Ying Yan

Works (7)

Updated: July 7th, 2023 21:18

2021 journal article

Conditional knockdown of transformer in sheep blow fly suggests a role in repression of dosage compensation and potential for population suppression

PLOS Genetics, 17(10), e1009792.

By: M. Williamson n, Y. Yan n & M. Scott n 

Ed(s): S. Palli

MeSH headings : Animals; Animals, Genetically Modified; Australia; Calliphoridae / genetics; Diptera / genetics; Dosage Compensation, Genetic / genetics; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Female; Genes, Insect / genetics; Genes, X-Linked / genetics; Male; Pupa / genetics; RNA Interference / physiology; RNA Splicing / genetics; RNA-Binding Proteins / genetics; Sheep; Transcription Factors / genetics; X Chromosome / genetics
TL;DR: Results suggest that Lctra promotes somatic sexual differentiation and inhibits X chromosome dosage compensation in female L. cuprina and may be essential for initiation of dosage compensation suppression in female embryos. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: November 15, 2021

2020 journal article

Building a transgenic sexing strain for genetic control of the Australian sheep blow fly Lucilia cuprina using two lethal effectors

BMC Genetics, 21(S2).

By: Y. Yan n & M. Scott n 

author keywords: Sterile insect technique (SIT); Tetracycline transactivator (tTA); Head involution defective (hid); Genetic pest management
MeSH headings : Animals; Animals, Genetically Modified; Calliphoridae / embryology; Calliphoridae / genetics; Embryonic Development; Female; Genes, Lethal; Genetic Fitness; Insect Control; Sheep / parasitology; Tetracycline / pharmacology
TL;DR: The combination of two tTA-dependent lethal effectors could improve strain stability under mass rearing and could reduce the risk of resistance in the field if fertile males are released. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 19, 2021

2020 journal article

Using Moderate Transgene Expression to Improve the Genetic Sexing System of the Australian Sheep Blow Fly Lucilia cuprina

Insects, 11(11), 797.

By: Y. Yan*, M. Williamson n & M. Scott n 

author keywords: livestock pest; Lucilia cuprina; genetic control; pro-apoptotic gene; sterile insect technique; genetic sexing; tetracycline-off system; insect transgenesis
TL;DR: It is shown that effective male-only strains can be made by combining driver/effector lines that have moderate transgene expression/activity, and such a “moderate strategy” could be considered for the TESS development in other pest species. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: December 21, 2020

2019 journal article

Improved transgenic sexing strains for genetic control of the Australian sheep blow fly Lucilia cuprina using embryo-specific gene promoters

Molecular Genetics and Genomics, 295(2), 287–298.

By: Y. Yan n, M. Williamson n, R. Davis n, A. Andere*, C. Picard * & M. Scott n 

author keywords: Sterile insect technique; Transgenic; Lucilia cuprina; Genetic control; Cellularization gene
MeSH headings : Animals; Animals, Genetically Modified; Australia; Diptera / genetics; Diptera / pathogenicity; Embryonic Development / genetics; Female; Insect Proteins / genetics; Male; Pest Control, Biological; Promoter Regions, Genetic; Sheep / genetics; Sheep / parasitology; Tetracycline / biosynthesis
TL;DR: These new embryonic L. cuprina transgenic sexing strains hold great promise for genetic control programs and the system reported here might also be transferable to other major calliphorid livestock pests such as the New World screwworm, Cochliomyia hominivorax. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: December 2, 2019

2017 journal article

Building early-larval sexing systems for genetic control of the Australian sheep blow fly Lucilia cuprina using two constitutive promoters

Scientific Reports, 7(1).

By: Y. Yan n, R. Linger n & M. Scott n 

MeSH headings : Animals; Animals, Genetically Modified; Australia; Diptera / genetics; Diptera / growth & development; Diptera / metabolism; Embryo, Nonmammalian; Female; Genes, Insect; Genes, Lethal; Larva / genetics; Larva / growth & development; Larva / metabolism; Male; Pest Control, Biological / methods; Promoter Regions, Genetic; Sex Differentiation; Sheep / parasitology; Sheep Diseases / prevention & control; Tetracycline / pharmacology; Transcriptional Activation / drug effects
TL;DR: Investigating the idea of isolating and employing the promoters from the Lucilia spitting image and actin 5C genes to drive tTA expression in embryos and later stages found it to be effective for assembling an effective TSS. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Towards next generation maggot debridement therapy: transgenic Lucilia sericata larvae that produce and secrete a human growth factor

BMC Biotechnology, 16(1).

By: R. Linger n, E. Belikoff n, Y. Yan n, F. Li n, H. Wantuch  n, H. Fitzsimons *, M. Scott n 

author keywords: Maggot debridement therapy (MDT); Platelet-derived growth factor (PDGF); Excretions/secretions (ES); Growth factor treatment; Diabetic foot ulcer; Tetracycline transactivator; Lucilia sericata; Wound healing
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

A transgenic embryonic sexing system for the Australian sheep blow fly Lucilia cuprina

Scientific Reports, 5(1).

By: Y. Yan n & M. Scott n 

MeSH headings : Animals; Animals, Genetically Modified / genetics; Australia; Diptera / drug effects; Diptera / genetics; Female; Genes, Insect / drug effects; Genes, Insect / genetics; Genes, Lethal / drug effects; Genes, Lethal / genetics; Male; Pest Control, Biological / methods; Pupa / drug effects; Pupa / genetics; Sexual Behavior / physiology; Sheep / parasitology; Tetracycline / pharmacology; Transgenes / drug effects; Transgenes / genetics
TL;DR: Embryonic sexing strains were made by combining the Lsbnk-tTA and tetO-Lshid components into a single gene construct, which will facilitate transfer of the technology to other major calliphorid livestock pests. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

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