Yunlong Zhang

Works (10)

Updated: April 24th, 2025 09:20

2023 article

Tolyporphins–Exotic Tetrapyrrole Pigments in a Cyanobacterium—A Review

Nguyen, K.-U., Zhang, Y., Liu, Q., Zhang, R., Jin, X., Taniguchi, M., … Lindsey, J. S. (2023, August 18). Molecules, Vol. 28.

By: K. Nguyen n, Y. Zhang n, Q. Liu n, R. Zhang n, X. Jin  n, M. Taniguchi n , E. Miller n , J. Lindsey n 

author keywords: bacteriochlorin; bioinformatics; biosynthesis; chlorophyll; cyanobacteria; field biology; gene cluster; genomics; natural products; tolyporphins
MeSH headings : Tetrapyrroles; Cyanobacteria / genetics; Porphyrins / pharmacology; Cardiac Glycosides
topics (OpenAlex): Marine Sponges and Natural Products; Porphyrin and Phthalocyanine Chemistry; Photosynthetic Processes and Mechanisms
TL;DR: The identification of putative biosynthetic gene clusters in the HT-58-2 cyanobacterial genome and accompanying studies suggest a new biosynthesis paradigm in the tetrapyrrole arena, which stands alone in the large pigments-of-life family. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 2, 2023

2022 article

Tailoring the AIE Chromogen 2-(2-Hydroxyphenyl)benzothiazole for Use in Enzyme-Triggered Molecular Brachytherapy

Wu, Z., Dou, J., Nguyen, K.-U., Eppley, J. C., Siwawannapong, K., Zhang, Y., & Lindsey, J. S. (2022, December 8). Molecules, Vol. 27.

By: Z. Wu n, J. Dou n, K. Nguyen n, J. Eppley  n, K. Siwawannapong n, Y. Zhang n, J. Lindsey n 

author keywords: aggregation; cancer; insolubilization; molecular design; phosphodiester; precipitation; radiotherapy
MeSH headings : Prodrugs; Brachytherapy; Benzothiazoles; Polyethylene Glycols
topics (OpenAlex): Luminescence and Fluorescent Materials; Nanoplatforms for cancer theranostics; Click Chemistry and Applications
TL;DR: Several 2-(2-hydroxyphenyl)benzothiazole substrates that readily aggregate in aqueous solution (and afford AIE) were elaborated, taking a step forward on the long road toward molecular brachytherapy. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023

2021 article

Identification of Putative Biosynthetic Gene Clusters for Tolyporphins in Multiple Filamentous Cyanobacteria

Jin, X., Zhang, Y., Zhang, R., Nguyen, K.-U., Lindsey, J. S., & Miller, E. S. (2021, July 28). Life, Vol. 8.

By: X. Jin n, Y. Zhang n, R. Zhang n, K. Nguyen n, J. Lindsey n  & E. Miller n 

author keywords: tolyporphins; tetrapyrroles; cyanobacteria; biosynthetic gene cluster; Brasilonema; Nostoc; Oculatella
topics (OpenAlex): Algal biology and biofuel production; Photosynthetic Processes and Mechanisms; Biocrusts and Microbial Ecology
TL;DR: Phylogenetic analysis based on 16S rRNA and a common component of the BGCs, TolD, points to a close evolutionary history between each strain and their respective tolyporphins BGC, and a collection of candidate cyanobacteria for genetic and biochemical analysis pertaining to these unusual tetrapyrrole macrocycles. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021

2020 article

Chromogenic agents built around a multifunctional double-triazine framework for enzymatically triggered cross-linking under physiological conditions

Fujita, H., Zhang, Y., Wu, Z., & Lindsey, J. S. (2020, January 1). New Journal of Chemistry, Vol. 44, pp. 3856–3867.

By: H. Fujita  n, Y. Zhang n, Z. Wu n & J. Lindsey n 

topics (OpenAlex): Click Chemistry and Applications; Synthesis and Characterization of Heterocyclic Compounds; Chemical Synthesis and Analysis
TL;DR: Ratiometric absorption of the integral coumarin dye with the indigoid scaffold showed a low yield of oligomerization, which suggests future molecular designs might employ longer linkers and/or substituents with greater water solubility. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 6, 2020

2020 article

Engineering of an archaeal phosphodiesterase to trigger aggregation-induced emission (AIE) of synthetic substrates

Zhang, Y., Wu, Z., Takashima, I., Nguyen, K.-U., Matsumoto, N., & Lindsey, J. S. (2020, January 1). New Journal of Chemistry, Vol. 44, pp. 14266–14277.

By: Y. Zhang n, Z. Wu n, I. Takashima  n, K. Nguyen n, N. Matsumoto n & J. Lindsey n 

topics (OpenAlex): Luminescence and Fluorescent Materials; Nicotinic Acetylcholine Receptors Study; Molecular Sensors and Ion Detection
TL;DR: The development of enzymatically triggered substrates and the complementary heterologous enzymes may support diverse applications in the life sciences. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 14, 2020

2019 journal article

Cellular localization of tolyporphins, unusual tetrapyrroles, in a microbial photosynthetic community determined using hyperspectral confocal fluorescence microscopy

Photosynthesis Research, 141(3), 259–271.

