Yi Xiao

Canoura, J., Alkhamis, O., Venzke, M., Ly, P. T., & Xiao, Y. (2024, March 1). Developing Aptamer-Based Colorimetric Opioid Tests. JACS AU, Vol. 3. https://doi.org/10.1021/jacsau.3c00801

Yang, K., Alkhamis, O., Canoura, J., Bryant, A., Gong, E. M., Barbu, M., … Landry, D. W. (2024, February 13). Exploring the Landscape of Aptamers: From Cross-Reactive to Selective to Specific, High-Affinity Receptors for Cocaine. JACS AU, Vol. 2. https://doi.org/10.1021/jacsau.3c00781

Alkhamis, O., Canoura, J., Wu, Y., Emmons, N. A., Wang, Y., Honeywell, K. M., … Xiao, Y. (2024). High-Affinity Aptamers for <i>In Vitro</i> and <i>In Vivo</i> Cocaine Sensing. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 146(5), 3230–3240. https://doi.org/10.1021/jacs.3c11350

Canoura, J., Liu, Y., Alkhamis, O., & Xiao, Y. (2023). Aptamer-Based Fentanyl Detection in Biological Fluids. ANALYTICAL CHEMISTRY, 95(49), 18258–18267. https://doi.org/10.1021/acs.analchem.3c04104

Alkhamis, O., Canoura, J., Willis, C., Wang, L., Perry, J., & Xiao, Y. (2023). Comparison of Aptamer Signaling Mechanisms Reveals Disparities in Sensor Response and Strategies to Eliminate False Signals. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145(22), 12407–12422. https://doi.org/10.1021/jacs.3c03640

Canoura, J., Liu, Y., Perry, J., Willis, C., & Xiao, Y. (2023, April 25). Suite of Aptamer-Based Sensors for the Detection of Fentanyl and Its Analogues. ACS SENSORS, Vol. 4. https://doi.org/10.1021/acssensors.2c02463

Alkhamis, O., Canoura, J., Ly, P. T., & Xiao, Y. (2023, June 14). Using Exonucleases for Aptamer Characterization, Engineering, and Sensing. ACCOUNTS OF CHEMICAL RESEARCH, Vol. 6. https://doi.org/10.1021/acs.accounts.3c00113

Alkhamis, O., Canoura, J., Bukhryakov, K. V., Tarifa, A., DeCaprio, A. P., & Xiao, Y. (2022). DNA Aptamer-Cyanine Complexes as Generic Colorimetric Small-Molecule Sensors. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 61(3). https://doi.org/10.1002/anie.202112305

Canoura, J., Alkhamis, O., Liu, Y., Willis, C., & Xiao, Y. (2022, December 30). High-throughput quantitative binding analysis of DNA aptamers using exonucleases. NUCLEIC ACIDS RESEARCH, Vol. 12. https://doi.org/10.1093/nar/gkac1210

Jin, X., Liu, Y., Alkhamis, O., Canoura, J., Bacon, A., Xu, R., … Xiao, Y. (2022, July 7). Near-Infrared Dye-Aptamer Assay for Small Molecule Detection in Complex Specimens. ANALYTICAL CHEMISTRY, Vol. 7. https://doi.org/10.1021/acs.analchem.2c01095

Alkhamis, O., & Xiao, Y. (2022, December 27). Systematic Study of in Vitro Selection Stringency Reveals How To Enrich High-Affinity Aptamers. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 12. https://doi.org/10.1021/jacs.2c09522

Yu, H., Alkhamis, O., Canoura, J., Liu, Y., & Xiao, Y. (2021). Advances and Challenges in Small‐Molecule DNA Aptamer Isolation, Characterization, and Sensor Development. Angewandte Chemie International Edition, 60(31), 16800–16923. https://doi.org/10.1002/anie.202008663

Liu, Y., Alkhamis, O., Liu, X., Yu, H., Canoura, J., & Xiao, Y. (2021). Aptamer-Integrated Multianalyte-Detecting Paper Electrochemical Device. ACS Applied Materials & Interfaces, 13(15), 17330–17339. https://doi.org/10.1021/acsami.1c01822

Yu, H. X., & Xiao, Y. (2021). Aptamers that bind to natural and synthetic cannabinoids (Patent No. US10907163B1).

Canoura, J., Liu, Y. Z., & Xiao, Y. (2021). Development of Aptamer-Based Sensors for Sensitive and Specific Detection of Fentanyl Opioids. Presented at the Pittcon Conference and Expo.

Liu, Y., Canoura, J., Alkhamis, O., & Xiao, Y. (2021). Immobilization Strategies for Enhancing Sensitivity of Electrochemical Aptamer-Based Sensors. ACS Applied Materials & Interfaces, 13(8), 9491–9499. https://doi.org/10.1021/acsami.0c20707

Yu, H., Luo, Y., Alkhamis, O., Canoura, J., Yu, B., & Xiao, Y. (2021). Isolation of Natural DNA Aptamers for Challenging Small-Molecule Targets, Cannabinoids. Analytical Chemistry, 93(6), 3172–3180. https://doi.org/10.1021/acs.analchem.0c04592

Yu, H. X., Luo, Y. P., & Xiao, Y. (2021). Materials and methods for colorimetric detection of small molecule targets (Patent No. US10948504B2).

Yang, W. J., Yu, H. X., Liu, Y. Z., & Xiao, Y. (2021). Method for isolating cross-reactive aptamer and use thereof (Patent No. US10907162B2).

