. Heeger, K. Plaxco

MeSH headings : Binding Sites; Cations / chemistry; DNA / chemistry; DNA, Single-Stranded / chemistry; Hydrophobic and Hydrophilic Interactions; Nucleic Acid Conformation; Polymers / chemistry; Static Electricity; Water / chemistry
Sources: Crossref, ORCID
Added: August 3, 2021

2010 journal article

Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing

Proceedings of the National Academy of Sciences, 107(35), 15373โ€“15378.

By: M. Cho*, Y. Xiao*โ€‰, J. Nie*, R. Stewart*, A. Csordas*, S. Ohโ€‰*, J. Thomson*, H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: high-throughput DNA sequencing; PDGF-BB; Quantitative Selection of Aptamers through Sequencing; MicroMagnetic Separation device
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / genetics; Aptamers, Nucleotide / metabolism; Base Sequence; Becaplermin; Binding, Competitive; Cloning, Molecular; DNA, Single-Stranded / chemistry; DNA, Single-Stranded / genetics; DNA, Single-Stranded / metabolism; Gene Library; Kinetics; Microfluidics / methods; Platelet-Derived Growth Factor / genetics; Platelet-Derived Growth Factor / metabolism; Protein Binding; Proto-Oncogene Proteins c-sis; Reproducibility of Results; SELEX Aptamer Technique / methods; Sequence Analysis, DNA / methods
Sources: Crossref, ORCID
Added: July 11, 2021

2010 journal article

Sensitive and Selective Amplified Fluorescence DNA Detection Based on Exonuclease III-Aided Target Recycling

Journal of the American Chemical Society, 132(6), 1816โ€“1818.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : DNA / analysis; DNA / chemistry; DNA / metabolism; Exodeoxyribonucleases / metabolism; Fluorescent Dyes / chemistry; Models, Molecular; Molecular Probes / chemistry; Nucleic Acid Conformation; Nucleic Acid Hybridization
Sources: Crossref, ORCID
Added: July 11, 2021

2010 report

Signal-on architecture for electronic oligonucleotide-based detectors

(Patent No. US7803542B2).

By: Y. Xiaoโ€‰, A. Lubin & K. Plaxco

Source: NC State University Libraries
Added: July 27, 2021

2009 journal article

An Electrochemical Sensor for Single Nucleotide Polymorphism Detection in Serum Based on a Triple-Stem DNA Probe

Journal of the American Chemical Society, 131(42), 15311โ€“15316.

By: Y. Xiao*โ€‰, X. Louโ€‰*, T. Uzawaโ€‰*, K. Plakos*, K. Plaxcoโ€‰* & H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Biosensing Techniques; Cattle; DNA / blood; DNA / genetics; DNA Probes / analysis; DNA Probes / genetics; Electrochemical Techniques; Polymorphism, Single Nucleotide
Sources: Crossref, ORCID
Added: July 11, 2021

2009 journal article

Continuous, Real-Time Monitoring of Cocaine in Undiluted Blood Serum via a Microfluidic, Electrochemical Aptamer-Based Sensor

Journal of the American Chemical Society, 131(12), 4262โ€“4266.

By: J. Swensen*, Y. Xiao*โ€‰, B. Fergusonโ€‰*, A. Lubin*, R. Laiโ€‰*, A. Heeger*, K. Plaxcoโ€‰*, H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide; Biosensing Techniques / instrumentation; Cocaine / analysis; Cocaine / blood; DNA / chemistry; Dose-Response Relationship, Drug; Electrochemistry / instrumentation; Electrochemistry / methods; Equipment Design; Humans; Microfluidic Analytical Techniques; Microfluidics / instrumentation; Optics and Photonics; Serum; Time Factors
Sources: Crossref, ORCID
Added: July 11, 2021

2009 chapter

Electrochemical Approaches to Aptamer-Based Sensing

In Functional Nucleic Acids for Analytical Applications (pp. 179โ€“197).

