Works (19)
Updated: August 20th, 2024 05:00
2024 journal article
Controlled Stiffness of Direct-Write, Near-Field Electrospun Gelatin Fibers Generates Differences in Tenocyte Morphology and Gene Expression
Journal of Biomechanical Engineering, 146(9).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: May 17, 2024
2022 article
Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials
Biehl, A., Martins, A. M. G. M., Davis, Z. G. G., Sze, D., Collins, L., Mora-Navarro, C., … Freytes, D. O. O. (2022, December 12). BIOMATERIALS SCIENCE, Vol. 12.
MeSH headings : Tissue Engineering / methods; Proteomics; Extracellular Matrix / chemistry; Hydrogels / chemistry; Biocompatible Materials / analysis; Tissue Scaffolds
TL;DR:
The present study is the first proof-of-concept towards the development of a standardized protocol that can be used to derive multiple ECM biomaterials via a previously established automated system and showed gelation and rheological properties consistent with previous ECM hydrogels.
(via Semantic Scholar)
open access via pubs.rsc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023
2021 article
Extracellular Matrix Hydrogels Promote Expression of Muscle-Tendon Junction Proteins
Gaffney, L. S., Davis, Z. G., Mora-Navarro, C., Fisher, M. B., & Freytes, D. O. (2021, March 25). (Vol. 3). Vol. 3.
TL;DR:
Tissue specific extracellular matrix (ECM) derived from muscle and tendon is used to determine how cells of each tissue interact with the microenvironment of the opposite tissue resulting in junction specific features and markers that should be included in tissue models of the muscletendon unit.
(via Semantic Scholar)
Source: ORCID
Added: August 27, 2021
2021 article
Extracellular Matrix Hydrogels Promote Expression of Muscle-Tendon Junction Proteins
Gaffney, L. S., Davis, Z. G., Mora-Navarro, C., Fisher, M. B., & Freytes, D. O. (2021, November 2). TISSUE ENGINEERING PART A, Vol. 11.
author keywords: extracellular matrix; engineered tissues; myotendinous junction; paxillin
MeSH headings : Collagen / metabolism; Collagen Type I / metabolism; Culture Media, Conditioned; Extracellular Matrix / metabolism; Hydrogels; Muscles; Paxillin / metabolism; Tendons / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 15, 2021
2021 journal article
Processing variables of direct-write, near-field electrospinning impact size and morphology of gelatin fibers
Biomedical Materials, 16(4), 045017.
author keywords: tissue engineering; gelatin; additive manufacturing; direct-write electrospinning; parametric control
MeSH headings : Biopolymers / chemistry; Electrochemical Techniques / methods; Gelatin / chemistry; Nanofibers / chemistry; Nanotechnology; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR:
This system is capable of replicating the fibrous structure of musculoskeletal tissues with biologically relevant materials which will provide a durable platform for the analysis of single cell-fiber interactions to help better understand the impact scaffold materials and dimensions have on cell behavior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: May 24, 2021
2021 conference paper
Variable stiffness of direct-written gelatin fibers with crosslinking technique: Toward a tendon tissue-on-a-chip model
Society for Biomaterials Annual Meeting.
Source: ORCID
Added: July 2, 2022
2020 conference paper
Gelatin and Acetic Acid Concentrations Along with Needle Gauge and Height Affect the Morphology and Diameter of Direct-Write, Near-Field Electrospun Gelatin Solution
Summer Biomechanics, Bioengineering, and Biotransport Conference.
Source: ORCID
Added: July 2, 2022
2020 article
Processing variables of direct-write, near-field electrospinning impact size and morphology of gelatin fibers
Davis, Z. G., Hussain, A. F., & Fisher, M. B. (2020, September 19). (Vol. 9). Vol. 9.
Source: ORCID
Added: August 27, 2021
2020 article
Processing variables of direct-write, near-field electrospinning impact size and morphology of gelatin fibers
(2020, October). NC State University Functional Tissue Engineering Seminar Series.
