Yan Zou

Works (7)

Updated: July 5th, 2023 15:52

2015 journal article

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

CHEMICAL COMMUNICATIONS, 51(26), 5702–5705.

By: K. Brown n, Y. Zou n, D. Shirvanyants*, J. Zhang  n, S. Samanta *, P. Mantravadi *, N. Dokholyan *, A. Deiters n

MeSH headings : Humans; Molecular Conformation; Optics and Photonics; Photolysis / radiation effects; Protein Multimerization / radiation effects; Sirolimus / chemistry; Sirolimus / radiation effects; Tacrolimus Binding Protein 1A / chemistry; Ultraviolet Rays
topics (OpenAlex): Photoreceptor and optogenetics research; Photochromic and Fluorescence Chemistry; Click Chemistry and Applications
TL;DR: An optically activated rapamycin dimer is developed that does not induce FKBP12-FRB dimerization until exposed to light, and applied to control kinase, protease, and recombinase function. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Efficacy of C-N Coupling Reactions with a New Multinuclear Copper Complex Catalyst and Its Dissociation into Mononuclear Species

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011(22), 4154–4159.

By: Y. Zou n, H. Lin n, P. Maggard n  & A. Deiters n

author keywords: Reaction mechanisms; Nitrogen heterocycles; C-N coupling; Cross-coupling; Arylation; Copper; Homogeneous catalysis
topics (OpenAlex): Catalytic Cross-Coupling Reactions; Cyclopropane Reaction Mechanisms
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(3), 420–423.

By: A. Karginov  n, Y. Zou n, D. Shirvanyants n, P. Kota  n, N. Dokholyan  n, D. Young n, K. Hahn  n, A. Deiters n

MeSH headings : Dimerization; Focal Adhesion Protein-Tyrosine Kinases / metabolism; HEK293 Cells; Humans; Light; Models, Molecular; Molecular Dynamics Simulation; Sirolimus / chemistry; Tacrolimus Binding Proteins / chemistry; Tacrolimus Binding Proteins / metabolism
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Click Chemistry and Applications; Neurobiology and Insect Physiology Research
TL;DR: A new system for light-induced protein dimerization in living cells is developed using a photocaged analogue of rapamycin together with an engineered Rapamycin binding domain and focal adhesion kinase as a target, which demonstrated successful light-mediated regulation of protein interaction and localization in live cells. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Photochemical control of bacterial signal processing using a light-activated erythromycin

MOLECULAR BIOSYSTEMS, 7(9), 2554–2557.

By: L. Gardner n, Y. Zou n, A. Mara n, T. Cropp * & A. Deiters n

MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Erythromycin / pharmacology; Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli / radiation effects; Exoribonucleases / genetics; Exoribonucleases / metabolism; Light; Photochemistry / methods
topics (OpenAlex): Photoreceptor and optogenetics research; bioluminescence and chemiluminescence research; Photochromic and Fluorescence Chemistry
TL;DR: This work engineered the MphR(A)/promoter system to enable photochemical activation of gene expression in E. coli, and applied this photochemical gene switch to the construction of a light-triggered logic gate, aLight-controlled band-pass filter, as well as spatial and temporal control of geneexpression. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Synthesis of the Pyridine Core of Cyclothiazomycin

ORGANIC LETTERS, 13(16), 4352–4355.

By: Y. Zou n, Q. Liu  n & A. Deiters n

MeSH headings : Anti-Bacterial Agents / chemical synthesis; Molecular Structure; Peptides, Cyclic / chemistry; Pyridines / chemical synthesis; Thiazoles / chemistry
topics (OpenAlex): Chemical Synthesis and Analysis; Synthesis and Biological Evaluation
TL;DR: A highly convergent synthesis of the pyridine core of the thiopeptide antibiotic cyclothiazomycin has been developed based on a [2-2+2] cyclotrimerization key step. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Total Synthesis of Cryptoacetalide

JOURNAL OF ORGANIC CHEMISTRY, 75(15), 5355–5358.

By: Y. Zou n & A. Deiters n

MeSH headings : Chromatography, High Pressure Liquid; Diterpenes / chemical synthesis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure
topics (OpenAlex): Synthetic Organic Chemistry Methods; Biological Activity of Diterpenoids and Biflavonoids; Advanced Synthetic Organic Chemistry
TL;DR: The first total synthesis of the tetracyclic terpene natural product cryptoacetalide is reported, with key steps a microwave-mediated cyclo-trimerization reaction to construct the central benzene ring, and a light-mediated radical cyclization to assemble the spiro-ketal moiety. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Synthesis of Anthracene and Azaanthracene Fluorophores via [2+2+2] Cyclotrimerization Reactions

ORGANIC LETTERS, 10(20), 4661–4664.

By: Y. Zou n, D. Young n, A. Cruz-Montanez n & A. Deiters n

MeSH headings : Anthracenes / chemical synthesis; Anthracenes / chemistry; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Benzene / chemistry; Cell Line; Cyclization; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Humans; Molecular Structure; Pyridines / chemistry
topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications; Catalytic Cross-Coupling Reactions
TL;DR: A highly convergent [2-2+2] cyclotrimerization approach to anthracenes and 2-azaanthracenes has been developed that allows for the facile introduction of the anthracene moiety on alkyne and nitrile bearing molecules and the rapid construction of compound arrays. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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