By: M. Barnhart-Dailey *, Y. Zhang n, R. Zhang n, S. Anthony *, J. Aaron *, E. Miller n , J. Lindsey n , J. Timlin *

author keywords: Bacteriochlorin; Chlorophyll; Cyanobacteria; Membrane; Multivariate curve resolution
MeSH headings : Adaptation, Physiological; Bacteriochlorophyll A / chemistry; Chlorophyll A / chemistry; Cyanobacteria / metabolism; Cyanobacteria / ultrastructure; Darkness; Microscopy, Confocal; Microscopy, Fluorescence; Photosynthesis; Porphyrins / chemistry; Porphyrins / metabolism; Tetrapyrroles / chemistry; Tetrapyrroles / metabolism
topics (OpenAlex): Photosynthetic Processes and Mechanisms; Porphyrin and Phthalocyanine Chemistry; Algal biology and biofuel production
TL;DR: This work quantifies the relative abundance and envelope localization of tolyporphins in single cells, and illustrates the ability to identify novel tetrapyrroles in the presence of chlorophyll a in a photosynthetic microorganism within a non-axenic culture. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 23, 2019

2018 journal article

Genome sequence, metabolic properties and cyanobacterial attachment of Porphyrobacter sp. HT-58-2 isolated from a filamentous cyanobacterium–microbial consortium

Microbiology, 164(10), 1229–1239.

By: R. Hughes n, X. Jin n, Y. Zhang n, R. Zhang n, S. Tran n, P. Williams *, J. Lindsey n , E. Miller n 

author keywords: alphaproteobacteria; fluorescence in situ hybridization (FISH); tolyporphins; bacteriochlorin; photosynthetic gene cluster
MeSH headings : Alphaproteobacteria / classification; Alphaproteobacteria / genetics; Alphaproteobacteria / metabolism; Alphaproteobacteria / physiology; Bacterial Proteins / genetics; Base Sequence; Chromosome Mapping; Cyanobacteria / metabolism; DNA, Bacterial / genetics; Genome, Bacterial / genetics; In Situ Hybridization, Fluorescence; Microbial Consortia; Phylogeny; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA
topics (OpenAlex): Microbial Community Ecology and Physiology; Genomics and Phylogenetic Studies; Photosynthetic Processes and Mechanisms
TL;DR: The studies reported herein expand the description of the community of predominantly alphaproteobacteria associated with the filamentous HT- 58-2 cyanobacterium and isolate a dominant bacterium, Porphyrobacter sp. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 7, 2019

2017 article

Genome Sequence and Composition of a Tolyporphin-Producing Cyanobacterium-Microbial Community

Hughes, R.-A., Zhang, Y., Zhang, R., Williams, P. G., Lindsey, J. S., & Miller, E. S. (2017, July 29). Applied and Environmental Microbiology, Vol. 83.

By: R. Hughes n, Y. Zhang n, R. Zhang n, P. Williams *, J. Lindsey n  & E. Miller n 

author keywords: cyanobacteria; genome analysis; phylogenetic analysis; tetrapyrroles; tolyporphin
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Biosynthetic Pathways; Cyanobacteria / chemistry; Cyanobacteria / genetics; Cyanobacteria / growth & development; Cyanobacteria / metabolism; Genome, Bacterial; Metagenomics; Multigene Family; Phylogeny; Porphyrins / biosynthesis; Porphyrins / chemistry
topics (OpenAlex): Porphyrin Metabolism and Disorders; Photosynthetic Processes and Mechanisms; Microbial Community Ecology and Physiology
TL;DR: It is found that the HT-58-2 culture is composed of the cyanobacterium and a community of associated bacteria, complicating the question of which organisms make tolyporphins, and an intriguing gene cluster that contains tetrapyrrole biosynthesis genes and a collection of unknown genes suggests a possible role in toly porphin biosynthesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

Mass spectrometric detection of chlorophyll a and the tetrapyrrole secondary metabolite tolyporphin A in the filamentous cyanobacterium HT-58-2. Approaches to high-throughput screening of intact cyanobacteria

Zhang, Y., Zhang, R., Nazari, M., Bagley, M. C., Miller, E. S., Williams, P. G., … Lindsey, J. S. (2017, November 1). Journal of Porphyrins and Phthalocyanines, Vol. 21, pp. 759–768.

By: Y. Zhang n, R. Zhang n, M. Nazari  n, M. Bagley n, E. Miller n , P. Williams *, D. Muddiman n , J. Lindsey n 

author keywords: IR-MALDESI-FTMS; MS/MS; MALDI-TOF-MS; chlorophyll; bacteriochlorin; high-throughput screening
topics (OpenAlex): Porphyrin and Phthalocyanine Chemistry; Marine and coastal ecosystems; Marine Toxins and Detection Methods
TL;DR: Examination by MALDI-TOF-MS of lipophilic crude extracts of small-scale HT-58-2 samples without chromatographic fractionation enabled semi-quantitation of tolyporphin A over a 41-day growth period. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Quantitation of Tolyporphins, Diverse Tetrapyrrole Secondary Metabolites with Chlorophyll-Like Absorption, from a Filamentous Cyanobacterium-Microbial Community

Phytochemical Analysis, 29(2), 205–216.

By: Y. Zhang n, R. Zhang n, R. Hughes n, J. Dai *, J. Gurr*, P. Williams *, E. Miller n , J. Lindsey n 

author keywords: HPLC; mass spectrometry; absorption spectroscopy with multicomponent analysis; nitrogen deprivation; growth curve
MeSH headings : Chlorophyll / chemistry; Chlorophyll A; Chromatography, High Pressure Liquid / methods; Cyanobacteria / growth & development; Cyanobacteria / metabolism; Porphyrins / analysis; Porphyrins / chemistry; Reference Standards; Reproducibility of Results; Spectrum Analysis / methods; Tetrapyrroles / analysis
topics (OpenAlex): Porphyrin and Phthalocyanine Chemistry; Photosynthetic Processes and Mechanisms; Algal biology and biofuel production
TL;DR: The quantitative methods developed herein should facilitate investigation of the biosynthesis of tolyporphins (and other tetrapyrroles) as well as examination of other strains for production of tolporph Ins. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

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