2012 article
Phosphoinositide Signaling
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 63, Vol. 63, pp. 409–429.
author keywords: phosphatidylinositol; inositol lipids; plant; PIP modulin; flux; networking
MeSH headings : Cell Nucleus / metabolism; Humans; Light; Phosphatidylinositol Phosphates / metabolism; Phosphatidylinositols / biosynthesis; Phosphatidylinositols / metabolism; Phosphorylation; Plant Development / physiology; Signal Transduction / physiology
TL;DR:
In this review, the inositol family of negatively charged phospholipids and their functions as molecular sensors and regulators of metabolic flux in plants are discussed.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
All things flow and change…even in the stillest matter there is unseen flux and movement. Attributed to Heraclitus (530–470 BC) From The Story of Philosophy by Will Durant ( 28 ) Heraclitus, a Greek philosopher, was thinking on a much larger scale than molecular signaling; however, his visionary comments are an important reminder for those studying signaling today. Even in unstimulated cells, signaling pathways are in constant metabolic flux and provide basal signals that travel throughout the organism. In addition, negatively charged phospholipids, such as the polyphosphorylated inositol phospholipids, provide a circuit board of on/off switches for attracting or repelling proteins that define the membranes of the cell. This template of charged phospholipids is sensitive to discrete changes and metabolic fluxes—e.g., in pH and cations—which contribute to the oscillating signals in the cell. The inherent complexities of a constantly fluctuating system make understanding how plants integrate and process signals challenging. In this review we discuss one aspect of lipid signaling: the inositol family of negatively charged phospholipids and their functions as molecular sensors and regulators of metabolic flux in plants.