By: Y. Xiao*โ€‰ & K. Plaxcoโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Sources: Crossref, ORCID
Added: July 11, 2021

2009 journal article

Fluorescence Detection of Single-Nucleotide Polymorphisms with a Single, Self-Complementary, Triple-Stem DNA Probe

Angewandte Chemie International Edition, 48(24), 4354โ€“4358.

By: Y. Xiao*โ€‰, K. Plakos*, X. Louโ€‰*, R. Whiteโ€‰*, J. Qian*, K. Plaxcoโ€‰*, H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: DNA; fluorescent probes; self-complementary sequences; single-nucleotide polymorphisms
MeSH headings : Base Sequence; DNA Probes / chemistry; DNA Probes / genetics; Fluorescent Dyes / chemistry; Polymorphism, Single Nucleotide; Spectrometry, Fluorescence; Thermodynamics
Sources: Crossref, ORCID
Added: August 3, 2021

2009 journal article

Generation of Highly Specific Aptamers via Micromagnetic Selection

Analytical Chemistry, 81(13), 5490โ€“5495.

By: J. Qian*, X. Louโ€‰*, Y. Zhangโ€‰*, Y. Xiao*โ€‰ & H. Sohโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Base Sequence; Magnetics; Microfluidics / methods; Molecular Sequence Data; SELEX Aptamer Technique / instrumentation; SELEX Aptamer Technique / methods; Streptavidin / analysis; Substrate Specificity
Sources: Crossref, ORCID
Added: July 11, 2021

2009 journal article

High Specificity, Electrochemical Sandwich Assays Based on Single Aptamer Sequences and Suitable for the Direct Detection of Small-Molecule Targets in Blood and Other Complex Matrices

Journal of the American Chemical Society, 131(20), 6944โ€“6945.

By: X. Zuoโ€‰*, Y. Xiao*โ€‰ & K. Plaxcoโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Adenosine Triphosphate / analysis; Adenosine Triphosphate / blood; Aptamers, Nucleotide / chemistry; Biosensing Techniques / methods; Blood Chemical Analysis / methods; Cocaine / analysis; Cocaine / blood; Electrochemical Techniques / methods; Sensitivity and Specificity
Sources: Crossref, ORCID
Added: July 11, 2021

2009 journal article

Label-Free Colorimetric Screening of Nuclease Activity and Substrates by Using Unmodified Gold Nanoparticles

ChemBioChem, 10(12), 1973โ€“1977.

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: high-throughput screening; nanoparticles; nucleases; nucleoside monophosphates; substrate selectivity
MeSH headings : Colorimetry / methods; Endonucleases / chemistry; Endonucleases / isolation & purification; Endonucleases / metabolism; Gold / chemistry; Metal Nanoparticles / chemistry; Sensitivity and Specificity; Substrate Specificity; Surface Properties
Sources: Crossref, ORCID
Added: July 11, 2021

2009 journal article

Micromagnetic selection of aptamers in microfluidic channels

Proceedings of the National Academy of Sciences, 106(9), 2989โ€“2994.

By: X. Louโ€‰*, J. Qian*, Y. Xiao*โ€‰, L. Viel*, A. Gerdonโ€‰*, E. Lagally*, P. Atzbergerโ€‰*, T. Tarasow*, A. Heeger*, H. Sohโ€‰*

co-author countries: Italy ๐Ÿ‡ฎ๐Ÿ‡น United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: microchannel; recombinant Botulinum neurotoxin type A; systematic evolution of ligands by exponential enrichment
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / isolation & purification; Databases, Nucleic Acid; Magnetics; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Nucleic Acid Conformation
Sources: Crossref, ORCID
Added: July 11, 2021

2009 journal article

On the Signaling of Electrochemical Aptamer-Based Sensors: Collision- and Folding-Based Mechanisms

Electroanalysis, 21(11), 1267โ€“1271.

