2020 journal article

Clickable, acid labile immunosuppressive prodrugs for in vivo targeting

Biomaterials Science, 8(1), 266–277.

By: H. Wang *, M. Sobral*, T. Snyder, Y. Brudno* , V. Gorantla * & D. Mooney *

TL;DR: Dibenzocyclooctyne-modified prodrugs of the immunosuppressive drugs tacrolimus, rapamycin and mycophenolic acid are developed and targeted conjugation both in vitro and in vivo to azido-modified hydrogels via Click chemistry is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: July 8, 2023

Clickable immunosuppressive prodrugs enablein vivoreplenishment of drugs in biomaterial depots to maintain long-term immunosuppression in tissue/organ transplantation.