Paudyal, J., Wang, P., Zhou, F., Liu, Y., Cai, Y., & Xiao, Y. (2021, December 15). Platinum-Nanoparticle-Modified Single-Walled Carbon Nanotube-Laden Paper Electrodes for Electrocatalytic Oxidation of Methanol. ACS APPLIED NANO MATERIALS, Vol. 12. https://doi.org/10.1021/acsanm.1c03186

Canoura, J., Yu, H., Alkhamis, O., Roncancio, D., Farhana, R., & Xiao, Y. (2020). Accelerating Post-SELEX Aptamer Engineering Using Exonuclease Digestion. Journal of the American Chemical Society, 143(2), 805–816. https://doi.org/10.1021/jacs.0c09559

Liu, Y. Z., Yu, H. X., Alkhamis, O., Moliver, J., & Xiao, Y. (2020). Achieving Near-ideal Binding Spectra using Subideal Bioreceptors. Presented at the Pittcon 2020, Chicago, Illinois.

Xiao, Y. (2020). Beauty Through Simplicity – Problem-Driven Aptamer Science. Invited talk presented at the NC State University, Raleigh, NC.

Yu, H., Chen, Z., Liu, Y., Alkhamis, O., Song, Z., & Xiao, Y. (2020). Fabrication of Aptamer‐Modified Paper Electrochemical Devices for On‐Site Biosensing. Angewandte Chemie International Edition, 60(6), 2993–3000. https://doi.org/10.1002/anie.202008231

Xiao, Y. (2020). Isolation of Class-specific Aptamers and Development of Sensors for Instantaneous Detection of Synthetic Cathinones. Presented at the Pittcon, Chicago, IL.

Alkhamis, O., Yang, W., Farhana, R., Yu, H., & Xiao, Y. (2020). Label-free profiling of DNA aptamer-small molecule binding using T5 exonuclease. Nucleic Acids Research, 48(20), e120–e120. https://doi.org/10.1093/nar/gkaa849

Xiao, Y., Luo, Y. P., & Yu, H. X. (2020). Materials and methods for colorimetric detection of small molecule targets (Patent No. US10725058B2).

Xiao, Y., & Yu, H. X. (2020). Materials and methods for rapid and sensitive detection of small-molecule targets (Patent No. US10550395B2).

Xiao, Y., & Yu, H. X. (2020). Materials and methods for rapid and specific detection of synthetic cathinones (Patent No. US10683507B2).

Yang, W. J., Yu, H. X., Liu, Y. Z., & Xiao, Y. (2020). Method for isolating cross-reactive aptamer and use thereof (Patent No. US10655132B1).

Canoura, J., Farhana, R., Roncancio, R., & Xiao, Y. (2020). Screening of aptamer mutants for enhanced target specificity using a dual exonuclease digestion assay. Presented at the Pittcon 2020, Chicago, Illinois.

Liu, Y., Yu, H., Alkhamis, O., Moliver, J., & Xiao, Y. (2020). Tuning Biosensor Cross-Reactivity Using Aptamer Mixtures. Analytical Chemistry, 92(7), 5041–5047. https://doi.org/10.1021/acs.analchem.9b05339

Yu, H. X., Canoura, J., Guntupalli, B., & Xiao, Y. (2019). A Cooperative-Binding Split Aptamer Assay for Rapid, Specific and Ultra-Sensitive Fluorescence Detection of Cocaine in Saliva. Presented at the Pittcon 2019, Philadelphia, Pennsylvania.

Xiao, Y. (2019). Beauty Through Simplicity – Functionalized Aptamers for On-Site Small-Molecule Detection. Presented at the Pittcon 2019, Philadelphia, Pennsylvania.

Liu, Y. Z., Alkhamis, O., Yu, H. X., & Xiao, Y. (2019). Development of Electrochemical Aptamer-Based Sensors for On-Site Synthetic Cathinone Detection. Presented at the Pittcon 2019, Philadelphia, Pennsylvanis.

Xiao, Y., Guntupalli, B., & Paudyal, J. (2019). Highly conductive porous paper-based metal thin films (Patent No. US10290386B2).

Yu, H. X., Yang, W. J., Alkhamis, O., Canoura, J., Yang, K.-A., & Xiao, Y. (2019). In Vitro Isolation of Small-Molecule-Binding Aptamers with Intrinsic Dye-Displacement Functionality. Presented at the Pittcon 2019, Philadelphia, Pennsylvania.

Yang, W., Yu, H., Alkhamis, O., Liu, Y., Canoura, J., Fu, F., & Xiao, Y. (2019). In vitro isolation of class-specific oligonucleotide-based small-molecule receptors. Nucleic Acids Research, 47(12), e71–e71. https://doi.org/10.1093/nar/gkz224

Alkhamis, O., Canoura, J., Yu, H., Liu, Y., & Xiao, Y. (2019). Innovative engineering and sensing strategies for aptamer-based small-molecule detection. TrAC Trends in Analytical Chemistry, 121, 115699. https://doi.org/10.1016/j.trac.2019.115699

Wang, Z. W., Yu, H. X., Canoura, J., Liu, Y. Z., Alkhamis, O., Fu, F. F., & Xiao, Y. (2019). Introducing Structure-Switching Functionality into Small-Molecule-Binding Aptamers via Nuclease-Directed Truncation. Presented at the Pittcon 2019, Philadelphia, Pennsylvania.

Luo, Y., Yu, H., Alkhamis, O., Liu, Y., Lou, X., Yu, B., & Xiao, Y. (2019). Label-Free, Visual Detection of Small Molecules Using Highly Target-Responsive Multimodule Split Aptamer Constructs. Analytical Chemistry, 91(11), 7199–7207. https://doi.org/10.1021/acs.analchem.9b00507

Wu, Y., Belmonte, I., Sykes, K. S., Xiao, Y., & White, R. J. (2019). Perspective on the Future Role of Aptamers in Analytical Chemistry. Analytical Chemistry, 91(24), 15335–15344. https://doi.org/10.1021/acs.analchem.9b03853

Yang, W. J., Yu, H. X., Alkhamis, O., Fu, F. F., & Xiao, Y. (2019). Rapid, naked-eye screening for synthetic cathinones based on cross-reactive aptamers. Presented at the Pittcon 2019, Philadelphia, Pennsylvania.