By: Y. Xiao*โ€‰, T. Uzawaโ€‰*, R. Whiteโ€‰*, D. DeMartini* & K. Plaxcoโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Aptamer-based sensors; Folding and unfolding; Biosensors; Aptamers; Thrombin; IgE
Sources: Crossref, ORCID
Added: July 11, 2021

2009 journal article

i-Motif Quadruplex DNA-Based Biosensor for Distinguishing Single- and Multiwalled Carbon Nanotubes

Journal of the American Chemical Society, 131(38), 13813โ€“13818.

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Base Sequence; Biosensing Techniques; DNA / chemistry; G-Quadruplexes; Humans; Nanotubes, Carbon / chemistry; Telomere / chemistry
Sources: Crossref, ORCID
Added: July 11, 2021

2008 journal article

Optimization of Electrochemical Aptamer-Based Sensors via Optimization of Probe Packing Density and Surface Chemistry

Langmuir, 24(18), 10513โ€“10518.

By: R. Whiteโ€‰*, N. Phares*, A. Lubin*, Y. Xiao*โ€‰ & K. Plaxcoโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Biosensing Techniques; Cocaine / chemistry; DNA / chemistry; Electrochemistry / methods; Electrodes; Equipment Design; Humans; Nucleic Acid Conformation; Oligonucleotides / chemistry; Oxidation-Reduction; RNA / chemistry; Surface Properties; Thrombin / chemistry
Sources: Crossref, ORCID
Added: July 11, 2021

2008 journal article

Optimization of a Reusable, DNA Pseudoknot-Based Electrochemical Sensor for Sequence-Specific DNA Detection in Blood Serum

Analytical Chemistry, 81(2), 656โ€“661.

By: K. Cashโ€‰*, A. Heeger*, K. Plaxcoโ€‰* & Y. Xiao*โ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Base Sequence; Biosensing Techniques; DNA / blood; DNA / chemistry; Electrochemistry; Electrodes; Gold / chemistry
Sources: Crossref, ORCID
Added: July 11, 2021

2007 report

Catalytic polynucleotide and its use for determination of analytes

(US Patent No. 20070254282).

By: I. Willner, Y. Xiaoโ€‰, V. Pavlov & T. Niazov

Source: NC State University Libraries
Added: September 11, 2021

2007 journal article

Electrochemical Detection of Parts-Per-Billion Lead via an Electrode-Bound DNAzyme Assembly

Journal of the American Chemical Society, 129(2), 262โ€“263.

By: Y. Xiao*โ€‰, A. Roweโ€‰* & K. Plaxcoโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Biosensing Techniques / methods; DNA, Catalytic / chemistry; Electrochemistry; Electrodes; Lead / analysis; Sensitivity and Specificity
Sources: Crossref, ORCID
Added: July 11, 2021

2007 journal article

Label-Free Electrochemical Detection of DNA in Blood Serum via Target-Induced Resolution of an Electrode-Bound DNA Pseudoknot

Journal of the American Chemical Society, 129(39), 11896โ€“11897.

By: Y. Xiao*โ€‰, X. Quโ€‰*, K. Plaxcoโ€‰* & A. Heeger*

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : DNA / blood; DNA Probes / chemistry; DNA, Single-Stranded / chemistry; Electrochemistry / methods; Electrodes; Gold / chemistry; Humans; Nucleic Acid Conformation; Polyethylene Glycols / chemistry; Sensitivity and Specificity
Sources: Crossref, ORCID
Added: July 11, 2021

2007 journal article

Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing

Nature Protocols, 2(11), 2875โ€“2880.

By: Y. Xiao*โ€‰, R. Laiโ€‰* & K. Plaxcoโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / analysis; Biosensing Techniques; DNA / analysis; DNA / chemistry; DNA Probes / chemistry; Electrochemistry; Electrodes; Nucleic Acid Conformation; Oligonucleotide Probes / chemistry; Oxidation-Reduction
Sources: Crossref, ORCID
Added: July 11, 2021

2006 chapter

Catalytic Beacons for the Detection of DNA and Telomerase Activity

In D. Morrison, F. Milanovich, D. Ivnitski, & T. R. Austin (Eds.), Defense against Bioterror (pp. 199โ€“205).

