Casey Michelle Theriot

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Foley, M. H., Walker, M. E., Stewart, A. K., O'Flaherty, S., Gentry, E. C., Patel, S., … Theriot, C. M. (2023, March 13). NATURE MICROBIOLOGY, Vol. 3.

Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120(19).

Bile acid distributions, sex-specificity, and prognosis in colorectal cancer

BIOLOGY OF SEX DIFFERENCES, 13(1).

Prolonged oral antimicrobial administration prevents doxorubicin-induced loss of active intestinal stem cells

GUT MICROBES, 14(1).

Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis

Pike, C. M., Tam, J., Melnyk, R. A., & Theriot, C. M. (2022, July 7). INFECTION AND IMMUNITY.

The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia

MSPHERE, 7(2).

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

NATURE COMMUNICATIONS, 12(1).

Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium

[Review of ]. MICROORGANISMS, 9(2).

Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(6).

Mechanisms of Colonization Resistance Against Clostridioides difficile

JOURNAL OF INFECTIOUS DISEASES, 223, S194–S200.

Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice

PLOS ONE, 16(2).

Clostridioides difficile carriage in animals and the associated changes in the host fecal microbiota

ANAEROBE, 66.

Diversification of host bile acids by members of the gut microbiota

[Review of ]. GUT MICROBES, 11(2), 158–171.

Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(12), 6792–6800.

Role of Microbiota-Derived Bile Acids in Enteric Infections

Theriot, C. M., & Petri, W. A., Jr. (2020, June 25). CELL, Vol. 181, pp. 1452–1454.

Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice

JOURNAL OF MEDICINAL CHEMISTRY, 63(13), 6898–6908.

Ursodeoxycholic Acid (UDCA) Mitigates the Host Inflammatory Response during Clostridioides difficile Infection by Altering Gut Bile Acids

INFECTION AND IMMUNITY, 88(6).

Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract

PLOS PATHOGENS, 15(3).

Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers

PLOS ONE, 14(10).

Human fecal metabolomic profiling could inform Clostridioides difficile infection diagnosis and treatment

Theriot, C. M., & Fletcher, J. R. (2019, September 3). JOURNAL OF CLINICAL INVESTIGATION, Vol. 129, pp. 3539–3541.

A Small Molecule-Screening Pipeline to Evaluate the Therapeutic Potential of 2-Aminoimidazole Molecules Against Clostridium difficile

FRONTIERS IN MICROBIOLOGY, 9.

Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics

MSYSTEMS, 3(2).

Dosing Regimen of Enrofloxacin Impacts Intestinal Pharmacokinetics and the Fecal Microbiota in Steers

Frontiers in Microbiology, 9.

MICROBIOME Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells

Science, 360(6391), 876-.

Restoration of short chain fatty acid and bile acid metabolism following fecal microbiota transplantation in patients with recurrent Clostridium difficile infection

Seekatz, A. M., Theriot, C. M., Rao, K., Chang, Y.-M., Freeman, A. E., Kao, J. Y., & Young, V. B. (2018, October). ANAEROBE, Vol. 53, pp. 64–73.

Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse Model

MSPHERE, 3(2).

The Lactobacillus Bile Salt Hydrolase Repertoire Reveals Niche-Specific Adaptation

MSPHERE, 3(3).

Inhibition of spore germination, growth, and toxin activity of clinically relevant C-difficile strains by gut microbiota derived secondary bile acids

Thanissery, R., Winston, J. A., & Theriot, C. M. (2017, June). ANAEROBE, Vol. 45, pp. 86–100.

Introduction to the special issue highlighting Anaerobe 2016

Cox, L. M., Theriot, C. M., & Fichorova, R. N. (2017, June). ANAEROBE, Vol. 45, pp. 1–2.

Mathematical Modeling of the Effects of Nutrient Competition and Bile Acid Metabolism by the Gut Microbiota on Colonization Resistance Against Clostridium difficile

In Association for Women in Mathematics Series (pp. 137–161).

Antibiotic-Induced Alterations of the Gut Microbiota Alter Secondary Bile Acid Production and Allow for Clostridium difficile Spore Germination and Outgrowth in the Large Intestine

MSphere, 1(1).

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (118).

Impact of microbial derived secondary bile acids on colonization resistance against Clostridium difficile in the gastrointestinal tract

ANAEROBE, 41, 44–50.

Metabolic Model-Based Integration of Microbiome Taxonomic and Metabolomic Profiles Elucidates Mechanistic Links between Ecological and Metabolic Variation

MSystems, 1(1).

Fecal Microbiota Transplantation Eliminates Clostridium difficile in a Murine Model of Relapsing Disease

Infection and Immunity, 83(10), 3838–3846.

Interactions Between the Gastrointestinal Microbiome and Clostridium difficile

Annual Review of Microbiology, 69(1), 445–461.

Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice

Immunology, 144(4), 587–597.

Alteration of the Murine Gastrointestinal Microbiota by Tigecycline Leads to Increased Susceptibility to Clostridium difficile Infection

Antimicrobial Agents and Chemotherapy, 58(5), 2767–2774.

Antibiotic-Associated Diarrhea

In Encyclopedia of Metagenomics (pp. 1–7).

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection

Nature Communications, 5(1).

Clostridium difficile-induced colitis in mice is independent of leukotrienes

Anaerobe, 30, 90–98.

Dynamics and Establishment of Clostridium difficile Infection in the Murine Gastrointestinal Tract

Infection and Immunity, 83(3), 934–941.

Effects of Tigecycline and Vancomycin Administration on Established Clostridium difficile Infection

Antimicrobial Agents and Chemotherapy, 59(3), 1596–1604.

Acute infection of mice with Clostridium difficile leads to eIF2α phosphorylation and pro-survival signalling as part of the mucosal inflammatory response

Immunology, 140(1), 111–122.

Microbial and metabolic interactions between the gastrointestinal tract and Clostridium difficile infection

Gut Microbes, 5(1), 86–95.

The Complete Campylobacter jejuni Transcriptome during Colonization of a Natural Host Determined by RNAseq

PLoS ONE, 8(8), e73586.

Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strains

Gut Microbes, 2(6), 326–334.

Improving the Catalytic Activity of Hyperthermophilic Pyrococcus horikoshii Prolidase for Detoxification of Organophosphorus Nerve Agents over a Broad Range of Temperatures

Archaea, 2011, 1–9.

The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection

Gut Microbes, 2(3), 145–158.

Hydrolysis of organophosphorus compounds by microbial enzymes

Applied Microbiology and Biotechnology, 89(1), 35–43.

Improving the catalytic activity of hyperthermophilic Pyrococcus prolidases for detoxification of organophosphorus nerve agents over a broad range of temperatures

Applied Microbiology and Biotechnology, 87(5), 1715–1726.

Characterization of two proline dipeptidases (prolidases) from the hyperthermophilic archaeon Pyrococcus horikoshii

Applied Microbiology and Biotechnology, 86(1), 177–188.

Erratum to: Characterization of two proline dipeptidases (prolidases) from the hyperthermophilic archaeon Pyrococcus horikoshii

Applied Microbiology and Biotechnology, 86(1), 393–393.

biotechnological applications of recombinant microbial prolidases

[Review of ]. Advances in applied microbiology, vol 68, 68, 99-.