Zhenzhen Wang

Works (14)

Updated: April 25th, 2025 17:54

2024 article

Inhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction

Li, J., Sun, S., Zhu, D., Mei, X., Lyu, Y., Huang, K., … Cheng, K. (2024, August 26). Circulation, Vol. 150, pp. 710–723.

By: J. Li n, S. Sun, D. Zhu* , X. Mei*, Y. Lyu n, K. Huang n , Y. Li n , S. Liu* ...

author keywords: CD36; extracellular vesicles; exosomes; inhalation; myocardial infarction
MeSH headings : Animals; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardial Infarction / physiopathology; Exosomes / metabolism; Mice; Mice, Inbred C57BL; Administration, Inhalation; Disease Models, Animal; Swine; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Male; Ventricular Function, Left; Humans; Myocardium / metabolism; Myocardium / pathology; Stem Cells / metabolism; CD36 Antigens / metabolism; CD36 Antigens / genetics
topics (OpenAlex): Extracellular vesicles in disease; Cardiovascular Effects of Exercise; Tissue Engineering and Regenerative Medicine
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 1, 2024

2024 article

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

Wang, Z., Hu, S., Popowski, K. D., Liu, S., Zhu, D., Mei, X., … Cheng, K. (2024, March 12). Nature Communications, Vol. 15.

By: Z. Wang n, S. Hu* , K. Popowski n , S. Liu*, D. Zhu* , X. Mei n, J. Li*, Y. Hu * ...

MeSH headings : Cricetinae; Female; Animals; Humans; Mice; SARS-CoV-2; COVID-19; Angiotensin-Converting Enzyme 2; Exosomes; Tissue Distribution; Spike Glycoprotein, Coronavirus; Antibodies, Neutralizing
topics (OpenAlex): Extracellular vesicles in disease; SARS-CoV-2 and COVID-19 Research; COVID-19 Clinical Research Studies
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Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 article

A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus

Wang, Z., Li, Z., Shi, W., Zhu, D., Hu, S., Dinh, P.-U. C., & Cheng, K. (2023, June 23). Science Advances, Vol. 9.

By: Z. Wang n, Z. Li n, W. Shi  n, D. Zhu n , S. Hu n , P. Dinh n, K. Cheng n

MeSH headings : Cricetinae; Animals; Humans; Mice; Influenza Vaccines; SARS-CoV-2; Influenza, Human; Influenza A Virus, H1N1 Subtype; Pandemics; COVID-19 / prevention & control; COVID-19 Vaccines; Influenza A virus
topics (OpenAlex): Influenza Virus Research Studies; SARS-CoV-2 and COVID-19 Research; Respiratory viral infections research
TL;DR: The Flu-RBD VLP vaccine is a promising candidate for combating COVID-19, influenza A, and coinfection and elicited a strong neutralization activity against both SARS-CoV-2 Delta pseudovirus and wild-type influenza A H1N1 inactivated virus in mice. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2023

2023 journal article

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection

Nature Materials, 2.

By: X. Mei n, J. Li n, Z. Wang n, D. Zhu n , K. Huang n , S. Hu n , K. Popowski n , K. Cheng n

topics (OpenAlex): SARS-CoV-2 and COVID-19 Research; SARS-CoV-2 detection and testing; COVID-19 diagnosis using AI
TL;DR: A physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel, named spherical hydrogels inhalation for enhanced lung defence (SHIELD), which is conveniently delivered via a dry powder inhaler and made with food-grade materials and does not affect normal respiratory functions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 6, 2023

2023 article

Pericardial Delivery of SDF‐1α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling

Luo, L., Li, Y., Bao, Z., Zhu, D., Chen, G., Li, W., … Li, Z. (2023, September 4). Advanced Materials, Vol. 9.