By: Y. Xiao*โ€‰, V. Pavlov*, T. Niazov*, A. Dishon, M. Kotler & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ

Ed(s): D. Morrison, F. Milanovich, D. Ivnitski & T. Austin

Sources: Crossref, ORCID
Added: August 3, 2021

2006 report

Novel sensors with nanoparticle probe

(Patent Application No. WO2006008742).

By: I. Willner, V. Pavlov, M. Zayatz, T. Niazov, B. Shlyahovsky, Y. Xiaoโ€‰, R. Buron

Source: NC State University Libraries
Added: September 11, 2021

2006 journal article

Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex

Proceedings of the National Academy of Sciences, 103(45), 16677โ€“16680.

By: Y. Xiao*โ€‰, A. Lubin*, B. Baker*, K. Plaxcoโ€‰* & A. Heeger*

co-author countries: Bulgaria ๐Ÿ‡ง๐Ÿ‡ฌ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: biosensors; electron transfer; gold electrode; methylene blue; signal-on
MeSH headings : Base Sequence; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; DNA / analysis; DNA / chemistry; DNA / genetics; Electrochemistry; Electrodes; Gold; Methylene Blue; Microchemistry; Molecular Probe Techniques; Quartz
Sources: Crossref, ORCID
Added: July 11, 2021

2005 journal article

A Reagentless Signal-On Architecture for Electronic, Aptamer-Based Sensors via Target-Induced Strand Displacement

Journal of the American Chemical Society, 127(51), 17990โ€“17991.

By: Y. Xiao*โ€‰, B. Piorek*, K. Plaxcoโ€‰* & A. Heeger*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Aptamers, Nucleotide / chemistry; Biosensing Techniques / methods; DNA / chemistry; Electrochemistry; Gold / chemistry; Thrombin / chemistry
Sources: Crossref, ORCID
Added: July 11, 2021

2005 journal article

An OsII-Bisbipyridine-4-Picolinic Acid Complex Mediates the Biocatalytic Growth of Au Nanoparticles: Optical Detection of Glucose and Acetylcholine Esterase Inhibition

Chemistry - A European Journal, 11(9), 2698โ€“2704.

By: Y. Xiao*โ€‰, V. Pavlov*, B. Shlyahovsky* & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
author keywords: enzymes; gold; inhibitors; nanotechnology; sensors
MeSH headings : 2,2'-Dipyridyl / chemistry; Catalysis; Cholinesterase Inhibitors / analysis; Cholinesterase Inhibitors / chemistry; Glucose / analysis; Gold / chemistry; Nanostructures / chemistry; Organometallic Compounds / chemistry; Osmium / chemistry; Picolinic Acids / chemistry; Spectrophotometry, Ultraviolet
Sources: Crossref, ORCID
Added: July 11, 2021

2005 journal article

Inhibition of the Acetycholine Esterase-Stimulated Growth of Au Nanoparticles:โ€‰ Nanotechnology-Based Sensing of Nerve Gases

Nano Letters, 5(4), 649โ€“653.

By: V. Pavlov*, Y. Xiao*โ€‰ & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
MeSH headings : Acetylcholinesterase / chemistry; Acetylcholinesterase / drug effects; Biosensing Techniques; Chemical Warfare Agents / analysis; Cholinesterase Inhibitors / pharmacology; Gold / chemistry; Nanostructures / chemistry; Nanotechnology / methods; Oxidation-Reduction; Paraoxon / pharmacology
Sources: Crossref, ORCID
Added: July 11, 2021

2005 journal article

Label-Free Electronic Detection of Thrombin in Blood Serum by Using an Aptamer-Based Sensor

Angewandte Chemie International Edition, 44(34), 5456โ€“5459.

