Works (1)

Updated: July 14th, 2023 21:16

2008 journal article

Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and-4 Receptors in a Helper T-H2 Cell Line


By: K. Comfort n & J. Haugh n

author keywords: Cytokine receptor; Lymphocyte; Clonal expansion; Kinetic analysis; STAT; Phosphatidylinositol 3-kinase
TL;DR: It is found that IL-4 partially inhibits IL-2 receptor-mediated pathways (PI3K/Akt, Ras/Erk, and STAT5a/b) and does not prolong their transient kinetics, but this mode of antagonism, but not the effects on cell proliferation, is overcome at higher concentrations ofIL-2 that are sufficient to saturate the signaling responses. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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