author keywords: C. difficile; toxin; bile acid; pathogenesis; structure

MeSH headings : Bacterial Toxins / chemistry; Bacterial Toxins / metabolism; Bile Acids and Salts / metabolism; Caco-2 Cells; Clostridioides difficile / growth & development; Clostridioides difficile / metabolism; Clostridium Infections / microbiology; HCT116 Cells; Humans; Intestines / physiology; Receptors, Cell Surface / metabolism

TL;DR: It is shown that intestinal bile acids, which are known to play a role in C. difficile germination and outgrowth, also directly bind and inhibit TcdB toxin, the primary virulence determinant of C. diffuse disease. (via Semantic Scholar)