By: Y. Xiao*โ€‰, A. Lubin*, A. Heeger* & K. Plaxcoโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: aptamers; biosensors; DNA structures; electron transfer; thrombin
MeSH headings : Aptamers, Nucleotide / chemistry; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Electrochemistry; Humans; Models, Biological; Sensitivity and Specificity; Thrombin / analysis
Sources: Crossref, ORCID
Added: August 3, 2021

2005 journal article

Optical and Electrochemical Detection of NADH and of NAD+-Dependent Biocatalyzed Processes by the Catalytic Deposition of Copper on Gold Nanoparticles

Small, 1(2), 213โ€“216.

By: B. Shlyahovsky*, E. Katz*, Y. Xiao*โ€‰, V. Pavlov* & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
author keywords: copper; enzymes; gold; nanoparticles; sensors
MeSH headings : Biosensing Techniques; Catalysis; Copper / chemistry; Electrochemistry / methods; Electrodes; Gold / chemistry; Metal Nanoparticles / chemistry; Microscopy, Electron, Scanning; NAD / chemistry; Nanotechnology / methods; Propylamines; Silanes / chemistry; Surface Properties; Temperature
Sources: Crossref, ORCID
Added: July 11, 2021

2005 journal article

Shape and color of Au nanoparticles follow biocatalytic processes

Langmuir, 21(13), 5659โ€“5662.

By: Y. Xiao*โ€‰, B. Shlyahovsky*, I. Popovโ€‰*, V. Pavlov* & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
MeSH headings : Ascorbic Acid; Catalysis; Crystallography; Gold Compounds; Microscopy, Electron; Models, Molecular; NAD / chemistry; NADP / chemistry; Nanostructures / chemistry; Oxidation-Reduction
Sources: Web Of Science, ORCID
Added: August 7, 2021

2004 journal article

Amplified Chemiluminescence Surface Detection of DNA and Telomerase Activity Using Catalytic Nucleic Acid Labels

Analytical Chemistry, 76(7), 2152โ€“2156.

By: V. Pavlov*, Y. Xiao*โ€‰, R. Gill*, A. Dishon*, M. Kotlerโ€‰* & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
MeSH headings : Base Sequence; DNA / analysis; DNA / chemistry; DNA / metabolism; DNA, Catalytic / chemistry; Gold / pharmacology; HeLa Cells; Hemin / metabolism; Humans; Luminescence; Luminescent Measurements; Molecular Sequence Data; Photoaffinity Labels / chemistry; Surface Properties; Telomerase / analysis; Telomerase / metabolism
Sources: Crossref, ORCID
Added: July 11, 2021

2004 journal article

Aptamer-Functionalized Au Nanoparticles for the Amplified Optical Detection of Thrombin

Journal of the American Chemical Society, 126(38), 11768โ€“11769.

By: V. Pavlov*, Y. Xiao*โ€‰, B. Shlyahovsky* & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
MeSH headings : Animals; Gold / chemistry; Humans; Immunoglobulin G / analysis; Immunoglobulin G / chemistry; Nanostructures / chemistry; Oligonucleotides / chemistry; Optics and Photonics; Sensitivity and Specificity; Serum Albumin / analysis; Serum Albumin / chemistry; Spectrum Analysis / methods; Thrombin / analysis
Sources: Crossref, ORCID
Added: July 11, 2021

2004 journal article

Catalytic Beacons for the Detection of DNA and Telomerase Activity

Journal of the American Chemical Society, 126(24), 7430โ€“7431.

