Works Published in 2019
Displaying all 20 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Microfluidic Technologies for High Throughput Screening Through Sorting and On-Chip Culture of <i>C. elegans</i>
Molecules.
MeSH headings : Animals; Caenorhabditis elegans / genetics; Cell Movement / genetics; High-Throughput Screening Assays; Lab-On-A-Chip Devices; Oligonucleotide Array Sequence Analysis / methods; Protein Transport / genetics
TL;DR:
This review of microfluidic technologies that have been used to increase the throughput of genetic and chemical screens in C. elegans will discuss screens for neurobiology, aging, development, behavior, and many other biological processes.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 31, 2023
2019 journal article
Automated Imaging, Tracking, and Analytics Pipeline for Differentiating Environmental Effects on Root Meristematic Cell Division
Frontiers in Plant Science, 10.
author keywords: light sheet imaging; image analysis; cell cycle progression; heat stress and iron deficiency stresses; combined stresses
TL;DR:
It is observed that iron deficiency, in combination with temporary heat stress, suppresses the expression of iron deficiency-responsive pPYE::LUC (POPEYE::luciferase) and pBTS::L UC (BRUTUS::lUC) reporter genes and root growth was suppressed less under combined iron deficiency and heat stress than under either single stress condition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID
Added: September 14, 2020
2019 article
DERIVATION OF HUMAN TROPHOBLAST STEM CELLS FROM HUMAN PLURIPOTENT STEM CELLS
Mischler, A., Karakis, V., San Miguel, A., & Rao, B. (2019, August). PLACENTA, Vol. 83, pp. E59–E59.
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID
Added: April 20, 2020
2019 journal article
Oxygen and hydrogen isotopes in human hair and tap water: Modeling relationships in a modern Mexican population
Human Biology, 90(3), 197–211.
Contributors: C. Juarez, R. Ramey, D. Flaherty & B. Akpa*
author keywords: delta H-2; delta O-18; MEXICO; TAP WATER; HAIR
TL;DR:
Data from this Mexican population did not exhibit the strong relationships between isotope values of 18O and 2H in tap water and hair that have been characteristic of other populations studied to date, and the results with parameters based on the American supermarket diet were disappointing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
14. Life Below Water
(Web of Science)
Source: ORCID
Added: April 7, 2020
2019 article
tuxnet: a simple interface to process RNA sequencing data and infer gene regulatory networks
PLANT JOURNAL.
author keywords: Arabidopsis thaliana; gene regulatory network inference; graphical user interface; RNA sequencing processing; stem cell maintenance; technical advance
MeSH headings : Algorithms; Arabidopsis / genetics; Bayes Theorem; Computational Biology; Gene Expression Regulation, Plant; Gene Regulatory Networks / genetics; Genome, Plant / genetics; Sequence Analysis, RNA; Transcriptome
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: ORCID
Added: January 13, 2020
2019 journal article
Discovery and Evaluation of Peptide Ligands for Selective Adsorption and Release of Cas9 Nuclease on Solid Substrates
BIOCONJUGATE CHEMISTRY, 30(12), 3057–3068.
MeSH headings : Adsorption; Amino Acid Sequence; Binding Sites; CRISPR-Associated Protein 9 / isolation & purification; CRISPR-Associated Protein 9 / metabolism; Drug Discovery; Ligands; Molecular Docking Simulation; Peptide Library; Peptides / metabolism; Resins, Synthetic / chemistry; Substrate Specificity
TL;DR:
This work represents the first effort at developing short synthetic Cas9-binding peptides and demonstrates their applicability as affinity ligands for the purification of a Cas nuclease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 13, 2020
2019 journal article
Stem-cell-ubiquitous genes spatiotemporally coordinate division through regulation of stem-cell-specific gene networks
NATURE COMMUNICATIONS, 10.
MeSH headings : Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis / growth & development; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Asymmetric Cell Division / genetics; Asymmetric Cell Division / physiology; Cell Differentiation; Cell Division; Gene Expression Regulation, Plant / genetics; Gene Regulatory Networks / genetics; Plant Roots / cytology; Plant Roots / genetics; Plant Roots / growth & development; Stem Cells / cytology; Stem Cells / metabolism; Transcription Factors / metabolism; Transcriptome; Ubiquitination / genetics; Ubiquitins / genetics
TL;DR:
In the Arabidopsis root, a stem-cell-ubiquitous gene, TESMIN-LIKE CXC2 (TCX2), controls stem cell division by regulating stem cell-type specific networks and orchestrates the coordinated division of different stem cell types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID
Added: December 30, 2019
2019 journal article
Molecular Dynamics Simulations of Kir2.2 and Cholesterol Reveal State- and Concentration-Dependent Binding Sites
Biophysical Journal, 116(3), 41a.
