Works (35)

Updated: August 2nd, 2023 10:20

2021 journal article

Evaluation of UBE3A antibodies in mice and human cerebral organoids

SCIENTIFIC REPORTS, 11(1).

By: D. Sen n, Z. Drobna n & A. Keung n

co-author countries: United States of America 🇺🇸
MeSH headings : Angelman Syndrome / genetics; Angelman Syndrome / pathology; Animals; Antibodies / genetics; Antibodies / immunology; Autistic Disorder / genetics; Autistic Disorder / pathology; Cerebellum / cytology; Disease Models, Animal; Genomic Imprinting; Humans; Mice; Neural Stem Cells / metabolism; Neurons / metabolism; Neurons / pathology; Organoids / cytology; Pluripotent Stem Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / immunology
Source: Web Of Science
Added: July 19, 2021

2020 journal article

Activation of Lrrk2 and alpha-Synuclein in substantia nigra, striatum, and cerebellum after chronic exposure to arsenite

TOXICOLOGY AND APPLIED PHARMACOLOGY, 408.

By: Z. Drobna n

co-author countries: United States of America 🇺🇸
author keywords: Lrrk2; alpha-Synuclein; Arsenite; Striatum; Substantia nigra; Cerebellum
MeSH headings : Animals; Arsenic Poisoning / genetics; Arsenic Poisoning / metabolism; Arsenic Poisoning / physiopathology; Arsenites / toxicity; Cerebellum / drug effects; Cerebellum / metabolism; Corpus Striatum / drug effects; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / metabolism; Male; Mice, Inbred C57BL; Muscle Strength / drug effects; Phosphorylation / drug effects; Substantia Nigra / drug effects; Substantia Nigra / metabolism; Transcriptome / drug effects; alpha-Synuclein / metabolism
Source: Web Of Science
Added: December 11, 2020

2020 journal article

Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A

STEM CELL REPORTS, 15(4), 845–854.

By: D. Sen n, A. Voulgaropoulos n, Z. Drobna n & A. Keung n

co-author countries: United States of America 🇺🇸
MeSH headings : Angelman Syndrome / pathology; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cerebrum / metabolism; Genomic Imprinting / drug effects; Humans; Neurons / drug effects; Neurons / metabolism; Organoids / drug effects; Organoids / metabolism; Time Factors; Topoisomerase Inhibitors / pharmacology; Ubiquitin-Protein Ligases / metabolism
Source: Web Of Science
Added: November 9, 2020

2019 journal article

Bisphenol F has different effects on preadipocytes differentiation and weight gain in adult mice as compared with Bisphenol A and S

TOXICOLOGY, 420, 66–72.

By: Z. Drobna n, A. Talarovicova n, H. Schrader n, T. Fennell n, R. Snyder n & E. Rissman n

co-author countries: United States of America 🇺🇸
author keywords: Bisphenol; Metabolism; Fat; BPF; Alternatives to BPA; Diabetes
MeSH headings : 3T3-L1 Cells; Adipocytes / drug effects; Adipocytes / metabolism; Adipogenesis / drug effects; Adipogenesis / genetics; Animals; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Phenols / toxicity; Sulfones / toxicity; Time Factors; Weight Gain / drug effects
Source: Web Of Science
Added: June 17, 2019

2019 journal article

Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice

ENDOCRINOLOGY, 160(8), 1854–1867.

By: J. Wolstenholme*, Z. Drobna n, A. Henriksen*, J. Goldsby*, R. Stevenson*, J. Irvin n, J. Flaws*, E. Rissman n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Benzhydryl Compounds / toxicity; Brain / drug effects; Brain / metabolism; Female; Fetus / drug effects; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins / physiology; Phenols / toxicity; Post-Synaptic Density / drug effects; Social Behavior
Source: Web Of Science
Added: August 19, 2019

2018 journal article

Transgenerational Effects of Bisphenol A on Gene Expression and DNA Methylation of Imprinted Genes in Brain

ENDOCRINOLOGY, 159(1), 132–144.