By: Y. Xiao*โ€‰, V. Pavlov*, T. Niazov*, A. Dishon*, M. Kotlerโ€‰* & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
MeSH headings : Catalysis; Cell Count; DNA / analysis; DNA / metabolism; DNA, Catalytic / chemistry; DNA, Catalytic / metabolism; Enzyme Activation; HeLa Cells; Humans; Molecular Probe Techniques; Nucleic Acid Conformation; Nucleic Acid Hybridization; Nucleic Acids / chemistry; Photochemistry; Sensitivity and Specificity; Telomerase / analysis; Telomerase / chemistry; Telomerase / metabolism; Time Factors
Sources: Crossref, ORCID
Added: July 11, 2021

2004 journal article

Catalytic Growth of Au Nanoparticles by NAD(P)H Cofactors: Optical Sensors for NAD(P)+-Dependent Biocatalyzed Transformations

Angewandte Chemie International Edition, 43(34), 4519โ€“4522.

By: Y. Xiao*โ€‰, V. Pavlov*, S. Levine*, T. Niazov*, G. Markovitch* & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
author keywords: biosensors; cofactors; enzymes; gold; nanostructures
MeSH headings : Biosensing Techniques / methods; Catalysis; Gold / chemistry; NAD / chemistry; NADP / chemistry; Nanostructures; Oxidation-Reduction; Particle Size; Quartz
Sources: Crossref, ORCID
Added: July 11, 2021

2004 journal article

DNAzyme-Functionalized Au Nanoparticles for the Amplified Detection of DNA or Telomerase Activity

Nano Letters, 4(9), 1683โ€“1687.

By: T. Niazov*, V. Pavlov*, Y. Xiao*โ€‰, R. Gill* & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
Sources: Crossref, ORCID
Added: July 11, 2021

2004 journal article

Electrical contacting of glucose oxidase by DNA-templated polyaniline wires on surfaces

Electrochemistry Communications, 6(10), 1057โ€“1060.

By: L. Shiโ€‰*, Y. Xiao*โ€‰ & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
author keywords: poly(aniline-aniline boronic acid) wires; DNA template; apo-glucose oxidase; reconstitution; biosensor
Sources: Crossref, ORCID
Added: July 11, 2021

2004 journal article

Lighting Up Biochemiluminescence by the Surface Self-Assembly of DNA-Hemin Complexes

ChemBioChem, 5(3), 374โ€“379.

By: Y. Xiao*โ€‰, V. Pavlov*, R. Gill*, T. Bourenko* & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
author keywords: biocatalysis; DNA; hemin; luminescence; monolayers; self-assembly
MeSH headings : Base Sequence; DNA, Catalytic / chemistry; Enzymes, Immobilized; Hemin / chemistry; Hydrogen Peroxide; Luminescent Measurements; Luminol; Nucleic Acid Conformation
Sources: Crossref, ORCID
Added: August 3, 2021

2003 journal article

"Plugging into Enzymes": Nanowiring of Redox Enzymes by a Gold Nanoparticle

Science, 299(5614), 1877โ€“1881.

By: Y. Xiao*โ€‰

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Apoenzymes / chemistry; Apoenzymes / metabolism; Ascorbic Acid / metabolism; Ascorbic Acid / pharmacology; Biosensing Techniques; Catalysis; Crystallization; Electrochemistry; Electrodes; Electrons; Flavin-Adenine Dinucleotide / chemistry; Glucose / metabolism; Glucose Oxidase / chemistry; Glucose Oxidase / metabolism; Gold; Nanotechnology; Oxidation-Reduction; Oxygen / metabolism
Sources: Crossref, ORCID
Added: July 11, 2021

2003 journal article

Electrocatalytic intercalator-induced winding of double-stranded DNA with polyaniline

Chemical Communications, (13), 1540.

By: Y. Xiao*โ€‰, A. Kharitonov*, F. Patolskyโ€‰*, Y. Weizmannโ€‰* & I. Willnerโ€‰*

co-author countries: Israel ๐Ÿ‡ฎ๐Ÿ‡ฑ
MeSH headings : Aniline Compounds / chemistry; DNA / chemistry; DNA, Catalytic / chemistry; Electrodes
Sources: Crossref, ORCID
Added: July 11, 2021

2002 journal article

Electrooxidative coupling of a toluidine blue O terminated self-assembled monolayer studied by electrochemistry and surface enhanced Raman spectroscopy

Journal of Electroanalytical Chemistry, 518(2), 123โ€“130.