By: L. Luo *, Y. Li *, Z. Bao*, D. Zhu n , G. Chen *, W. Li*, Y. Xiao*, Z. Wang n ...

author keywords: cardiac arrhythmias; electrical coupling; endogenous repair; inflammation regulation; myocardial infarction; SDF-1
MeSH headings : Humans; Chemokine CXCL12 / metabolism; Hydrogels; Myocardial Infarction / metabolism; Myocytes, Cardiac / metabolism; Inflammation
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Cardiac Fibrosis and Remodeling
TL;DR: SDF‐1α‐encapsulated Puerarin (PUE) hydrogel (SDF‐1α@PUE) is capable of enhancing endogenous stem cell homing and simultaneously polarizing the recruited monocyte/macrophages into a repairing phenotype, demonstrating a promising therapeutic platform for MI that not only facilitates heart regeneration but also reduces the risk of cardiac arrhythmias. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023

2022 article

Decoy Exosomes Offer Protection Against Chemotherapy‐Induced Toxicity

Fan, M., Li, H., Shen, D., Wang, Z., Liu, H., Zhu, D., … Li, Z. (2022, September 4). Advanced Science, Vol. 9.

By: M. Fan*, H. Li *, D. Shen *, Z. Wang n, H. Liu*, D. Zhu n , Z. Wang n, L. Li* ...

author keywords: cardio-oncology; cardiotoxicity; chemotherapy; exosome; tetrahedral DNA nanostructure
MeSH headings : Humans; Exosomes / genetics; Exosomes / metabolism; Cardiotoxicity / etiology; Cardiotoxicity / prevention & control; Cardiotoxicity / metabolism; Quality of Life; Neoplasms; Antineoplastic Agents / toxicity; Antineoplastic Agents / metabolism; Chemical and Drug Induced Liver Injury / metabolism
topics (OpenAlex): Extracellular vesicles in disease; RNA Interference and Gene Delivery; Nanoplatforms for cancer theranostics
TL;DR: This decoy exosome strategy serves as a promising therapy to reduce chemo‐induced toxicity and can also promote macrophage polarization into the M2 type for tissue repair. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 12, 2022

2022 article

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Wang, Z., Popowski, K. D., Zhu, D., Juan Abad, B. L., Wang, X., Liu, M., … Cheng, K. (2022, July 4). Nature Biomedical Engineering, Vol. 7.

By: Z. Wang n, K. Popowski n , D. Zhu n , B. Juan Abad n, X. Wang  n, M. Liu n, H. Lutz  n, N. Naeyer* ...

MeSH headings : Animals; Antibodies, Neutralizing; CD8-Positive T-Lymphocytes; COVID-19 / prevention & control; COVID-19 Vaccines; Exosomes; Humans; Mice; Mice, Inbred BALB C; SARS-CoV-2; Viral Vaccines
topics (OpenAlex): SARS-CoV-2 and COVID-19 Research; Extracellular vesicles in disease; Inhalation and Respiratory Drug Delivery
TL;DR: The design and preclinical testing of an inhalable virus-like-particle as a COVID-19 vaccine that, after lyophilisation, is stable at room temperature for over three months and elicits systemic and mucosal immune responses in small animals is reported. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022

2022 article

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3

Zhu, D., Liu, S., Huang, K., Wang, Z., Hu, S., Li, J., … Cheng, K. (2022, October 13). Circulation Research, Vol. 10, pp. E135–E150.

By: D. Zhu n , S. Liu n, K. Huang n , Z. Wang n, S. Hu n , J. Li n, Z. Li n, K. Cheng n

author keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell
MeSH headings : Humans; Exosomes / metabolism; Forkhead Box Protein O3 / genetics; Forkhead Box Protein O3 / metabolism; Mesenchymal Stem Cells / metabolism; Myocardial Infarction / pathology; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Heart Injuries / metabolism
topics (OpenAlex): Heat shock proteins research; Cardiac Fibrosis and Remodeling; Extracellular vesicles in disease
TL;DR: A novel mechanism underlying the immunomodulation effects of MSC exosomes is revealed and provides a promising candidate (PP2A/p-Akt/Foxo3 signaling pathway) with a favorable delivery route (intrapericardial injection) for cardiac repair. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 14, 2022

2022 article

Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy

Zhang, C., Zhang, W., Zhu, D., Li, Z., Wang, Z., Li, J., … Zhong, B. (2022, January 15). Journal of Nanobiotechnology, Vol. 1.