By: Z. Drobna n, A. Henriksen*, J. Wolstenholme*, C. Montiel n, P. Lambeth*, S. Shang*, E. Harris*, C. Zhou* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Benzhydryl Compounds / toxicity; Brain / drug effects; Brain / metabolism; Crosses, Genetic; DNA Methylation / drug effects; Endocrine Disruptors / toxicity; Epigenesis, Genetic / drug effects; Female; Fetal Development / drug effects; Gene Expression Regulation, Developmental / drug effects; Hypothalamus, Anterior / drug effects; Hypothalamus, Anterior / metabolism; Lactation; Male; Maternal Exposure / adverse effects; Mice, Inbred Strains; Neurons / drug effects; Neurons / metabolism; Phenols / toxicity; Pregnancy; Preoptic Area / drug effects; Preoptic Area / metabolism; RNA, Long Noncoding / agonists; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; Random Allocation; Septal Nuclei / drug effects; Septal Nuclei / metabolism; Sex Characteristics
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure

Archives of Toxicology, 91(1), 189–202.

By: M. Huang*, C. Douillet*, M. Su*, K. Zhou*, T. Wu*, W. Chen*, J. Galanko*, Z. Drobná* ...

co-author countries: United States of America 🇺🇸
author keywords: Arsenic; Metabolomics; As3mt knockout; Mice; Urine; Plasma
MeSH headings : Amino Acids / metabolism; Animals; Arsenic / blood; Arsenic / metabolism; Arsenic / toxicity; Arsenic / urine; Arsenic Poisoning / blood; Arsenic Poisoning / enzymology; Arsenic Poisoning / metabolism; Arsenic Poisoning / urine; Arsenicals / blood; Arsenicals / metabolism; Arsenicals / urine; Biomarkers / blood; Biomarkers / urine; Biotransformation; Carbohydrate Metabolism / drug effects; Drug Resistance; Energy Metabolism / drug effects; Female; Lipid Metabolism / drug effects; Male; Metabolome / drug effects; Methylation; Methyltransferases / genetics; Methyltransferases / metabolism; Mice, Inbred C57BL; Mice, Knockout; Sex Characteristics; Toxicokinetics; Water Pollutants, Chemical / blood; Water Pollutants, Chemical / metabolism; Water Pollutants, Chemical / toxicity; Water Pollutants, Chemical / urine
Source: Crossref
Added: December 21, 2020

2017 journal article

Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 51(1), 625–633.

By: J. Laine, K. Bailey, A. Olshan, L. Smeester, Z. Drobna n, M. Styblo, C. Douillet, G. Garcia-Vargas* ...

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
MeSH headings : Arsenic; Arsenicals; Environmental Exposure; Female; Humans; Infant, Newborn; Metabolomics; Mexico; Pregnancy
Source: Web Of Science
Added: August 6, 2018

2017 journal article

The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

DIABETES CARE, 40(1), 46–53.

By: M. Grau-Perez*, C. Kuo*, M. Spratlen*, K. Thayer*, M. Mendez*, R. Hamman*, D. Dabelea*, J. Adgate* ...

co-author countries: Taiwan, Province of China 🇹🇼 United States of America 🇺🇸
MeSH headings : Adolescent; Arsenic / blood; Biomarkers / blood; Case-Control Studies; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 2 / blood; Environmental Exposure / analysis; Female; Folic Acid / blood; Humans; Male; Vitamin B 12 / blood; Young Adult
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis

REPRODUCTIVE TOXICOLOGY, 61, 28–38.

By: Z. Drobna n, E. Martin*, K. Kim*, L. Smeester*, P. Bommarito*, M. Rubio-Andrade*, G. Garcia-Vargas*, M. Styblo*, F. Zou*, R. Fry*

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
author keywords: AS3MT; Arsenic; Genotype; Prenatal exposure; Birth outcomes
MeSH headings : Adolescent; Adult; Arsenic / metabolism; Arsenic / urine; Female; Genotype; Humans; Infant, Newborn; Male; Methyltransferases / genetics; Polymorphism, Single Nucleotide; Pregnancy; Pregnancy Outcome; Risk Assessment; Sex Factors; Young Adult
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Arsenic exposure and cardiometabolic risk in Chihuahua, Mexico

Toxicology Letters, 259, S32–S33.