Source: ORCID
Added: July 2, 2022
2019 conference paper
Effects of solvent and gelatin concentration on near-field, direct-write electrospinning of gelatin
Summer Biomechanics, Bioengineering, and Biotransport Conference.
Source: ORCID
Added: July 2, 2022
2019 journal article
Parametric control of fiber morphology and tensile mechanics in scaffolds with high aspect ratio geometry produced via melt electrowriting for musculoskeletal soft tissue engineering
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 99, 153–160.
author keywords: Musculoskeletal soft tissue; Additive manufacturing; Scaffold geometry; Tissue engineering
MeSH headings : Anisotropy; Biomimetics; Collagen / chemistry; Electrochemistry; Extracellular Matrix / metabolism; Materials Testing; Temperature; Tensile Strength; Tissue Engineering / instrumentation; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The need to tailor MEW process parameters in scaffolds with high aspect ratio geometry in order to consistently generate specific structural and mechanical properties is highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 30, 2019
2019 journal article
Parametric control of fiber morphology and tensile mechanics in scaffolds with high aspect ratio geometry produced via melt electrowriting for musculoskeletal soft tissue engineering
Journal of the Mechanical Behavior of Biomedical Materials, 99, 153–160.
Source: ORCID
Added: August 27, 2021
2018 journal article
Orthogonal click reactions enable the synthesis of ECM-mimetic PEG hydrogels without multi-arm precursors
JOURNAL OF MATERIALS CHEMISTRY B, 6(30), 4929–4936.
TL;DR:
Characterization and in vitro testing demonstrated that the hydrogels created have highly tunable physicochemical properties and excellent cytocompatiiblity and that stoichiometric control over the crosslinking reaction can be leveraged to leave unreacted norbornene groups in the hydrogram for subsequent hydrogel functionalization via bioorthogonal inverse-electron demand Diels-Alder click reactions with s-tetrazines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2018
2017 conference paper
A direct-write, near-field electrospinning system for creating 3D printed scaffolds with nanoscale structure
NC State University Spring Undergraduate Research Symposium.
Source: ORCID
Added: July 2, 2022
2017 journal article
A flow bioreactor system compatible with real-time two-photon fluorescence lifetime imaging microscopy
BIOMEDICAL MATERIALS, 13(2).
author keywords: FLIM; HUVEC; multiphoton imaging; endothelial cells; 3D cell culture; 2P-FLIM
MeSH headings : Bioreactors; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Cell Movement; Human Umbilical Vein Endothelial Cells; Humans; Hydrodynamics; Microscopy, Fluorescence / methods; Photons; Shear Strength; Stress, Mechanical; Wound Healing
TL;DR:
A bioreactor that combines high-resolution contact-free imaging and continuous flow in a closed system that is compatible with various types of microscopes is designed and used to investigate the effects of low shear stress on human umbilical vein endothelial cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 conference paper
Synthesis and Characterization of Modular PEG-Peptide Bioinks
Biomedical Engineering Society Annual Meeting.
Source: ORCID
Added: July 2, 2022
2016 conference paper
A Flow Bioreactor Enabling Simultaneous High-Resolution Microscopy of Monolayer Cultures
Biomedical Engineering Society Annual Meeting.
Source: ORCID
Added: July 2, 2022
2016 journal article
Paenibacillus larvae Phage Tripp Genome Has 378-Base-Pair Terminal Repeats
Genome Announcements, 4(1).
TL;DR:
Paenibacillus larvae bacteriophage Tripp was isolated from an American foulbrood diseased honey bee hive in North Carolina, USA and is currently unique in Genbank.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 19, 2020
2015 conference paper
Uncommon -2 Programmed Translational Frameshift in a Bacteriophage Tripp Transposase Gene
NC State University Spring Undergraduate Research Symposium.
Source: ORCID
Added: July 2, 2022
Education
Updated: August 5th, 2024 08:37
2018 - 2023
NC State University Raleigh, NC, US
Doctorate of Philosophy
Biomedical Engineering
2014 - 2018
North Carolina State University Raleigh, NC, US
bachelors of science
Material Science and Engineering
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