Works Published in 1989
Displaying all 7 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
1989 journal article
Synthetic lipid second messenger, sn-1,2-didecanoylglycerol: A complete tumor promoter in mouse skin
Cancer Research, 49(16), 4455–4458.
Sources: NC State University Libraries, ORCID
Added: May 5, 2022
1989 journal article
Hepatic tumor-promoting chlorinated hydrocarbons stimulate protein kinase C activity
Carcinogenesis, 10(5), 851–856.
MeSH headings : Animals; Brain / enzymology; Calcium / pharmacology; Carcinogens; Chlordan / pharmacology; Female; Hydrocarbons, Fluorinated / pharmacology; Liver / enzymology; Liver Neoplasms / chemically induced; Mice; Protein Kinase C / metabolism; Skin / enzymology; Tetradecanoylphorbol Acetate / pharmacology
TL;DR:
It is demonstrated that a wide variety of chlorinated hydrocarbons, which are considered hepatic tumor promoters, stimulate protein kinase C activity in vitro and chlordane was the most potent organochlorine pesticide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: April 10, 2022
1989 journal article
Comparison of epidermal protein kinase C activity, ornithine decarboxylase induction and DNA synthesis stimulated by TPA or dioctanoylglycerol in mouse strains with differing susceptibility to TPA-induced tumor promotion
Carcinogenesis, 10(5), 833–838.
MeSH headings : Animals; Brain / drug effects; Brain / metabolism; DNA Replication / drug effects; Diglycerides / pharmacology; Enzyme Induction; Female; Glycerides / pharmacology; Kinetics; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Ornithine Decarboxylase / biosynthesis; Protein Kinase C / metabolism; Skin / drug effects; Skin / metabolism; Species Specificity; Tetradecanoylphorbol Acetate / pharmacology
TL;DR:
The level of epidermal PKC activity in CD-1, DBA/2 and C57BL/6 mice exhibit no strain differences when stimulated by TPA or DiC8 using lysine-rich histone as a phosphate acceptor substrate, and the resistant strain demonstrated a 'hyperinducibility' of epidersmal ODC activity by T PA or Di C8.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: April 9, 2022
1989 journal article
Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver. Pituitary control of hepatic NADPH cytochrome P-450 reductase
Molecular Pharmacology, 35(4), 519–525.
Source: NC State University Libraries
Added: November 16, 2021
1989 journal article
Interaction of Anticancer Drugs with Hepatic Monooxygenase Enzymes
Drug Metabolism Reviews, 20(2-4), 395–439.
MeSH headings : Animals; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biotransformation; Cytochrome P-450 Enzyme System / metabolism; Humans; Liver / drug effects; Liver / enzymology; Mixed Function Oxygenases / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020
1989 journal article
Female-Predominant Rat Hepatic P-450 Forms j (IIE1) and 3 (IIA1) Are under Hormonal Regulatory Controls Distinct from Those of the Sex-Specific P-450 Forms
Endocrinology, 124(6), 2954–2966.
MeSH headings : Aging; Animals; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Estrenes / pharmacology; Female; Growth Hormone / pharmacology; Hypophysectomy; Isoenzymes / genetics; Isoenzymes / metabolism; Liver / growth & development; Male; Metribolone; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Orchiectomy; Ovariectomy; Rats; Rats, Inbred F344; Rats, Inbred Strains; Reference Values; Sex Factors
TL;DR:
These studies demonstrate that these female-predominant hepatic P-450 enzymes are regulated by different mechanisms, and that both are under hormonal regulatory controls distinct from those that govern expression of the female-specific hepatic enzymes.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020
1989 journal article
Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone
Archives of Biochemistry and Biophysics, 271(2), 508–514.
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases; Chorionic Gonadotropin / pharmacology; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Estrenes / pharmacology; Gonadotropin-Releasing Hormone / pharmacology; Hypothalamus / drug effects; Hypothalamus / physiology; Liver / enzymology; Male; Metribolone; Microsomes, Liver / enzymology; Orchiectomy; Pituitary Gland / drug effects; Pituitary Gland / physiology; Polychlorinated Biphenyls / pharmacology; RNA, Messenger / metabolism; Rats; Rats, Inbred Strains; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases / metabolism; Testis / drug effects; Testis / physiology; Testosterone / blood
TL;DR:
The present study demonstrates that the consequential reduction in serum testosterone levels in HCB-treated rats is not causally related to the reduction in hepatic P450 2c levels, indicating that HCB must also act on some other regulatory mechanism involved in the expression of this protein.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020
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