Gao, H., Zhao, J., Huang, Y., Cheng, X., Wang, S., Han, Y., … Lou, X. (2019). Universal Design of Structure-Switching Aptamers with Signal Reporting Functionality. Analytical Chemistry, 91(22), 14514–14521. https://doi.org/10.1021/acs.analchem.9b03368

Xiao, Y. (2018). Aptamer-based Assays for On-site Drug Detection. Presented at the Pittcon 2018, Orlando, Florida.

Xiao, Y. (2018). Beauty through simplicity – functionalized aptamers for on-site small-molecule detection. Invited talk presented at the University of Notre Dame, South Bend, Indiana.

Liang, P., Canoura, J., Yu, H., Alkhamis, O., & Xiao, Y. (2018). Dithiothreitol-Regulated Coverage of Oligonucleotide-Modified Gold Nanoparticles To Achieve Optimized Biosensor Performance. ACS Applied Materials & Interfaces, 10(4), 4233–4242. https://doi.org/10.1021/acsami.7b16914

Yu, H., Yang, W., Alkhamis, O., Canoura, J., Yang, K.-A., & Xiao, Y. (2018). In vitro isolation of small-molecule-binding aptamers with intrinsic dye-displacement functionality. Nucleic Acids Research, 46(8), e43–e43. https://doi.org/10.1093/nar/gky026

Wang, Z., Yu, H., Canoura, J., Liu, Y., Alkhamis, O., Fu, F., & Xiao, Y. (2018). Introducing structure-switching functionality into small-molecule-binding aptamers via nuclease-directed truncation. Nucleic Acids Research, 46(13), e81–e81. https://doi.org/10.1093/nar/gky305

Liang, P. P., Yu, H. X., & Xiao, Y. (2018). Materials and methods for rapid visualization of NAD(P)H (Patent No. US10000790B2).

Canoura, J., Wang, Z., Yu, H., Alkhamis, O., Fu, F., & Xiao, Y. (2018). No Structure-Switching Required: A Generalizable Exonuclease-Mediated Aptamer-Based Assay for Small-Molecule Detection. Journal of the American Chemical Society, 140(31), 9961–9971. https://doi.org/10.1021/jacs.8b04975

Yu, H. X., Canoura, J., Guntupalli, B., Lou, X. H., & Xiao, Y. (2018). Rapid and sensitive detection of small-molecule targets via enzyme-assisted target recycling based on cooperative binding split aptamers. Presented at the Pittcon 2018, Orlando, Florida.

Yu, H., Canoura, J., Guntupalli, B., Alkhamis, O., & Xiao, Y. (2018). Sensitive Detection of Small-Molecule Targets Using Cooperative Binding Split Aptamers and Enzyme-Assisted Target Recycling. Analytical Chemistry, 90(3), 1748–1758. https://doi.org/10.1021/acs.analchem.7b03625

Wang, Z. W., Canoura, J., Yu, H. X., & Xiao, Y. (2018). Utilizing nuclease screening of ligand-aptamer complexes to enhance specificity of an aptamer-based cocaine assay. Presented at the 2017 Society of Forensic Toxicologists-International Association of Forensic Toxicologists (SOFT-TIAFT) Joint Meeting, Boca Raton, Florida.

Yu, H., Xu, X., Liang, P., Loh, K. Y., Guntupalli, B., Roncancio, D., & Xiao, Y. (2017). A Broadly Applicable Assay for Rapidly and Accurately Quantifying DNA Surface Coverage on Diverse Particles. Bioconjugate Chemistry, 28(4), 933–943. https://doi.org/10.1021/acs.bioconjchem.6b00660

Yu, H., Canoura, J., Guntupalli, B., Lou, X., & Xiao, Y. (2017). A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. Chemical Science, 8(1), 131–141. https://doi.org/10.1039/c6sc01833e

Yu, H. X., Canoura, J., Guntupalli, B., & Xiao, Y. (2017). A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. Poster presented at the Gordon Research Conference: Nucleosides, Nucleotides & Oligonucleotides, Salve Regina University, Newport, RI.

Roncancio, D., Yu, H. X., Xu, X. W., & Xiao, Y. (2017). A label-free aptamer-fluorophore assembly for highly sensitive and specific detection of cocaine. Presented at the Pittcon 2017, Chicago, Illinois.

Yu, H. X., Canoura, J., Guntupalli, B., & Xiao, Y. (2017). Cooperative-binding split aptamer assays for rapid, specific and ultra-sensitive detection of small-molecule targets in biofluid samples. Invited talk presented at the 2017 American Chemical Society Florida Annual Meeting and Exposition, Tampa, FL.

Xiao, Y. (2017). Gold nanoparticle-based assays for rapid and sensitive colorimetric and electrochemical biosensing. Presented at the Nano Florida 2017, Florida International University, Miami, FL.

Liang, P. P., Guntupalli, B., Yu, H. X., & Xiao, Y. (2017). Gold nanoparticle-based, paper devices for rapid and sensitive colorimetric and electrochemical biosensing. Invited talk presented at the 2017 American Chemical Society Florida Annual Meeting and Exposition, Tampa, FL.

Roncancio, D., Yu, H. X., Xu, X. W., & Xiao, Y. (2017). Materials and methods for rapid and specific detection of cocaine (Patent No. US9804178B2).

Yu, H. X., Canoura, J., Guntupalli, B., Lou, X. H., & Xiao, Y. (2017). Rapid and sensitive detection of small-molecule targets via enzyme-assisted target recycling based on cooperative binding split aptamers. Poster presented at the Gordon Research Conference: Nucleosides, Nucleotides & Oligonucleotides, Salve Regina University, Newport, RI.

