2023 journal article

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Targeting Wnt/β-catenin signaling using XAV939 nanoparticles in tumor microenvironment-conditioned macrophages promote immunogenicity

Heliyon.

By: C. Pundkar ^*, F. Antony ^*, X. Kang ^*, A. Mishra ^*, R. Babu ^*, P. Chen ^*, F. Li ^*, A. Suryawanshi^* 

10.1016/j.heliyon.2023.e16688

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UN Sustainable Development Goal Categories

3. Good Health and Well-being (OpenAlex)

Source: ORCID

Added: July 21, 2024

The aberrant activation of Wnt/β-catenin signaling in tumor cells and immune cells in the tumor microenvironment (TME) promotes malignant transformation, metastasis, immune evasion, and resistance to cancer treatments. The increased Wnt ligand expression in TME activates β-catenin signaling in antigen (Ag)-presenting cells (APCs) and regulates anti-tumor immunity. Previously, we showed that activation of Wnt/β-catenin signaling in dendritic cells (DCs) promotes induction of regulatory T cell responses over anti-tumor CD4