By: C. Zhang  n, W. Zhang *, D. Zhu n , Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu *, K. Cheng n, B. Zhong *

Contributors: C. Zhang  n, W. Zhang *, D. Zhu n , Z. Li n, Z. Wang n, J. Li n, X. Mei n, W. Xu *, K. Cheng n, B. Zhong *

author keywords: Osteoporosis; CXCR4; Secretome; Mesenchymal stem cells; Bone targeting; Nanoparticles
MeSH headings : Animals; Cell Membrane / chemistry; Cell Membrane / metabolism; Disease Models, Animal; Endothelial Cells / chemistry; Endothelial Cells / metabolism; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / metabolism; Nanoparticle Drug Delivery System; Nanoparticles; Osteoporosis / metabolism; Rats; Receptors, CXCR4 / metabolism; Secretome / metabolism
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics; Graphene and Nanomaterials Applications
TL;DR: In a rat model of osteoporosis, MSC-Sec/CXCR4 NP were found to accumulate in bone, and such treatment inhibited osteoclast differentiation while promoting osteogenic proliferation. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 24, 2022

2021 article

Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair

Wang, X., Hu, S., Li, J., Zhu, D., Wang, Z., Cores, J., … Huang, K. (2021, November 18). ACS Applied Materials & Interfaces, Vol. 12, pp. 55767–55779.

By: X. Wang  n, S. Hu n , J. Li n, D. Zhu n , Z. Wang n, J. Cores n, K. Cheng n, G. Liu *, K. Huang n 

Contributors: X. Wang  n, S. Hu n , J. Li n, D. Zhu n , Z. Wang n, J. Cores n, K. Cheng n, G. Liu *, K. Huang n 

author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
topics (OpenAlex): Extracellular vesicles in disease; Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 21, 2022

2021 article

Injection of ROS‐Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair

Li, Z., Zhu, D., Hui, Q., Bi, J., Yu, B., Huang, Z., … Wang, X. (2021, February 4). Advanced Functional Materials, Vol. 31.

By: Z. Li n, D. Zhu n , Q. Hui *, J. Bi *, B. Yu *, Z. Huang *, S. Hu n , Z. Wang n ...

Contributors: Z. Li n, D. Zhu n , Q. Hui *, J. Bi *, B. Yu *, Z. Huang *, S. Hu n , Z. Wang n ...

author keywords: bFGF; heart repair; intrapericardial delivery; pericardial cavity; ROS responsive hydrogels
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Cardiac Structural Anomalies and Repair; Electrospun Nanofibers in Biomedical Applications
TL;DR: A ROS‐sensitive cross‐linked poly(vinyl alcohol) (PVA) hydrogel is synthesized to deliver basic fibroblast growth factor (bFGF) for myocardial repair and protects cardiac function and reduces fibrosis in the post‐I/R heart, with enhanced angiomyogenesis. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 22, 2021

2021 article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

Hu, S., Wang, X., Li, Z., Zhu, D., Cores, J., Wang, Z., … Cheng, K. (2021, June 8). Nano Today, Vol. 8.

By: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

Contributors: S. Hu n , X. Wang  n, Z. Li n, D. Zhu n , J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
topics (OpenAlex): Extracellular vesicles in disease; Cardiovascular Effects of Exercise
TL;DR: It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021

2020 article

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse

Xie, M., Li, J., Zhang, S., Zhu, D., Mei, X., Wang, Z., … Cheng, K. (2020, December 3). Bioactive Materials, Vol. 6, pp. 1777–1788.

By: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

Contributors: M. Xie n, J. Li n, S. Zhang n, D. Zhu n , X. Mei n, Z. Wang n, X. Cheng n, Z. Li n, S. Wang *, K. Cheng n

author keywords: Contraceptive; Hydrogel; Anti-viral; Libido; Erectile function
topics (OpenAlex): Ovarian function and disorders; Reproductive Biology and Fertility; Sperm and Testicular Function
TL;DR: A novel TGN contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN) yielded a higher contraceptive success rate than that of the commercial contraceptive gel (Contragel®), and has the added benefits to prevent sexually transmitted diseases and improve male libido and erection function during sexual intercourse. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 6, 2021

2020 article

Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP8induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode

Wang, Z., Jork, N., Bittner, T., Wang, H., Jessen, H. J., & Shears, S. B. (2020, January 1). Chemical Science.

By: Z. Wang*, N. Jork *, T. Bittner *, H. Wang *, H. Jessen * & S. Shears *

topics (OpenAlex): RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques; Cellular transport and secretion
TL;DR: Thermosensitive liposomes were used to deliver inositol pyrophosphates into cultured cells and cargo release was induced within 5 min irradiation by a high power, near infra-red, light emitting diode. (via Semantic Scholar)
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Source: Web Of Science
Added: October 19, 2020

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