Canoura, J., Wang, Z. W., Yu, H. X., & Xiao, Y. (2017). Utilizing dual-enzyme selectivity for the identification of aptamer binding domains and the development of sensitive fluorescence detection of small-molecule targets. Presented at the FIU Annual Scholarly Forum, Graduate Student Appreciation Week (GSAW), Florida International University, Miami, FL.

Canoura, J., Wang, Z. W., Yu, H. X., & Xiao, Y. (2017). Utilizing nuclease screening of ligand-aptamer complexes to enhance specificity of an aptamer-based cocaine assay. Poster presented at the Gordon Research Conference: Nucleosides, Nucleotides & Oligonucleotides, Salve Regina University, Newport, RI.

Yu, H. X., Canoura, J., Guntupalli, B., & Xiao, Y. (2016). A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. Presented at the Pittcon 2017, Chicago, Illinois.

Yu, H. X., Guntupalli, B., & Xiao, Y. (2016). A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. Presented at the 2016 Conference of Undergraduate Research at FIU (CURFIU), Miami, FL.

H.X., Y., B., G., & Y, X. (2016). A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. Presented at the FIU Annual Scholarly Forum, Graduate Student Appreciation Week (GSAW), Florida International University, Miami, FL.

Roncancio, D., Yu, H. X., Xu, X. W., Wu, S., Liu, R., Debord, J., … Xiao, Y. (2016). A label-free aptamer-fluorophore assembly for highly sensitive and specific detection of cocaine. Presented at the 2016 Conference of Undergraduate Research at FIU (CURFIU), Miami, FL.

Guntupalli, B., Liang, P. P., Lee, J. H., Yang, Y. H., Yu, H. X., Canoura, J., … Xiao, Y. (2016). Ambient filtration method to rapidly prepare highly conductive, paper-based porous gold films for electrochemical biosensing. Presented at the 2016 Conference of Undergraduate Research at FIU (CURFIU), Miami, FL.

Xiao, Y. (2016). Bringing biosensors to the bedside. Invited talk presented at the University of Miami, Medical Campus - Batchelor Children's Research Institute, Miami, FL.

Liang, P. P., Yu, H. X., Guntupalli, B., & Xiao, Y. (2016). Paper-based device for rapid visualization of NADH based on dissolution of gold nanoparticles. Poster presented at the 2016 Conference of Undergraduate Research at FIU (CURFIU), Miami, FL.

Xiao, Y. (2016). Paper-based devices for rapid and sensitive colorimetric and electrochemical biosensing. Invited talk presented at the 2016 ACS Florida Annual Meeting and Exposition, Tampa, FL.

Xu, Q., Lou, X., Wang, L., Ding, X., Yu, H., & Xiao, Y. (2016). Rapid, Surfactant-Free, and Quantitative Functionalization of Gold Nanoparticles with Thiolated DNA under Physiological pH and Its Application in Molecular Beacon-Based Biosensor. ACS Applied Materials & Interfaces, 8(40), 27298–27304. https://doi.org/10.1021/acsami.6b08350

Canoura, J., Wang, Z. W., Yu, H. X., Ng, B., Roncancio, D., & Xiao, Y. (2016). Utilizing nuclease screening of ligand-aptamer complexes to enhance specificity of an aptamer-based cocaine assay. Poster presented at the 2016 ACS Florida Annual Meeting and Exposition, Tampa, FL.

Liang, P. P., Yu, H. X., & Xiao, Y. (2015). A paper-based device for rapid visualization of NADH based on dissolution of gold nanoparticles. Poster presented at the 2015 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts.

Guntupalli, B., Liang, P., Lee, J.-H., Yang, Y., Yu, H., Canoura, J., … Xiao, Y. (2015). Ambient Filtration Method To Rapidly Prepare Highly Conductive, Paper-Based Porous Gold Films for Electrochemical Biosensing. ACS Applied Materials & Interfaces, 7(49), 27049–27058. https://doi.org/10.1021/acsami.5b09612

Guntupalli, B., Liang, P. P., Yang, Y. H., He, J., Li, W. Z., & Xiao, Y. (2015). Ambient filtration method to rapidly prepare highly conductive, paper-based porous gold films. Presented at the 2015 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts.

Wang, Z. W., Yu, H. X., Ng, B., Roncancio, D., Canoura, J., & Xiao, Y. (2015). Amplified colorimetric detection of cocaine in oral fluid based on exonuclease-assisted aptamer strand recycling. Poster presented at the Society of Forensic Toxicologists (SOFT) 2015 Annual Meeting, Atlanta, Georgia.

Xiao, Y. (2015). Aptamer-based, exonuclease-amplified, paper device for point of collection screening of cocaine and methamphetamine in oral fluid. Invited talk presented at the Forensic Science R&D Grantees Meeting, Orlando, FL.

Xiao, Y. (2015). Base-pair mismatch detection. Invited talk presented at the FIU Biomolecular Sciences Institute Symposium on DNA Repair and Genome Stability: In honor of the 2015 Nobel Prize in Chemistry for DNA Repair, Miami, FL.

Xiao, Y. (2015). Bringing biosensors to the bedside. Recruitment talk presented at the Division of Health and Natural Sciences, Florida Memorial University, Miami, FL.