By: M. Mendez*, C. González-Horta*, B. Sánchez-Ramírez*, L. Ballinas-Casarrubias*, R. Cerón, D. Morales, F. Terrazas, C. María* ...

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
Source: Crossref
Added: December 21, 2020

2016 journal article

Association Between Variants in Arsenic (+3 Oxidation State) Methyltranserase (AS3MT) and Urinary Metabolites of Inorganic Arsenic: Role of Exposure Level

TOXICOLOGICAL SCIENCES, 153(1), 112–123.

By: X. Xu, Z. Drobna n, V. Voruganti, K. Barron, C. Gonzalez-Horta*, B. Sanchez-Ramirez*, L. Ballinas-Casarrubias*, R. Hernandez Ceron ...

co-author countries: France 🇫🇷 Mexico 🇲🇽 United States of America 🇺🇸
author keywords: Arsenic (+3 oxidation state) methyltranserase polymorphism; arsenic; drinking water; urinary arsenic; arsenic metabolites; methylation capacity
MeSH headings : Adult; Arsenic / analysis; Arsenic / toxicity; Arsenic / urine; Cross-Sectional Studies; Drinking Water / chemistry; Environmental Exposure; Female; Genotype; Humans; Limit of Detection; Male; Methyltransferases / genetics; Methyltransferases / metabolism; Polymorphism, Single Nucleotide
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Oxidation state specific analysis of arsenic species in tissues of wild-type and arsenic (+ 3 oxidation state) methyltransferase-knockout mice

Journal of Environmental Sciences, 49, 104–112.

By: J. Currier*, C. Douillet*, Z. Drobná* & M. Stýblo*

co-author countries: United States of America 🇺🇸
author keywords: Arsenic speciation analysis; Hydride generation-cryotrapping-atomic absorption spectrometry; Arsenic (+3 oxidation state) methyltransferase; As3mt knockout mice
MeSH headings : Animals; Arsenic / toxicity; Arsenicals / pharmacology; Male; Methyltransferases; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Water Pollutants, Chemical / toxicity
Source: Crossref
Added: December 21, 2020

2015 journal article

Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer

Chemical Research in Toxicology, 28(6), 1144–1155.

By: J. Rager*, S. Tilley*, S. Tulenko*, L. Smeester*, P. Ray*, A. Yosim*, J. Currier*, M. Ishida* ...

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
MeSH headings : Adult; Aged; Arsenic / metabolism; Arsenic / toxicity; Cell Transformation, Neoplastic / chemically induced; DNA Methylation / drug effects; DNA Methylation / genetics; Female; Humans; Middle Aged; Urinary Bladder Neoplasms / chemically induced; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / pathology; Urothelium / cytology; Urothelium / drug effects; Young Adult
Source: Crossref
Added: February 5, 2020

2013 journal article

Arsenic and the Epigenome: Interindividual Differences in Arsenic Metabolism Related to Distinct Patterns of DNA Methylation

Journal of Biochemical and Molecular Toxicology, 27(2), 106–115.

By: K. Bailey*, M. Wu*, W. Ward*, L. Smeester*, J. Rager*, G. García-Vargas, L. Del Razo*, Z. Drobná*, M. Stýblo*, R. Fry*

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
MeSH headings : Arsenic / pharmacokinetics; Arsenic / toxicity; Arsenic Poisoning / genetics; Arsenic Poisoning / metabolism; Arsenic Poisoning / pathology; Biomarkers / metabolism; DNA Methylation / drug effects; Diabetes Mellitus / chemically induced; Diabetes Mellitus / genetics; Diabetes Mellitus / metabolism; Diabetes Mellitus / pathology; Epigenesis, Genetic / drug effects; Epigenomics / methods; Female; Genome-Wide Association Study; Humans; Leukocytes / metabolism; Leukocytes / pathology; Male
Source: Crossref
Added: December 21, 2020

2013 journal article

Prenatal arsenic exposure and the epigenome: Altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood

Environmental and Molecular Mutagenesis, 55(3), 196–208.

