2023 article
Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia
Mercer, M. A., Davis, J. L., McKenzie, H. C., Messenger, K. M., Schaefer, E., Council-Troche, R. M. A., & Werre, S. R. (2023, February 24). JOURNAL OF VETERINARY INTERNAL MEDICINE.
author keywords: acetaminophen; fever; horse; pyrexia
MeSH headings : Horses; Animals; Acetaminophen / therapeutic use; Acetaminophen / pharmacology; Endotoxemia / drug therapy; Endotoxemia / veterinary; Cross-Over Studies; Chromatography, Liquid / veterinary; Tandem Mass Spectrometry / veterinary; Horse Diseases
TL;DR:
Acetaminophen is an option for antipyresis in clinical cases, particularly when administration of traditional NSAIDs is contraindicated, as reported by previous studies in healthy horses.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 13, 2023
AbstractBackgroundAcetaminophen has been evaluated in horses for treatment of musculoskeletal pain but not as an antipyretic.ObjectivesTo determine the pharmacokinetics and efficacy of acetaminophen compared to placebo and flunixin meglumine in adult horses with experimentally induced endotoxemia.AnimalsEight university owned research horses with experimentally induced endotoxemia.MethodsRandomized placebo controlled crossover study. Horses were treated with acetaminophen (30 mg/kg PO; APAP), flunixin meglumine (1.1 mg/kg, PO; FLU), and placebo (PO; PLAC) 2 hours after administration of LPS. Plasma APAP was analyzed via LC‐MS/MS. Serial CBC, lactate, serum amyloid A, heart rate and rectal temperature were evaluated. Serum IL‐1β, IL‐6, IL‐8, IL‐10, and TNF‐α were evaluated by an equine‐specific multiplex assay.ResultsMean maximum plasma APAP concentration was 13.97 ± 2.74 μg/mL within 0.6 ± 0.3 hour after administration. At 4 and 6 hours after treatment, both APAP (P = <.001, P = .03, respectively) and FLU (P = .0045 and P < .001, respectively) had a significantly greater decrease in rectal temperature compared to placebo. FLU caused greater heart rate reduction than APAP at 4 and 6 hours (P = .004 and P = .04), and PLAC at 4 hours (P = .05) after treatment.Conclusions and Clinical ImportanceThe pharmacokinetics of acetaminophen in endotoxemic horses differ from those reported by previous studies in healthy horses. Acetaminophen is an option for antipyresis in clinical cases, particularly when administration of traditional NSAIDs is contraindicated.