By: H. Ju*, Y. Xiao*โ€‰, X. Lu* & H. Chen*

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ
author keywords: chemically modified electrode; surface enhanced Raman spectroscopy; electropolymerization; monolayers; toluidine blue O; electrooxidative coupling
Sources: Crossref, ORCID
Added: July 11, 2021

2001 journal article

Anion adsorption on an Au colloid monolayer based cysteamine-modified gold electrode

Chemical Research in Chinese Universities, 17(2), 159โ€“167.

By: X. Hu, Y. Xiaoโ€‰ & H. Chen

Source: NC State University Libraries
Added: September 11, 2021

2000 journal article

Direct Electrochemistry of Horseradish Peroxidase Immobilized on a Colloid/Cysteamine-Modified Gold Electrode

Analytical Biochemistry, 278(1), 22โ€“28.

By: X. Yiโ€‰*, J. Huang-Xianโ€‰* & C. Hong-Yuan*

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ
author keywords: horseradish peroxidase; direct electrochemistry; Au colloid; cysteamine; biosensor; self-assembled monolayers
MeSH headings : Biosensing Techniques / instrumentation; Colloids; Cysteamine; Electrochemistry; Electrodes; Electron Transport; Enzymes, Immobilized; Gold; Horseradish Peroxidase / metabolism; Hydrogen Peroxide / analysis
Sources: Crossref, ORCID
Added: August 3, 2021

1999 journal article

A reagentless hydrogen peroxide sensor based on incorporation of horseradish peroxidase in poly(thionine) film on a monolayer modified electrode

Analytica Chimica Acta, 391(3), 299โ€“306.

By: Y. Xiao*โ€‰, H. Juโ€‰* & H. Chen*

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ
author keywords: hydrogen peroxide sensor; poly(thionine) film; coimmobilization; horseradish peroxidase; thionine monolayer; gold electrode
Sources: Crossref, ORCID
Added: July 11, 2021

1999 journal article

Adsorption characteristics of Fe(CN)63โˆ’/4โˆ’ on Au colloids as monolayer films on cysteamine-modified gold electrode

Journal of Electroanalytical Chemistry, 466(1), 26โ€“30.

By: X. Huโ€‰*, Y. Xiao*โ€‰ & H. Chenโ€‰*

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ
author keywords: colloidal gold; self-assembled monolayers; gold electrode
Sources: Crossref, ORCID
Added: July 11, 2021

1999 journal article

Hydrogen peroxide sensor based on horseradish peroxidase-labeled Au colloids immobilized on gold electrode surface by cysteamine monolayer

Analytica Chimica Acta, 391(1), 73โ€“82.

By: Y. Xiao*โ€‰, H. Juโ€‰* & H. Chenโ€‰*

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ
author keywords: self-assembled monolayers; HRP-labeled Au colloids; cysteamine; hydrogen peroxide; sensors; electrochemical sensors
Sources: Crossref, ORCID
Added: July 11, 2021

1998 journal article

Amperometric Biosensor for Glucose Based on a Nanometer-Sized Microband Gold Electrode Coimmobilized with Glucose Oxidase and Poly(o-phenylenediamide)

Electroanalysis, 10(8), 541โ€“545.

By: H. Ju, D. Zhou, Y. Xiao*โ€‰ & H. Chen

author keywords: glucose sensors; nanometer-sized biosensors; o-phenylenediamide; glucose oxidase; electrochemical polymerization; microband gold electrodes
Sources: Crossref, ORCID
Added: July 11, 2021

Employment

Updated: October 26th, 2021 22:06

2021 - present

North Carolina State University Raleigh, NC, US
Department of Chemistry

2011 - 2021

Florida International University MIAMI, FL, US
Associate Professor Chemistry and Biochemistry