Works (8)
Updated: July 5th, 2023 15:55
2011 journal article
Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells
NANOMEDICINE, 6(5), 777–791.
Contributors: n, W. Baeumer & N. Monteiro-Riviere n
author keywords: cellular uptake; dendritic cells; endocytosis; LPS; nanoparticles; quantum dot nanoparticles; scavenger receptor
MeSH headings : Animals; B7-1 Antigen / immunology; B7-2 Antigen / immunology; Cell Differentiation; Cell Survival; Cells, Cultured; Dendritic Cells / cytology; Dendritic Cells / immunology; Endocytosis; Granulocyte-Macrophage Colony-Stimulating Factor / immunology; Lipopolysaccharides / immunology; Monocytes / cytology; Monocytes / immunology; Quantum Dots; Swine
TL;DR:
Light is shed on the mechanism of QD655-COOH uptake in DCs and that cellular uptake pathways are dependent on cell type and cell differentiation, suggesting suppression with DC maturation.
(via Semantic Scholar)
open access via europepmc.org (repository)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Endocytic mechanisms and toxicity of a functionalized fullerene in human cells
TOXICOLOGY LETTERS, 191(2-3), 149–157.
Contributors: n, J. Yang *, A. Barron * & N. Monteiro-Riviere n
author keywords: Derivatized fullerene; Endocytosis; Cytotoxicity; Human epidermal keratinocytes; Cellular uptake; Nanoparticle
MeSH headings : Adenosine Triphosphate / metabolism; Cell Line; Cell Proliferation / drug effects; Cell Survival / drug effects; Coloring Agents; Drug Delivery Systems; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Fullerenes / chemistry; Fullerenes / toxicity; Humans; Lysosomes / drug effects; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Molecular; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles
TL;DR:
Results showed that the endocytic pathways could be mediated by caveolae/lipid rafts and cytoskeletal components and a scavenger receptor inhibitor completely blocked the uptake of Baa-Lys(FITC)-(Lys)(8)-OH, suggesting a specific endocytics pathway was strongly involved in Baa(F ITC)- (Lys)8-OH cellular uptake.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 article
Immunogenicity of Lactobacillus gasseri-FliC as an oral mucosal vaccine adjuvant for HIV
RETROVIROLOGY, Vol. 6.
TL;DR:
The immunogenicity of a novel Lactobacillus gasseri mucosal vaccine vector for use in oral delivery of HIV antigens is investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes
TOXICOLOGY IN VITRO, 24(2), 546–551.
Contributors: n & N. Monteiro-Riviere n
author keywords: Nanomaterials; Multi-walled carbon nanotubes; Lectins; Endocytic pathways; Melanosome transfer pathway; Cellular uptake
MeSH headings : Epidermal Cells; Humans; Keratinocytes / drug effects; Keratinocytes / metabolism; Lotus / chemistry; Solanum lycopersicum / chemistry; Microscopy, Electron, Transmission; Nanotubes, Carbon / ultrastructure; Peas / chemistry; Plant Lectins / pharmacology
TL;DR:
Lectins are inhibitors of the melanosome transfer pathway was used to study the uptake of MWCNT in keratinocytes, to see if they played a role in reducing the cellular uptake of carbon nanotubes in HEK, and studies confirmed that lectin cocktails decreased M WCNT interaction at the cell surface and uptake.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 article
Mechanisms of Quantum Dot Nanoparticle Cellular Uptake
Zhang, L. W., & Monteiro-Riviere, N. A. (2009, July). TOXICOLOGICAL SCIENCES, Vol. 110, pp. 138–155.
