2009 journal article
An Adjustable Triple-Bifurcation Unit Model for Air-Particle Flow Simulations in Human Tracheobronchial Airways
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 131(2).
author keywords: bifurcation; computational fluid dynamics; flow simulation; lung; nanoparticles; physiological models; pneumodynamics; turbulence
MeSH headings : Air; Bronchi / physiology; Computer Simulation; Humans; Lung / physiology; Models, Biological; Particle Size; Respiratory Mechanics; Trachea / physiology
TL;DR:
The present study revealed that turbulent air-particle flow may propagate to G5 for the assumed inhalation flow rate, and geometry and upstream effects are more pronounced for micron particle deposition than for nanoparticle deposition.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
A new methodology for a swift and accurate computer simulation of large segments of the human lung airways is presented. Focusing on a representative tracheobronchial (TB) region, i.e., G0–G15, nano- and micron particle transports have been simulated for Qin=30l∕min, employing an experimentally validated computer model. The TB tree was geometrically decomposed into triple-bifurcation units with kinematically adjusted multilevel outlet/inlet conditions. Deposition patterns and maximum concentrations differ greatly between nanoparticles (1⩽dp⩽150nm) and micron particles (1⩽dp⩽10μm), which may relate uniquely to health impacts. In comparison with semi-analytical particle deposition results, it is shown that such simple “lung models” cannot predict local deposition values but can match computer simulation results for the entire TB region within 2.5–26%. The present study revealed that turbulent air-particle flow may propagate to G5 for the assumed inhalation flow rate. Geometry and upstream effects are more pronounced for micron particle deposition than for nanoparticle deposition.