Zhao, T., Liu, R., Ding, X., Zhao, J., Yu, H., Wang, L., … Xiao, Y. (2015). Nanoprobe-Enhanced, Split Aptamer-Based Electrochemical Sandwich Assay for Ultrasensitive Detection of Small Molecules. Analytical Chemistry, 87(15), 7712–7719. https://doi.org/10.1021/acs.analchem.5b01178

Liang, P., Yu, H., Guntupalli, B., & Xiao, Y. (2015). Paper-Based Device for Rapid Visualization of NADH Based on Dissolution of Gold Nanoparticles. ACS Applied Materials & Interfaces, 7(27), 15023–15030. https://doi.org/10.1021/acsami.5b04104

Yu, H. X., Wang, Z. W., Ng, B., Canoura, J., & Xiao, Y. (2015). Simple, rapid and ultra-sensitive fluorescence detection of cocaine in oral fluid based on cooperative binding split aptamer. Presented at the Society of Forensic Toxicologists (SOFT) 2015 Annual Meeting, Atlanta, Georgia.

Roncancio, D., Yu, H., Xu, X., Wu, S., Liu, R., Debord, J., … Xiao, Y. (2014). A Label-Free Aptamer-Fluorophore Assembly for Rapid and Specific Detection of Cocaine in Biofluids. Analytical Chemistry, 86(22), 11100–11106. https://doi.org/10.1021/ac503360n

Roncancio, D., Wu, S., Yu, H. X., Xu, X. W., Liu, R., Debord, J., … Xiao, Y. (2014). A label-free aptamer-fluorophore assembly for highly sensitive and specific detection of cocaine. Poster presented at the 2014 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts.

Wu, S., Liang, P., Yu, H., Xu, X., Liu, Y., Lou, X., & Xiao, Y. (2014). Amplified Single Base-Pair Mismatch Detection via Aggregation of Exonuclease-Sheared Gold Nanoparticles. Analytical Chemistry, 86(7), 3461–3467. https://doi.org/10.1021/ac4040373

Wu, S., Liang, P. P., Yu, H. X., Xu, X. W., Liu, Y., Lou, X. H., & Xiao, Y. (2014). Amplified single base-pair mismatch detection via the aggregation of exonuclease-sheared gold nanoparticles. Poster presented at the 2014 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts.

Xiao, Y. (2014). Bringing biosensors to the bedside. Recruitment talk presented at the Department of Chemistry, St. Thomas University, Miami, FL.

Xu, X. W., Guntupalli, B., Yu, H. X., & Xiao, Y. (2014). Target recycling-based assay for rapid and accurate determination of DNA surface coverage on gold nanoparticles. Presented at the 2014 Materials Research Society (MRS) Fall Meeting & Exhibit, Boston, Massachusetts.

Guntupalli, B., Liang, P. P., Dai, J. Y., Yang, Y. H., He, J., Li, W. Z., & Xiao, Y. (2013). Ambient filtration method to prepare paper-based electroactive nanoporous gold thin film for detection of dopamine and serotonin. Presented at the 89th Florida Annual Meeting and Exposition, Palm Harbor, FL.

Xiao, Y. (2013). Bringing biosensors to the bedside. Recruitment talk presented at the Department of Chemistry, University of Tampa, Tampa, FL.

Deborggraeve, S., Dai, J. Y., Xiao, Y., & Soh, H. T. (2013). Controlling the function of DNA nanostructures with specific trigger sequences. Chem. Commun., 49(4), 397–399. https://doi.org/10.1039/c2cc36878a

Oh, S. S., Plakos, K., Xiao, Y., Eisenstein, M., & Soh, H. T. (2013). In Vitro Selection of Shape-Changing DNA Nanostructures Capable of Binding-Induced Cargo Release. ACS Nano, 7(11), 9675–9683. https://doi.org/10.1021/nn404079v

Xiao, Y., Dai, J. Y., Paudyal, J., Guntupalli, B., Liang, P. P., Pubillones, F., … Wang, X. T. (2013). Paper-based single-walled carbon nanotube thin film for catalytic detection of nicotinamide adenine dinucleotide in human blood. Invited talk presented at the 89th Florida Annual Meeting and Exposition, Palm Harbor, FL.

Lou, X., Zhao, T., Liu, R., Ma, J., & Xiao, Y. (2013). Self-Assembled DNA Monolayer Buffered Dynamic Ranges of Mercuric Electrochemical Sensor. Analytical Chemistry, 85(15), 7574–7580. https://doi.org/10.1021/ac401680c

Xiao, Y. (2012). Biosensors, biotechnologies and biomaterials. Presented at the 9th International Symposium on Persistent Toxic Substances, Miami, FL.

Feng, L., Zhao, C., Xiao, Y., Wu, L., Ren, J., & Qu, X. (2012). Electrochemical DNA three-way junction based sensor for distinguishing chiral metallo-supramolecular complexes. Chemical Communications, 48(55), 6900. https://doi.org/10.1039/c2cc32496b

Ahmad, K. M., Xiao, Y., & Soh, H. T. (2012). Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution. Nucleic Acids Research, 40(22), 11777–11783. https://doi.org/10.1093/nar/gks899

Xiao, Y. (2011). Bringing biosensors to the bedside. Recruitment talk presented at the Department of Chemistry, Barry University, Miami, FL.

