Yunlong Zhang

Works (10)

Updated: October 3rd, 2023 05:01

2023 review

Tolyporphins-Exotic Tetrapyrrole Pigments in a Cyanobacterium-A Review

[Review of ]. MOLECULES, 28(16).

By: K. Nguyen n, Y. Zhang n, Q. Liu n, R. Zhang n, X. Jin  n, M. Taniguchi n , E. Miller n , J. Lindsey n 

author keywords: bacteriochlorin; bioinformatics; biosynthesis; chlorophyll; cyanobacteria; field biology; gene cluster; genomics; natural products; tolyporphins
TL;DR: The identification of putative biosynthetic gene clusters in the HT-58-2 cyanobacterial genome and accompanying studies suggest a new biosynthesis paradigm in the tetrapyrrole arena, which stands alone in the large pigments-of-life family. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 2, 2023

2022 journal article

Tailoring the AIE Chromogen 2-(2-Hydroxyphenyl)benzothiazole for Use in Enzyme-Triggered Molecular Brachytherapy

MOLECULES, 27(24).

By: Z. Wu n, J. Dou n, K. Nguyen n, J. Eppley  n, K. Siwawannapong n, Y. Zhang n, J. Lindsey n 

author keywords: aggregation; cancer; insolubilization; molecular design; phosphodiester; precipitation; radiotherapy
MeSH headings : Prodrugs; Brachytherapy; Benzothiazoles; Polyethylene Glycols
TL;DR: Several 2-(2-hydroxyphenyl)benzothiazole substrates that readily aggregate in aqueous solution (and afford AIE) were elaborated, taking a step forward on the long road toward molecular brachytherapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023

2021 journal article

Identification of Putative Biosynthetic Gene Clusters for Tolyporphins in Multiple Filamentous Cyanobacteria

LIFE-BASEL, 11(8).

By: X. Jin n, Y. Zhang n, R. Zhang n, K. Nguyen n, J. Lindsey n  & E. Miller n 

author keywords: tolyporphins; tetrapyrroles; cyanobacteria; biosynthetic gene cluster; Brasilonema; Nostoc; Oculatella
TL;DR: Phylogenetic analysis based on 16S rRNA and a common component of the BGCs, TolD, points to a close evolutionary history between each strain and their respective tolyporphins BGC, and a collection of candidate cyanobacteria for genetic and biochemical analysis pertaining to these unusual tetrapyrrole macrocycles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021

2020 journal article

Chromogenic agents built around a multifunctional double-triazine framework for enzymatically triggered cross-linking under physiological conditions

NEW JOURNAL OF CHEMISTRY, 44(10), 3856–3867.

By: H. Fujita  n, Y. Zhang n, Z. Wu n & J. Lindsey n 

TL;DR: Ratiometric absorption of the integral coumarin dye with the indigoid scaffold showed a low yield of oligomerization, which suggests future molecular designs might employ longer linkers and/or substituents with greater water solubility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 6, 2020

2020 journal article

Engineering of an archaeal phosphodiesterase to trigger aggregation-induced emission (AIE) of synthetic substrates

NEW JOURNAL OF CHEMISTRY, 44(33), 14266–14277.

By: Y. Zhang n, Z. Wu n, I. Takashima n, K. Nguyen n, N. Matsumoto n & J. Lindsey n 

TL;DR: The development of enzymatically triggered substrates and the complementary heterologous enzymes may support diverse applications in the life sciences. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 14, 2020

2019 journal article

Cellular localization of tolyporphins, unusual tetrapyrroles, in a microbial photosynthetic community determined using hyperspectral confocal fluorescence microscopy

Photosynthesis Research, 141(3), 259–271.

By: M. Barnhart-Dailey*, Y. Zhang n, R. Zhang n, S. Anthony*, J. Aaron *, E. Miller n , J. Lindsey n , J. Timlin*

author keywords: Bacteriochlorin; Chlorophyll; Cyanobacteria; Membrane; Multivariate curve resolution
MeSH headings : Adaptation, Physiological; Bacteriochlorophyll A / chemistry; Chlorophyll A / chemistry; Cyanobacteria / metabolism; Cyanobacteria / ultrastructure; Darkness; Microscopy, Confocal; Microscopy, Fluorescence; Photosynthesis; Porphyrins / chemistry; Porphyrins / metabolism; Tetrapyrroles / chemistry; Tetrapyrroles / metabolism
TL;DR: This work quantifies the relative abundance and envelope localization of tolyporphins in single cells, and illustrates the ability to identify novel tetrapyrroles in the presence of chlorophyll a in a photosynthetic microorganism within a non-axenic culture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 23, 2019

2018 journal article

Genome sequence, metabolic properties and cyanobacterial attachment of Porphyrobacter sp. HT-58-2 isolated from a filamentous cyanobacterium–microbial consortium

Microbiology, 164(10), 1229–1239.

