Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior
Proceedings of the National Academy of Sciences, 112(27), E3555–E3563.
author keywords: Drosophila Genetic Reference Panel; genome-wide association mapping; extreme QTL mapping; advanced intercross population; epistasis
MeSH headings : Aggression; Animals; Crosses, Genetic; Drosophila Proteins / genetics; Drosophila Proteins / physiology; Drosophila melanogaster / classification; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Evolution, Molecular; Genes, Insect / genetics; Genes, Insect / physiology; Genetic Variation; Genome, Insect / genetics; Humans; Inbreeding; Mutation; RNA Interference; Species Specificity
TL;DR:
This work performed genome-wide association analyses using the inbred, sequenced lines of the Drosophila melanogaster Genetic Reference Panel and an advanced intercross population derived from the most and least aggressive DGRP lines to identify genes that have been previously implicated in aggressive behavior as well as many novel loci.
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