Works (1)
Updated: July 14th, 2023 21:16
2008 journal article
Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and-4 Receptors in a Helper T-H2 Cell Line
CELLULAR AND MOLECULAR BIOENGINEERING, 1(2-3), 163–172.
author keywords: Cytokine receptor; Lymphocyte; Clonal expansion; Kinetic analysis; STAT; Phosphatidylinositol 3-kinase
TL;DR:
It is found that IL-4 partially inhibits IL-2 receptor-mediated pathways (PI3K/Akt, Ras/Erk, and STAT5a/b) and does not prolong their transient kinetics, but this mode of antagonism, but not the effects on cell proliferation, is overcome at higher concentrations ofIL-2 that are sufficient to saturate the signaling responses.
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Added: August 6, 2018
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