By: J. Rager*, K. Bailey*, L. Smeester*, S. Miller*, J. Parker*, J. Laine*, Z. Drobná*, J. Currier* ...

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
author keywords: gene expression; arsenic; prenatal; epigenetics; microRNAs
MeSH headings : Adaptive Immunity / physiology; Adult; Arsenic / toxicity; Arsenic / urine; Biomarkers / metabolism; Cohort Studies; Drinking Water / chemistry; Epigenesis, Genetic; Epigenomics; Female; Fetal Blood / drug effects; Fetal Blood / metabolism; Gene Expression Profiling; Genome-Wide Association Study; Humans; Infant, Newborn; Maternal Exposure; MicroRNAs / metabolism; Pregnancy; RNA, Messenger / metabolism; Signal Transduction; Transcription, Genetic; Water Pollutants, Chemical / toxicity
Source: Crossref
Added: December 21, 2020

2012 journal article

Environmental exposure to arsenic, AS3MT polymorphism and prevalence of diabetes in Mexico

Journal of Exposure Science & Environmental Epidemiology, 23(2), 151–155.

By: Z. Drobná*, L. Del Razo*, G. García-Vargas*, L. Sánchez-Peña*, A. Barrera-Hernández*, M. Stýblo*, D. Loomis*

co-author countries: France 🇫🇷 Mexico 🇲🇽 United States of America 🇺🇸
author keywords: biomonitoring; disease; emerging contaminants; metals
MeSH headings : Adolescent; Adult; Arsenic / metabolism; Arsenic / toxicity; Diabetes Mellitus / epidemiology; Environmental Exposure; Female; Humans; Male; Methyltransferases / genetics; Mexico / epidemiology; Middle Aged; Polymorphism, Single Nucleotide; Prevalence; Young Adult
Source: Crossref
Added: January 21, 2021

2012 journal article

Methylation of arsenic by recombinant human wild-type arsenic (+3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: Role of glutathione

Toxicology and Applied Pharmacology, 264(1), 121–130.

By: L. Ding*, R. Saunders*, Z. Drobná*, F. Walton*, P. Xun*, D. Thomas*, M. Stýblo*

co-author countries: United States of America 🇺🇸
author keywords: Arsenic methylation; AS3MT polymorphism; Thioredoxin reductase; Glutathione
MeSH headings : Animals; Arsenicals / metabolism; Arsenites / metabolism; Glutathione / metabolism; Humans; Methylation / drug effects; Methyltransferases / genetics; Methyltransferases / metabolism; Phosphines / metabolism; Polymorphism, Genetic; Rats; S-Adenosylmethionine / metabolism; Thioredoxin-Disulfide Reductase / metabolism
Source: Crossref
Added: January 21, 2021

2012 journal article

The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic

Toxicology and Applied Pharmacology, 264(3), 439–450.

By: V. Tsang*, R. Fry*, M. Niculescu*, J. Rager*, J. Saunders*, D. Paul*, S. Zeisel*, M. Waalkes*, M. Stýblo*, Z. Drobná*

co-author countries: United States of America 🇺🇸
author keywords: Arsenic; Folate; Epigenetics; DNA methylation; Transplacental exposure; CD1 mice
MeSH headings : Animals; Arsenites / administration & dosage; Arsenites / toxicity; Epigenomics; Female; Fetal Weight / drug effects; Fetus / drug effects; Folic Acid / administration & dosage; Folic Acid / blood; Folic Acid / pharmacology; Gene Expression Regulation, Developmental / drug effects; Liver / drug effects; Liver / embryology; Liver / metabolism; Male; Mice; Pregnancy; S-Adenosylhomocysteine / metabolism; S-Adenosylmethionine / metabolism; Sodium Compounds / administration & dosage; Sodium Compounds / toxicity
Source: Crossref
Added: January 21, 2021

2011 journal article

Epigenetic Changes in Individuals with Arsenicosis

Chemical Research in Toxicology, 24(2), 165–167.