By: R. Hughes n, X. Jin n, Y. Zhang n, R. Zhang n, S. Tran n, P. Williams *, J. Lindsey n , E. Miller n 

author keywords: alphaproteobacteria; fluorescence in situ hybridization (FISH); tolyporphins; bacteriochlorin; photosynthetic gene cluster
MeSH headings : Alphaproteobacteria / classification; Alphaproteobacteria / genetics; Alphaproteobacteria / metabolism; Alphaproteobacteria / physiology; Bacterial Proteins / genetics; Base Sequence; Chromosome Mapping; Cyanobacteria / metabolism; DNA, Bacterial / genetics; Genome, Bacterial / genetics; In Situ Hybridization, Fluorescence; Microbial Consortia; Phylogeny; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA
TL;DR: The studies reported herein expand the description of the community of predominantly alphaproteobacteria associated with the filamentous HT- 58-2 cyanobacterium and isolate a dominant bacterium, Porphyrobacter sp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 7, 2019

2017 journal article

Genome Sequence and Composition of a Tolyporphin-Producing Cyanobacterium-Microbial Community

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83(19).

By: R. Hughes n, Y. Zhang n, R. Zhang n, P. Williams *, J. Lindsey n  & E. Miller n 

author keywords: cyanobacteria; genome analysis; phylogenetic analysis; tetrapyrroles; tolyporphin
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Biosynthetic Pathways; Cyanobacteria / chemistry; Cyanobacteria / genetics; Cyanobacteria / growth & development; Cyanobacteria / metabolism; Genome, Bacterial; Metagenomics; Multigene Family; Phylogeny; Porphyrins / biosynthesis; Porphyrins / chemistry
TL;DR: It is found that the HT-58-2 culture is composed of the cyanobacterium and a community of associated bacteria, complicating the question of which organisms make tolyporphins, and an intriguing gene cluster that contains tetrapyrrole biosynthesis genes and a collection of unknown genes suggests a possible role in toly porphin biosynthesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Mass spectrometric detection of chlorophyll a and the tetrapyrrole secondary metabolite tolyporphin A in the filamentous cyanobacterium HT-58-2. Approaches to high-throughput screening of intact cyanobacteria

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 21(11), 759–768.

By: Y. Zhang n, R. Zhang n, M. Nazari  n, M. Bagley n, E. Miller n , P. Williams *, D. Muddiman n , J. Lindsey n 

author keywords: IR-MALDESI-FTMS; MS/MS; MALDI-TOF-MS; chlorophyll; bacteriochlorin; high-throughput screening
TL;DR: Examination by MALDI-TOF-MS of lipophilic crude extracts of small-scale HT-58-2 samples without chromatographic fractionation enabled semi-quantitation of tolyporphin A over a 41-day growth period. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Quantitation of Tolyporphins, Diverse Tetrapyrrole Secondary Metabolites with Chlorophyll-Like Absorption, from a Filamentous Cyanobacterium-Microbial Community

Phytochemical Analysis, 29(2), 205–216.

By: Y. Zhang n, R. Zhang n, R. Hughes n, J. Dai*, J. Gurr*, P. Williams *, E. Miller n , J. Lindsey n 

author keywords: HPLC; mass spectrometry; absorption spectroscopy with multicomponent analysis; nitrogen deprivation; growth curve
MeSH headings : Chlorophyll / chemistry; Chlorophyll A; Chromatography, High Pressure Liquid / methods; Cyanobacteria / growth & development; Cyanobacteria / metabolism; Porphyrins / analysis; Porphyrins / chemistry; Reference Standards; Reproducibility of Results; Spectrum Analysis / methods; Tetrapyrroles / analysis
TL;DR: The quantitative methods developed herein should facilitate investigation of the biosynthesis of tolyporphins (and other tetrapyrroles) as well as examination of other strains for production of tolporph Ins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

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