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Sources: Crossref, ORCID
Added: December 16, 2019
2019 journal article
One thousand plant transcriptomes and the phylogenomics of green plants
NATURE, 574(7780), 679-+.
Contributors: J. Leebens-Mack, M. Barker, E. Carpenter, M. Deyholos, M. Gitzendanner, S. Graham, I. Grosse, Z. Li
TL;DR:
It is found that large expansions of gene families preceded the origins of green plants, land plants and vascular plants, whereas whole-genome duplications are inferred to have occurred repeatedly throughout the evolution of flowering plants and ferns.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 18, 2019
2019 journal article
Characterizing the involvement of FaMADS9 in the regulation of strawberry fruit receptacle development
Plant Biotechnology Journal, 18(4), 929–943.
MeSH headings : Bayes Theorem; Fragaria / genetics; Fragaria / growth & development; Fruit / growth & development; Gene Expression Regulation, Plant; Gene Silencing; MADS Domain Proteins / genetics; Metabolome; Plant Proteins / genetics; Plants, Genetically Modified
TL;DR:
The inference of a gene regulatory network, based on a dynamic Bayesian approach, among the genes differentially expressed in the transgenic receptacles at the white and red stages, identified the genes KAN1, DIV, ZFN2 and GTE7 as putative targets of FaMADS9.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: November 11, 2019
2019 journal article
Relating nitrogen concentration and light intensity to the growth and lipid accumulation of Dunaliella viridis in a photobioreactor
Journal of Applied Phycology, 31(6), 3397–3409.
Contributors: Y. Lai n, A. Karam n, H. Sederoff n , J. Ducoste n & F. Reyes n
author keywords: Dunaliella viridis; Chlorophyta; Lipid; Light; Nitrogen; Photobioreactor
TL;DR:
The data show that D. viridis accumulates cellular carbohydrates as a primary carbon and energy storage product and then converts the cellular carbohydrates into cellular lipids as a secondary storage product when nitrogen is depleted, suggesting the possible use of real-time light data as a method for in situ quantification of biomass concentration and chlorophyll a concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: October 30, 2019
2019 journal article
Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana
MOLECULAR CELL, 76(1), 177-+.
MeSH headings : Arabidopsis / drug effects; Arabidopsis / genetics; Arabidopsis / metabolism; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cell Nucleus / metabolism; Cytoplasm / metabolism; Gene Expression Regulation, Plant; Indoleacetic Acids / pharmacology; Intrinsically Disordered Proteins / chemistry; Intrinsically Disordered Proteins / genetics; Intrinsically Disordered Proteins / metabolism; Plant Growth Regulators / pharmacology; Protein Binding; Protein Folding; Protein Interaction Domains and Motifs; Structure-Activity Relationship; Transcription Factors / chemistry; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
The data suggest a model in which ARF nucleo-cytoplasmic partitioning regulates auxin responsiveness, providing a mechanism for cellular competence for auxin signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 21, 2019
2019 journal article
Modular one-pot assembly of CRISPR arrays enables library generation and reveals factors influencing crRNA biogenesis
NATURE COMMUNICATIONS, 10.
MeSH headings : Base Sequence; CRISPR-Associated Proteins / metabolism; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; DNA / genetics; Endonucleases / metabolism; Gene Library; Genetic Techniques; HEK293 Cells; Humans; Nucleic Acid Conformation; Plasmids / metabolism; RNA / biosynthesis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Saccharomyces cerevisiae / metabolism
TL;DR:
A modular, one-pot scheme called CRATES to construct CRISPR arrays and array libraries that can facilitate diverse multiplexing applications and help identify factors impacting crRNA biogenesis is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 22, 2019
2019 journal article
Driving the Scalability of DNA-Based Information Storage Systems
ACS SYNTHETIC BIOLOGY, 8(6), 1241–1248.
author keywords: synthetic biology; DNA storage; information storage; nested architecture; file access; DNA sequencing
MeSH headings : DNA / chemistry; DNA / genetics; Databases, Nucleic Acid; High-Throughput Nucleotide Sequencing; Information Storage and Retrieval / methods; Sequence Analysis, DNA / methods; Synthetic Biology / methods
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 15, 2019
2019 journal article
Affordable Microfluidic Bead-Sorting Platform for Automated Selection of Porous Particles Functionalized with Bioactive Compounds
SCIENTIFIC REPORTS, 9(1).
