2005 journal article

RacGap50C Negatively Regulates Wingless Pathway Activity During Drosophila Embryonic Development

Genetics, 169(4), 2075–2086.

By: W. Jones* & A. Bejsovec*

MeSH headings : Alleles; Animals; Armadillo Domain Proteins; Axin Protein; Body Patterning; Crosses, Genetic; Drosophila Proteins / biosynthesis; Drosophila Proteins / chemistry; Drosophila Proteins / metabolism; Epidermis / embryology; Epidermis / metabolism; GTPase-Activating Proteins / chemistry; GTPase-Activating Proteins / metabolism; GTPase-Activating Proteins / physiology; Gene Expression Regulation, Developmental; Green Fluorescent Proteins / metabolism; In Situ Hybridization; Mutation; Phenotype; Protein Binding; Proto-Oncogene Proteins / biosynthesis; RNA / metabolism; Repressor Proteins / genetics; Signal Transduction; Trans-Activators / biosynthesis; Transgenes; Wings, Animal / embryology; Wnt1 Protein
TL;DR: Two mutant lines that modify wg-mediated epidermal patterning represent the first loss-of-function mutations in the RacGap50C gene, which suggests that the mutant embryos suffer from ectopic Wg pathway activation. (via Semantic Scholar)
Source: Crossref
Added: November 16, 2019

Abstract