MeSH headings : Animals; Biocatalysis; DNA (Cytosine-5-)-Methyltransferases / genetics; DNA (Cytosine-5-)-Methyltransferases / metabolism; DNA Methylation; Embryonic Development / genetics; Female; Gene Expression Regulation, Developmental; HEK293 Cells; Hedgehog Proteins / genetics; Humans; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Signal Transduction / genetics; Wnt Proteins / genetics

TL;DR: It is shown that catalytically inactive Dnmt3b rescues a majority of methylation and expression changes in the absence of DnMT3b during mouse embryonic development and is linked to a control of major developmental pathways, including Wnt and hedgehog signaling. (via Semantic Scholar)