Ferguson, B. S., Buchsbaum, S. F., Wu, T.-T., Hsieh, K., Xiao, Y., Sun, R., & Soh, H. T. (2011). Genetic Analysis of H1N1 Influenza Virus from Throat Swab Samples in a Microfluidic System for Point-of-Care Diagnostics. Journal of the American Chemical Society, 133(23), 9129–9135. https://doi.org/10.1021/ja203981w

Oh, S. S., Ahmad, K. M., Cho, M., Kim, S., Xiao, Y., & Soh, H. T. (2011). Improving Aptamer Selection Efficiency through Volume Dilution, Magnetic Concentration, and Continuous Washing in Microfluidic Channels. Analytical Chemistry, 83(17), 6883–6889. https://doi.org/10.1021/ac201269f

Olmsted, I. R., Xiao, Y., Cho, M., Csordas, A. T., Sheehan, J. H., Meiler, J., … Bornhop, D. J. (2011). Measurement of Aptamer–Protein Interactions with Back-Scattering Interferometry. Analytical Chemistry, 83(23), 8867–8870. https://doi.org/10.1021/ac202823m

Hsieh, K., White, R. J., Ferguson, B. S., Plaxco, K. W., Xiao, Y., & Soh, H. T. (2011). Polarity-Switching Electrochemical Sensor for Specific Detection of Single-Nucleotide Mismatches. Angewandte Chemie International Edition, 50(47), 11176–11180. https://doi.org/10.1002/anie.201103482

Ahmad, K. M., Oh, S. S., Kim, S., McClellen, F. M., Xiao, Y., & Soh, H. T. (2011). Probing the Limits of Aptamer Affinity with a Microfluidic SELEX Platform. PLoS ONE, 6(11), e27051. https://doi.org/10.1371/journal.pone.0027051

Wang, J., Liu, Y., Teesalu, T., Sugahara, K. N., Kotamrajua, V. R., Adams, J. D., … Soh, H. T. (2011). Selection of phage-displayed peptides on live adherent cells in microfluidic channels. Proceedings of the National Academy of Sciences, 108(17), 6909–6914. https://doi.org/10.1073/pnas.1014753108

Zuo, X., Xia, F., Patterson, A., Soh, H. T., Xiao, Y., & Plaxco, K. W. (2011). Two-Step, PCR-Free Telomerase Detection by Using Exonuclease III-Aided Target Recycling. ChemBioChem, 12(18), 2745–2747. https://doi.org/10.1002/cbic.201100592

Xia, F., White, R. J., Zuo, X., Patterson, A., Xiao, Y., Kang, D., … Heeger, A. J. (2010). An Electrochemical Supersandwich Assay for Sensitive and Selective DNA Detection in Complex Matrices. Journal of the American Chemical Society, 132(41), 14346–14348. https://doi.org/10.1021/ja104998m

Xia, F., Zuo, X., Yang, R., Xiao, Y., Kang, D., Vallee-Belisle, A., … Plaxco, K. W. (2010). Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes. Proceedings of the National Academy of Sciences, 107(24), 10837–10841. https://doi.org/10.1073/pnas.1005632107

Csordas, A., Gerdon, A. E., Adams, J. D., Qian, J., Oh, S. S., Xiao, Y., & Soh, H. T. (2010). Detection of Proteins in Serum by Micromagnetic Aptamer PCR (MAP) Technology. Angewandte Chemie International Edition, 49(2), 355–358. https://doi.org/10.1002/anie.200904846

Xiao, Y., Dane, K. Y., Uzawa, T., Csordas, A., Qian, J., Soh, H. T., … Plaxco, K. W. (2010). Detection of Telomerase Activity in High Concentration of Cell Lysates Using Primer-Modified Gold Nanoparticles. Journal of the American Chemical Society, 132(43), 15299–15307. https://doi.org/10.1021/ja106513f

Hsieh, K., Xiao, Y., & Tom Soh, H. (2010). Electrochemical DNA Detection via Exonuclease and Target-Catalyzed Transformation of Surface-Bound Probes. Langmuir, 26(12), 10392–10396. https://doi.org/10.1021/la100227s

Oh, S. S., Plakos, K., Lou, X., Xiao, Y., & Soh, H. T. (2010). In vitro selection of structure-switching, self-reporting aptamers. Proceedings of the National Academy of Sciences, 107(32), 14053–14058. https://doi.org/10.1073/pnas.1009172107

Xia, F., Zuo, X., Yang, R., White, R. J., Xiao, Y., Kang, D., … Plaxco, K. W. (2010). Label-Free, Dual-Analyte Electrochemical Biosensors: A New Class of Molecular-Electronic Logic Gates. Journal of the American Chemical Society, 132(25), 8557–8559. https://doi.org/10.1021/ja101379k

Xia, F., Zuo, X., Yang, R., Xiao, Y., Kang, D., Vallée-Bélisle Alexis, … Plaxco, K. W. (2010). On the Binding of Cationic, Water-Soluble Conjugated Polymers to DNA: Electrostatic and Hydrophobic Interactions. Journal of the American Chemical Society, 132(4), 1252–1254. https://doi.org/10.1021/ja908890q

Cho, M., Xiao, Y., Nie, J., Stewart, R., Csordas, A. T., Oh, S. S., … Soh, H. T. (2010). Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing. Proceedings of the National Academy of Sciences, 107(35), 15373–15378. https://doi.org/10.1073/pnas.1009331107

Zuo, X., Xia, F., Xiao, Y., & Plaxco, K. W. (2010). Sensitive and Selective Amplified Fluorescence DNA Detection Based on Exonuclease III-Aided Target Recycling. Journal of the American Chemical Society, 132(6), 1816–1818. https://doi.org/10.1021/ja909551b

Xiao, Y., Lubin, A. A., & Plaxco, K. W. (2010). Signal-on architecture for electronic oligonucleotide-based detectors (Patent No. US7803542B2).

