2015 journal article
Directed Enzymatic Activation of 1-D DNA Tiles
ACS NANO, 9(2), 1072–1079.
author keywords: DNA self assembly; DNA Polymerase; DNA tile; directed assembly; sequential assembly
MeSH headings : DNA / chemistry; DNA-Directed DNA Polymerase / metabolism; Enzyme Activation; Nanostructures / chemistry; Nanotechnology / methods
TL;DR:
A simplified version of the Activatable tile assembly model is experimentally demonstrate the simultaneous assembly of protected DNA tiles and stepwise activated assembly where a set of inert tiles are activated sequentially one after another as a result of attachment to a growing 1-D assembly.
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3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
The tile assembly model is a Turing universal model of self-assembly where a set of square shaped tiles with programmable sticky sides undergo coordinated self-assembly to form arbitrary shapes, thereby computing arbitrary functions. Activatable tiles are a theoretical extension to the Tile assembly model that enhances its robustness by protecting the sticky sides of tiles until a tile is partially incorporated into a growing assembly. In this article, we experimentally demonstrate a simplified version of the Activatable tile assembly model. In particular, we demonstrate the simultaneous assembly of protected DNA tiles where a set of inert tiles are activated via a DNA polymerase to undergo linear assembly. We then demonstrate stepwise activated assembly where a set of inert tiles are activated sequentially one after another as a result of attachment to a growing 1-D assembly. We hope that these results will pave the way for more sophisticated demonstrations of activated assemblies.