Contributors: n & N. Monteiro-Riviere n
author keywords: quantum dot nanoparticles; endocytosis; lipid rafts; G-protein-coupled receptor; scavenger receptor; cytotoxicity
MeSH headings : Actins / metabolism; Cell Membrane / metabolism; Cell Membrane / ultrastructure; Cells / drug effects; Cells / metabolism; Cytoplasm / metabolism; Cytoplasm / ultrastructure; Cytoskeleton / drug effects; Endosomes / drug effects; Flow Cytometry; Free Radical Scavengers / pharmacology; Humans; Immunohistochemistry; Indicators and Reagents; Keratinocytes / drug effects; Lysosomes / metabolism; Lysosomes / ultrastructure; Membrane Microdomains / drug effects; Membrane Potentials / drug effects; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Pinocytosis / drug effects; Quantum Dots; Spectrometry, Fluorescence; Transport Vesicles / drug effects; Transport Vesicles / metabolism
TL;DR:
It is shown that QD with a carboxylic acid surface coating were recognized by lipid rafts but not by clathrin or caveolae in human epidermal keratinocytes (HEKs) and endocytic pathways are primarily regulated by the G-protein-coupled receptor associated pathway and low density lipoprotein receptor/scavenger receptor.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes
TOXICOLOGY AND APPLIED PHARMACOLOGY, 228(2), 200–211.
Contributors: n, W. Yu *, V. Colvin * & N. Monteiro-Riviere n
author keywords: quantum dot; nanoparticles; skin penetration; cytokines; keratinocytes; cellular uptake; inflammation; skin
MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Fluorescence; Fluorometry / methods; Humans; Hydrogen-Ion Concentration; Interleukins / metabolism; Keratinocytes / chemistry; Keratinocytes / drug effects; Keratinocytes / ultrastructure; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Particle Size; Polyethylene Glycols / chemistry; Quantum Dots; Receptor Protein-Tyrosine Kinases / metabolism; Receptor, EphA3; Spectrometry, Mass, Electrospray Ionization / methods; Swine; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Results indicate that porcine skin penetration of QD621 is minimal and limited primarily to the outer SC layers, yet if the skin were damaged allowing direct QD exposure to skin or keratinocytes, an inflammatory response could be initiated.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line
TOXICOLOGY AND APPLIED PHARMACOLOGY, 234(2), 222–235.
Contributors: N. Monteiro-Riviere n , A. Inman n & n
author keywords: Carbon; Nanomaterials; Carbon black; Single-walled carbon nanotubes; C-60; nC(60); Quantum dots; Calcein AM; Live/Dead; NR; MTT; Celltiter 96 (R) AQueous One; Alamar Blue; Celltiter-Blue (R); CytoTox One (TM); Flow cytometry; Human epidermal keratinocytes; Toxicity; Viability assays
MeSH headings : Cell Line; Cell Survival / drug effects; Drug Evaluation, Preclinical; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Humans; Keratinocytes / drug effects; Light; Microscopy, Electron, Transmission; Nanoparticles / toxicity; Oxazines; Quantum Dots; Scattering, Radiation; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles; Trypan Blue; Xanthenes
TL;DR:
This study shows that, unlike small molecules, CNM interact with assay markers to cause variable results with classical toxicology assays and may not be suitable for assessing nanoparticle cytotoxicity, therefore, more than one assay may be required when determining nanoparticle toxicity for risk assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes
INTERNATIONAL JOURNAL OF TOXICOLOGY, 26(2), 103–113.
Contributors: n, L. Zeng *, A. Barron * & N. Monteiro-Riviere n
author keywords: cytokines; keratmocytes; nanomaterials; nanotoxicology; single-wall carbon nanotubes; skin
MeSH headings : Aminocaproic Acid / chemistry; Cell Line; Cell Survival / drug effects; Cytokines / metabolism; Cytoplasmic Vesicles / drug effects; Cytoplasmic Vesicles / metabolism; Cytoplasmic Vesicles / ultrastructure; Dose-Response Relationship, Drug; Drug Antagonism; Drug Carriers / chemistry; Drug Carriers / toxicity; Drug Combinations; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Microscopy, Electron, Transmission; Nanotechnology; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Poloxamer / pharmacology; Surface-Active Agents / pharmacology
TL;DR:
Human epidermal keratinocytes (HEKs) were dosed with 6-Aminohexanoic acid–derivatized single-wall carbon nanotubes and data showed that the lower concentration of 0.000005 mg/ml of AHA-SWNTs maintains cell viability and induces a mild cytotoxicity, but the higher concentration demonstrated an irritation response by the increase in IL-8.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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