Xiao, Y., Lou, X., Uzawa, T., Plakos, K. J. I., Plaxco, K. W., & Soh, H. T. (2009). An Electrochemical Sensor for Single Nucleotide Polymorphism Detection in Serum Based on a Triple-Stem DNA Probe. Journal of the American Chemical Society, 131(42), 15311–15316. https://doi.org/10.1021/ja905068s

Swensen, J. S., Xiao, Y., Ferguson, B. S., Lubin, A. A., Lai, R. Y., Heeger, A. J., … Soh, H. T. (2009). Continuous, Real-Time Monitoring of Cocaine in Undiluted Blood Serum via a Microfluidic, Electrochemical Aptamer-Based Sensor. Journal of the American Chemical Society, 131(12), 4262–4266. https://doi.org/10.1021/ja806531z

Xiao, Y., & Plaxco, K. W. (2009). Electrochemical Approaches to Aptamer-Based Sensing. In Functional Nucleic Acids for Analytical Applications (pp. 179–197). https://doi.org/10.1007/978-0-387-73711-9_7

Xiao, Y., Plakos, K. J. I., Lou, X., White, R. J., Qian, J., Plaxco, K. W., & Soh, H. T. (2009). Fluorescence Detection of Single-Nucleotide Polymorphisms with a Single, Self-Complementary, Triple-Stem DNA Probe. Angewandte Chemie International Edition, 48(24), 4354–4358. https://doi.org/10.1002/anie.200900369

Qian, J., Lou, X., Zhang, Y., Xiao, Y., & Soh, H. T. (2009). Generation of Highly Specific Aptamers via Micromagnetic Selection. Analytical Chemistry, 81(13), 5490–5495. https://doi.org/10.1021/ac900759k

Zuo, X., Xiao, Y., & Plaxco, K. W. (2009). High Specificity, Electrochemical Sandwich Assays Based on Single Aptamer Sequences and Suitable for the Direct Detection of Small-Molecule Targets in Blood and Other Complex Matrices. Journal of the American Chemical Society, 131(20), 6944–6945. https://doi.org/10.1021/ja901315w

Lou, X., Xiao, Y., Wang, Y., Mao, H., & Zhao, J. (2009). Label-Free Colorimetric Screening of Nuclease Activity and Substrates by Using Unmodified Gold Nanoparticles. ChemBioChem, 10(12), 1973–1977. https://doi.org/10.1002/cbic.200900355

Lou, X., Qian, J., Xiao, Y., Viel, L., Gerdon, A. E., Lagally, E. T., … Soh, H. T. (2009). Micromagnetic selection of aptamers in microfluidic channels. Proceedings of the National Academy of Sciences, 106(9), 2989–2994. https://doi.org/10.1073/pnas.0813135106

Xiao, Y., Uzawa, T., White, R. J., DeMartini, D., & Plaxco, K. W. (2009). On the Signaling of Electrochemical Aptamer-Based Sensors: Collision- and Folding-Based Mechanisms. Electroanalysis, 21(11), 1267–1271. https://doi.org/10.1002/elan.200804564

Peng, Y., Wang, X., Xiao, Y., Feng, L., Zhao, C., Ren, J., & Qu, X. (2009). i-Motif Quadruplex DNA-Based Biosensor for Distinguishing Single- and Multiwalled Carbon Nanotubes. Journal of the American Chemical Society, 131(38), 13813–13818. https://doi.org/10.1021/ja9051763

White, R. J., Phares, N., Lubin, A. A., Xiao, Y., & Plaxco, K. W. (2008). Optimization of Electrochemical Aptamer-Based Sensors via Optimization of Probe Packing Density and Surface Chemistry. Langmuir, 24(18), 10513–10518. https://doi.org/10.1021/la800801v

Cash, K. J., Heeger, A. J., Plaxco, K. W., & Xiao, Y. (2008). Optimization of a Reusable, DNA Pseudoknot-Based Electrochemical Sensor for Sequence-Specific DNA Detection in Blood Serum. Analytical Chemistry, 81(2), 656–661. https://doi.org/10.1021/ac802011d

Willner, I., Xiao, Y., Pavlov, V., & Niazov, T. (2007). Catalytic polynucleotide and its use for determination of analytes (US Patent No. 20070254282).

Xiao, Y., Rowe, A. A., & Plaxco, K. W. (2007). Electrochemical Detection of Parts-Per-Billion Lead via an Electrode-Bound DNAzyme Assembly. Journal of the American Chemical Society, 129(2), 262–263. https://doi.org/10.1021/ja067278x

Xiao, Y., Qu, X., Plaxco, K. W., & Heeger, A. J. (2007). Label-Free Electrochemical Detection of DNA in Blood Serum via Target-Induced Resolution of an Electrode-Bound DNA Pseudoknot. Journal of the American Chemical Society, 129(39), 11896–11897. https://doi.org/10.1021/ja074218y

Xiao, Y., Lai, R. Y., & Plaxco, K. W. (2007). Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing. Nature Protocols, 2(11), 2875–2880. https://doi.org/10.1038/nprot.2007.413

Xiao, Y., Pavlov, V., Niazov, T., Dishon, A., Kotler, M., & Willner, I. (2006). Catalytic Beacons for the Detection of DNA and Telomerase Activity. In D. Morrison, F. Milanovich, D. Ivnitski, & T. R. Austin (Eds.), Defense against Bioterror (pp. 199–205). https://doi.org/10.1007/1-4020-3384-2_15

Willner, I., Pavlov, V., Zayatz, M., Niazov, T., Shlyahovsky, B., Xiao, Y., & Buron, R. (2006). Novel sensors with nanoparticle probe (Patent Application No. WO2006008742).