By: L. Smeester*, J. Rager, K. Bailey, X. Guan*, N. Smith, G. García-Vargas, L. Del Razo*, Z. Drobná* ...

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
MeSH headings : Arsenic / toxicity; Arsenic Poisoning / genetics; CpG Islands; DNA Methylation; Environmental Exposure / adverse effects; Epigenesis, Genetic; Humans; Mexico; Water Pollutants, Chemical / toxicity; Water Supply
Source: Crossref
Added: August 28, 2020

2011 journal article

Identification of theGST-T1andGST-M1Null Genotypes Using High Resolution Melting Analysis

Chemical Research in Toxicology, 25(1), 216–224.

By: Z. Drobná*, L. Del Razo*, G. Garcia-Vargas*, B. Sánchez-Ramírez*, C. González-Horta*, L. Ballinas-Casarrubias*, D. Loomis*, M. Stýblo*

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
MeSH headings : Adult; Aged; DNA / genetics; Female; Genotype; Glutathione Transferase / genetics; Hepatocytes / enzymology; Humans; Male; Mexico; Middle Aged; Multiplex Polymerase Chain Reaction / methods; Polymorphism, Genetic; beta-Globins / genetics
Source: Crossref
Added: January 21, 2021

2010 journal article

Interspecies differences in metabolism of arsenic by cultured primary hepatocytes

Toxicology and Applied Pharmacology, 245(1), 47–56.

By: Z. Drobná*, F. Walton*, A. Harmon*, D. Thomas* & M. Stýblo*

co-author countries: United States of America 🇺🇸
author keywords: Arsenic; Primary hepatocytes; Metabolism; As3mt; Mammalian species
MeSH headings : Animals; Arsenic / metabolism; Arsenic / toxicity; Cells, Cultured; Dogs; Female; Glutathione / metabolism; Hepatocytes / drug effects; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Macaca mulatta; Male; Methylation; Methyltransferases / metabolism; Mice; Middle Aged; Rabbits; Rats; Species Specificity
Source: Crossref
Added: January 21, 2021

2009 journal article

Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions

Toxicology and Applied Pharmacology, 239(2), 200–207.

By: O. Valenzuela*, Z. Drobná*, E. Hernández-Castellanos*, L. Sánchez-Peña*, G. García-Vargas*, V. Borja-Aburto*, M. Stýblo*, L. Del Razo*

co-author countries: Mexico 🇲🇽 United States of America 🇺🇸
author keywords: Arsenic-skin lesion; AS3MT polymorphism; Arsenic metabolism
MeSH headings : Adolescent; Adult; Arsenic / toxicity; Arsenic / urine; Case-Control Studies; Cross-Sectional Studies; DNA / genetics; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Female; Gene Frequency; Genotype; Humans; Male; Methyltransferases / genetics; Mexico / epidemiology; Middle Aged; Mouth Mucosa / cytology; Polymorphism, Single Nucleotide; Precancerous Conditions / chemically induced; Precancerous Conditions / enzymology; Precancerous Conditions / epidemiology; Precancerous Conditions / genetics; Skin Neoplasms / chemically induced; Skin Neoplasms / enzymology; Skin Neoplasms / epidemiology; Skin Neoplasms / genetics; Water Pollutants, Chemical / toxicity; Water Pollutants, Chemical / urine; Young Adult
Source: Crossref
Added: January 21, 2021

2009 journal article

Disruption of the Arsenic (+3 Oxidation State) Methyltransferase Gene in the Mouse Alters the Phenotype for Methylation of Arsenic and Affects Distribution and Retention of Orally Administered Arsenate

Chemical Research in Toxicology, 22(10), 1713–1720.

By: Z. Drobna*, H. Naranmandura*, K. Kubachka*, B. Edwards*, K. Herbin-Davis*, M. Styblo*, X. Le*, J. Creed* ...