MeSH headings : Combinatorial Chemistry Techniques / instrumentation; Humans; Image Processing, Computer-Assisted; Immunoglobulin G / chemistry; Lab-On-A-Chip Devices; Microfluidic Analytical Techniques / instrumentation; Peptide Library; Porosity; Proof of Concept Study; Unsupervised Machine Learning
TL;DR:
A low-cost microfluidics-based platform enabling automated screening of small porous beads from solid-phase peptide libraries with high sensitivity and specificity, to identify leads with high binding affinity for a biological target is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: May 28, 2019
2019 journal article
The Lateral Root Cap Acts as an Auxin Sink that Controls Meristem Size
CURRENT BIOLOGY, 29(7), 1199-+.
MeSH headings : Arabidopsis / growth & development; Arabidopsis / metabolism; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cytokinins / genetics; Cytokinins / metabolism; Indoleacetic Acids / metabolism; Meristem / growth & development; Meristem / metabolism; Plant Roots / growth & development; Plant Roots / metabolism
TL;DR:
Overall, the results indicate that the lateral root cap serves as an auxin sink that, under the control of cytokinin, regulates meristem size and root growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: April 15, 2019
2019 journal article
DOF2.1 Controls Cytokinin-Dependent Vascular Cell Proliferation Downstream of TMO5/LHW
CURRENT BIOLOGY, 29(3), 520-+.
MeSH headings : Arabidopsis / genetics; Arabidopsis / physiology; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Cambium / physiology; Cell Proliferation / genetics; Cytokinins / metabolism; Plant Roots / genetics; Plant Roots / growth & development; Trans-Activators / genetics; Trans-Activators / metabolism; Transcription Factors, General / genetics; Transcription Factors, General / metabolism; Xylem / physiology
TL;DR:
The results suggest that DOF2.1 and its closest homologs control vascular cell proliferation, thus leading to radial expansion of the root.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID
Added: February 18, 2019
2019 journal article
Mobile PEAR transcription factors integrate hormone and miRNA cues to prime cambial growth
Nature, 565(7740), 490–494.
MeSH headings : Arabidopsis / cytology; Arabidopsis / genetics; Arabidopsis / growth & development; Arabidopsis / metabolism; Arabidopsis Proteins / biosynthesis; Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cambium / cytology; Cambium / genetics; Cambium / growth & development; Cambium / metabolism; Cell Division / genetics; Cues; Cytokinins / metabolism; Gene Expression Regulation, Plant; Indoleacetic Acids / metabolism; MicroRNAs / genetics; MicroRNAs / metabolism; Phloem / cytology; Phloem / metabolism; Plant Growth Regulators / metabolism; Plant Roots / cytology; Plant Roots / genetics; Plant Roots / growth & development; Plant Roots / metabolism; Signal Transduction; Transcription Factors / biosynthesis; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic
TL;DR:
During root procambial development there exists a network in which a module that links PEAR and HD-ZIP III transcription factors integrates spatial information of the hormonal domains and miRNA gradients to provide adjacent zones of dividing and more-quiescent cells, which forms a foundation for further radial growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: February 8, 2019
2019 journal article
Computational prediction of gene regulatory networks in plant growth and development
Current Opinion in Plant Biology, 47, 96–105.
MeSH headings : Computational Biology / methods; Gene Regulatory Networks; Models, Genetic; Plant Development / genetics; Reproducibility of Results
TL;DR:
Computational frameworks integrating large-scale heterogeneous datasets are needed for a more accurate and comprehensive inference of gene regulatory networks, or GRNs, in the context of plant growth and development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Web Of Science, ORCID
Added: February 8, 2019
2019 journal article
Engineering Epigenetic Regulation Using Synthetic Read-Write Modules
CELL, 176(1-2), 227-+.
TL;DR:
This work established an orthogonal epigenetic regulatory system in mammalian cells using N6-methyladenine (m6A), a DNA modification not commonly found in metazoan epigenomes, and used this system and mathematical models to construct regulatory circuits that induce m6A-dependent transcriptional states, promote their spatial propagation, and maintain epigenetic memory of the states.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Source: Web Of Science
Added: January 28, 2019
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