Xiao, Y., Lubin, A. A., Baker, B. R., Plaxco, K. W., & Heeger, A. J. (2006). Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex. Proceedings of the National Academy of Sciences, 103(45), 16677–16680. https://doi.org/10.1073/pnas.0607693103

Xiao, Y., Piorek, B. D., Plaxco, K. W., & Heeger, A. J. (2005). A Reagentless Signal-On Architecture for Electronic, Aptamer-Based Sensors via Target-Induced Strand Displacement. Journal of the American Chemical Society, 127(51), 17990–17991. https://doi.org/10.1021/ja056555h

Xiao, Y., Pavlov, V., Shlyahovsky, B., & Willner, I. (2005). An OsII-Bisbipyridine-4-Picolinic Acid Complex Mediates the Biocatalytic Growth of Au Nanoparticles: Optical Detection of Glucose and Acetylcholine Esterase Inhibition. Chemistry - A European Journal, 11(9), 2698–2704. https://doi.org/10.1002/chem.200400988

Pavlov, V., Xiao, Y., & Willner, I. (2005). Inhibition of the Acetycholine Esterase-Stimulated Growth of Au Nanoparticles:  Nanotechnology-Based Sensing of Nerve Gases. Nano Letters, 5(4), 649–653. https://doi.org/10.1021/nl050054c

Xiao, Y., Lubin, A. A., Heeger, A. J., & Plaxco, K. W. (2005). Label-Free Electronic Detection of Thrombin in Blood Serum by Using an Aptamer-Based Sensor. Angewandte Chemie International Edition, 44(34), 5456–5459. https://doi.org/10.1002/anie.200500989

Shlyahovsky, B., Katz, E., Xiao, Y., Pavlov, V., & Willner, I. (2005). Optical and Electrochemical Detection of NADH and of NAD+-Dependent Biocatalyzed Processes by the Catalytic Deposition of Copper on Gold Nanoparticles. Small, 1(2), 213–216. https://doi.org/10.1002/smll.200400057

Xiao, Y., Shlyahovsky, B., Popov, I., Pavlov, V., & Willner, I. (2005). Shape and color of Au nanoparticles follow biocatalytic processes. Langmuir, 21(13), 5659–5662. https://doi.org/10.1021/la050308+

Pavlov, V., Xiao, Y., Gill, R., Dishon, A., Kotler, M., & Willner, I. (2004). Amplified Chemiluminescence Surface Detection of DNA and Telomerase Activity Using Catalytic Nucleic Acid Labels. Analytical Chemistry, 76(7), 2152–2156. https://doi.org/10.1021/ac035219l

Pavlov, V., Xiao, Y., Shlyahovsky, B., & Willner, I. (2004). Aptamer-Functionalized Au Nanoparticles for the Amplified Optical Detection of Thrombin. Journal of the American Chemical Society, 126(38), 11768–11769. https://doi.org/10.1021/ja046970u

Xiao, Y., Pavlov, V., Niazov, T., Dishon, A., Kotler, M., & Willner, I. (2004). Catalytic Beacons for the Detection of DNA and Telomerase Activity. Journal of the American Chemical Society, 126(24), 7430–7431. https://doi.org/10.1021/ja031875r

Xiao, Y., Pavlov, V., Levine, S., Niazov, T., Markovitch, G., & Willner, I. (2004). Catalytic Growth of Au Nanoparticles by NAD(P)H Cofactors: Optical Sensors for NAD(P)+-Dependent Biocatalyzed Transformations. Angewandte Chemie International Edition, 43(34), 4519–4522. https://doi.org/10.1002/anie.200460608

Niazov, T., Pavlov, V., Xiao, Y., Gill, R., & Willner, I. (2004). DNAzyme-Functionalized Au Nanoparticles for the Amplified Detection of DNA or Telomerase Activity. Nano Letters, 4(9), 1683–1687. https://doi.org/10.1021/nl0491428

Shi, L., Xiao, Y., & Willner, I. (2004). Electrical contacting of glucose oxidase by DNA-templated polyaniline wires on surfaces. Electrochemistry Communications, 6(10), 1057–1060. https://doi.org/10.1016/j.elecom.2004.08.004

Xiao, Y., Pavlov, V., Gill, R., Bourenko, T., & Willner, I. (2004). Lighting Up Biochemiluminescence by the Surface Self-Assembly of DNA-Hemin Complexes. ChemBioChem, 5(3), 374–379. https://doi.org/10.1002/cbic.200300794

Xiao, Y. (2003). "Plugging into Enzymes": Nanowiring of Redox Enzymes by a Gold Nanoparticle. Science, 299(5614), 1877–1881. https://doi.org/10.1126/science.1080664

Xiao, Y., Kharitonov, A. B., Patolsky, F., Weizmann, Y., & Willner, I. (2003). Electrocatalytic intercalator-induced winding of double-stranded DNA with polyaniline. Chemical Communications, (13), 1540. https://doi.org/10.1039/b301749d

Ju, H., Xiao, Y., Lu, X., & Chen, H. (2002). Electrooxidative coupling of a toluidine blue O terminated self-assembled monolayer studied by electrochemistry and surface enhanced Raman spectroscopy. Journal of Electroanalytical Chemistry, 518(2), 123–130. https://doi.org/10.1016/s0022-0728(01)00702-1

Hu, X. Y., Xiao, Y., & Chen, H. Y. (2001). Anion adsorption on an Au colloid monolayer based cysteamine-modified gold electrode. Chemical Research in Chinese Universities, 17(2), 159–167.

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Xiao, Y., Ju, H.-X., & Chen, H.-Y. (1999). A reagentless hydrogen peroxide sensor based on incorporation of horseradish peroxidase in poly(thionine) film on a monolayer modified electrode. Analytica Chimica Acta, 391(3), 299–306. https://doi.org/10.1016/s0003-2670(99)00254-8

Hu, X.-Y., Xiao, Y., & Chen, H.-Y. (1999). Adsorption characteristics of Fe(CN)63−/4− on Au colloids as monolayer films on cysteamine-modified gold electrode. Journal of Electroanalytical Chemistry, 466(1), 26–30. https://doi.org/10.1016/s0022-0728(99)00113-8

Xiao, Y., Ju, H.-X., & Chen, H.-Y. (1999). Hydrogen peroxide sensor based on horseradish peroxidase-labeled Au colloids immobilized on gold electrode surface by cysteamine monolayer. Analytica Chimica Acta, 391(1), 73–82. https://doi.org/10.1016/s0003-2670(99)00196-8

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