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
MeSH headings : Administration, Oral; Animals; Arsenates / administration & dosage; Arsenates / pharmacokinetics; Arsenates / urine; Arsenic Poisoning; Arsenicals / metabolism; Arsenicals / urine; Female; Genotype; Humans; Male; Methyltransferases / genetics; Methyltransferases / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Tissue Distribution
Source: Crossref
Added: January 21, 2021

2009 journal article

Metabolism of arsenic in human liver: the role of membrane transporters

Archives of Toxicology, 84(1), 3–16.

By: Z. Drobná*, F. Walton*, D. Paul*, W. Xing*, D. Thomas* & M. Stýblo*

co-author countries: United States of America 🇺🇸
author keywords: Arsenic; Human liver; Membrane transport
MeSH headings : Aged; Aged, 80 and over; Animals; Arsenic / metabolism; Cell Membrane / metabolism; Cells, Cultured; Female; Glucose Transporter Type 2 / metabolism; Humans; Liver / metabolism; Male; Membrane Transport Proteins / metabolism; Methylation; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins / metabolism
Source: Crossref
Added: January 21, 2021

2008 journal article

Oxidation state specific generation of arsines from methylated arsenicals based on l-cysteine treatment in buffered media for speciation analysis by hydride generation-automated cryotrapping-gas chromatography-atomic absorption spectrometry with the multiatomizer

Spectrochimica Acta Part B: Atomic Spectroscopy, 63(3), 396–406.

By: T. Matoušek*, A. Hernández-Zavala*, M. Svoboda*, L. Langrová*, B. Adair*, Z. Drobná*, D. Thomas*, M. Stýblo*, J. Dědina*

co-author countries: Czechia 🇨🇿 United States of America 🇺🇸
author keywords: speciation analysis; arsenic; hydride generation atomic absorption spectrometry; cryotrapping; multiatornizer
Source: Crossref
Added: January 21, 2021

2008 journal article

Speciation analysis of arsenic in biological matrices by automated hydride generation-cryotrapping-atomic absorption spectrometry with multiple microflame quartz tube atomizer (multiatomizer)

J. Anal. At. Spectrom., 23(3), 342–351.

By: A. Hernández-Zavala*, T. Matoušek*, Z. Drobná*, D. Paul*, F. Walton*, B. Adair*, J. Dědina*, D. Thomas*, M. Stýblo*

co-author countries: Czechia 🇨🇿 United States of America 🇺🇸
Source: Crossref
Added: January 21, 2021

2006 journal article

shRNA Silencing of AS3MT Expression Minimizes Arsenic Methylation Capacity of HepG2 Cells

Chemical Research in Toxicology, 19(7), 894–898.

By: Z. Drobná*, W. Xing*, D. Thomas* & M. Stýblo*

co-author countries: United States of America 🇺🇸
MeSH headings : Arsenic / metabolism; Arsenic / toxicity; Base Sequence; Cell Line, Tumor; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Methylation / drug effects; Methyltransferases / antagonists & inhibitors; Methyltransferases / genetics; Methyltransferases / metabolism; Molecular Sequence Data; RNA Interference; RNA, Small Interfering / metabolism; RNA, Small Interfering / pharmacology
Source: Crossref
Added: January 21, 2021

2005 journal article

Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype

Toxicology and Applied Pharmacology, 204(2), 164–169.

By: J. Li*, S. Waters*, Z. Drobna*, V. Devesa*, M. Styblo* & D. Thomas*

co-author countries: United States of America 🇺🇸
author keywords: arsenic; inorganic arsenic; oxidation state
MeSH headings : Animals; Arsenic / metabolism; Base Sequence / genetics; Chromosomes, Human, Pair 8 / genetics; Cysteine / chemistry; Cysteine / genetics; Evolution, Molecular; Gene Deletion; Gene Expression Profiling / methods; Genotype; Humans; Methylation; Methyltransferases / genetics; Methyltransferases / metabolism; Mice; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Pan troglodytes / genetics; Pan troglodytes / metabolism; Phenotype; Rats; Species Specificity; Time Factors
Source: Crossref
Added: August 28, 2020

2005 journal article

Commonalities in Metabolism of Arsenicals

Environmental Chemistry, 2(3), 161.

By: B. Adair, S. Waters, V. Devesa, Z. Drobna*, M. Styblo & D. Thomas

author keywords: arsenic; bioavailability; contaminant uptake; metabolism-affecting agents
Source: Crossref
Added: August 28, 2020

2005 journal article

Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase

Toxicology and Applied Pharmacology, 207(2), 147–159.

By: Z. Drobna*, S. Waters*, V. Devesa*, A. Harmon*, D. Thomas* & M. Styblo*

co-author countries: United States of America 🇺🇸
author keywords: As; methyltransferase; AS3MT; metabolism; toxicity; urinary bladder; human
MeSH headings : Animals; Arsenic / metabolism; Arsenic / toxicity; Cell Line; Cell Survival / drug effects; Methylation; Methyltransferases / physiology; Rats; Urinary Bladder / drug effects; Urinary Bladder / metabolism
Source: Crossref
Added: August 28, 2020

2004 journal article

Comprehensive analysis of arsenic metabolites by pH-specific hydride generation atomic absorption spectrometry

J. Anal. At. Spectrom., 19(11), 1460–1467.

By: V. Devesa*, L. Maria Del Razo, B. Adair*, Z. Drobná*, S. Waters*, M. Hughes*, M. Stýblo*, D. Thomas*

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: January 21, 2021

2004 journal article

Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes

Toxicology and Applied Pharmacology, 198(3), 424–433.

By: F. Walton*, A. Harmon*, D. Paul*, Z. Drobna*, Y. Patel* & M. Styblo*

co-author countries: United States of America 🇺🇸
author keywords: arsenic; diabetes; methylation; glucose uptake; insulin; GLUT4; PKB; Akt
MeSH headings : Animals; Arsenicals / adverse effects; Arsenicals / metabolism; Arsenicals / pharmacology; Cell Survival / drug effects; Cells, Cultured; Diabetes Mellitus, Type 2 / chemically induced; Glucose / metabolism; Insulin / pharmacology; Methylation; Mice
Source: Crossref
Added: February 25, 2021

2004 journal article

Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes

Toxicology and Applied Pharmacology, 201(2), 166–177.

By: Z. Drobná*, S. Waters*, F. Walton*, E. LeCluyse*, D. Thomas* & M. Stýblo*

co-author countries: United States of America 🇺🇸
author keywords: arsenic; metabolism; methylation; variation; human; hepatocyte; cyt19
MeSH headings : Adult; Aromatase / biosynthesis; Aromatase / genetics; Arsenic / metabolism; Cell Differentiation / drug effects; Cells, Cultured; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Genotype; Hepatocytes / metabolism; Humans; Infant; Male; Methylation; Middle Aged; Poisons / metabolism; RNA, Messenger / biosynthesis; Reverse Transcriptase Polymerase Chain Reaction
Source: Crossref
Added: January 21, 2021

2004 journal article

Reversal of P-glycoprotein mediated vincristine resistance of L1210/VCR cells by analogues of pentoxifylline

European Journal of Pharmaceutical Sciences, 21(2-3), 283–293.

By: I. Kupsáková*, A. Rybár*, P. Dočolomanský*, Z. Drobná*, U. Stein*, W. Walther*, M. Barančı́k*, A. Breier*

co-author countries: Germany 🇩🇪 Slovakia 🇸🇰
author keywords: P-glycoprotein; L1210 cell line; multidrug resistance; xanthines; pentoxifylline analogues; vincristine; structure-activity relationship
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism; Animals; Antineoplastic Agents, Phytogenic / chemistry; Antineoplastic Agents, Phytogenic / pharmacology; Cell Line, Tumor; Crystallization; Drug Resistance, Neoplasm / drug effects; Inhibitory Concentration 50; Leukemia L1210; Linear Models; Mice; Models, Biological; Pentoxifylline / analogs & derivatives; Pentoxifylline / chemistry; Pentoxifylline / pharmacology; Quantitative Structure-Activity Relationship; Vincristine / chemistry; Vincristine / pharmacology
Source: Crossref
Added: January 21, 2021

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